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WO2020001918A1 - Procédé d'électroformage d'une aiguille creuse pourvue d'un trou latéral - Google Patents

Procédé d'électroformage d'une aiguille creuse pourvue d'un trou latéral Download PDF

Info

Publication number
WO2020001918A1
WO2020001918A1 PCT/EP2019/064137 EP2019064137W WO2020001918A1 WO 2020001918 A1 WO2020001918 A1 WO 2020001918A1 EP 2019064137 W EP2019064137 W EP 2019064137W WO 2020001918 A1 WO2020001918 A1 WO 2020001918A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
mould
hole
forming surface
undercut
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2019/064137
Other languages
English (en)
Inventor
Jacqueline TROSBORG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of WO2020001918A1 publication Critical patent/WO2020001918A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D1/00—Electroforming
    • C25D1/02—Tubes; Rings; Hollow bodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D1/00—Electroforming
    • C25D1/10—Moulds; Masks; Masterforms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles

Definitions

  • the present invention relates to a method of manufacturing a needle mould with a metal seed layer, wherein the needle mould is adapted for electroforming a hollow needle with a side-hole.
  • the invention further relates to a needle mould with a metal seed layer for electroforming a hollow needle with a side-hole.
  • the invention further relates to a meth od of using the mould for electroforming a hollow needle with a side-hole, and an electro- formed hollow needle with a side-hole obtained by the method.
  • a needle mould with a metal seed layer wherein the needle mould is adapted for electroforming a hollow needle with a side-hole
  • the needle mould comprises a plain upper surface with a recess, wherein the recess defines an opening, a bottom, and wherein the recess further defines a central axial axis (x) being parallel to a normal vector of the upper surface, wherein the central axial axis (x) defines a positive axial direction from the bottom towards the open ing and a radial axis (r) normal to the axial axis (x), and wherein the recess is adapted to be radially extendable, and wherein the recess comprises:
  • the extending the radially extendable mould com prises separating a first mould portion from a second mould portion along a separation line and moving the two mould portions away from each other and in the radial direction.
  • the method further comprises lubricating the depos ited metal seed layer, and thereby providing a lubrication layer.
  • the protrusion 114 forms a radially ex tending undercut 116, and the undercut forms a surface providing at least a portion of the side-hole forming surface (110) .
  • the side-hole forming surface 110 defines a side- hole forming position 112 of the needle forming surface 106.
  • the radial extension of the radially extendable recess at the side-hole forming position defines a first radial length 126, wherein the undercut de fines a second radial length 128 being smaller than the first length, whereby the needle mould is adapted to release the formed hollow needle.
  • the recess 104 is adapted to be radially extendable, and the recess 104 comprises side surfaces 105 extending from the opeining 102 to the bottom 103 and providing a needle forming surface 106 for forming the outer surface 174 of the hollow needle 170 with a side-hole 172.
  • the needle forming surface 106 comprises a side-hole forming structure 108 comprising a protrusion 114 protruding towards the central axis.
  • the protrusion is adapted to shield a side-hole forming surface 110 against deposition of the metal seed layer 150, and the protrusion (114) forms a radially extending undercut (116).

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne un procédé d'électroformage d'une aiguille creuse pourvue d'un trou latéral, le procédé consistant à utiliser un moule d'aiguille radialement extensible (100) présentant une structure de formation de trou latéral en saillie (108) et une couche de germe métallique (150), la couche de germe métallique étant déposée sur une surface de formation d'aiguille (106) à l'exception d'une surface de formation de trou latéral (110) au niveau de la position de formation de trou latéral. Le procédé comprend en outre l'électroformage d'un métal et la réalisation d'une couche d'aiguille métallique électroformée (160) sur la couche de germe métallique déposée (150), la couche d'aiguille métallique électroformée (160) fournissant une structure de paroi de couche d'aiguille (162) entourant une lumière interne (164) et un trou latéral (166) étant ainsi formé dans la structure de paroi (162) au niveau d'une position de formation de trou latéral. Le procédé comprend en outre l'extension du moule d'aiguille radialement extensible (100) et ainsi la libération de la couche d'aiguille métallique électroformée (160) du moule d'aiguille (100), la couche d'aiguille métallique électroformée (160) comprenant une partie de corps (176), la partie de corps (176) étant une partie de corps de l'aiguille creuse (170) pourvue du trou latéral (172).
PCT/EP2019/064137 2018-06-27 2019-05-30 Procédé d'électroformage d'une aiguille creuse pourvue d'un trou latéral Ceased WO2020001918A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18180062.4 2018-06-27
EP18180062 2018-06-27

Publications (1)

Publication Number Publication Date
WO2020001918A1 true WO2020001918A1 (fr) 2020-01-02

Family

ID=62814832

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2019/064137 Ceased WO2020001918A1 (fr) 2018-06-27 2019-05-30 Procédé d'électroformage d'une aiguille creuse pourvue d'un trou latéral

Country Status (1)

Country Link
WO (1) WO2020001918A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021261554A1 (fr) * 2020-06-24 2021-12-30 テルモ株式会社 Aiguille de ponction médicale et procédé de fabrication d'aiguille de ponction médicale
WO2023020873A1 (fr) * 2021-08-20 2023-02-23 IQS Group s.r.o. Micro-aiguilles et leur procédé de fabrication

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005087305A1 (fr) 2004-03-12 2005-09-22 Agency For Science, Technology And Research Procedes et moules s'utilisant dans la fabrication de micro-aiguilles a orifice lateral
US20060202385A1 (en) * 2003-11-10 2006-09-14 Agency For Science Technology And Research Microneedles and microneedle fabrication
US20090093775A1 (en) * 2007-10-03 2009-04-09 Raju Remesh S O Govinda Microstructures
US20180085533A1 (en) * 2015-04-01 2018-03-29 Novo Nordisk A/S Electroformed Needle Cannula

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060202385A1 (en) * 2003-11-10 2006-09-14 Agency For Science Technology And Research Microneedles and microneedle fabrication
WO2005087305A1 (fr) 2004-03-12 2005-09-22 Agency For Science, Technology And Research Procedes et moules s'utilisant dans la fabrication de micro-aiguilles a orifice lateral
US20100305516A1 (en) * 2004-03-12 2010-12-02 Yuan Xu Methods and moulds for use in fabricating side-ported microneedles
US20090093775A1 (en) * 2007-10-03 2009-04-09 Raju Remesh S O Govinda Microstructures
US20180085533A1 (en) * 2015-04-01 2018-03-29 Novo Nordisk A/S Electroformed Needle Cannula

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHANDRASEKARPUSHPAVANAM: "Pulse and pulse reverse plating-Conceptual, advantages and applications", ELECTROCHIMICA ACTA, vol. 53, 2008, pages 3313 - 3322, XP022452641, DOI: doi:10.1016/j.electacta.2007.11.054

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021261554A1 (fr) * 2020-06-24 2021-12-30 テルモ株式会社 Aiguille de ponction médicale et procédé de fabrication d'aiguille de ponction médicale
JPWO2021261554A1 (fr) * 2020-06-24 2021-12-30
JP7591571B2 (ja) 2020-06-24 2024-11-28 テルモ株式会社 医療用穿刺針及び医療用穿刺針の製造方法
WO2023020873A1 (fr) * 2021-08-20 2023-02-23 IQS Group s.r.o. Micro-aiguilles et leur procédé de fabrication
GB2611282A (en) * 2021-08-20 2023-04-05 Iqs Group S R O Microneedles and method for their manufacture

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