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WO2019233367A8 - Streptomyces strain and application thereof in production of staurosporine - Google Patents

Streptomyces strain and application thereof in production of staurosporine Download PDF

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Publication number
WO2019233367A8
WO2019233367A8 PCT/CN2019/089782 CN2019089782W WO2019233367A8 WO 2019233367 A8 WO2019233367 A8 WO 2019233367A8 CN 2019089782 W CN2019089782 W CN 2019089782W WO 2019233367 A8 WO2019233367 A8 WO 2019233367A8
Authority
WO
WIPO (PCT)
Prior art keywords
staurosporine
application
production
streptomyces strain
strain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2019/089782
Other languages
French (fr)
Chinese (zh)
Other versions
WO2019233367A1 (en
Inventor
方佳双
张辉
项仁鑫
邓爱文
王微芬
应灵萍
姜南
王继栋
滕云
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Hisun Pharmaceutical Co Ltd
Original Assignee
Zhejiang Hisun Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Hisun Pharmaceutical Co Ltd filed Critical Zhejiang Hisun Pharmaceutical Co Ltd
Publication of WO2019233367A1 publication Critical patent/WO2019233367A1/en
Publication of WO2019233367A8 publication Critical patent/WO2019233367A8/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/46—Streptococcus ; Enterococcus; Lactococcus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

A streptomyces strain and an application thereof, and a method for preparing staurosporine by culturing the strain. The strain is named as streptomyces sp. HS-HY-153, and the preservation number thereof is CGMCC NO. 14806.
PCT/CN2019/089782 2018-06-04 2019-06-03 Streptomyces strain and application thereof in production of staurosporine Ceased WO2019233367A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810572019.1A CN108676757B (en) 2018-06-04 2018-06-04 Streptomyces strain and application thereof in producing staurosporine
CN201810572019.1 2018-06-04

Publications (2)

Publication Number Publication Date
WO2019233367A1 WO2019233367A1 (en) 2019-12-12
WO2019233367A8 true WO2019233367A8 (en) 2020-09-10

Family

ID=63809976

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/089782 Ceased WO2019233367A1 (en) 2018-06-04 2019-06-03 Streptomyces strain and application thereof in production of staurosporine

Country Status (2)

Country Link
CN (1) CN108676757B (en)
WO (1) WO2019233367A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108676757B (en) * 2018-06-04 2020-08-11 浙江海正药业股份有限公司 Streptomyces strain and application thereof in producing staurosporine
KR102235779B1 (en) * 2019-06-19 2021-04-01 국립해양생물자원관 Streptomyces sp. SNC087 associated from sea water, producing method of staurosporine using the strain, culturing method of the strain, and pure culture thereof
CN110642872B (en) * 2019-11-18 2020-12-22 湖北宏中药业股份有限公司 Method for extracting staurosporine
CN113122591B (en) * 2019-12-30 2022-11-22 上海医药工业研究院 A method for producing staurosporine by fermentation
CN111296417B (en) * 2020-04-01 2021-04-20 广东省农业科学院植物保护研究所 Star-Jiawei suspending agent and preparation method and application thereof
CN111793618A (en) * 2020-08-05 2020-10-20 广东新达瑞生物科技有限公司 Breeding and preparation method of staurosporine producing bacteria
CN112048530B (en) * 2020-09-08 2021-10-29 浙江海正药业股份有限公司 Method for promoting staurosporine accumulation
CN112746036B (en) * 2020-12-08 2021-08-24 浙江珲达生物科技有限公司 Streptomyces and method for producing pseudouridine by fermenting same
CN115806913B (en) * 2022-10-21 2023-09-08 福建省农业科学院植物保护研究所 Streptomyces nojiriensis strain 9-13 and its applications
CN116144538B (en) * 2022-12-30 2024-04-26 西南大学 A yellow dark-colored Streptomyces capable of preventing and treating clubroot and its application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7608420B2 (en) * 2003-04-22 2009-10-27 Lonza Ag Process for the recovery of staurosporine from a fermentation broth
KR20100069073A (en) * 2008-12-16 2010-06-24 한국해양연구원 Microorganism producing staurosporine and manufacturing method for staurosporine using the microorganism
CN107603922B (en) * 2017-11-06 2019-10-18 海南大学 Sponge symbiotic Streptomyces and its fermentation method and application for producing staurosporine
CN108048369B (en) * 2018-01-26 2020-06-19 中国医学科学院医药生物技术研究所 Marine streptomycete for producing staurosporine and preparation method thereof
CN108676757B (en) * 2018-06-04 2020-08-11 浙江海正药业股份有限公司 Streptomyces strain and application thereof in producing staurosporine

Also Published As

Publication number Publication date
WO2019233367A1 (en) 2019-12-12
CN108676757A (en) 2018-10-19
CN108676757B (en) 2020-08-11

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