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WO2020073966A1 - Lubrifiant soluble dans l'eau, son procédé de préparation et son utilisation - Google Patents

Lubrifiant soluble dans l'eau, son procédé de préparation et son utilisation Download PDF

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Publication number
WO2020073966A1
WO2020073966A1 PCT/CN2019/110433 CN2019110433W WO2020073966A1 WO 2020073966 A1 WO2020073966 A1 WO 2020073966A1 CN 2019110433 W CN2019110433 W CN 2019110433W WO 2020073966 A1 WO2020073966 A1 WO 2020073966A1
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Prior art keywords
water
lubricating fluid
soluble
lubricant
hyaluronate
Prior art date
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Ceased
Application number
PCT/CN2019/110433
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English (en)
Chinese (zh)
Inventor
范馨仪
王玉玲
毛华
张晓鸥
王海英
李德杰
郭文逸
耿凤
郭学平
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bloomage Biotech Co Ltd
Shandong Bloomage Hyinc Biopharm Co Ltd
Original Assignee
Bloomage Biotech Co Ltd
Shandong Bloomage Hyinc Biopharm Co Ltd
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Publication of WO2020073966A1 publication Critical patent/WO2020073966A1/fr
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Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/452—Lubricants

Definitions

  • the invention relates to a lubricating fluid, in particular to a water-soluble lubricating fluid and a preparation method thereof, which belong to the technical field of lubricants.
  • the patent CN201610660504.5 discloses a water-soluble condom lubricating fluid, which is composed of glycerin, sodium hyaluronate, sodium citrate, methyl proline, and water.
  • the lubricating fluid passed the accelerated aging test (placed in a 70 °C stability test box for 7 days) in the "Natural Latex Condom Technical Requirements and Experimental Methods" test, which caused the natural latex condom to whitish and swell;
  • the pH of the lubricating fluid is 7-9, which is alkaline, will increase the pH of the female vagina, and easily cause vaginal pH destruction.
  • the lubricating fluid also includes preservative ingredients.
  • preservatives will cause allergic and inflammatory effects on the female reproductive system. Therefore, it is urgent to develop a water-soluble condom lubricating fluid with good compatibility with natural latex, good infiltration, and high safety.
  • the present invention provides a water-soluble lubricating fluid, which does not contain preservatives, and improves the lubricating fluid and condom through the selection of various components, especially the selection of compatibility promoting additives Compatibility, stability, infiltration, and safety avoid whitening and swelling of the condom, ensure the quality and safety of the condom, and improve the user's experience.
  • the invention also provides a preparation method of the above-mentioned water-soluble lubricating liquid.
  • the method is simple in process, easy to operate, and convenient for industrial application.
  • a water-soluble lubricating fluid includes the following active ingredients in the following mass percentages: compound polyol 10-30%, hyaluronic acid salt 0.05-1%, compatibility promoting aid 3-15%, water make up 100 %.
  • the water-soluble lubricating fluid preferably includes the following mass percentages of active ingredients: compound polyol 15-25%, hyaluronate 0.3-0.8%, compatibility promoting aid 5-12%, water make up 100% .
  • the effective component of the water-soluble lubricating fluid may further include a pH-adjusting agent, and the amount of the pH-adjusting agent is used to maintain the pH of the water-soluble lubricating fluid at 5.5-6.5.
  • the pH adjusting agent can select components commonly used in the art, such as sodium citrate, lactic acid, etc. The selection of this component has little effect on the performance of the lubricating fluid.
  • the water-soluble lubricating fluid does not contain a preservative component, which reduces the adverse reactions to the human body when used.
  • the compound polyol is any two or more of propylene glycol, glycerin, polyethylene glycol and butylene glycol, preferably a mixture of glycerin, propylene glycol and butylene glycol.
  • the compound polyol not only plays a lubricating role, but also has a certain antiseptic effect. Therefore, without the addition of preservatives, the lubricating fluid can still meet the requirements of the microbiological content standard in the "Single Use Hygiene Products Specification".
  • the weight average molecular weight of the hyaluronate salt ranges from 1.3 million to 1.8 million, preferably from 1.5 to 1.6 million.
  • the compatibility-promoting auxiliary is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol.
  • the mass ratio of lauramide propyl betaine, water-soluble shea butter and dimethiconol is (1-3): (3-6): (0.5-2.5), More preferably, it is 2: 3: 1.
  • the hyaluronate is a water-soluble salt of hyaluronic acid, such as sodium hyaluronate, zinc hyaluronate, magnesium hyaluronate, potassium hyaluronate, etc., preferably sodium hyaluronate, and the water is preferably For deionized water.
  • the lubricity of the lubricating fluid is improved on the basis of ensuring safety and easy cleaning; through the amphoteric characteristics of the compatibility assistant, the water-soluble components in the lubricating fluid are The main component of natural rubber latex, cis-1,4-polyisoprene, is tightly combined, which improves the compatibility of the lubricating fluid and natural rubber latex, and avoids the phenomenon of swelling of free water-soluble components into the polymer chain, thereby Ensures the quality and safety of condoms and improves the user's experience; the improved compatibility of lubricating fluids and natural latex shortens the wetting time of the lubricating fluids and condoms, saving storage costs; and finally, the water-soluble lubrication in the present invention
  • the liquid does not contain preservatives, which prevents the adverse reactions caused by the use of preservatives. While meeting the microbiological content standard in the "Specifications for Disposable Hyg
  • the dynamic viscosity of the lubricating fluid of the present invention is 1000-2000 mpa.s, preferably 1500-2000 mpa.s, and the dynamic friction coefficient ⁇ value is 0.45-0.85, preferably 0.45-0.51.
  • the natural rubber latex condom covered with the lubricating fluid of the present invention is transparent and moist after being tested in accordance with the accelerated aging test (placed in a 70 ° C stability test box for 7 days) in the Technical Requirements and Experimental Methods of Natural Latex Condoms No whitish swelling occurs, ensuring the quality of condoms.
  • the present invention also provides a method for preparing the above-mentioned water-soluble lubricating fluid, which includes the following steps:
  • step (b) Add water to the mixture of step (a), and then increase the temperature while stirring. When the temperature reaches 40 ° C-60 ° C, add the compatibility promoting additive, and stir at this temperature until a clear and transparent solution is obtained;
  • step (c) Add a pH adjusting agent to the clear and transparent solution of step (b) to adjust the pH of the solution to 5.5-6.5 to obtain a water-soluble lubricating liquid.
  • step (b) it is preferable to add a compatibility promoting aid when the temperature reaches 45 ° C.
  • the present invention also provides the application of the above-mentioned water-soluble lubricating fluid as a lubricant, which is a lubricant for family planning products, a medical device, or a human body, preferably a condom.
  • the lubricating fluid of the present invention uses compound polyols, hyaluronate, compatibility-promoting aids, etc. as effective ingredients, does not contain preservatives and other components that are prone to adverse reactions to the human body, and has simple, natural, safe, and no residues. Easy to prepare. Through the special additives and the mutual coordination of the effective ingredients, the lubricity of the lubricating fluid is better than that of the oil lubricating fluid.
  • the lubricating fluid of the present invention improves the compatibility and stability of the water-soluble lubricating fluid and the natural latex condom, solves the problem that the water-soluble lubricating fluid and the condom will make it whitish and swell, ensuring the quality of the condom and optimizing User experience. Furthermore, the lubricating fluid of the present invention shortens the infiltration time of the lubricating fluid and the natural latex condom and saves costs.
  • Figure 1 shows the results of 70 °C accelerated test of each lubricating fluid for 7 days
  • Example 2 is the infiltration situation when the natural latex condom of Example 1 is included in 50d, 100d, 150d, and 180d;
  • Example 3 is the infiltration situation when the natural latex condom of Example 2 is included in 50d, 100d, 150d, and 180d;
  • Example 4 is the infiltration situation when the natural latex condom of Example 3 contains 50d, 100d, 150d, and 180d;
  • Example 5 is the infiltration situation when the natural latex condom of Example 11 is included in 50d, 100d, 150d, and 180d;
  • Fig. 6 shows the infiltration of natural latex condoms containing oil-based lubricating fluid at 50d, 100d, 150d, and 180d.
  • the content of each component is a mass percentage content.
  • a water-soluble lubricating fluid the formulation of which is as follows (wt%): 5% glycerin, 5% propylene glycol, 10% butylene glycol, 0.5% sodium hyaluronate, 6% compatibility promoter, pH adjustment Appropriate amount of agent, make up 100% with deionized water.
  • the compatibility promoting agent is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol in a mass ratio of 2: 3: 1, and the pH adjusting agent is lemon Sodium, the molecular weight of the sodium hyaluronate is 1.5-1.6 million.
  • the preparation method is as follows:
  • step (b) The mixture obtained in step (a) is heated while stirring, and when the temperature reaches 45 ° C, a compatibility promoting aid is added thereto;
  • a water-soluble lubricating fluid the formulation of which is as follows (wt%): 6.25% of glycerin, 6.25% of propylene glycol, 12.5% of butanediol, 0.3% of sodium hyaluronate, 12% of compatibility promoting aid, pH adjustment Appropriate amount of agent, make up 100% with deionized water.
  • the compatibility promoting agent is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol in a mass ratio of 2: 3: 1, and the pH adjusting agent is sodium citrate
  • the molecular weight of the sodium hyaluronate is 1.5-1.6 million.
  • the preparation method is the same as that in Example 1, and the obtained lubricating liquid is colorless and transparent.
  • a water-soluble lubricating fluid the formulation of which is as follows (wt%): glycerin 3.75%, propylene glycol 3.75%, butylene glycol 7.5%, sodium hyaluronate 0.8%, compatibility promoting aid 5%, pH adjustment Appropriate amount of agent, make up 100% with deionized water.
  • the compatibility promoting agent is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol in a mass ratio of 2: 3: 1, and the pH adjusting agent is sodium citrate
  • the molecular weight of the sodium hyaluronate is 1.5-1.6 million.
  • the preparation method is the same as that in Example 1, and the obtained lubricating liquid is colorless and transparent.
  • a water-soluble lubricating fluid the formulation of which is as follows (wt%): glycerol 2.5%, propylene glycol 2.5%, butylene glycol 5%, sodium hyaluronate 0.55%, compatibility promoting aid 9%, pH adjustment Appropriate amount of agent, make up 100% with deionized water.
  • the compatibility-enhancing aid is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol in a mass ratio of 2: 3: 1.
  • the pH adjusting agent is lactic acid.
  • the molecular weight of the sodium hyaluronate is 1.5-1.6 million.
  • the preparation method is the same as that in Example 1, and the obtained lubricating liquid is colorless and transparent.
  • a water-soluble lubricating fluid the formulation of which is as follows (wt%): glycerol 15%, propylene glycol 10%, butylene glycol 5%, sodium hyaluronate 0.05%, compatibility promoting aid 15%, pH adjustment Appropriate amount of agent, make up 100% with deionized water.
  • the compatibility promoting agent is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol in a mass ratio of 2: 3: 1, and the pH adjusting agent is sodium citrate
  • the molecular weight of the sodium hyaluronate is 1.5-1.6 million.
  • the preparation method is the same as that in Example 1, and the obtained lubricating liquid is colorless and transparent.
  • a water-soluble lubricating fluid its formulation is as follows (wt%): glycerol 1.5%, propylene glycol 3.5%, butylene glycol 5%, sodium hyaluronate 1%, compatibility-promoting aid 3%, pH adjustment Appropriate amount of agent, make up 100% with deionized water.
  • the compatibility promoting agent is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol in a mass ratio of 2: 3: 1, and the pH adjusting agent is sodium citrate
  • the molecular weight of the sodium hyaluronate is 1.5-1.6 million.
  • the preparation method is the same as that in Example 1, and the obtained lubricating liquid is colorless and transparent.
  • the water-soluble lubricating fluid prepared according to the method of Example 1 is different: in step (b), when the temperature reaches 40 ° C, a compatibility promoting aid is added thereto.
  • the water-soluble lubricating fluid is prepared according to the method of Example 1, except that in step (b), when the temperature reaches 60 ° C, a compatibility promoting aid is added thereto.
  • the water-soluble lubricating fluid is prepared according to the method of Example 1, except that the molecular weight of sodium hyaluronate is 1.3-1.4 million.
  • the water-soluble lubricating fluid is prepared according to the method of Example 1, except that the molecular weight of sodium hyaluronate is 170-1.8 million.
  • a water-soluble lubricating fluid the formulation of which is as follows (wt%): 10% butylene glycol, 10% glycerol, 0.5% sodium hyaluronate, 6% compatibility promoter, 6% pH adjuster, remove Ionized water makes up 100%.
  • the compatibility promoting agent is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol in a mass ratio of 2: 3: 1, and the pH adjusting agent is lactic acid
  • the molecular weight of the sodium hyaluronate is 1.5-1.6 million.
  • the preparation method is the same as that in Example 1, and the obtained lubricating liquid is colorless and transparent.
  • a water-soluble lubricating fluid its formula is as follows (wt%): glycerol 10%, butylene glycol 5%, polyethylene glycol 5%, sodium hyaluronate 0.5%, compatibility-promoting aid 6%, Appropriate amount of pH regulator, deionized water makes up 100%.
  • the compatibility promoting agent is a mixture of lauramide propyl betaine, water-soluble shea butter and dimethiconol in a mass ratio of 2: 3: 1, and the pH adjusting agent is lemon Sodium.
  • the preparation method is the same as that in Example 1, and the obtained lubricating liquid is colorless and transparent.
  • the water-soluble lubricating fluid is prepared according to the method of Example 1, except that the compatibility-promoting auxiliary agent is lauramide propyl betaine, water-soluble shea butter and polydimethyl methacrylate with a mass ratio of 1: 6: 2.5. A mixture of silanol.
  • the water-soluble lubricating fluid is prepared according to the method of Example 1, except that the compatibility-enhancing aid is lauramide propyl betaine, water-soluble shea butter and polydimethyl methacrylate in a mass ratio of 3: 4: 1.5.
  • the compatibility-enhancing aid is lauramide propyl betaine, water-soluble shea butter and polydimethyl methacrylate in a mass ratio of 3: 4: 1.5.
  • a mixture of silanol is prepared according to the method of Example 1, except that the compatibility-enhancing aid is lauramide propyl betaine, water-soluble shea butter and polydimethyl methacrylate in a mass ratio of 3: 4: 1.5.
  • a mixture of silanol is lauramide propyl betaine, water-soluble shea butter and polydimethyl methacrylate in a mass ratio of 3: 4: 1.5.
  • the formula of the lubricating fluid is as follows (wt%): 5% glycerin, 5% propylene glycol, 10% butylene glycol, 0.5% sodium hyaluronate, an appropriate amount of pH adjusting agent, and 100% deionized water.
  • the pH adjusting agent is sodium citrate, and the molecular weight of the sodium hyaluronate is 1.5-1.6 million.
  • the preparation method is as follows:
  • the lubricating fluid was prepared according to the formula and method of Example 1, except that the compatibility-enhancing aids were cocamidopropyl betaine, water-soluble almond oil, and cyclopentamer in a mass ratio of 2: 3: 1. Methylsiloxane mixture.
  • the water-soluble lubricating fluid used in the condom of the present invention has a simple formula, does not add preservatives, and is harmless to the human body. Through the selection and matching of ingredients and contents, the lubricating fluid of the present invention has good lubricity and high safety, and has good compatibility with natural latex condoms under ordinary storage conditions, high stability, short infiltration time, and no whitish swelling problem.
  • the lubricating fluids are: water-soluble lubricating fluid (components: water, glycerol, sodium hydroxide, sodium polyacrylate, carbomer, benzyl alcohol, p-hydroxybenzoic acid, commercially available ), Oily lubricating fluid (components: cyclomethicone, dimethicone, aloe, commercially available), lubricating fluid of Example 1, lubricating fluid of Example 2, comparative example 1 Lubricating fluid, lubricating fluid of Comparative Example 2.
  • the water-soluble lubricating fluid, the lubricating fluids of Comparative Example 1 and Comparative Example 2 will make the natural latex condom whitish and swell, while the lubricating fluids of Examples 1 and 2 of the present invention have good compatibility with natural latex condoms It is no different from oil-based lubricating fluid, and no whitish swelling occurs.
  • the lubricating fluids obtained in other examples were also tested in accordance with the accelerated aging test (placed in a 70 ° C stability test box for 7 days) in the "Natural Latex Condom Technical Requirements and Test Methods", and the results were the same as those in Examples 1 and 2.
  • the compatibility of the lubricating fluid of each embodiment with the natural latex condom is very good, and will not cause the natural latex condom to whitish and swell.
  • the test conditions are 25 ° C at normal temperature, 45% humidity, and protected from light.
  • the natural latex condom is completely transparent after being stretched out, it indicates that it is completely infiltrated as shown in Figure 2-6.
  • the lubricating fluid and oily lubricating fluid of Examples 1, 2, 3, 11 (composition: cyclopolydimethylsiloxane Alkane, dimethicone, aloe, commercially available) the infiltration of natural rubber latex condoms with time, as can be seen from the figure, it contains the water soluble in Examples 1, 2, 3 and 11 of the present invention
  • Condoms with synthetic lubricating fluids can take up to 160 days to fully infiltrate, while condoms containing oily lubricants require at least 180 days.
  • the dynamic viscosities of the lubricating fluids in Examples 1-14 are all 1000-2000 mPa.s, and the dynamic friction coefficients are all between 0.45-0.70.
  • the dynamic friction coefficient ⁇ of the lubricating fluid of the present invention is at least 51.0% lower than that of Comparative Example 1, at least 43.1% lower than that of Comparative Example 2, at least 62.6% lower than that of commercial oil-based lubricating fluid, and at least 35.8% lower than that of commercial water-soluble lubricating fluid.
  • the lubricity of the water-soluble lubricating fluid in the present invention is superior to the commercially available oil-based lubricating fluid, the commercially available water-soluble lubricating fluid, and the lubricating fluids of Comparative Examples 1 and 2.
  • Condoms containing lubricating fluids of other examples were also tested in accordance with the water leakage test in "Technical Requirements and Experimental Methods of Natural Latex Condoms", and the results were the same as in Example 1, which proved that the lubricating fluids and natural latex condoms of each example The stability is very good, will not change the quality of natural latex condoms.
  • SPF grade SD rats were selected for vaginal mucosal irritation test.
  • Example 1 of the present invention is non-irritating to rat vaginal mucosa (no congestion, no edema), while the other four lubricants have different degrees of effects on rat vaginal mucosa stimulate.
  • the lubricating fluid of the remaining examples was used to test the vaginal mucosal stimulation of SPF SD rats.
  • the results showed that the lubricating fluid of each example was the same as the lubricating fluid of Example 1.
  • the vaginal mucosa of SPF SD rats was No irritation.
  • both the water-soluble lubricating fluid and the lubricating fluid of Example 1 are easier to clean than the oil-based lubricating fluid, and the lubricating fluid of Example 1 is superior to the oil-based lubricating fluid and the water-soluble lubricating fluid in terms of lubricity and duration. It is 16.5% higher than oily lubricating fluid and 21.6% higher than water-soluble lubricating fluid. According to the feedback from the subjects, it is found that female subjects pay more attention to the ease of cleaning of condoms, while male subjects pay more attention to the length of condom lubrication. On these two points, condoms containing the lubricating fluid of Example 1 Both meet the different needs of husband and wife.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)

Abstract

La présente invention concerne un lubrifiant soluble dans l'eau, son procédé de préparation et son utilisation. Le lubrifiant comprend un polyol combiné, un sel d'acide hyaluronique, un adjuvant de compatibilisation et ne contient pas de conservateurs ni d'autres ingrédients à l'origine de réactions corporelles indésirables. Le lubrifiant est fabriqué à partir d'ingrédients simples et sûrs, ne laisse pas de résidus après nettoyage et est facile à préparer. Grâce aux effets combinés de cet adjuvant spécifique et des ingrédients actifs, la capacité de lubrification du lubrifiant est rendue supérieure à celle des lubrifiants à base d'huile. Dans le lubrifiant de la présente invention, la stabilité et la compatibilité entre le lubrifiant soluble dans l'eau et un préservatif en latex naturel sont améliorées, ce qui résout le problème du blanchissement et de la distension des préservatifs au contact d'un lubrifiant soluble dans l'eau, garantissant la qualité du préservatif et améliorant l'expérience d'utilisation de l'utilisateur. De plus, dans le lubrifiant de la présente invention, la durée d'humidification du lubrifiant et du préservatif en latex naturel est réduite, ce qui réduit les coûts.
PCT/CN2019/110433 2018-10-12 2019-10-10 Lubrifiant soluble dans l'eau, son procédé de préparation et son utilisation Ceased WO2020073966A1 (fr)

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CN201811187475.0 2018-10-12
CN201811187475.0A CN109200345B (zh) 2018-10-12 2018-10-12 一种水溶性润滑液及其制备方法和应用

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CN110898259B (zh) * 2019-12-22 2021-10-19 上海名流卫生用品股份有限公司 一种仿人体润滑剂及其制备方法和应用
CN113041405B (zh) * 2021-03-22 2022-06-10 山东华熙海御生物医药有限公司 一种含透明质酸和四氢嘧啶的人体润滑液及其制备方法和应用
CN113209163A (zh) * 2021-05-21 2021-08-06 河南依维意实业有限公司 一种含透明质酸功效型水溶性润滑剂及其制备方法
CN116421791A (zh) * 2021-12-30 2023-07-14 华熙生物科技股份有限公司 一种医用腔道润滑组合物及其制备方法和应用
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