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WO2017128170A1 - Inhalateur de poudre sèche de type réservoir - Google Patents

Inhalateur de poudre sèche de type réservoir Download PDF

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Publication number
WO2017128170A1
WO2017128170A1 PCT/CN2016/072472 CN2016072472W WO2017128170A1 WO 2017128170 A1 WO2017128170 A1 WO 2017128170A1 CN 2016072472 W CN2016072472 W CN 2016072472W WO 2017128170 A1 WO2017128170 A1 WO 2017128170A1
Authority
WO
WIPO (PCT)
Prior art keywords
drug
main body
dry powder
cover
powder inhaler
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2016/072472
Other languages
English (en)
Chinese (zh)
Inventor
张凯
崔畅
王扬成
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Omni Pharmaceutical Co Ltd
Yangtze River Pharmaceutical Group Co Ltd
Original Assignee
Suzhou Omni Pharmaceutical Co Ltd
Yangtze River Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suzhou Omni Pharmaceutical Co Ltd, Yangtze River Pharmaceutical Group Co Ltd filed Critical Suzhou Omni Pharmaceutical Co Ltd
Priority to PCT/CN2016/072472 priority Critical patent/WO2017128170A1/fr
Publication of WO2017128170A1 publication Critical patent/WO2017128170A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators

Definitions

  • the invention relates to the field of medical equipment, in particular to a reservoir type dry powder inhaler.
  • Dry powder inhaler refers to the filling of a drug powder in a drug reservoir. The patient inhales through the inhaler, disperses the powder into a mist, and then inhales into the trachea or the lungs to exert a therapeutic effect.
  • Current dry powder inhalers are respiratory-sensitive, and the source of drug dispersion and powder is derived from the patient's inhalation. Since the drug is filled in a powder form, the drug loading amount can be high; as a solid state, the stability of the drug is favorable. In particular, the respiratory touch is administered, and the patient's degree of cooperation is high. Therefore, in the past 10 years, the dry powder inhaler has developed rapidly. Not only short-term dry powder inhalers are most attractive as a topical medication for the treatment of the trachea or lungs, but in the long run, they have a more important potential advantage in systemic transport of biomolecules, antibiotics and genetic engineering drugs.
  • the particle size distribution of the drug powder in the special airflow environment of the respiratory tract should be within a certain range. It is generally believed that a particle size of 3 to 7 ⁇ m can be deposited well in the bronchus, and a thickness of 1 to 3 ⁇ m can be deposited in a deep region of the lung. Particles larger than 7 ⁇ m are easily trapped by the upper respiratory tract, and too small particles are easily exhaled from the patient's breathing after entering the terminal bronchus.
  • the fine drug powder has a large surface tension, is easy to agglomerate, and has poor fluidity, making it difficult to fill and dispense.
  • lactose 80 to 300 ⁇ m
  • the drug powder is dispersed and attached to the surface of the carrier, the fluidity is greatly improved, and the dose accuracy is improved, so that it is widely used.
  • the object of the present invention is to solve the problems existing in the prior art, and in particular to provide a reservoir type dry powder inhaler which has long storage time, high safety, simple and effective inhalation mode, and simple and reliable counting method.
  • the invention provides a reservoir type dry powder inhaler, a reservoir type dry powder inhaler, comprising a base, a main body, a one-way control device, a counting component, a medicine cover plate, an air passage component and a nozzle component, wherein
  • the base is located at a lower portion of the main body, the counting member is disposed in the base, and the nozzle member is located at an upper portion of the main body;
  • the counting member includes a gear member and a one-way control device; and the one-way control device ensures that only one direction of rotation of the main body is transmitted to the gear member;
  • the upper part of the main body is mounted with a top cover, and the middle part is provided with a medicine cover plate, and the medicine cover plate is fixed in the main body through the bracket
  • the airway component is a double arcuate structure.
  • a main body cover is added to the main body, and the main body cover protects the nozzle component.
  • a spring device is arranged between the bracket and the medicine cover, and the spring ensures that the medicine cover is tightly coupled with the lower wall of the main body.
  • the upper surface of the medicine cover is provided with a column structure, and the column structure is located in the drug storage chamber when the body rotates.
  • the gear component comprises a main gear, a driven gear, a pinion gear, a digital rack and a limiting device, wherein the main gear is installed in a middle portion of the base, and when the main gear rotates, the driven gear that meshes with the main gear rotates, The other end of the moving gear is pinched, and the pinion meshes with the digital rack mounted on the inner periphery of the base at the same time, and the main gear rotates once, which drives the digital rack to move in one direction.
  • the one-way control device is mounted on the gear member and includes a one-way shaft and a one-way cover.
  • a display window is arranged on the base, and the result of the rotation of the counting device once is displayed by digital in the display window.
  • the drug delivery chamber is a trapezoidal concave structure or a circular concave structure, the volume of which is the dose required for one administration.
  • the dry type inhaler of the depot type according to claim 1 wherein a longitudinal direction between the medicine cover and the top cover is further separated by a desiccant storage chamber, and a desiccant is placed in the desiccant storage chamber. Keep the inside of the device dry.
  • the upper cover is divided into two parts, a first upper cover and a second upper cover respectively, the first upper cover is a storage compartment upper cover, and the second upper cover is a main component upper cover.
  • the drug reservoir can be filled with one or more drugs.
  • the drug is selected from the group consisting of a ⁇ 2 agonist, one or more of formoterol, salbutamol, and salmeterol.
  • the drug is selected from the group consisting of glucocorticoids, one or more of budesonide, fluticasone, and ciclesonide.
  • the drug is selected from the group consisting of an anticholinergic drug, one or more selected from the group consisting of adiponium bromide and ipratropium bromide.
  • the invention provides a reservoir type dry powder inhaler, which has the advantages of:
  • the main body is vertically divided into a drug storage chamber, a drug absorption channel and a drying chamber, and has a simple structure and is convenient for drug storage and retrieval.
  • the drug delivery bin has a simple structure, flexible setting method, reliable use and low cost, and if not inhaled after filling the drug storage bin, The filling drug can also be switched to the storage chamber again to prevent powder leakage and deliquescence.
  • Adding a column to the medicine cover plate can stir the powder to make the filling amount more balanced, increase the dispersibility and fluidity of the powder, and help the dosage of each dose to be more accurate.
  • dry powder inhaler overall structure is simple, smart design, safe and reliable, to meet the needs of users.
  • FIG. 1 is a schematic view of the overall assembly of an embodiment of the present invention
  • Figure 2 is a cross-sectional view showing an embodiment of the present invention.
  • an embodiment of the present invention is a reservoir type dry powder inhaler comprising a base 1, a main body 2, a unidirectional control device 3, a counting member 4, an air passage member 5, and a nozzle member. 6.
  • the base 1 is located at a lower portion of the main body 2
  • the counting member 4 is disposed in the base 1 and the main body 2
  • the nozzle member 6 is located at an upper portion of the main body 2.
  • the counting member 4 includes a gear member 41 and a one-way control device 42.
  • the gear member 41 includes The main gear 411 installed in the middle of the base 1 rotates when the main gear 411 rotates, and the driven gear 412 that meshes with the main gear 411 rotates.
  • the other end pinion 413 of the driven gear 412 is kneaded, and the pinion 413 is simultaneously mounted with the number mounted on the inner periphery of the base.
  • the rack 414 is engaged, and the main gear is rotated once, and the digital rack is driven once in one direction.
  • the one-way control device 3 includes a one-way shaft 31 mounted on a main gear, and a one-way shaft 32 that ensures that only one direction of rotation of the main body 2 is transmitted to the gear member 41; 2, the upper part is mounted on the upper cover 21, the middle part is mounted with the medicine cover 22, and the upper cover 21 is divided into two parts, a first upper cover 211 and a second upper cover 212, respectively, and the first upper cover 211 is a storage compartment upper cover, The upper cover 212 is a cover for other components of the main body.
  • the medicine cover 22 is fixed in the main body 2 by the bracket 23, and the bracket 23 is disposed on the one-way shaft 32; the medicine cover 22 and the top cover 24 in the main body 2 are longitudinally separated into a medicine storage chamber 25, A desiccant storage chamber 26 and a drug suction channel 27; a spring 28 is disposed between the stent 23 and the drug cover 22 to press the drug cover 22 against the lower edge of the drug storage chamber or the drug suction channel.
  • the upper surface of the medicine cover 22 is provided with a drug delivery chamber 221, and the drug delivery chamber 221 is switched between the drug storage chamber 25 and the drug suction channel 27 during the rotation of the body 2.
  • the drug delivery chamber 221 has a trapezoidal concave structure and in other cases may have a circular concave structure or other shape structure, but the volume of the drug delivery chamber 221 is generally The dose required for one administration.
  • the upper surface of the medicine cover 22 is further provided with a column 222 which is located in the drug storage chamber 25 when the body 2 is rotated.
  • a spring device 231 is disposed between the bracket 23 and the medicine cover 22, and the spring device 231 presses the medicine cover against the lower edge of the suction passage.
  • a desiccant is placed in the desiccant storage chamber 26 to keep the inside of the device dry.
  • the nozzle member 6 is located above the main body, and the air passage member 7 has a double arc-shaped structure, which is located in the nozzle member, and one end is connected to the suction passage 27 on the main body.
  • a main body cover 7 is attached to the main body 2, and the main body cover 7 protects the nozzle member.
  • a display window 11 may be disposed on the base 1, and the result of the rotation of the counting member 4 once is numerically displayed in the display window 11.
  • the dry powder inhaler can be divided into single dose and multiple dose according to the dosage.
  • the multi-dose type can be divided into the manufacturer pre-dispensing type (blister type) and the reservoir type.
  • the inhaler according to the present invention is a reservoir type, and is composed of a counter, a reservoir, a trough, an air passage, a powder dispersing member, and a desiccant storage chamber.
  • the working principle and process of the invention include:
  • the base portion can be held by the left hand, and the main body portion can be held by the right hand and rotated counterclockwise until the limit angle cannot be rotated.
  • the limit angle is achieved by providing two square pillars in the lower part of the main body. When the main body rotates, the square pillars collide with the bracket blocks fixed on the base, and the brackets are restricted to continue to rotate.
  • the limit modes of the forward and reverse rotation are the same; when the main body rotates counterclockwise, the one-way shaft rotation in the one-way control device is driven, and the one-way shaft drives the driving gear to rotate, the driving gear The rotation will drive the driven gear and the pinion to rotate, the main body rotates once, and the digital rack moves a unit, and the number can be displayed through the counting display window associated with the digital rack.
  • the drug storage compartment on the medicine cover is switched from below the drug storage chamber to below the drug suction channel, and the dry powder inhaler enters the drug absorption state.
  • the user can use the mouth to contain the nozzle, inhale hard, and a negative pressure will be generated in the channel, and the powder will flow with the airflow to reach the lungs of the patient, and the effect of the drug treatment can be achieved.
  • the main body rotates clockwise, until it can not be rotated, this is a reset.
  • the one-way shaft does not transmit the rotation to the main gear of the counting device due to the action of the one-way control device, so the number displayed on the counting display window associated with the counting device does not change over the entire cycle.
  • the counting device will move once, and the number will change by one unit, so as to accurately count the purpose of the patient's drug taking times.
  • the drug delivery chamber on the medicine cover is switched from below the drug suction channel to the lower side of the drug storage chamber, and the dosage of one unit dose is maintained, and Prevent leakage or deliquescence in the inhalation channel.
  • the drug absorption amount is constant every time, and the effective statistical drug absorption frequency is 60 times; at the same time, the medicine cover plate of the embodiment is provided with a column mechanism, and the column mechanism is stored during the cycle of the body rotation.
  • the drug room movement can effectively stir the powder in the drug storage chamber to make the drug add-on More uniform, strengthen the dispersion of the powder, stir the powder back and forth to achieve the powder flow, to ensure that the powder can enter the medicine silo on the medicine board.
  • the present embodiment provides a desiccant storage chamber, and a desiccant is added thereto to maintain the dryness of the inside of the dry powder inhaler.
  • Counter The digital rack in this embodiment will be printed with numbers. After each inhalation, the number of times that the remaining medicine can be taken can be read. The final number is fed back to the patient from the digital rack.
  • the dry powder inhaler in this embodiment may be covered with a main body cover to protect the cleaning of the nozzle member.
  • This embodiment uses aerodynamic principles to design a double circular arc-shaped airway.
  • the drug and carrier powder can generate sufficient turbulence when passing through the airway, disperse the aggregated mass and make the drug and carrier. Separate sufficiently to produce the largest proportion of particles of optimal particle size. The contradiction between drug powder dispersion and airflow resistance is well solved, and the best effect is obtained.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne un inhalateur de poudre sèche de type réservoir, comprenant une base (1), un corps principal (2), une partie de comptage (4), une partie de canal d'air (5) et une partie buse d'aspiration (6). La base (1) est située au niveau de la partie inférieure du corps principal (2) ; la partie de comptage (4) comprend une partie d'engrenage (41) et un dispositif de commande unidirectionnel (42) ; un couvercle supérieur (21) est monté sur la partie supérieure du corps principal (2) ; et une plaque de recouvrement de médicament (22) est montée sur la partie centrale ; l'espace entre la plaque de recouvrement de médicament (22) et un couvercle supérieur (24) dans le corps principal (2) est divisé longitudinalement en une chambre de stockage de médicament (25) et un canal d'inhalation de médicament (27) ; et une cabine de distribution de médicament (221) est disposée sur une surface supérieure de la plaque de recouvrement de médicament (22), et la cabine de distribution de médicament (221) passe de la chambre de stockage de médicament (25) vers le canal d'inhalation de médicament (27) pendant la rotation du corps principal (2). L'inhalateur de poudre sèche facilite le stockage et la prise d'un médicament. La partie de canal d'air (5) étant dans une forme arquée circulaire double, un débit de gaz sous pression raisonnable peut être garanti dans le canal d'inhalation pendant l'inhalation, ce qui améliore évidemment la dispersion d'un médicament en poudre. Avec la configuration de colonne verticale de la plaque de recouvrement de médicament (22), la dose de chaque administration est plus précise.
PCT/CN2016/072472 2016-01-28 2016-01-28 Inhalateur de poudre sèche de type réservoir Ceased WO2017128170A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/072472 WO2017128170A1 (fr) 2016-01-28 2016-01-28 Inhalateur de poudre sèche de type réservoir

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2016/072472 WO2017128170A1 (fr) 2016-01-28 2016-01-28 Inhalateur de poudre sèche de type réservoir

Publications (1)

Publication Number Publication Date
WO2017128170A1 true WO2017128170A1 (fr) 2017-08-03

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PCT/CN2016/072472 Ceased WO2017128170A1 (fr) 2016-01-28 2016-01-28 Inhalateur de poudre sèche de type réservoir

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109908442A (zh) * 2019-01-25 2019-06-21 苏州艾莱科劢德电子科技有限公司 一种基于声音的干粉吸入器的流速侦测装置
CN110064110A (zh) * 2019-05-29 2019-07-30 上海理工大学 一种容积旋钮式干粉储存吸入装置
CN115970104A (zh) * 2022-12-09 2023-04-18 中国药科大学 一种新型储库型干粉吸入器

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1662270A (zh) * 2002-05-14 2005-08-31 佩尔洛斯公司 吸入器及其制造方法
CN1684731A (zh) * 2002-09-21 2005-10-19 艾文蒂斯药品有限公司 吸入器
US20090120436A1 (en) * 2007-11-09 2009-05-14 Hitachi, Ltd. Powder medicine administering apparatus
CN104168940A (zh) * 2012-01-23 2014-11-26 赛诺菲股份有限公司 吸入装置
CN204521855U (zh) * 2015-03-13 2015-08-05 丁要武 吸粉器及连接于该吸粉器的吸粉器本体上的药匣组件
CN105031782A (zh) * 2015-06-30 2015-11-11 上海臣邦医药科技有限公司 一种提高粉雾剂给药装置加药量计量准确性的方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1662270A (zh) * 2002-05-14 2005-08-31 佩尔洛斯公司 吸入器及其制造方法
CN1684731A (zh) * 2002-09-21 2005-10-19 艾文蒂斯药品有限公司 吸入器
US20090120436A1 (en) * 2007-11-09 2009-05-14 Hitachi, Ltd. Powder medicine administering apparatus
CN104168940A (zh) * 2012-01-23 2014-11-26 赛诺菲股份有限公司 吸入装置
CN204521855U (zh) * 2015-03-13 2015-08-05 丁要武 吸粉器及连接于该吸粉器的吸粉器本体上的药匣组件
CN105031782A (zh) * 2015-06-30 2015-11-11 上海臣邦医药科技有限公司 一种提高粉雾剂给药装置加药量计量准确性的方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109908442A (zh) * 2019-01-25 2019-06-21 苏州艾莱科劢德电子科技有限公司 一种基于声音的干粉吸入器的流速侦测装置
CN110064110A (zh) * 2019-05-29 2019-07-30 上海理工大学 一种容积旋钮式干粉储存吸入装置
CN115970104A (zh) * 2022-12-09 2023-04-18 中国药科大学 一种新型储库型干粉吸入器

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