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WO2019004812A1 - Système de détection précoce du syndrome du pied diabétique - Google Patents

Système de détection précoce du syndrome du pied diabétique Download PDF

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Publication number
WO2019004812A1
WO2019004812A1 PCT/MX2018/000056 MX2018000056W WO2019004812A1 WO 2019004812 A1 WO2019004812 A1 WO 2019004812A1 MX 2018000056 W MX2018000056 W MX 2018000056W WO 2019004812 A1 WO2019004812 A1 WO 2019004812A1
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WO
WIPO (PCT)
Prior art keywords
thz
patient
foot
terahertz
windows
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/MX2018/000056
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English (en)
Spanish (es)
Inventor
Enrique CASTRO CAMUS
Mariana ALFARO GÓMEZ
Goretti Guadalupe HERNÁNDEZ CARDOSO
Arturo Ignacio HERNÁNDEZ SERRANO
Sandra Carolina ROJAS LANDEROS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centro De Investigaciones En Optica Ac
Original Assignee
Centro De Investigaciones En Optica Ac
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centro De Investigaciones En Optica Ac filed Critical Centro De Investigaciones En Optica Ac
Publication of WO2019004812A1 publication Critical patent/WO2019004812A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/08—Auxiliary means for directing the radiation beam to a particular spot, e.g. using light beams
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/3581—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation
    • G01N21/3586—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared light; using Terahertz radiation by Terahertz time domain spectroscopy [THz-TDS]

Definitions

  • the present invention directed to the technical field of early diagnosis devices. More particularly, the present invention relates to an early detection system of! diabetic foot syndrome by Terahertz image.
  • the so-called "diabetic foot” or “diabetic foot syndrome” is a common consequence of Mel! Itus Diabetes (DM), where the foot of the diabetic person presents, in many cases, a combination of microvascular and neurological deterioration that results in poor irrigation and loss of sensation in the feet.
  • DM Mel! Itus Diabetes
  • the combination of these two conditions results in dehydration of the skin, which in turn becomes more fragile, coupled with a compromised ability to feel small injuries.
  • podiatric evaluation is known that is the most used for diabetic patients before ulcers occur, it is a subjective test known as the monofilament that assesses neurological deterioration. This test consists of pricking the patient's foot with a flexible tip and asking the patient to report when they feel pressure, when the patient fails to report a number of punctures, the test is considered positive.
  • the terahertz image according to the invention is an excellent tool for diagnosis.
  • Another object of the invention is to provide a system and method for early detection of! diabetic foot syndrome that provides quantitative and objective information on the deterioration of the foot to prevent injury and the subsequent partial or total amputation of the limb,
  • a further object of the present invention is to provide a system and method of early detection of diabetic foot syndrome that performs a complete image of the sole from point-to-point skin hydration, to detect problems locally before that injuries are generated.
  • Another additional object of the present invention is to provide a method of early detection of the syndrome of! Diabetic foot objective, quantitative, non-invasive.
  • an early detection system! diabetic foot syndrome which is conformed by: a raised platform with a seat where it will be placed! patient; a base structure aligned with said raised platform, which comprises a top support plate; and a lower support plate; wherein said upper support plate comprises in turn a pair of windows made of a material transparent to Terahertz radiation (THz), wherein the patient places the feet; an image capturing system of THz placed on said lower support plate under the windows; and a PC having a graphical control interface, which is in communication with said image acquisition system to have control thereof and which comprises an algorithm to generate a foot hydration image; said THz image acquisition system is formed by a pair of lenses placed in an angled manner; a Teraheriz photoconductive emitting medium aligned with the first lens to emit a THz signal towards the patient's feet through the windows; a Terahertz photoconductive sensing means aligned with the second lens which receives the THz signal reflected by the patient's feet, wherein
  • THz image acquisition system
  • the present invention relates to a non-invasive method of early diagnosis of diabetic foot syndrome, which comprises the steps of:
  • Figure 1 is a perspective view of the early detection system of diabetic foot syndrome of the present invention.
  • Figure 2 is a perspective view of the raised platform with seat of! Diabetic foot syndrome early detection system of the present invention.
  • FIG. 3 is a perspective view of the base structure and the Terahertz image capture system (THz) of the diabetic foot syndrome early detection system of the present invention.
  • THz Terahertz image capture system
  • FIG 4 is a perspective view showing in detail the Terahertz image capture system (THz) of the diabetic foot syndrome early detection system of the present invention.
  • THz Terahertz image capture system
  • Figure 5 is a schematic view showing measurement of terahertz pulses.
  • Figure 6 is a perspective view of a second embodiment of the early detection system of diabetic foot syndrome of the present invention.
  • Figure 7 shows a comparative example of a hydration image of a healthy foot and a diabetic foot.
  • Said detection system 1000 is generally formed by a substantially rectangular raised platform 1100; a chair or seat 1200 where the patient will be seated to be diagnosed; a substantially rectangular base structure 1300 aligned with said raised platform; an image acquisition system of Terahertz (THz) 1400; and a PC.
  • THz Terahertz
  • the raised platform 1100 is formed by a support plate 1110 attached to a frame with four legs 1120, wherein said elevated platform 1100 is configured to support said chair or seat 1200 where it will be made the measurement of the humidity of the feet of the patient.
  • said base structure 1300 is formed by an upper support plate 1310, and a lower support plate 1320 joined together by means of a frame with legs 1330.
  • Said plate upper support 1310 further comprises a pair of rectangular openings or windows 1340, the cuates each comprising a panel made of a material transparent to Terahertz radiation, such as polyethylene, polystyrene, tops, TPX, Bend ⁇ ay or the like.
  • Said windows 1340 are configured so that the patient supports the soles of the feet, to perform the measurement of Terahertz pulses.
  • the support plates 1110 and upper support plates 1310 are smooth, in alternative embodiments, said plates have a non-skid and / or thermal coating, to prevent the user from stepping on it from said plates and this could interfere in the measurement of Terahertz pulses.
  • said Terahertz image capture system (THz) 1400 is located under the windows 1340 to move to along these to perform the measurement of all terahertz pulses of the entire plant of each foot.
  • said Terahertz image acquisition system (THz) 1400 is formed by a base plate 1410, attached to said lower support plate 1320, a positioning system formed by a first longitudinal translation means 1420 , and a second transverse translation means 1430.
  • Each of said translation means 1420 ' , 1430 comprises a housing 1421, 1431 having inside it a positioning block 1422, 1432, which moves from one end to the other of said housing 1421, 1431 by means of an auger 1423, 1433, driven by a motor 1424, 1434.
  • Said Terahertz image capture system (THz) 1400 further comprises an image acquisition means 1440 which is formed by a support plate 1441 having a substantially T-shaped shape, wherein in its upper part, said support plate 1441 comprises a pair of lenses 1442, 1443 of high density polyethylene or other material!
  • the pairs are slightly angulated in a way found between them, at an angle that is in a range of between 0 or 90 ° in such a way that their focal point coincides with the exact position where they cross the two optical axes, forming an "emission-reception" geometry at an angle in the preferred embodiment of 12 ° to 15 °, (see Figure 5); a Terahertz photoconductive emitting means 1444 aligned with the first lens 1442 to emit a THz signal towards the patient's feet through the windows 1340, a Terahertz photoconductive sensing means 1445 aligned with the second lens 1443 which receives the signal from THz reflected by the patient's feet as shown in Figure 5.
  • the image acquisition means 1440 is linked to the positioning block 1432 of the second transverse translation means 1430, and said second transverse translation means 1430 is in turn connected to the positioning block 1422 of the first longitudinal translation means 1420, such that said first longitudinal translation means 1420 translationally moves to said second transverse translation means 1430, which in turn translationally moves said image acquisition means 1440, for Positioning said image capturing means 1440 across the length and width of each window to perform the measurement of the Terahertz pulses in the entire floor of each of the patient's feet.
  • the Terahertz systems 1444 and 1445 used are fired by an ultrafast laser which in the preferred embodiment produces pulses of 90 fs with a repetition rate of 100 MHz, with an average power of 120 mW and a length of central wave of 1550 nm.
  • the pulses are divided into two parts, the first is coupled to a fiber and sent to a photoconductive emitter of InGaAs 1444 in order to produce terahertz pulses.
  • the second part of the pulse is sent to a delay line controlled by the computer and later it is collected to a fiber and finally it is sent to a photoconductive detector of InGaAs 1445,
  • the ultrafast laser produces pulses of 90 fs
  • another type of ultrafast lasers can be used with different pulse and frequencies without departing from the scope of the present invention.
  • other types of photoconductive emitters and detectors can be used that perform the same function, without departing from the scope of the present invention.
  • Said photoconductive detector means of Terahertz 1445 is connected to a signal acquirer and this in turn to said PC either wired or wirelessly (see Figure 6 as reference), to send the measurements of the.
  • Terahertz pulses of the entire floor of each of the feet of the user wherein said measurements are made by emitting THz signals towards the sole of the patient's foot, by means of said photoconductive emitter of Terahertz, and subsequently receiving the signals of THz reflected by said plants from the patient's feet.
  • Said PC comprises a graphical control interface by means of which the user interacts and controls the system, said PC is in communication with said system of capturing images through said photoconductive detector means of Terahertz 1445 to have control thereof and by means of a Algorithm generates a hydration image of the foot.
  • Said algorithm realizes said hydration image of the foot from the radiation reflected in terahertz by means of the following operations:
  • c) Perform the Founer transform of the two halves of the signal of the points corresponding to the foot separately.
  • d) calculate the Fresnei coefficient of the foot using the first Founer transform as a reference and the second as the sample and taking into account the empirical calibration factor.
  • e) use an optimization method such as or least squares adjustment to find the water content from the Fresnei coefficient mentioned in the above numeral, adjusting the volumetric fraction of water and dry tissue in an effective medium model (co o) LLL or Maxweil-Garnet) combined with the theoretical expressions that relate the dielectric function, the refractive index and the Fresnei coefficient (see Fov / ⁇ es.Introduction to Modenr Optics).
  • g Calculate the numerical values such as average " hydration, hydration in the big toe and in the heel.
  • An example of the hydration image generated by the PC algorithm is shown in Figure 7, where the teraher ⁇ z image a) refers to a healthy foot and the terahertz image (b) refers to a diabetic foot.
  • the algorithm used performs the image of hydration of the foot by means of a Fresnel coefficient
  • another type of algorithm can be used which in turn uses an effective medium model without departing of the scope of the present invention
  • the PC and the capture system 1400 are turned on, the patient is then seated in the chair 1200 and instructed to place the feet in the windows of the upper support plate and not to move them;
  • the measurement of terahertz pulses is carried out in the time domain of the reflection along the entire floor of each foot of the patient, through the operations of:
  • a second mode of the early defection system of! diabetic foot syndrome of the present invention numbered 2000, wherein the elevated platform and the The base structure is integrated into a single supporting plate 2100 supported by a single frame 2200 with six legs, wherein the rear part of said frame has a section without upper support plate 2100, in which the seat 2300 where it is placed the patient is directly attached to said frame 2200. Also, on the front of said frame 2200 is the lower support plate 2400 attached to the front and center legs of said frame 2200, where the 2500 collection system is placed .
  • the front part of the upper support plate 2100 comprises the windows 2110 where the patient's feet are placed.
  • Said early detection system 2000 further comprises a safety rail 2600, which helps the patient to move safely on the upper support plate 2100 to sit on the seat, and a removable step 2800, which facilitates the The patient is placed on the upper support plate 2100.
  • the upper support plate 2100 comprises a coating of anion-slip material to prevent the patient from slipping.
  • the modalities of the early detection system of the diabetic foot syndrome and its respective components described above are presented for illustrative purposes only, since a person skilled in the art can perform numerous variations thereof, provided they are designed in accordance with the principles of the present invention.
  • the present invention includes all the modalities that a person skilled in the art can propose based on the concepts contained in the present description, in accordance with the following claims.

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

L'invention concerne un système de détection précoce du syndrome du pied diabétique. Ledit système est formé d'une plate-forme élevée avec un siège, sur lequel sera placé le patient ; une structure de base, laquelle comprend une plaque d'appui supérieure et une plaque de support inférieure ; ladite plaque d'appui supérieure comprenant une paire de fenêtres constituées d'un matériau transparent, dans lesquelles le patient place ses pieds ; un système d'acquisition d'images térahertz (THz) situé dans ladite plaque de support inférieure en-dessous des fenêtres ; et un PC, lequel communique avec ledit système d'acquisition des images pour avoir le contrôle de celui-ci et comprend un algorithme pour générer une image d'hydratation du pied ; ledit système d'acquisition d'images THz étant formé d'une paire de lentilles placées de manière angulaire ; un moyen émetteur photoconducteur térahertz pour émettre un signal THz vers les pieds du patient ; un moyen capteur photoconducteur térahertz lequel reçoit le signal THz réfléchi par les pieds du patient, ledit signal THz réfléchi correspondant à une mesure d'impulsion THz dans le domaine de réflexion ; un système de positionnement, lequel déplace les lentilles et les moyens d'émission et de détection le long des fenêtres pour capter les impulsions THz le long de toute la plante des deux pieds ; ledit PC effectuant le traitement de chaque mesure desdites impulsions THz par le biais dudit algorithme et génèrant une image d'hydratation du pied et signalant des valeurs spécifiques d'hydratation au moyen de l'utilisation d'un coefficient de Fresnel.
PCT/MX2018/000056 2017-06-30 2018-06-21 Système de détection précoce du syndrome du pied diabétique Ceased WO2019004812A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MX2017008794A MX2017008794A (es) 2017-06-30 2017-06-30 Sistema de detección temprana del síndrome de pie diabético.
MXMX/A/2017/008794 2017-06-30

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200293806A1 (en) * 2019-03-14 2020-09-17 Canon Kabushiki Kaisha Camera system and facility
US12313731B2 (en) 2019-03-14 2025-05-27 Canon Kabushiki Kaisha Processing system

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US20080039718A1 (en) * 2006-08-12 2008-02-14 Philometron Platform for detection of tissue structure change
EP2990195A1 (fr) * 2014-08-25 2016-03-02 Profol Kunststoffe GmbH Film composite multicouches gaufré et contrecollé par fusion

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080039718A1 (en) * 2006-08-12 2008-02-14 Philometron Platform for detection of tissue structure change
EP2990195A1 (fr) * 2014-08-25 2016-03-02 Profol Kunststoffe GmbH Film composite multicouches gaufré et contrecollé par fusion

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BUSCH S F ET AL.: "Optical Properties of 3D Printable Plastics in the THz Regime and their Application for 3D Printed THz Optics", JOURNAL OF INFRARED, MILLIMETER, AND TERAHERTZ WAVES, vol. 35, no. 12, 18 December 2014 (2014-12-18), New York LLC usa, pages 993 - 997, XP055565870, ISSN: 1866-6892, Retrieved from the Internet <URL:https://www.researchgate.net/publication/278182972_Optical_Properties_of_3D_Printable_Plastics_in_the_THz_Regime_and_their_Application_for_3D_Printed_THz_Optics> [retrieved on 20181004] *
E. V. FEDULOVA ET AL.: "Studying of dielectric properties of polymers in the terahertz frequency range", PROCEEDINGS OF THE SPIE, vol. 8337, no. 833701, 28 February 2012 (2012-02-28), pages 1 - 9, XP055565862, ISSN: 1605-7422, Retrieved from the Internet <URL:https://www.spiedigitallibrary.org/conference-proceedings-of-spie/8337/83370I/Studying-of-dielectric-properties-of-polymers-in-the-terahertz-frequency/10.1117/12.923855.short> [retrieved on 20181004] *
HERNANDEZ-CARDOSO G G ET AL.: "Terahertz imaging for early screening of diabetic foot syndrome: a proof of concept", SCIENTIFIC REPORTS, vol. 7, 3 February 2017 (2017-02-03), UK, pages 42124, XP055565355, ISSN: 2045-2322, Retrieved from the Internet <URL:https://www.nature.com/articles/srep42124> [retrieved on 20180110] *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200293806A1 (en) * 2019-03-14 2020-09-17 Canon Kabushiki Kaisha Camera system and facility
US12313731B2 (en) 2019-03-14 2025-05-27 Canon Kabushiki Kaisha Processing system

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