WO2019173832A3 - Nouveaux promédicaments à base de cytokine - Google Patents
Nouveaux promédicaments à base de cytokine Download PDFInfo
- Publication number
- WO2019173832A3 WO2019173832A3 PCT/US2019/021654 US2019021654W WO2019173832A3 WO 2019173832 A3 WO2019173832 A3 WO 2019173832A3 US 2019021654 W US2019021654 W US 2019021654W WO 2019173832 A3 WO2019173832 A3 WO 2019173832A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cytokine
- prodrugs
- cytokine prodrugs
- making
- methods
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
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Abstract
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19717636.5A EP3762406A2 (fr) | 2018-03-09 | 2019-03-11 | Promédicaments à base de cytokine |
| US16/979,404 US20210260163A1 (en) | 2018-03-09 | 2019-03-11 | Novel cytokine prodrugs |
| JP2020571344A JP7515412B2 (ja) | 2018-03-09 | 2019-03-11 | 新規のサイトカインプロドラッグ |
| CN201980017081.7A CN113166220A (zh) | 2018-03-09 | 2019-03-11 | 创新细胞因子前药 |
| CA3115461A CA3115461A1 (fr) | 2018-03-09 | 2019-03-11 | Nouveaux promedicaments a base de cytokine |
| JP2024106766A JP2024153636A (ja) | 2018-03-09 | 2024-07-02 | 新規のサイトカインプロドラッグ |
| US18/960,740 US20250127858A1 (en) | 2018-03-09 | 2024-11-26 | Novel cytokine prodrugs |
Applications Claiming Priority (12)
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| US201862640969P | 2018-03-09 | 2018-03-09 | |
| US62/640,969 | 2018-03-09 | ||
| US201862643104P | 2018-03-14 | 2018-03-14 | |
| US62/643,104 | 2018-03-14 | ||
| US201862644384P | 2018-03-17 | 2018-03-17 | |
| US62/644,384 | 2018-03-17 | ||
| US201862644577P | 2018-03-18 | 2018-03-18 | |
| US62/644,577 | 2018-03-18 | ||
| US201862680707P | 2018-06-05 | 2018-06-05 | |
| US62/680,707 | 2018-06-05 | ||
| US201962801649P | 2019-02-06 | 2019-02-06 | |
| US62/801,649 | 2019-02-06 |
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| US16/979,404 A-371-Of-International US20210260163A1 (en) | 2018-03-09 | 2019-03-11 | Novel cytokine prodrugs |
| US18/960,740 Continuation US20250127858A1 (en) | 2018-03-09 | 2024-11-26 | Novel cytokine prodrugs |
Publications (3)
| Publication Number | Publication Date |
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| WO2019173832A2 WO2019173832A2 (fr) | 2019-09-12 |
| WO2019173832A3 true WO2019173832A3 (fr) | 2019-10-17 |
| WO2019173832A4 WO2019173832A4 (fr) | 2020-01-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2019/021654 Ceased WO2019173832A2 (fr) | 2018-03-09 | 2019-03-11 | Nouveaux promédicaments à base de cytokine |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20210260163A1 (fr) |
| EP (1) | EP3762406A2 (fr) |
| JP (2) | JP7515412B2 (fr) |
| CN (1) | CN113166220A (fr) |
| CA (1) | CA3115461A1 (fr) |
| WO (1) | WO2019173832A2 (fr) |
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| US11896648B2 (en) | 2020-10-22 | 2024-02-13 | Gilead Sciences, Inc. | Interleukin-2 variant proteins fused to human IgG4 Fc and uses thereof |
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2019
- 2019-03-11 CA CA3115461A patent/CA3115461A1/fr active Pending
- 2019-03-11 JP JP2020571344A patent/JP7515412B2/ja active Active
- 2019-03-11 US US16/979,404 patent/US20210260163A1/en not_active Abandoned
- 2019-03-11 WO PCT/US2019/021654 patent/WO2019173832A2/fr not_active Ceased
- 2019-03-11 CN CN201980017081.7A patent/CN113166220A/zh active Pending
- 2019-03-11 EP EP19717636.5A patent/EP3762406A2/fr active Pending
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2024
- 2024-07-02 JP JP2024106766A patent/JP2024153636A/ja active Pending
- 2024-11-26 US US18/960,740 patent/US20250127858A1/en active Pending
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| US11896648B2 (en) | 2020-10-22 | 2024-02-13 | Gilead Sciences, Inc. | Interleukin-2 variant proteins fused to human IgG4 Fc and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024153636A (ja) | 2024-10-29 |
| US20250127858A1 (en) | 2025-04-24 |
| CA3115461A1 (fr) | 2019-09-12 |
| WO2019173832A2 (fr) | 2019-09-12 |
| US20210260163A1 (en) | 2021-08-26 |
| CN113166220A (zh) | 2021-07-23 |
| EP3762406A2 (fr) | 2021-01-13 |
| JP2021515599A (ja) | 2021-06-24 |
| JP7515412B2 (ja) | 2024-07-12 |
| WO2019173832A4 (fr) | 2020-01-02 |
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