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WO2019211768A1 - Obtention d'extraits de cannabis à partir de biomasse pour une utilisation dans des aliments - Google Patents

Obtention d'extraits de cannabis à partir de biomasse pour une utilisation dans des aliments Download PDF

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Publication number
WO2019211768A1
WO2019211768A1 PCT/IB2019/053563 IB2019053563W WO2019211768A1 WO 2019211768 A1 WO2019211768 A1 WO 2019211768A1 IB 2019053563 W IB2019053563 W IB 2019053563W WO 2019211768 A1 WO2019211768 A1 WO 2019211768A1
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WIPO (PCT)
Prior art keywords
target compounds
biomass
solvent
food
cannabis
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2019/053563
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English (en)
Inventor
Tomasz Popek
Steven Splinter
Anna BAKOWSKA-BARCZAK
Harmandeep KAUR
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Radient Technologies Inc
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Radient Technologies Inc
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Publication of WO2019211768A1 publication Critical patent/WO2019211768A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/348—Cannabaceae
    • A61K36/3482—Cannabis
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0211—Solvent extraction of solids in combination with an electric or magnetic field
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0292—Treatment of the solvent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0223—Moving bed of solid material
    • B01D11/0226—Moving bed of solid material with the general transport direction of the solids parallel to the rotation axis of the conveyor, e.g. worm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents

Definitions

  • the present disclosure is generally related to pharmacologically active ingredients present in a cannabis biomass, and more particularly related to a method and apparatus for deriving a final form of cannabis extract with active cannabinoids suitable for use in food products.
  • Cannabis is a genus belonging to the family of cannabaceae. Three common species include Cannabis sativa, Cannabis indica, and Cannabis ruderalis. The genus has been indigenous to Central Asia and the Indian subcontinent. Cannabis has a long history being used for medicinal, therapeutic, and recreational purposes. The importance of cannabis in therapeutics is emphasized by the ever-increasing number of research publication related to the new indications for cannabis. For example, pharmaceutical research companies are presently developing new natural cannabinoid formulations and delivery systems to meet various regulatory requirements. Cannabis is known, for example, to be capable of relieving nausea (such as that accompanying
  • cannabis or “cannabis biomass” encompasses the Cannabis sativa plant and also variants thereof, including subspecies sativa, indica and ruderalis, cannabis cultivars, and cannabis chemovars (varieties characterised by chemical composition), which naturally contain different amounts of the individual cannabinoids, and also plants which are the result of genetic crosses.
  • cannabis chemovars variants characterised by chemical composition
  • the term “cannabis biomass” is to be interpreted accordingly as encompassing plant material derived from one or more cannabis plants.
  • Cannabis biomass contains a unique class of terpeno-phenolic compounds known as cannabinoids or phytocannabinoids, which have been extensively studied since the discovery of the chemical structure of tetrahydrocannabinol (Delta-9-THC), commonly known as THC. Over 113 phytocannabinoids have been identified.
  • cannabinoids are generally produced by glandular trichomes that occur on most aerial surfaces of the plant.
  • the cannabinoids are biosynthesized in the plant in acidic forms known as acidic cannabinoids.
  • the acidic cannabinoids may be slowly decarboxylated during drying of harvested plant material. Decarboxylation may be hastened by heating the cannabis biomass, such as when the cannabis biomass is smoked or vaporized.
  • the principle cannabinoids present in cannabis are the Delta-9-tetrahydrocannabinolic acid (Delta-9-THCA) and cannabidiolic acid (CBDA).
  • the Delta-9-THCA does not have its own psychoactive properties as is, but may be decarboxylated to Delta-9-tetrahydrocannabinol (Delta-9- THC), which is the most potent psychoactive cannabinoid among known cannabinoids.
  • the neutral form of CBDA is cannabidiol (CBD), which is a major cannabinoid substituent in hemp cannabis.
  • CBD is non-psychoactive and is widely known to have therapeutic potential for a variety of medical conditions.
  • the proportion of cannabinoids in the plant may vary from species to species, as well as vary within the same species at different times and seasons. Furthermore, the proportion of cannabinoids in a plant may further depend upon soil, climate, and harvesting methods. Thus, based on the proportion of the cannabinoids present in a plant variety, the psychoactive and medicinal effects obtained from different plant varieties may vary.
  • a specific variety of cannabis may be considered more effective or potent than others (e.g., in providing the desired physiological effect at a desired level in an individual).
  • some specific combinations of pharmacologically active compounds in a cannabis variety may be more desirable in comparison to other varieties.
  • the retention of the full mix of cannabinoids present in the original plant may be desirable for some varieties, while other varieties may be preferred in altered form due to the variances in the specific cannabinoid composition and concentrations. Such variance is further exacerbated by the presence of certain terpenoid or phenolic compounds, which may have pharmacological activity of their own and which may be desired at different concentrations in different combinations.
  • compounds may be extracted from cannabis by using conventional methods of extraction, such as maceration, decoction, or solvent extraction.
  • conventional methods may suffer from various limitations and disadvantages (e.g., extraction times may be very high so as to be impractical to scale).
  • subjecting the biomass to a prolonged extraction process may risk modification of the plant profile, negative effects on terpenes, or otherwise cause other undesirable effects that lower the quality or purity of the end product.
  • Traditional methods of extraction may therefore hamper quality and purity of the final product.
  • final concentrated or purified active compounds are often diluted or dispersed into an oil, fat or other lipid-based excipient or carrier to a desired concentration for certain uses (e.g., in a pharmaceutical, food, or cosmetic formulation).
  • SFE supercritical fluid extraction
  • SFE is also inefficient and therefore not conducive to high throughputs, as well as environmentally damaging (e.g., producing large amounts of the greenhouse gas carbon dioxide as a by-product).
  • Embodiments of the present invention provide extraction methods for usage of cannabis extracts in food products.
  • Exemplary methods for extracting pharmacologically active compounds from a biomass may therefore include preparing cannabis biomass, adding a solvent to the prepared cannabis biomass to form a slurry where the solvent may be a carrier fluid that is suitable for inclusion in a final formulation, and extracting target compounds from the slurry using a continuous flow extraction apparatus, and separating a spent biomass from the solvent by a downstream process.
  • a final form of cannabis extract suitable for use in food with active cannabinoids may be obtained and further formulated and processed to form a final food product.
  • FIG. 1 is a block diagram representation of an exemplary system for obtaining cannabis extracts for usage in food products.
  • FIG. 2 is a flow chart illustrating exemplary methods for obtaining cannabis extracts for usage in food products.
  • Embodiments of the present disclosure include systems and methods for extracting pharmacologically active compounds from a biomass may therefore include preparing cannabis biomass, adding a solvent to the prepared cannabis biomass to form a slurry where the solvent may be a carrier fluid that is suitable for inclusion in a final formulation, extracting target compounds from the slurry using a continuous flow extraction apparatus, and separating a spent biomass from the solvent by a downstream process.
  • Such extracted target compounds may include Delta-9-THC, Delta-9-THCA, CBDA, CBD, other cannabinoids, and terpenes.
  • FIG. 1 is a block diagram representation of an exemplary system 100 for obtaining cannabis extracts for use in food
  • FIG. 2 is a flow chart illustrating an exemplary method 200 for obtaining cannabis extracts for use in food.
  • System 100 of FIG. 1 includes a raw biomass holding chamber 102, into which a raw biomass may be provided in step 202 of FIG. 2.
  • the raw biomass may be present in the form of dried, ground, non-decarboxylated flowers (buds) of cannabis plants. Any part of the cannabis biomass that contains cannabinoids can be used. In some embodiments, the average particle size of the raw biomass may lie between 0.5 - 10 mm.
  • the raw biomass may contain target compounds that need to be extracted.
  • the raw biomass may be heated to approximately 125° C for approximately 45 minutes to decarboxylate cannabinoids carboxylic acids present in the biomass. The mass of decarboxylated cannabis following such treatment may be reduced (e.g., approximately 11.7% weight loss).
  • the raw biomass may be dried, non- decarboxylated cannabis biomass.
  • the raw biomass may be fresh, non- dried, non-decarboxylated cannabis biomass.
  • the raw biomass may be sampled and analyzed in sampling chamber 120.
  • the raw biomass may be analyzed to determine cannabinoid content and a cannabinoid profile of the raw biomass.
  • Such analysis may be performed using an Ultra High performance Liquid Chromatography coupled with Mass
  • UPLC-MS UPLC-MS detection technique.
  • a terpene profile of the raw biomass may be determined using a Gas Chromatography-Mass Spectrometry Detection (GC-MS).
  • the sampling techniques may help in determining the cannabinoid content and the cannabinoid profile of the raw biomass (e.g. THC, THCA, CBD, CBDA and total cannabinoids present in the raw biomass).
  • the raw biomass may be ground into small particles to obtain a prepared biomass in biomass preparation chamber 104.
  • the prepared biomass may then be provided from biomass preparation chamber 104 to a prepared biomass holding chamber 106.
  • the prepared biomass may be used to form a slurry in step 208.
  • the slurry may be formed in a slurry formation chamber 108 where one or more solvents may be added to the prepared biomass from a solvent holding chamber 110.
  • the solvent added to the prepared biomass mass may be selected with different dielectric and solvent parameter properties.
  • the solvent added to the raw biomass mass may be selected with different dielectric and solvent parameter properties.
  • the solvent may be selected from an alcohol group, alkane group, and ketone group, or mixtures of such with water.
  • the solvent may be a carrier fluid such as a polyunsaturated fatty acid (PUFA), com oil, safflower oil, borage oil, flax oil, canola oil, cottonseed oil, soybean oil, olive oil, sunflower oil, coconut oil, palm oil, avocado oil, monoglycerides, diglycerides, triglycerides, medium chain triglycerides (MCT), long chain tryglycerides, lecithin, limonene, essential oils of spices, herbs, or other plants, fish oil, glycerol, glycols, or mixtures thereof.
  • PUFA polyunsaturated fatty acid
  • com oil com oil
  • safflower oil borage oil
  • flax oil canola oil
  • cottonseed oil soybean oil
  • olive oil sunflower oil
  • coconut oil coconut oil
  • palm oil avocado oil
  • MCT medium chain triglycerides
  • MCT medium chain tryglycerides
  • lecithin lecithin
  • the slurry may be transferred from the slurry formation chamber 108 to an extraction chamber 112 where such slurry is subject to heat at step 210.
  • the slurry may be transported using a set of mechanical conveyors (e.g. a slurry pump, screw conveyor worm gear).
  • the slurry may be subjected to a thermal process, such as provided by a microwave generator 114.
  • the slurry may be transported into an extractor.
  • the extractor may transport the slurry through a chamber (i.e. a tube or pipe). At least one portion of the chamber may be microwave transparent. This microwave transparent portion may allow microwaves, generated using a magnetron to pass through and heat the slurry inside the chamber.
  • the slurry may be heated to a certain temperature by exposing the slurry to the microwave to a predefined time with a predefined microwave energy density range.
  • the slurry may be heated to a temperature range of 15 - 70 °C with a contact time of 1 - 30 minutes, and microwave energy density range of 0.1 - 10 kW/kg.
  • the now-spent biomass and solvent(s) may be transferred to separation chamber 116, where the slurry is subject to filtration and separation at step 212.
  • Such filtration and separation within filtration unit 116 may result in isolating the slurry components from each other: the spent biomass and the solvent(s) containing the extracted compounds.
  • the spent biomass and the solvent(s) containing the extracted compounds may be transferred into spent biomass storage unit 118 and solvent recovery chamber 122, respectively.
  • the separation process may be performed using one or more of several methods, such as filtration, centrifugation, and other similar processes. In a preferred embodiment, the separation process may include use of a filter press.
  • the spent biomass may be sampled at step 214.
  • Sampling of the spent biomass may be performed in a sampling chamber 120.
  • the spent biomass may be sampled and analyzed to determine remaining cannabinoid content and cannabinoid profile.
  • the spent biomass may be sampled and analyzed using several methods. The analysis may be performed using an Ultra High Performance Liquid Chromatography coupled with Mass Spectrometry detection (UPLC-MS). Further, terpene profile of the raw biomass may be determined using a Gas Chromatography-Mass Spectrometry Detection (GC-MS).
  • UPLC-MS Ultra High Performance Liquid Chromatography coupled with Mass Spectrometry detection
  • terpene profile of the raw biomass may be determined using a Gas Chromatography-Mass Spectrometry Detection (GC-MS).
  • GC-MS Gas Chromatography-Mass Spectrometry Detection
  • waste spent biomass may be incinerated or mixed with a deactivating agent by a disposal system 128.
  • a deactivating agent In one case, clay may be used as the deactivating agent.
  • the solvent may be recovered from the solvent / extract mixture and a desolventized active cannabinoid extract may be obtained at step 218.
  • the desolventized extract may be provided to the formulation chamber 124.
  • the solvent may be recovered from the desolventized extract by an evaporation or distillation process and stored in the solvent holding chamber 110.
  • separation may be effected by thin film evaporation such as wiped film evaporation or by short-path distillation.
  • the separation may be effected under vacuum.
  • the solvent may be used in another extraction processes.
  • the extracted active cannabinoid extract fluid may be present in the form of a resin of pure active cannabinoids.
  • the extract active cannabinoid extract fluid may be stored in the formulation chamber 124.
  • the solvent may not be recovered from the solvent / extract mixture.
  • the solvent may be a carrier fluid such as a polyunsaturated fatty acid (PUFA), com oil, safflower oil, borage oil, flax oil, canola oil, cottonseed oil, soybean oil, olive oil, sunflower oil, coconut oil, palm oil, avocado oil, monoglycerides, diglycerides, triglycerides, medium chain triglycerides (MCT), long chain tryglycerides, lecithin, limonene, essential oils of spices, herbs, or other plants, fish oil, glycerol, glycols, or mixtures thereof.
  • the extract active cannabionoid extract fluid contained in the carrier fluid may be stored in the formulation chamber 124.
  • a decarboxylation unit may be included after the formulation chamber 124.
  • the decarboxylation unit may be used if the biomass from the raw biomass storage unit 102 had not been previously decarboxylated.
  • the active cannabinoid extract fluid may be heated in a heating apparatus.
  • the heating apparatus may be a microwave heating apparatus.
  • the microwaves generated using a magnetron may heat the formulated extract inside the microwave heating apparatus.
  • the fluid may be heated to a certain temperature by exposing the fluid to the microwave for a predefined time with a predefined microwave energy range.
  • the heating of the fluid may transform the acidic cannabinoids into their active (e.g. neutral) form.
  • the heating apparatus may be a conventional oven or oil baths, using the temperature range 80°C- 125°C for a time range of 30-300 minutes. In a preferred embodiment, the heating will be done at 100°C for 120 minutes.
  • sampling and analysis of active cannabinoid extract fluid may be performed.
  • Sampling of the active cannabinoid extract fluid may be performed in the sampling unit 120.
  • the active cannabinoid extract fluid may be analyzed using several techniques.
  • analysis of the active cannabinoid extract fluid may be performed to determine cannabinoid content and cannabinoid profile.
  • the analysis may be performed using an Ultra High Performance Liquid Chromatography coupled with Mass Spectrometry detection (UPLC-MS).
  • UPLC-MS Ultra High Performance Liquid Chromatography coupled with Mass Spectrometry detection
  • Terpene profile of the raw biomass may be determined using a Gas Chromatography-Mass Spectrometry Detection (GC-MS).
  • the sampling techniques may help determine the content and profile of the final formulated extract (e.g. THC, THCA, CBD, CBDA and total cannabinoids).
  • a food liquid may be added at step 220 to the extracted active cannabinoid extract fluid to form a product base.
  • a medium-chain triglyceride such as coconut oil may be used as the food liquid.
  • coconut oil may contain over 90% fatty acids. The fatty acids present in the coconut oil may be saturated, thus making the coconut oil resistant to heat. The oil may be semi-solid at room temperature and may last for a long duration without spoilage.
  • the coconut oil also has health benefits unto itself.
  • Coconut oil is rich in a fatty acid called lauric acid, which may improve cholesterol and help kill bacteria and other pathogens.
  • the fats in coconut oil may also boost metabolism and increase feelings of fullness compared to other fats.
  • Other food liquids may be selected, for e.g. butter, olive oil, and animal fats like lards, tallows, and bacon drippings, palm oils, avocado oil, fish oil, flax oil, canola oil, nut oils, seed oils, and vegetable oils.
  • the food liquid may be added to the extracted active cannabinoid extract fluid to form a liquid fluid product base carrier fluid.
  • the liquid fluid product base carrier fluid may be stored in a product holding chamber 126.
  • a final food product that includes the active cannabinoids may be obtained at step 222 and stored in a final product holding chamber 128.
  • the final liquid food may be blended or mixed for consistency.
  • the final liquid food with active cannabinoids may be used as an additive, for instance in a food product.
  • the food product may be a brownie; the additive that contains the active compounds of cannabis (e.g. THC and/or CBD) may be added to the brownie.
  • the desired concentration may be calculated for the end product. To obtain the desired results, specific measurements and testing of a given food product, the concentration of certain ingredients in a given amount of food product, and the typical serving of the food product.
  • a typical brownie may be, for example, a 5cm x 5cm x 2.5cm block, approximately 28 grams by weight, and containing 8g of total fat.
  • the product may have a desired dose of 10 mg of THC. Therefore, assuming all 8 grams of fat in the final product may be derived from the carrier fluid (coconut oil), the concentration of the carrier fluid may be 10 mg of THC per 8 g of formulation, or 1.25 mg of THC per lg of formulation (0.125%).
  • sampling of formulated extract may be performed at step 224.
  • Sampling of the formulated extract may be performed in the sampling unit 120.
  • the formulated extract may be sampled and analyzed using several techniques.
  • analysis of the final formulated extract may be performed to determine cannabinoid content and cannabinoid profile.
  • the analysis may be performed using an Ultra High Performance Liquid Chromatography coupled with Mass Spectrometry detection (UPLC-MS).
  • UPLC-MS Ultra High Performance Liquid Chromatography coupled with Mass Spectrometry detection
  • Terpene profile of the raw biomass may be determined using a Gas Chromatography-Mass Spectrometry Detection (GC-MS).
  • the sampling techniques may help determine the content and profile of the final formulated extract (e.g. THC, THC A, CBD, CBDA and total cannabinoids).
  • Table 1 illustrates percentage of THC in various phases of the extraction process described in FIG. 1.
  • the desired concentration of THC in the liquid food product base was calculated based on a preferred recipe. According to the recipe a single brownie (21.6 g) contains 2.3 g of canola oil. The desired THC dose level per brownie was 10 mg. Therefore, assuming that all of the canola oil required for preparation of brownies was to be derived from the liquid food product base, the concentration of the carrier fluid would be 10 mg of THC per 2.3 g of formulation, or 4.3 mg THC per 1 g of formulation (0.43%).
  • the prepared biomass consisted of dried, decarboxylated cannabis with an average particle size of 10 mm. The prepared biomass had a THC concentration of 13.7%.
  • the spent biomass may be separated from the solvent and extract mixture ("miscella") using one or more of several separation methods, which may be, for example, filtration, centrifuge, etc.
  • the solvent may then be evaporated out of the miscella using an evaporation process (e.g. vacuum evaporation).
  • the desolventized extract in the active cannabinoid fluid unit had a THC concentration of 60%.
  • the spent biomass in the spent biomass storage unit had a THC concentration of 0.8%.
  • a higher concentration of cannabinoid in the liquid food base may be desired, for example for ease of handling, transport, storage capacity, etc.
  • a single brownie (18 g) contains 2.3 g of canola oil.
  • the desired THC dosage level per brownie was 10 mg. Therefore, using 3% THC in canola oil as a liquid food base it was determined that 0.33 g of liquid food base would be required to prepare one brownie.
  • canola oil was mixed with the liquid extract before solvent removal at a ratio 5:1 (w/w extract/canola oil).
  • the canola oil may be mixed with cannabis extract also after solvent removal resulting in the same liquid food base containing 3% THC.
  • the concentration of THC in final liquid food base may be confirmed using the sampling unit 120.
  • the brownie recipe requires addition of 8 g of total fat per one brownie (28 grams).
  • the product has a desired dose of 10 mg of THC. Therefore, assuming all 8 grams of fat in the final product may be derived from the carrier fluid (MCT oil), the concentration of the carrier fluid was 10 mg of THC per 8 g of formulation, or 1.25 mg of THC per lg of formulation (0.125%).
  • MCT oil carrier fluid
  • the required amount of liquid food base was weighed and heated to 45-50 °C to allow proper mixing with MCT oil.
  • the MCT oil was preheated to 45-50 °C and added to the extract at the calculated ratio: 99.8 g of MCT oil per every 100 g of formulation.
  • the MCT oil maybe mixed with extract also before or during solvent removal resulting in the same liquid food base containing 0.125% THC.
  • the concentration of THC in final liquid food base may be confirmed using the sampling unit 120.
  • the desolventized extract in the active carmabinoid fluid unit may be formulated into a final formulated liquid food with active cannabinoids using at least one of a plurality of formulation methods. Based on the analysis of THC concentration in the active carmabinoid fluid (i.e. 60% THC) the canola oil was mixed with the desolventized extract at a ratio 1:1.25 (w/w extract/canola oil).
  • the canola oil may be mixed with cannabis extract prior to or during solvent removal in the solvent recovery unit, resulting in the same liquid food base containing 0.43% THC. The concentration of THC in final liquid food base may be confirmed using the sampling unit 120.
  • Table 2 illustrates examples of dosage recommendations based on the type of patient that may use the quantity and THC percentage from FIG. 2.
  • the THC percentage and quantity may depend upon the final formulated extract from the process described in FIG. 1 and the detailed breakdown shown in FIG. 2.
  • the patient type is an example of the ranges of medical history that a potential patient may have in order to better judge the interaction or tolerance they will have with THC.
  • the graphic may also be used in order to determine the interaction or tolerance of recreational users.
  • the recommended dosage may be based upon the patient type, lower dosages may be recommended for patients that have no-to-few interactions with cannabis and higher dosages may be recommended for patients that have had many interactions with cannabis.
  • the example quantity displays an amount (in milliliters) of the final formulated extract that is within the patients recommended dosage range
  • the example THC dosage displays the amount (in milligrams) of THC in the example quantity.
  • a patient may be medical user (which is most likely daily usage of THC) has a recommended dosage of 10 to 15 mg, using the final formulated extract from FIG. 2, the patient may use 0.5 milliliters of that final formulated extract in order to consume 15 milligrams of THC.
  • Table 3 illustrates the various quantities that may be used when applying the final formulated extract to various types of edibles in order to achieve a specific recommended dosage (in this example the THC dosages are provided for medical users or daily users of THC).
  • the figure also displays when preparing batches of edibles, the necessary quantity of the final formulated extract in order to achieve the proper dosage for each serving the batch will produce. For example, if the type of edible is a dessert such as a brownie and the quantity of the edible is 240 grams may produce 10 servings (or 10 brownies each 24 grams), the desired THC dosage (per serving) may be 15 milligrams and the amount of extract needed per serving may be 0.5 grams (i.e.
  • the total amount of the final formulated extract needed for the batch is 5 grams and the total amount of THC in the batch is 150 milligrams).
  • This downstream process begins by determining the desired THC dosage (per serving, if creating a batch of edibles), and dividing the THC dosage by THC percentage of the final formulated extract (in this case the THC percentage was 3%), which may result in the amount needed from the final formulated extract for each serving, and this number is multiplied by the amount of servings in order to determine the total amount of the final formulated extract.

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  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne un procédé d'extraction de cannabis destiné à être utilisé dans des produits alimentaires. Le procédé comprend la fourniture d'une biomasse brute de cannabis, qui est traitée pour obtenir une biomasse de cannabis préparée. La suspension peut être préparée par ajout d'un solvant à la biomasse de cannabis préparée. La suspension peut être chauffée dans un extracteur à écoulement continu pour extraire des composés cibles. Le solvant peut être séparé d'une biomasse usagée. En outre, le solvant peut être séparé des composés cibles par évaporation du solvant. En outre, l'extrait désolvantisé peut être traité en outre pour concentrer le fluide extrait de cannabinoïde actif extrait. Un fluide porteur approprié pour une utilisation dans des aliments peut être ajouté au fluide d'extrait de cannabinoïde actif extrait. Successivement, une formulation finale de fluide porteur appropriée pour une utilisation dans des aliments avec des cannabinoïdes actifs peut être obtenue. Les cannabinoïdes actifs extraits et le fluide porteur peuvent être présents dans un rapport allant de 0,125 % à 3 % en poids.
PCT/IB2019/053563 2018-05-03 2019-05-01 Obtention d'extraits de cannabis à partir de biomasse pour une utilisation dans des aliments Ceased WO2019211768A1 (fr)

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WO2022155741A1 (fr) * 2021-01-20 2022-07-28 2655626 Ontario Inc. Produits de cannabis activés et leurs procédés de préparation

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