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WO2020016926A1 - Composition non aqueuse pour cavité buccale - Google Patents

Composition non aqueuse pour cavité buccale Download PDF

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Publication number
WO2020016926A1
WO2020016926A1 PCT/JP2018/026699 JP2018026699W WO2020016926A1 WO 2020016926 A1 WO2020016926 A1 WO 2020016926A1 JP 2018026699 W JP2018026699 W JP 2018026699W WO 2020016926 A1 WO2020016926 A1 WO 2020016926A1
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WO
WIPO (PCT)
Prior art keywords
mass
oral composition
content
less
aqueous oral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2018/026699
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English (en)
Japanese (ja)
Inventor
直彦 井路端
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Zettoc Co Ltd
Original Assignee
Nippon Zettoc Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zettoc Co Ltd filed Critical Nippon Zettoc Co Ltd
Priority to JP2020530757A priority Critical patent/JP7075489B2/ja
Priority to CN201880092545.6A priority patent/CN112041030B/zh
Priority to PCT/JP2018/026699 priority patent/WO2020016926A1/fr
Publication of WO2020016926A1 publication Critical patent/WO2020016926A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a non-aqueous oral composition.
  • non-aqueous systems whose content is low even when they substantially do not contain water or contain water Oral compositions have been used.
  • the non-aqueous oral composition is compounded with a thickener such as hydroxypropylcellulose, carrageenan, and carnauba wax together with a relatively polar non-aqueous solvent other than water to ensure the properties and shape of the composition. .
  • an oral composition has been blended with a sodium alkylsulfate-based anionic surfactant such as sodium lauryl sulfate to enhance its detergency and foaming power (for example, Patent Documents 1 and 2). reference).
  • a sodium alkylsulfate-based anionic surfactant such as sodium lauryl sulfate to enhance its detergency and foaming power
  • sodium lauryl sulfate Although sodium lauryl sulfate has a high foaming power, it is highly irritating to the oral mucosa and gums. Further, the non-aqueous oral composition has a problem that even if the preparation itself does not substantially contain water or contains water, the content thereof is low, so that the stimulation of the oral mucosa of sodium lauryl sulfate is further increased. In addition, when a foaming agent that is less irritating to the oral mucosa is selected, there is a problem that a satisfactory foaming amount cannot be obtained with a non-aqueous oral composition.
  • An object of the present invention is to provide a non-aqueous oral composition which hardly undergoes solid-liquid separation or hardening during high-temperature storage, has high foaming power, and has low irritation to oral mucous membranes and gums.
  • the affinity between the non-aqueous solvent and hydroxypropylcellulose is increased, solid-liquid separation and hardening hardly occur even during high-temperature storage, and high foaming power, low irritation to oral mucosa and gums.
  • An aqueous oral composition can be provided.
  • Non-aqueous oral composition >>
  • an anionic surfactant of sodium alkylsulfate such as sodium lauryl sulfate
  • sodium lauryl sulfate has been blended into the oral composition as a foaming agent in order to enhance its detergency and foaming power.
  • the non-aqueous oral composition has a problem that it is highly irritating to the oral mucosa and gums.
  • the present inventors have found that in a non-aqueous oral composition, solid-liquid separation and hardening hardly occur during high-temperature storage, while suppressing irritation to the oral mucosa and gums, and exhibiting sufficient foaming power.
  • We conducted intensive research for the purpose As a result, by using the alkylolylalkyltaurine salt type anionic surfactant and the alkylamidopropylbetaine type amphoteric surfactant at a predetermined content, they act synergistically to cure or non-aqueous at high temperature storage.
  • Non-aqueous system with low irritation to oral mucous membrane and gums without separating the solvent and hydroxypropylcellulose and achieving foaming power comparable to that of using sodium lauryl sulfate, even if it does not contain sodium alkyl sulfate. It has been found that an oral composition can be provided.
  • the non-aqueous oral composition of the present invention is a non-aqueous oral composition containing hydroxypropylcellulose, selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol.
  • the content of at least one specific non-aqueous solvent is 30% by mass or more and 85% by mass or less
  • the content of the loylalkyltaurine salt type anionic surfactant is 0.1% by mass or more and 10% by mass or less
  • the content of the alkylamidopropylbetaine type amphoteric surfactant is 0.1% by mass or more and 10% by mass or less. It is characterized by being.
  • the above-described excellent effects can be obtained.
  • the amount of foam generated during use of the non-aqueous oral composition is moderately increased while suppressing the stability during storage at high temperatures and the irritation to the oral mucosa and gums, and the sustainability of the foam
  • foaming is less likely to occur, and the foam quality (elasticity of foam, fineness of texture, etc.) is improved, and the feeling of use of the non-aqueous oral composition becomes excellent.
  • the specific non-aqueous solvent is not contained or the content thereof is less than the lower limit even if the specific non-aqueous solvent is contained, the solid content (including those in a dissolved state) contained in the non-aqueous oral composition is not included. It becomes difficult to mix properly, and the feeling of use of the non-aqueous oral composition is significantly reduced.
  • the sum of the content of the specific non-aqueous solvent described above exceeds the upper limit, the content of other components is relatively reduced, and the foaming power (foaming during use of the non-aqueous oral composition) is reduced.
  • the amount, the persistence of the foam (the difficulty of dripping), the elasticity of the foam, the foam quality such as fineness of the texture, etc.) are remarkably reduced.
  • problems such as a remarkable decrease in foaming power and usability also occur.
  • foaming amount when using the non-aqueous oral composition foam persistence (difficulty of dripping), foam elasticity, foam quality such as fineness of texture, etc.) can be obtained. I can't.
  • the content of the alkylloylalkyl taurine salt type anionic surfactant exceeds the above upper limit, as in the case where the content is too low, sufficient foaming power (when using the non-aqueous oral composition, The foaming amount, foam persistence (difficulty of foam dripping), foam elasticity, and foam quality such as fineness of texture are not obtained.
  • the content is less than the lower limit even if it does not contain or contains an alkylamidopropyl betaine type amphoteric surfactant, even if it contains other foaming agents at a relatively high content, Sufficient foaming power (foaming amount when using the non-aqueous oral composition, foam continuity (difficulty of dripping), foam elasticity, foam quality such as fine texture) cannot be obtained. .
  • the content of the alkylamidopropyl betaine-type amphoteric surfactant exceeds the above upper limit, as in the case where the content is too small, sufficient foaming power (when using a non-aqueous oral composition, Foaming amount, foam persistence (difficulty of dripping), foam elasticity, foam quality such as fineness of texture, etc.) cannot be obtained.
  • the alkylloylalkyl taurine salt type anionic surfactant and the alkyl amidopropyl betaine type amphoteric surfactant are replaced with another surfactant, sufficient foaming power (non- When the aqueous oral composition is used, the amount of foam, the persistence of foam (the difficulty of dripping), the elasticity of foam, and the foam quality such as fineness of texture are not obtained.
  • the oral composition is a dentifrice, a liquid dentifrice, a dentifrice such as a lubricating dentifrice, a cream, an ointment, a patch, a mouthwash, a mouthwash, Refers to a composition applied in the oral cavity, such as chewing gum.
  • the non-aqueous oral composition refers to a water content of 0% by mass or more and 3% by mass or less based on the whole oral composition, and preferably 0% by mass or more and 1% by mass or less. , More preferably an oral composition substantially free of water (having a water content of 100 ppm or less).
  • the non-aqueous oral composition of the present invention contains hydroxypropylcellulose.
  • Hydroxypropylcellulose is a nonionic cellulose ether obtained by reacting cellulose with propylene oxide.
  • the viscosity is a value (mPa ⁇ s) measured using a rotational viscometer for a 2% by mass aqueous solution of each hydroxypropyl cellulose.
  • the hydroxypropyl cellulose constituting the non-aqueous oral composition of the present invention preferably has a viscosity determined as described above in the range of 150 mPa ⁇ s to 4000 mPa ⁇ s.
  • Hydroxypropylcellulose in a non-aqueous oral composition has the function of ensuring the properties and shape of the composition, improving the sustainability of foam generated during use, and making it less likely to cause dripping.
  • the content of hydroxypropylcellulose in the non-aqueous oral composition is not particularly limited, but is preferably from 0.1% by mass to 5.0% by mass, and more preferably from 0.3% by mass to 3.0% by mass.
  • the content is more preferably not more than 0.5% by mass and more preferably not more than 0.5% by mass and not more than 2.0% by mass.
  • the non-aqueous oral composition of the present invention contains a specific non-aqueous solvent (at least one selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol). Contains.
  • the specific non-aqueous solvent in the non-aqueous oral composition preferably mixes the solids in the non-aqueous oral composition to prevent the occurrence of non-uniform variation, and to reduce the viscosity of the non-aqueous oral composition. It exerts the function of suitably adjusting and contributes to improving the feeling of use of the non-aqueous oral composition.
  • the content of the specific non-aqueous solvent in the non-aqueous oral composition may be 30% by mass or more and 85% by mass or less, preferably 40% by mass or more and 80% by mass or less, and 50% by mass or more and 75% by mass or less. It is more preferably at most 60 mass%, more preferably at least 60 mass% and at most 70 mass%. Thereby, the above-described effects are more remarkably exhibited.
  • the specific non-aqueous solvent constituting the non-aqueous oral composition of the present invention may be at least one selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol.
  • the non-aqueous oral composition of the present invention preferably contains propylene glycol.
  • the non-aqueous oral composition of the present invention contains an alkylolylalkyltaurine salt type anionic surfactant.
  • Alkyloylalkyl taurine salt type anionic surfactant in the non-aqueous oral composition has a function of improving the foaming amount at the time of use of the non-aqueous oral composition, especially, alkylamidopropyl betaine type
  • the foaming power (foaming amount when using the non-aqueous oral composition, foam sustainability (difficulty of drooling), foam elasticity Properties, foam quality such as fineness of texture, etc.).
  • the content of the alkylloylalkyltaurine salt type anionic surfactant in the non-aqueous oral composition may be 0.1% by mass or more and 10% by mass or less, but is 0.3% by mass or more and 3.0% by mass. %, More preferably from 0.4% by mass to 2.0% by mass, and even more preferably from 0.5% by mass to 1.5% by mass. Thereby, the above-described effects are more remarkably exhibited.
  • alkyloylalkyltaurine salt type anionic surfactant examples include, for example, coconut oil fatty acid methyltaurine sodium (Nikko Chemicals), lauroylmethyltaurine sodium (Nikko Chemicals), myristoylmethyltaurine sodium (Nikko Chemicals), palmitoylmethyltaurine sodium (Nikko Chemicals) Nikko Chemicals) and sodium N-stearoyl-N-methyltaurine (Nikko Chemicals), among which sodium lauroylmethyltaurine is preferred.
  • the non-aqueous oral composition of the present invention contains an alkylamidopropylbetaine-type amphoteric surfactant.
  • the alkylamidopropyl betaine-type amphoteric surfactant has a function of improving the foaming amount when the non-aqueous oral composition is used.
  • Foaming power the amount of foaming when using the non-aqueous oral composition, the foam persistence (the difficulty of drooling), and the elasticity of foam by being contained at a predetermined content rate together with the ionic surfactant. Properties, foam quality such as fineness of texture, etc.).
  • the content of the alkylamidopropylbetaine-type amphoteric surfactant in the non-aqueous oral composition may be 0.1% by mass or more and 10% by mass or less, but 0.3% by mass or more and 3.0% by mass or less. Is preferably 0.4% by mass or more and 2.0% by mass or less, more preferably 0.5% by mass or more and 1.5% by mass or less. Thereby, the above-described effects are more remarkably exhibited.
  • alkylamidopropyl betaine type amphoteric surfactant examples include amidopropyl betaine laurate (NOF), cocamidopropyl betaine (Goldschmidt AG), palm kernel oil fatty acid amidopropyl betaine (NOF), and cocamidopropylhydroxysulfate Tine and the like can be mentioned, and among them, cocamidopropyl betaine is preferable.
  • the content of the alkylloylalkyltaurine salt type anionic surfactant is X1 [% by mass] and the content of the alkylamidopropyl betaine type amphoteric surfactant is X2 [% by mass] , 0.1 ⁇ X1 / X2 ⁇ 10, more preferably 0.2 ⁇ X1 / X2 ⁇ 5.0, and 0.4 ⁇ X1 / X2 ⁇ 3. More preferably, the relationship of 0 is satisfied.
  • the amount of foam generated at the time of using the non-aqueous oral composition, the persistence of the foam, and the foam quality are particularly excellent, and the feeling of use of the non-aqueous oral composition is further improved.
  • the sum (X1 + X2) of the content of the alkylloylalkyltaurine salt-type anionic surfactant and the content of the alkylamidopropylbetaine-type amphoteric surfactant in the nonaqueous oral composition is 0.6% by mass or more. It is preferably 6.0% by mass or less, more preferably 0.8% by mass or more and 4.0% by mass or less, even more preferably 1.0% by mass or more and 3.0% by mass or less.
  • the non-aqueous oral composition of the present invention may contain xanthan gum.
  • the content of xanthan gum in the nonaqueous oral composition is preferably from 0.1% by mass to 5.0% by mass, more preferably from 0.3% by mass to 3.0% by mass. , 0.5 mass% or more and 2.0 mass% or less. Thereby, the above-described effects are more remarkably exhibited.
  • the non-aqueous oral composition of the present invention may contain hydroxypropylmethylcellulose.
  • the content of hydroxypropylmethylcellulose in the non-aqueous oral composition is preferably from 0.1% by mass to 5.0% by mass, more preferably from 0.3% by mass to 3.0% by mass. More preferably, it is 0.5% by mass or more and 2.0% by mass or less. Thereby, the above-described effects are more remarkably exhibited.
  • the non-aqueous oral composition of the present invention may contain a component easily modified by water. Thereby, the effect of making the oral composition non-aqueous is more remarkably exhibited.
  • Components that are easily denatured by water include, for example, ⁇ -tricalcium phosphate ( ⁇ -TCP), fluorides, enzymes, antibacterial agents such as hinokitiol and triclosan, sodium chlorophyllin sodium, anti-oxidants such as lysozyme chloride and ⁇ -aminocaproic acid.
  • ⁇ -TCP ⁇ -tricalcium phosphate
  • fluorides e.g., fluorides, fluorides, enzymes, antibacterial agents such as hinokitiol and triclosan, sodium chlorophyllin sodium, anti-oxidants such as lysozyme chloride and ⁇ -aminocaproic acid.
  • inflammatory agents e.g., inflammatory agents, vitamins such as ascorbic acid and salts thereof, crude drugs, lactic acid bacteria, and the like, and one or more selected from these groups can be used.
  • ⁇ -Tricalcium phosphate has an extremely high remineralization promoting effect in the oral cavity, and is particularly effective for the prevention and restoration of caries.
  • ⁇ -TCP has the property of converting to an apatite compound in the presence of water, and its reaction is accelerated by the presence of fluoride or other calcium phosphate, causing a self-curing reaction. No stable formulation could be obtained in the oral compositions such as dentifrices.
  • fluoride examples include sodium fluoride, potassium fluoride, sodium monofluorophosphate, tin fluoride and the like.
  • Examples of the enzyme include lysozyme, mutanase, protease, amylase, dextranase, and the like, which have a lytic action and a proteolytic action. These enzymes have a property of being easily hydrolyzed in an oral composition containing water.
  • Hinokitiol is a compound known as a natural fungicide having strong antibacterial activity and a broad antibacterial spectrum
  • ⁇ -aminocaproic acid is a compound having an antiplasmin effect, a hemostatic effect, and an anti-inflammatory effect.
  • Ascorbic acid and its salts are known to be effective in preventing gingivitis, alveolar pyorrhea, etc. in addition to functioning as an antioxidant, but the decomposition reaction proceeds easily in the presence of water, Deterioration and discoloration occur.
  • ascorbic acid salts include sodium ascorbate, potassium ascorbate, calcium ascorbate, magnesium ascorbate and the like.
  • the non-aqueous oral composition of the present invention may contain components other than those described above.
  • Such components include abrasives, wetting agents other than those described above, solvents, binders other than those described above, fragrances, cleaning agents, sweeteners, pH adjusters, preservatives, and solubilizers. And foaming agents, lubricants, oils, coloring agents, chelating agents, humectants, antibacterial agents, anti-inflammatory agents, vitamins, crude drugs and the like other than those described above.
  • cleaning agent examples include silica-based abrasives such as silica gel, precipitated silica, hydrated silicic acid, silicic anhydride, aluminosilicate and zirconosilicate; dibasic calcium phosphate dihydrate and dibasic calcium phosphate anhydrate.
  • silica-based abrasives such as silica gel, precipitated silica, hydrated silicic acid, silicic anhydride, aluminosilicate and zirconosilicate; dibasic calcium phosphate dihydrate and dibasic calcium phosphate anhydrate.
  • Calcium hydrogen phosphate for dentifrice calcium carbonate such as light calcium carbonate and heavy calcium carbonate; calcium phosphate, dibasic calcium phosphate, tribasic magnesium phosphate, insoluble sodium metaphosphate, calcium pyrophosphate, aluminum hydroxide, aluminum oxide, magnesium carbonate, Examples include zirconium silicate, titanium dioxide, synthetic resin-based abrasives, alumina, zeolite, and the like, and one or more selected from these can be used in combination.
  • humectant other than the above for example, one or more selected from saccharides such as sorbitol, ethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, erythritol, mannitol, palatinose, trehalose, and other rare sugars They can be used in combination.
  • saccharides such as sorbitol, ethylene glycol, polypropylene glycol, xylitol, maltitol, lactitol, erythritol, mannitol, palatinose, trehalose, and other rare sugars They can be used in combination.
  • Examples of the solvent include ethanol, propyl alcohol, and isopropyl alcohol.
  • binders include, for example, carboxymethylcellulose, sodium carboxymethylcellulose, hydroxyethylcellulose, and salts and derivatives thereof; alginic acid, salts and derivatives thereof, gums such as carrageenan, and the like; synthesis of polyvinyl alcohol, sodium polyacrylate, and the like. Binders and the like can be mentioned, and one or more selected from these can be used in combination.
  • flavors include l-menthol, l-carvone, cinamic aldehyde, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol , Pinene, spiranthol, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol, ethyl maltol, gamma / delta decalactone, Gamma / Deltown decalactone, N-ethyl-p-menthan-3-carboxamide, menthyl lactate
  • sweetener for example, aspartame, saccharin sodium, acesulfame potassium, stevia and the like can be mentioned, and one or more selected from these can be used in combination.
  • pH adjuster examples include, for example, citric acid, phosphoric acid, malic acid, and a chemically possible salt thereof such as disodium hydrogen phosphate, sodium hydroxide, and the like. One or more selected from these can be used in combination so as to fall within the range.
  • preservatives include paraoxybenzoic acid esters, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, phenoxyethanol, alkyldiaminoethyl glycine hydrochloride, and one or more selected from these. Two or more can be used in combination.
  • solubilizer examples include sucrose fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and polyoxyethylene hardened castor.
  • solubilizer examples include sucrose fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and polyoxyethylene hardened castor.
  • examples thereof include oil and soybean phospholipid, and one or more selected from these can be used in combination.
  • foaming agents other than those described above include N-acyl amino acid salts such as sodium lauroyl sarcosine, sodium alkyl sulfosuccinate, sodium coconut fatty acid monoglycerin sulfonate, sodium ⁇ -olefin sulfonate, N-acyl glutamate, and 2-alkyl.
  • N-acyl amino acid salts such as sodium lauroyl sarcosine, sodium alkyl sulfosuccinate, sodium coconut fatty acid monoglycerin sulfonate, sodium ⁇ -olefin sulfonate, N-acyl glutamate, and 2-alkyl.
  • non-aqueous oral composition of the present invention does not exclude that it contains a small amount (for example, 0.1% by mass or less) of sodium lauryl sulfate, but it does not contain sodium lauryl sulfate. preferable.
  • lubricant for example, magnesium stearate, sucrose fatty acid ester, talc, hydrogenated oil and the like can be mentioned, and one or two or more selected from these can be used.
  • oils examples include coconut oil, olive oil, sesame oil, peanut oil, parsley oil, parsley seed oil, safflower oil and the like, and one or more selected from these can be used in combination.
  • colorant examples include tar dyes such as Blue No. 1, pigments such as titanium dioxide, various dyes, and the like, and one or two or more selected from these can be used.
  • humectant examples include amino acids or salts thereof, pyrrolidone carboxylic acid, mucin, hyaluronic acid or salts thereof, mucopolysaccharides such as chondroitin sulfate, sodium lactate, urea, panthenol, aloe extract, rosemary extract, thyme extract,
  • natural extract components such as tea extract (cha dry distillation extract) and so-called extracellular matrices such as collagen and elastin, and one or more selected from these can be used in combination.
  • antibacterial agent examples include phenol-based antibacterial agents such as isopropylmethylphenol, triclosan and thymol; cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, decalinium chloride, chlorhexidine hydrochloride, sodium chlorhexidine gluconate, bisabolol chlorhexidine, Lactoferrin and the like can be mentioned, and one or more selected from these can be used in combination.
  • phenol-based antibacterial agents such as isopropylmethylphenol, triclosan and thymol
  • cetylpyridinium chloride cetylpyridinium chloride
  • benzalkonium chloride benzethonium chloride
  • decalinium chloride chlorhexidine hydrochloride
  • sodium chlorhexidine gluconate sodium chlorhexidine gluconate
  • bisabolol chlorhexidine lactoferrin and the like
  • anti-inflammatory agent examples include lysozyme chloride, ⁇ -aminocaproic acid, aluminum hydroxyl allantoin, glycyrrhetinic acid, glycyrrhizinates, guaiazulene sulfonic acid, dl- ⁇ -tocopherol acetate, and the like. Species or a combination of two or more can be used.
  • vitamins examples include vitamin A such as retinoic acid and ⁇ -carotene, pantothenic acid or salts thereof, vitamin B such as niacin and biotin, vitamin E such as ⁇ -tocopherol, and folic acid. Or a combination of two or more selected from the following.
  • crude drugs for example, gougon, kikyo, jiou, chamomile, valerian, jujube, hop, lamenda, linden, karin, kinginka, kumazasa, gummy, clove, densitin ginseng, salvia, mukuroji, keihi, bukuro, peonies, hawk, Tea, vulture, psyllium, birch, carrot, sensyaku, turmeric, rosemary and the like can be mentioned, and one or more kinds selected from these can be used in combination.
  • the oral composition may contain the crude drug as described above, for example, by directly pulverizing a plant in a dry state, or water. Extracts extracted using an extraction solvent such as a solvent or an organic solvent, or an extraction medium such as a supercritical fluid, or a component contained as a component (extract) obtained by removing the extraction medium from the extract.
  • an extraction solvent such as a solvent or an organic solvent
  • an extraction medium such as a supercritical fluid
  • ⁇ 1 Production of non-aqueous oral composition
  • the non-aqueous oral composition according to each of Examples and Comparative Examples was produced as follows.
  • Example 1 First, at room temperature (23 ° C.), hydroxypropyl cellulose, propylene glycol as a specific non-aqueous solvent, sodium lauroylmethyltaurine as an alkyloylalkyltaurine salt type anionic surfactant, and alkylamidopropyl betaine type amphoteric surfactant was mixed in a predetermined ratio to prepare a base for a non-aqueous oral composition.
  • the nonaqueous oral composition base and ascorbic acid were mixed at a predetermined ratio, and the toothpaste as a nonaqueous oral composition having the composition shown in Table 1 was obtained. Agent was obtained.
  • Examples 2 to 19 Except that the compositions shown in Tables 1 and 2 were obtained by adjusting the types and proportions of the components used in the production of the nonaqueous oral composition base and the nonaqueous oral composition (dentifrice). Produced a toothpaste as a non-aqueous oral composition in the same manner as in Example 1.
  • Tables 1 and 2 show the compositions of the non-aqueous oral compositions according to the above Examples and Comparative Examples.
  • the unit of the content of each component is mass%.
  • the water content of the nonaqueous oral composition (toothpaste) of each of the above Examples and Comparative Examples was 100 ppm or less.
  • ⁇ 2-1 Difficulty of effervescence
  • 2 points effervescence
  • 1 point when foaming was easy: 0 points were scored, the average value of the points of 10 subjects was obtained, and the evaluation was made according to the following criteria.
  • A The average value of points is 1.8 points or more.
  • B The average value of the points is 1.4 or more and less than 1.8 points.
  • C The average value of the points is 1.0 point or more and less than 1.4 points.
  • D The average value of the points is 0.6 points or more and less than 1.0 points.
  • E Average point value is less than 0.6 point.
  • ⁇ 2-2 Foaming Amount: After brushing for 1 minute, the foam in the oral cavity was discharged into a test tube. Immediately after that, the foaming amount was measured, and the average value of 10 persons was obtained and evaluated according to the following criteria.
  • A The average value of the foam amount is 20 mL or more.
  • B The average value of the foam amount is 17 mL or more and less than 20 mL.
  • C The average value of the foam amount is 14 mL or more and less than 17 mL.
  • D The average value of the foam amount is 11 mL or more and less than 14 mL.
  • E The average value of the foam amount is less than 11 mL.
  • ⁇ 2-3 Foam quality evaluation
  • ⁇ 2-3-1 Foam elasticity
  • A The average value of points is 1.8 points or more.
  • B The average value of the points is 1.4 or more and less than 1.8 points.
  • C The average value of the points is 1.0 point or more and less than 1.4 points.
  • D The average value of the points is 0.6 points or more and less than 1.0 points.
  • E Average point value is less than 0.6 point.
  • A The average value of points is 1.8 points or more.
  • B The average value of the points is 1.4 or more and less than 1.8 points.
  • C The average value of the points is 1.0 point or more and less than 1.4 points.
  • D The average value of the points is 0.6 points or more and less than 1.0 points.
  • E Average point value is less than 0.6 point.
  • ⁇ 2-4 Irritability Regarding the irritancy to the oral mucosa and gums during brushing, each subject felt that the stimulation was weak: 2 points, and when they felt moderate stimulation: 1 point, the stimulation When feeling strong: the subject was scored at 0 points, the average value of the points of 10 subjects was obtained, and the evaluation was made according to the following criteria.
  • A The average value of points is 1.8 points or more.
  • B The average value of the points is 1.4 or more and less than 1.8 points.
  • C The average value of the points is 1.0 point or more and less than 1.4 points.
  • D The average value of the points is 0.6 points or more and less than 1.0 points.
  • E Average point value is less than 0.6 point.
  • ⁇ 2-5 Stability
  • the non-aqueous oral composition according to each of the above Examples and Comparative Examples was stored in a thermostat at 60 ° C. for 3 weeks, and properties were determined according to the following criteria.
  • the non-aqueous oral composition of the present invention is a non-aqueous oral composition containing hydroxypropylcellulose, and is selected from the group consisting of glycerin, diglycerin, propylene glycol, 1,3-butylene glycol and polyethylene glycol.
  • the content of at least one specific non-aqueous solvent is 30% by mass or more and 85% by mass or less, and the content of the alkyloylalkyltaurine salt type anionic surfactant is 0.1% by mass or more and 10% by mass or less.
  • the content of the alkyl amidopropyl betaine type amphoteric surfactant is 0.1% by mass or more and 10% by mass or less.
  • the affinity between the non-aqueous solvent and hydroxypropylcellulose during storage at high temperatures is increased, solid-liquid separation and hardening are unlikely to occur, and the foaming power is high, the irritation to the oral mucosa and gums is low, and the composition for non-aqueous oral cavity is used. Things can be provided. Therefore, the non-aqueous oral composition of the present invention has industrial applicability.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

Cette composition non aqueuse pour la cavité buccale selon la présente invention contient de l'hydroxypropylcellulose, et est caractérisée en ce que le taux de teneur d'un solvant non aqueux spécifique qui est au moins un choisi dans le groupe constitué par la glycérine, la diglycérine, le propylène glycol, le 1,3-butylène glycol et le polyéthylène glycol est de 30 à 85 % en masse, le taux de teneur d'un tensioactif cationique à base de sel d'alkylolyalkyltaurine est de 0,1 à 10 % en masse, et le taux de teneur d'un tensioactif amphotère d'alkylamidepropylbétaïne est de 0,1 à 10 % en masse.
PCT/JP2018/026699 2018-07-17 2018-07-17 Composition non aqueuse pour cavité buccale Ceased WO2020016926A1 (fr)

Priority Applications (3)

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JP2020530757A JP7075489B2 (ja) 2018-07-17 2018-07-17 非水系口腔用組成物
CN201880092545.6A CN112041030B (zh) 2018-07-17 2018-07-17 非水性口腔护理组合物
PCT/JP2018/026699 WO2020016926A1 (fr) 2018-07-17 2018-07-17 Composition non aqueuse pour cavité buccale

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PCT/JP2018/026699 WO2020016926A1 (fr) 2018-07-17 2018-07-17 Composition non aqueuse pour cavité buccale

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WO2020016926A1 true WO2020016926A1 (fr) 2020-01-23

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WO2023063269A1 (fr) * 2021-10-11 2023-04-20 ライオン株式会社 Composition non aqueuse pour la cavité buccale

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JPH0338516A (ja) * 1989-07-05 1991-02-19 Shiseido Co Ltd 口腔用組成物
WO2004041229A1 (fr) * 2002-11-07 2004-05-21 Nippon Zettoc Co.,Ltd. Base pour composition orale et composition orale
JP2006282550A (ja) * 2005-03-31 2006-10-19 Lion Corp 歯牙美白用セット
WO2007066497A1 (fr) * 2005-12-09 2007-06-14 Lion Corporation Composition de dentifrice
JP2014521707A (ja) * 2011-08-09 2014-08-28 グラクソ グループ リミテッド 新規組成物

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CN102365077B (zh) * 2009-03-30 2013-10-16 狮王株式会社 口腔用组合物
WO2016112208A2 (fr) * 2015-01-09 2016-07-14 Kineta One, Llp Applications topiques de peptides bloquant les canaux kv1.3 pour traiter l'inflammation de la peau
JP6589218B2 (ja) * 2015-09-14 2019-10-16 株式会社アイ・ティー・オー アンチプロオキシダント・グリセリルオクチルアスコルビン酸誘導体その製法及び用途

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JPH0338516A (ja) * 1989-07-05 1991-02-19 Shiseido Co Ltd 口腔用組成物
WO2004041229A1 (fr) * 2002-11-07 2004-05-21 Nippon Zettoc Co.,Ltd. Base pour composition orale et composition orale
JP2006282550A (ja) * 2005-03-31 2006-10-19 Lion Corp 歯牙美白用セット
WO2007066497A1 (fr) * 2005-12-09 2007-06-14 Lion Corporation Composition de dentifrice
JP2014521707A (ja) * 2011-08-09 2014-08-28 グラクソ グループ リミテッド 新規組成物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023063269A1 (fr) * 2021-10-11 2023-04-20 ライオン株式会社 Composition non aqueuse pour la cavité buccale
JP2023057209A (ja) * 2021-10-11 2023-04-21 ライオン株式会社 非水系口腔用組成物
JP7731755B2 (ja) 2021-10-11 2025-09-01 ライオン株式会社 非水系口腔用組成物

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CN112041030B (zh) 2023-08-15

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