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WO2019013573A3 - Procédé de préparation de 2-hydroxy-gamma-butyrolactone ou de 2,4-dihydroxy-butyrate - Google Patents

Procédé de préparation de 2-hydroxy-gamma-butyrolactone ou de 2,4-dihydroxy-butyrate Download PDF

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Publication number
WO2019013573A3
WO2019013573A3 PCT/KR2018/007923 KR2018007923W WO2019013573A3 WO 2019013573 A3 WO2019013573 A3 WO 2019013573A3 KR 2018007923 W KR2018007923 W KR 2018007923W WO 2019013573 A3 WO2019013573 A3 WO 2019013573A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
gamma
butyrolactone
butyrate
dihydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/007923
Other languages
English (en)
Korean (ko)
Other versions
WO2019013573A9 (fr
WO2019013573A2 (fr
Inventor
박성훈
김용환
이성국
심증엽
유태현
수만라마
응웬하이남
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNIST Academy Industry Research Corp
Original Assignee
UNIST Academy Industry Research Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UNIST Academy Industry Research Corp filed Critical UNIST Academy Industry Research Corp
Publication of WO2019013573A2 publication Critical patent/WO2019013573A2/fr
Publication of WO2019013573A3 publication Critical patent/WO2019013573A3/fr
Publication of WO2019013573A9 publication Critical patent/WO2019013573A9/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01046—Homoserine O-succinyltransferase (2.3.1.46)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01039—Homoserine kinase (2.7.1.39)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02004—Aspartate kinase (2.7.2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/08—Phosphoric triester hydrolases (3.1.8)
    • C12Y301/08001—Aryldialkylphosphatase (3.1.8.1), i.e. paraoxonase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/0102—Diaminopimelate decarboxylase (4.1.1.20)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01031—Phosphoenolpyruvate carboxylase (4.1.1.31)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01001—Acetate-CoA ligase (6.2.1.1)

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

La présente invention concerne : une voie de biosynthèse nouvellement démontrée utilisant la production d'homosérine à titre d'étape intermédiaire dans la préparation de 2-hydroxy-gamma-butyrol-acétone (HGBL) et d'un précurseur de celle-ci, l'acide 2,4-dihydroxybutanoïque; et une souche recombinée de gène comprenant ladite voie. Une HGBL ayant un groupe hydroxyle substitué en position 2 peut être utilisée comme intermédiaire important, pouvant être employé comme résine pour photoréserve, matière première pour produit médical, et matériau pour revêtir une surface métallique.
PCT/KR2018/007923 2017-07-12 2018-07-12 Procédé de préparation de 2-hydroxy-gamma-butyrolactone ou de 2,4-dihydroxy-butyrate Ceased WO2019013573A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170088465 2017-07-12
KR10-2017-0088465 2017-07-12

Publications (3)

Publication Number Publication Date
WO2019013573A2 WO2019013573A2 (fr) 2019-01-17
WO2019013573A3 true WO2019013573A3 (fr) 2019-03-28
WO2019013573A9 WO2019013573A9 (fr) 2019-05-02

Family

ID=65002668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/007923 Ceased WO2019013573A2 (fr) 2017-07-12 2018-07-12 Procédé de préparation de 2-hydroxy-gamma-butyrolactone ou de 2,4-dihydroxy-butyrate

Country Status (2)

Country Link
KR (1) KR102149044B1 (fr)
WO (1) WO2019013573A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102547254B1 (ko) * 2020-11-06 2023-06-30 주식회사 씨원바이오 효소를 이용한 2-하이드록시-γ-부티로락톤의 제조방법
DE102021101004B3 (de) 2021-01-19 2022-03-10 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Verfahren zur Herstellung von 2,4-Dihydroxybutyrat oder L-Threonin unter Nutzung eines mikrobiellen Stoffwechselweges
CN115948482B (zh) * 2023-02-07 2024-02-09 中国科学院天津工业生物技术研究所 一种2，4-二羟基丁酸生物合成途径的构建方法及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011100601A1 (fr) * 2010-02-11 2011-08-18 Metabolix, Inc. Procédé de production de gamma-butyrolactone
US20140296466A1 (en) * 2013-03-20 2014-10-02 Cj Cheiljedang Corporation Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms
US20150147793A1 (en) * 2012-07-11 2015-05-28 Adisseo France S.A.S. Method for the preparation of 2,4-dihydroxybutyrate
WO2016162442A1 (fr) * 2015-04-07 2016-10-13 Metabolic Explorer Micro-organisme modifié pour la production optimisée de 2,4-dihydroxyburyrate avec un écoulement de 2,4-dihydroxybutyrate amélioré

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011100601A1 (fr) * 2010-02-11 2011-08-18 Metabolix, Inc. Procédé de production de gamma-butyrolactone
US20150147793A1 (en) * 2012-07-11 2015-05-28 Adisseo France S.A.S. Method for the preparation of 2,4-dihydroxybutyrate
US20140296466A1 (en) * 2013-03-20 2014-10-02 Cj Cheiljedang Corporation Method for Producing Bio-Based Homoserine Lactone and Bio-Based Organic Acid from O-Acyl Homoserine Produced by Microorganisms
WO2016162442A1 (fr) * 2015-04-07 2016-10-13 Metabolic Explorer Micro-organisme modifié pour la production optimisée de 2,4-dihydroxyburyrate avec un écoulement de 2,4-dihydroxybutyrate amélioré

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE GenPept 19 January 2004 (2004-01-19), Database accession no. AAR95986.1 *
DATABASE Protein 3 June 2015 (2015-06-03), "lactate dehydrogenase [Cupriavidus necator]", XP055585124, retrieved from ncbi Database accession no. WP_011614641.1 *
DATABASE Protein 3 June 2015 (2015-06-03), "lactate dehydrogenase [Lactobacillus delbrueckii]", XP055585127, retrieved from ncbi Database accession no. WP_011543503.1 *
DATABASE Protein 31 May 2015 (2015-05-31), "MULTISPECIES: aminotransferase MtnE [Bacillus]", XP055585120, retrieved from ncbi Database accession no. WP_003244774.1 *

Also Published As

Publication number Publication date
KR20190007403A (ko) 2019-01-22
WO2019013573A9 (fr) 2019-05-02
KR102149044B1 (ko) 2020-08-28
WO2019013573A2 (fr) 2019-01-17

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