[go: up one dir, main page]

WO2019103451A1 - Appareil d'injection de médicament en poudre et composition pharmaceutique injectée à l'aide dudit appareil - Google Patents

Appareil d'injection de médicament en poudre et composition pharmaceutique injectée à l'aide dudit appareil Download PDF

Info

Publication number
WO2019103451A1
WO2019103451A1 PCT/KR2018/014346 KR2018014346W WO2019103451A1 WO 2019103451 A1 WO2019103451 A1 WO 2019103451A1 KR 2018014346 W KR2018014346 W KR 2018014346W WO 2019103451 A1 WO2019103451 A1 WO 2019103451A1
Authority
WO
WIPO (PCT)
Prior art keywords
housing
filling
agitator
stirrer
space
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/014346
Other languages
English (en)
Korean (ko)
Inventor
강원호
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ums Engineering Co Ltd
Original Assignee
Ums Engineering Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ums Engineering Co Ltd filed Critical Ums Engineering Co Ltd
Publication of WO2019103451A1 publication Critical patent/WO2019103451A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0076—Medicament distribution means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/60—Mixers with rotary stirring devices in fixed receptacles; Kneaders with stirrers rotating about a horizontal or inclined axis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/51—Mixing receptacles characterised by their material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B11/00—Wrapping, e.g. partially or wholly enclosing, articles or quantities of material, in strips, sheets or blanks, of flexible material
    • B65B11/50—Enclosing articles, or quantities of material, by disposing contents between two sheets, e.g. pocketed sheets, and securing their opposed free margins
    • B65B11/52—Enclosing articles, or quantities of material, by disposing contents between two sheets, e.g. pocketed sheets, and securing their opposed free margins one sheet being rendered plastic, e.g. by heating, and forced by fluid pressure, e.g. vacuum, into engagement with the other sheet and contents, e.g. skin-, blister-, or bubble- packaging
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B37/00—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged
    • B65B37/02—Supplying or feeding fluent-solid, plastic, or liquid material, or loose masses of small articles, to be packaged by gravity flow

Definitions

  • the present invention relates to a powder medicine filling apparatus, and more particularly, to a powder medicine filling apparatus for filling a powdery medicine into a packaging material and a pharmaceutical composition filled thereby.
  • Powdered medicaments are typically pre-packaged in blisters commonly used as packaging materials, and each blister contains a single dose of powder that is accurately and consistently measured.
  • Blisters protect powder medicines and powdered medicines from penetration of water and penetration of gases such as oxygen, in addition to shielding them from light and ultraviolet radiation which may have an adverse effect on the operation of the inhaler used to deliver the powder medicament to the patient do.
  • U.S. Patent No. 8,371,342 discloses a " filling device for metering volumetric measurements of powders ".
  • a powder is supplied through a tube located at the center, a filter is arranged on both sides of the tube, and a negative pressure is applied to the upper space to thereby suck the powder into the blister.
  • An object of the present invention is to provide a powder medicine filling device capable of simplifying the configuration of a powder filling device using an air pressure difference or the like.
  • the present invention also provides a powder medicine filling device capable of driving the filling device regardless of the size of the particles.
  • Another object of the present invention is to provide a powder medicine filling apparatus which can more effectively press powder medicine located mainly on the inner surface side of the housing, thereby improving the charging efficiency.
  • a powder medicine filling apparatus for filling powdery medicine in a filling space formed in a packing material
  • the powdery medicine filling apparatus comprising: a housing to which the powdery medicine is supplied; And a stirrer rotatably installed in the housing for sweeping the inner surface of the housing, the stirrer pressurizing the powdered medicament supplied to the housing with the rotating force to fill the filling space.
  • a charging hole communicating with the charging space may be formed in the lower portion of the housing.
  • the stirrer may be controlled to stop at a position where the charging hole is closed when charging is completed.
  • a discharge hole may be formed in the lower portion of the housing to discharge the air introduced into the filling space.
  • the discharge hole may be sequentially disposed in the charging hole with respect to the rotating direction of the agitator.
  • the housing may be formed in a cylindrical shape, and the agitator may be formed to sweep the entire inner surface of the housing.
  • the stirrer may be a curved plate.
  • the stirrer may be formed so that its end is rounded toward the opposite direction of the rotation direction.
  • the stirrer may be a plate having an arc-shaped cross section.
  • the end of the stirrer may be formed to have a gap with the inner surface of the housing.
  • the agitator includes an agitator main body extending and installed on a rotating shaft of the housing; And a filling vane formed at an end portion of the main body of the stirrer so as to correspond to the inner surface of the housing.
  • the charging wing may be a curved plate.
  • the pharmaceutical composition according to the present invention can be filled with a powder medicine filling device.
  • the mechanical mechanism is used, so that it is possible to simplify the configuration of the filling device using the air pressure difference or the like.
  • the charging device can be driven regardless of the size of the particles.
  • the agitator in the shape of a curved plate, the powder medicine mainly located on the inner surface of the housing can be pressed more effectively, so that the charging efficiency can be improved.
  • FIG. 1 is a view showing a powder medicine filling apparatus according to an embodiment of the present invention
  • FIG. 2 is a perspective view of the stirrer shown in FIG. 1; FIG.
  • Figures 3 and 4 illustrate filling a powdered medicament in a packaging material according to one embodiment of the present invention.
  • FIG. 5 illustrates a powder medicine filling apparatus according to another embodiment of the present invention.
  • first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another.
  • FIG. 2 is a perspective view of the stirrer shown in FIG. 1, and FIGS. 3 and 4 illustrate a powder medicine filling apparatus according to an embodiment of the present invention, Fig. 6 is a view showing the device filling the packaging material with the powder medicine.
  • the apparatus for filling a powder medicine comprises a housing 10 to which the powder medicine is supplied, the powder medicine filling apparatus comprising: a housing 10 to which the powder medicine is supplied; And a stirrer (20) which is rotatably installed in the housing (10) to sweep the inner surface of the housing (10) and which pressurizes the powder medicine supplied to the housing (10) ).
  • the housing 10 is formed in a cylindrical shape in the present embodiment, but not limited thereto, and any shape can be employed as long as at least one surface is curved so as to fill the powder medicine supplied into the filling space 32 have.
  • the powdered medicament may be supplied at various portions, such as the top or one side of the housing 10.
  • a housing space 12 through which the powder medicine is supplied is formed in the housing 10.
  • the accommodation space 12 may be designed to have a proper volume according to the type of the powder medicine, which is a space to which the powder medicine is supplied and is discharged for filling.
  • a rotary shaft 14 is provided along the longitudinal direction of the housing 10 made in a cylindrical shape.
  • the rotary shaft 14 is provided with a stirrer 20 so as to rotate together.
  • the rotary shaft 14 is disposed at the center on the longitudinal section of the housing 10, and the driving, stopping, rotating speed, and the like can be controlled by a separate driving source (not shown).
  • a filling hole 16 communicating with the filling space 32 is formed in the lower portion of the housing 10.
  • the filling hole 16 is a passage through which the powder medicine supplied to the accommodation space 12 is discharged.
  • the powder medicine discharged into the filling hole 16 is introduced into the filling space 32 of the packaging material 30 disposed at the lower side, 20).
  • a plurality of charging holes 16 may be formed in the lower portion of the housing 10, and the charging holes 16 may be arranged in a plurality of rows and columns.
  • the size of the filling hole 16 can be appropriately designed in consideration of the rotation cycle of the stirrer 20, the volume of the filling space 32, and the like.
  • a discharge hole 18 is formed in the lower portion of the housing 10 to discharge the air introduced into the filling space 32.
  • the discharge hole 18 is formed to prevent the powdered medicament 1 from being sufficiently filled due to the air introduced into the filling space 32 and is formed so as to follow the filling hole 16 with respect to the rotating direction of the stirrer 20 Respectively.
  • the discharge hole 18 is positioned adjacent to the agitator 20 rotated toward the charging hole 16 so that air introduced into the charging space 32 is discharged.
  • a plurality of discharge holes 18 may be formed in the lower portion of the housing 10, or may be arranged in a plurality of rows and columns.
  • the discharge hole 18 is formed in the lower portion of the housing 10 so that two holes are formed.
  • the present invention is not limited thereto, and only one filling hole 16 may be formed in the lower portion of the housing 10.
  • an agitator (20) is installed on the rotating shaft (14) inside the housing (10) and rotated.
  • the agitator 20 stirs and pressurizes the powdered medicament supplied to the receiving space 12 with a rotational force.
  • the stirrer 20 is configured to charge powdered medicines using a mechanical mechanism, and pressurization is performed by a rotational force without using an air pressure difference or the like, so that the apparatus can be configured more simply. Further, since the powder medicine in the housing 10 having a sufficient volume is filled into the packaging material 30 without supplying the powder medicine through the pipe, the charging device can be driven regardless of the size of the particles.
  • the agitator 20 may be formed to sweep the entire inner surface of the housing 10 formed in a cylindrical shape.
  • the stirrer 20 sweeps the inner surface of the housing 10 as described above, the powder medicine filled in the accommodation space 12 can be smoothly moved to the filling space 32 through the filling hole 16, Can be well filled into the filling space 32 without remaining powdered medicament.
  • the stirrer 20 is formed so as to sweep the inner surface of the housing 10 so that the stirrer 20 does not rotate while contacting the inner surface of the housing 10 but has a slight gap on the inner surface of the housing 10 So that the powder medicine is charged into the filling space 32 without leaving as much as possible on the inner surface of the housing 10.
  • the end portion of the agitator 20 should have a slight gap so as to be in contact with the inner surface of the housing 10 so that the inner surface is not damaged.
  • the stirrer 20 is made of a metal material and is damaged when it comes into contact with the inner surface of the housing 10.
  • the stirrer 20 is made of a flexible material such as an elastic material, a soft plastic, a nylon material or the like, the gap may be absent or slightly present.
  • the agitator 20 may be made of a curved plate as shown in Fig.
  • the end portion is rounded toward the opposite direction of the rotation direction. That is, the end portion of the agitator 20 is not rounded toward the rotating direction.
  • the agitator 20 having such a shape can more effectively press the powder medicine mainly located on the inner surface side of the housing 10, so that the charging efficiency can be improved.
  • the stirrer 20 may be made of a plate having an arc-shaped cross section.
  • the agitator 20 is rotated in the accommodation space 12 as shown in FIG. 3 to pressurize the powdered medicament.
  • the pressurized powder medicine is filled into the filling space 32 of the packing material 30 through the filling hole 16.
  • the powder medicine is charged into the filling space 32 by one rotation of the stirrer 20, Or may be charged by more than two turns.
  • the stirrer 20 should be controlled so as to be stopped at the position shown in Fig. 4, that is, at the position where the end of the stirrer 20 blocks the filling hole 16. This is because filling of the filling space 32 with the powder medicine at the moment when the stirrer 20 blocks the filling hole 16 is completed.
  • the stirrer 20 serves as a kind of valve for controlling the opening and closing of the charging hole 16.
  • FIG. 5 is a view showing a powder medicine filling apparatus according to another embodiment of the present invention.
  • the stirrer 20 includes an agitator main body 22 installed on the rotary shaft 14 of the housing 10 and extending therefrom; And a filling vane 24 formed at an end of the agitator main body 22 so as to correspond to an inner surface of the housing 10.
  • the agitator main body 22 and the charging vane 24 may be in the form of a plate integrally formed.
  • the stirrer 20 is configured such that the inner surface of the housing 10 is formed so as to be worn, so that the entire stirrer 20 is not made into a curved surface but curved at only the end.
  • the shape of the charging wing 24 is not limited to the curved shape, and any shape that can use the inner surface of the housing 10 may be employed.
  • an example of the pharmaceutical composition of the powder medicine to be filled into the powder medicine filling apparatus according to an embodiment of the present invention is as follows.
  • asthmatic or COPD therapeutic agents there may be mentioned, for example, Fluticasone, Salmeterol, Arformoterol, Budesonide, Fenoterol, Procaterol, Levalbuterol, ), Salbutamol, Albuterol, Terbutaline, Formoterol, Indacaterol, Olodaterol, Vilanterol, Ipratropium, Oxitropium, Aclidinium, Glycopyrronium, Tiotropium, Umeclidinium, Beclomethasone, Ciclesonide, Triamcinolone, Mometasone, or each salt thereof may be used.
  • a therapeutic agent for the treatment of inflammation such as Gefitinib, Erlotinib, Afatinib, Osimertinib, Olmutinib, Crizotinib, Seritinib Ceritinib) or each salt thereof may be used.
  • Levodopa or each salt thereof may be used as a therapeutic agent for Parkinson's disease or degenerative brain disease.
  • antibiotics quinolones or their salts can be used.
  • At least one selected from the group consisting of insulin, GLP (Glucagon-Like Peptide), Glucose-dependent Insulinotropic Polypeptide (GIP) and analog thereof can be used.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Health & Medical Sciences (AREA)
  • Fluid Mechanics (AREA)
  • Basic Packing Technique (AREA)
  • Supply Of Fluid Materials To The Packaging Location (AREA)

Abstract

La présente invention concerne un appareil d'injection de médicament en poudre et une composition pharmaceutique injectée à l'aide dudit appareil. L'appareil d'injection de médicament en poudre selon la présente invention injecte un médicament en poudre dans un espace d'injection formé dans un matériau d'emballage, et l'appareil peut comprendre : un logement dans lequel est introduit le médicament en poudre ; et un agitateur qui est installé rotatif dans le logement de façon à balayer la surface interne du logement, et qui applique une force de rotation sur le médicament en poudre introduit dans le logement et qui injecte le médicament en poudre dans l'espace d'injection.
PCT/KR2018/014346 2017-11-21 2018-11-21 Appareil d'injection de médicament en poudre et composition pharmaceutique injectée à l'aide dudit appareil Ceased WO2019103451A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0155923 2017-11-21
KR1020170155923A KR102056692B1 (ko) 2017-11-21 2017-11-21 분말 약제 충전장치 및 이에 의해 충전되는 약학조성물

Publications (1)

Publication Number Publication Date
WO2019103451A1 true WO2019103451A1 (fr) 2019-05-31

Family

ID=66631063

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/014346 Ceased WO2019103451A1 (fr) 2017-11-21 2018-11-21 Appareil d'injection de médicament en poudre et composition pharmaceutique injectée à l'aide dudit appareil

Country Status (2)

Country Link
KR (1) KR102056692B1 (fr)
WO (1) WO2019103451A1 (fr)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6062409U (ja) * 1983-10-05 1985-05-01 山口　豊春 供給装置
WO1997005019A1 (fr) * 1995-07-25 1997-02-13 I.M.A. Industria Macchine Automatiche S.P.A. Dispositif de distribution par charge permettant le remplissage de recipients avec des produits en poudre et analogues
JP2007055640A (ja) * 2005-08-23 2007-03-08 Shikoku Kakoki Co Ltd 定量ソフト充填装置及び定量ソフト充填装置を用いた定量ソフト充填方法
US8371342B2 (en) * 2007-09-27 2013-02-12 Harro Höfliger Verpackungsmaschinen GmbH Filling device for the volumetric metering of powder
CN204341417U (zh) * 2014-12-26 2015-05-20 刘运武 快速自动装袋机

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6062409U (ja) * 1983-10-05 1985-05-01 山口　豊春 供給装置
WO1997005019A1 (fr) * 1995-07-25 1997-02-13 I.M.A. Industria Macchine Automatiche S.P.A. Dispositif de distribution par charge permettant le remplissage de recipients avec des produits en poudre et analogues
JP2007055640A (ja) * 2005-08-23 2007-03-08 Shikoku Kakoki Co Ltd 定量ソフト充填装置及び定量ソフト充填装置を用いた定量ソフト充填方法
US8371342B2 (en) * 2007-09-27 2013-02-12 Harro Höfliger Verpackungsmaschinen GmbH Filling device for the volumetric metering of powder
CN204341417U (zh) * 2014-12-26 2015-05-20 刘运武 快速自动装袋机

Also Published As

Publication number Publication date
KR20190058180A (ko) 2019-05-29
KR102056692B1 (ko) 2019-12-17

Similar Documents

Publication Publication Date Title
US9339616B2 (en) Dry powder inhalers
ES2217008T3 (es) Inhalador.
EP2521584B1 (fr) Dispositif d'inhalation
AU2005209199B2 (en) Sublingual drug delivery device
ES2648144T3 (es) Dispositivo de administración nasal
CN1217714C (zh) 粉末状药品的储存系统以及配有该系统的吸入器
JP5829269B2 (ja) 流体投与装置
JP4477231B2 (ja) 調薬計数ユニットを備えた吸入デバイス
EP1066849A1 (fr) Dispositif et procede servant a administrer une quantite constante de poudre
ES2835865T3 (es) Mecanismo de avance de la tira de blísteres
JP2003508165A (ja) 物質送達装置
KR20060106627A (ko) 건조분말흡입기용 정량약제매거진
CZ163297A3 (en) Mechanism for indicating doses
CN1330564A (zh) 干粉吸入器
KR20110044999A (ko) 정량 투입 기기 및 캐비티 충전 방법
US20110139812A1 (en) Method For Dosing And Providing Powder In A Powder Provider, Such A Powder Provider Device And An Apparatus For Producing Packs
CN104136061A (zh) 改进型药物输送装置
WO2019103451A1 (fr) Appareil d'injection de médicament en poudre et composition pharmaceutique injectée à l'aide dudit appareil
ES2393473T3 (es) Procedimiento y dispositivo de producción de un dosificador múltiple para medicinas pulverulentas
WO2017128170A1 (fr) Inhalateur de poudre sèche de type réservoir
JP2003512138A (ja) 乾燥粉末医薬品の投与装置
WO2024167764A3 (fr) Sous-ensembles de compteur de dose destinés à être utilisés dans des inhalateurs de poudre sèche
KR200462631Y1 (ko) 막대형 약포지용 약 포장장치
HK1260175A1 (en) Inhalation device and method
HK1165272B (en) Pharmaceutical dosages delivery system

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18880299

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18880299

Country of ref document: EP

Kind code of ref document: A1