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WO2019093787A2 - Dispositif de capsule médicale - Google Patents

Dispositif de capsule médicale Download PDF

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Publication number
WO2019093787A2
WO2019093787A2 PCT/KR2018/013541 KR2018013541W WO2019093787A2 WO 2019093787 A2 WO2019093787 A2 WO 2019093787A2 KR 2018013541 W KR2018013541 W KR 2018013541W WO 2019093787 A2 WO2019093787 A2 WO 2019093787A2
Authority
WO
WIPO (PCT)
Prior art keywords
light
light source
unit
housing
control unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/013541
Other languages
English (en)
Korean (ko)
Other versions
WO2019093787A3 (fr
Inventor
윤영민
배희호
이아영
정상욱
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seoul Viosys Co Ltd
Original Assignee
Seoul Viosys Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR1020170147749A external-priority patent/KR20190052241A/ko
Application filed by Seoul Viosys Co Ltd filed Critical Seoul Viosys Co Ltd
Priority to CN201880009168.5A priority Critical patent/CN110234399B/zh
Publication of WO2019093787A2 publication Critical patent/WO2019093787A2/fr
Publication of WO2019093787A3 publication Critical patent/WO2019093787A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/42Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
    • A61B5/4216Diagnosing or evaluating gastrointestinal ulcers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0077Devices for viewing the surface of the body, e.g. camera, magnifying lens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14539Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring pH
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4848Monitoring or testing the effects of treatment, e.g. of medication
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6861Capsules, e.g. for swallowing or implanting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • A61N5/0603Apparatus for use inside the body for treatment of body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/0624Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • A61N5/0603Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0609Stomach and/or esophagus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/0658Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0661Radiation therapy using light characterised by the wavelength of light used ultraviolet

Definitions

  • the present invention relates to a medical capsule device.
  • Helicobacter pylori is the best known harmful bacteria in human gastrointestinal tract.
  • antibiotics are used as a method for treating bacterial infections such as Helicobacter pylori.
  • Helicobacter pylori it lives on the surface of the gastrointestinal mucosa or in the mucus. Therefore, there is a problem that the effective amount of the antibiotic does not sufficiently reach Helicobacter pylori.
  • the treatment of bacterial infection using antibiotics has problems such as diarrhea, abdominal pain, nausea, reflux esophagitis, and normal bacterial inhibition in the stomach. Also, if you stop taking antibiotics at random, side effects may occur that are difficult to treat because of resistance to antibiotics.
  • a problem to be solved by the present invention is to provide a medical capsule device capable of sterilizing harmful bacteria inside a organ without side effects.
  • Another object of the present invention is to provide a medical capsule device for alleviating the sterilization and inflammation of harmful bacteria in the organ.
  • Another object of the present invention is to provide a medical capsule device capable of safely and effectively treating inflammation and infection in a human body.
  • a medical capsule device including at least one light source part emitting ultraviolet rays or visible light, a power source part supplying power to the light source part, and a housing surrounding the light source part and the power source part .
  • a medical capsule device including at least one light source part emitting ultraviolet rays or visible light, a power source part supplying power to the light source part, and a housing surrounding the light source part and the power source part .
  • at least a part or the whole of the housing is made of a material through which ultraviolet rays or visible rays are transmitted.
  • a light emitting device comprising a housing made of a light transmitting material at least partially, a plurality of light source portions disposed inside the housing and including a sterilizing light source, a plurality of pH sensors for measuring a hydrogen ion concentration outside the housing, As shown in FIG.
  • the control unit is located inside the housing or outside the body.
  • the control unit detects the position of the housing and the infecting site using the information on the hydrogen ion concentration received from the plurality of pH sensors, and controls the light source unit to irradiate sterilizing light to the infected site.
  • the sterilizing light source includes a light source for a porphyrin target.
  • the light source for the porphyrin target emits light for the porphyrin target, which is the light that inactivates the source of infection with the porphyrin material.
  • a method of sterilizing an infant comprising: a housing made of at least a light-transmitting material; a photographing part disposed inside the housing and photographing the inside of the stomach; A plurality of pH sensors for measuring the concentration of hydrogen ions outside the housing, a storage unit for storing inflammation lesion information, and a control unit for controlling the light source unit and the photographing unit.
  • the storage unit and the control unit are located inside the housing or outside the body.
  • the control unit detects the position of the housing and the infecting site using the information on the hydrogen ion concentration received from the plurality of pH sensors, and controls the light source unit to irradiate sterilizing light to the infected site.
  • control unit detects the inflammation site using the image taken by the imaging unit and the inflammation lesion information stored in the storage unit, and controls the light source unit so that the inflammation treatment light is irradiated to the inflammation site.
  • control unit controls the irradiation time or amount of light to control the cumulative value of the light energy exposed at the same site.
  • the medical capsule device irradiates ultraviolet rays to bacteria, and it is possible to sterilize harmful bacteria inside the organ without side effects.
  • the medical capsule device may emit ultraviolet rays and visible rays to sterilize harmful bacteria in the organs and alleviate inflammation.
  • the medical capsule device according to another embodiment of the present invention can intensively sterilize specific bacteria using an antibody.
  • the medical capsule device can control the maximum energy of light irradiated to the same site to treat infection and inflammation safely and effectively in the human body.
  • FIG. 1 is an exemplary view showing a medical capsule device according to a first embodiment of the present invention.
  • FIG. 2 is an exemplary view showing a medical capsule apparatus according to a second embodiment of the present invention.
  • FIG 3 is an exemplary view showing a medical capsule device according to a third embodiment of the present invention.
  • FIG. 4 is a view illustrating an example of a medical capsule device according to a fourth embodiment of the present invention.
  • FIG. 5 is an exemplary view showing a medical capsule device according to a fifth embodiment of the present invention.
  • FIG. 6 is an exemplary view showing a medical capsule device according to a sixth embodiment of the present invention.
  • FIG. 7 is an exemplary view showing a medical capsule device according to a seventh embodiment of the present invention.
  • FIG. 8 is an exemplary view showing a medical capsule device according to an eighth embodiment of the present invention.
  • FIG. 9 is an exemplary view showing a medical capsule device according to a ninth embodiment of the present invention.
  • FIG. 10 is an exemplary view showing a medical capsule device according to a tenth embodiment of the present invention.
  • 11 to 13 are views illustrating an example of a medical capsule device according to an eleventh embodiment of the present invention.
  • FIG. 14 to 17 are illustrations showing various embodiments of the support portion of the medical capsule device.
  • FIG. 18 is a block diagram of a medical capsule device according to a twelfth embodiment of the present invention.
  • FIG. 19 is a block diagram of a medical capsule device according to a thirteenth embodiment of the present invention.
  • FIG. 20 is a block diagram of a medical capsule device according to a fourteenth embodiment of the present invention.
  • 21 is a block diagram of a medical capsule device according to a fifteenth embodiment of the present invention.
  • FIG. 1 The following embodiments are provided by way of example so that those skilled in the art can fully understand the spirit of the present invention. Therefore, the present invention is not limited to the embodiments described below, but may be embodied in other forms. It should be noted that, in the present specification, the reference numerals are added to the constituent elements of the drawings, and the same constituent elements are assigned the same number as much as possible even if they are displayed on different drawings. It is also to be understood that terms such as “ first, “ second, “ one side, “ “ second, “ “ top, “ And the constituent elements are not limited by these terms.
  • the medical capsule device of the present invention is an apparatus for treating inflammation and infection caused in a human stomach.
  • the medical capsule device reaches the stomach through the oral cavity and emits light to treat inflammation and infection in the stomach.
  • a medical capsule device includes at least one light source unit that emits ultraviolet light or visible light, a power source unit that supplies power to the light source unit, and a housing that surrounds the light source and the power source unit.
  • a light source unit that emits ultraviolet light or visible light
  • a power source unit that supplies power to the light source unit
  • a housing that surrounds the light source and the power source unit.
  • at least a part or the whole of the housing is made of a material through which ultraviolet rays or visible rays are transmitted.
  • the housing may include a body surrounding the light source and the power source, and a window through which ultraviolet or visible light is transmitted.
  • the housing may be made of an acid resistant material.
  • the medical capsule device may further include a timer for stopping power supply to the light source unit after a predetermined time has elapsed.
  • the medical capsule device may further include a first sensor for generating a first sensing signal when an acidic substance or a gastrin is sensed.
  • the power supply unit starts supplying power to the light source unit.
  • the medical capsule device may further include a second sensor for generating a second sensing signal upon sensing a basic substance.
  • the power supply unit stops supplying power to the light source unit.
  • the medical capsule device may further comprise an antibody attached to the housing.
  • the antigen binding site of the antibody may protrude in the direction of ultraviolet or visible light.
  • the medical capsule device may further comprise a sensor for detecting binding of the antibody to the antigen of the infectious agent or inflammatory factor.
  • the power supply unit starts supplying power to the light source unit.
  • the medical capsule device may include a plurality of light sources. At least one of the plurality of light sources may emit ultraviolet or visible light in different directions.
  • the light source unit may include a first light source that emits ultraviolet light and a second light source that emits visible light.
  • the housing may be made of a material through which ultraviolet rays and visible rays are at least partially or entirely transmitted.
  • the housing may include a body surrounding the first light source, the second light source, and the power source, and a window through which ultraviolet and visible light is transmitted.
  • the medical capsule device may further comprise a first antibody which binds to the antigen of the infectious agent and a second antibody which binds to the antigen of the inflammatory factor.
  • the antigen-binding sites of the first and second antibodies may be attached to the housing so as to protrude in the direction in which ultraviolet light and visible light are directed.
  • the medical capsule device may further include a third sensor for detecting the binding of the first antibody to the antigen of the infectious agent, and a fourth sensor for detecting the binding of the second antibody to the antigen of the inflammatory factor.
  • the power source unit When the third sensor detects the binding of the first antibody to the antigen of the infectious agent, the power source unit starts supplying power to the first light source. Further, when the fourth sensor senses the binding of the second antibody to the antigen of the inflammatory factor, the power source unit starts supplying power to the second light source.
  • the medical capsule device may further include a photographing unit photographing the outside of the housing.
  • a medical capsule device includes a housing made of a light-transmitting material at least partially, a plurality of light source parts disposed inside the housing, the light source part including a sterilizing light source, a plurality of pH A sensor, and a control unit for controlling the light source unit.
  • the control portion is located inside the housing or outside the body.
  • the control unit detects the position of the housing and the infecting site using the information on the hydrogen ion concentration received from the plurality of pH sensors, and controls the light source unit to irradiate the infecting site with sterilizing light.
  • the sterilizing light source includes a light source for a porphyrin target.
  • the light source for the porphyrin target emits light for the porphyrin target, which is the light for deactivating the infectious agent having the porphyrin substance.
  • the control unit controls the light source unit so that the light source unit does not emit light after the plurality of pH sensors first detect the hydrogen ion concentration below pH 4.0 and after the plurality of pH sensors all detect the hydrogen ion concentration above pH 4.0 .
  • the medical capsule device may further include a wireless communication unit located inside the housing.
  • control unit When the control unit is located outside the body, the control unit controls the light source unit through the wireless communication unit by wireless communication.
  • the medical capsule device further includes a storage unit for storing inflammatory lesion information including information on the color and shape of the gastrointestinal mucosa appearing in the inflamed site in the stomach, and a photographing unit disposed inside the housing for photographing the inside of the stomach .
  • the light source unit may further include a light source for treating inflammation.
  • the storage unit may be located inside the housing or outside the body.
  • the control unit detects the inflammation site using the image taken by the imaging unit and the inflammation lesion information stored in the storage unit, and controls the light source unit to irradiate the inflammation site with the inflammation treatment light.
  • control unit controls the photographing unit to photograph the inside of the camouflage at predetermined time intervals.
  • the control unit receives the inflammatory lesion information of the storage unit via the wireless communication unit by wireless communication.
  • control unit controls the light source unit and the photographing unit by wireless communication through the wireless communication unit.
  • the control unit controls the light source unit to irradiate light for treating inflammation at a position corresponding to the image if the image acquired by the imaging unit coincides with the irritation lesion information at a predetermined numerical value or more.
  • the control unit compares the image obtained in the past with the image in which the inflammation site is present and the image obtained in the past, and controls the light source unit so as not to emit light for treating the inflammation in the corresponding region if it is equal to or greater than a predetermined value.
  • the medical capsule apparatus may further include a light source for illumination that provides illumination necessary for shooting of the photographing section.
  • the sterilizing light includes at least one of red light and blue light.
  • the sterilizing light may further include UVC.
  • the light for treating inflammation may include at least one of UVA and UVB.
  • the medical capsule device may further include a support disposed inside the housing to fix the light source unit.
  • the support portion can be fixed to the inner wall of the housing. Or the support may be separate from the inner wall of the housing.
  • the medical capsule apparatus may further include a time control unit for controlling a time when light is irradiated to the same site.
  • the medical capsule apparatus may further include a speed sensor for measuring the speed of the housing and a light amount controller for controlling the intensity of light emitted from the light source unit using the speed of the housing measured by the speed sensor.
  • a medical capsule unit comprising a housing made of at least a light-transmitting material, a photographing unit disposed inside the housing, for photographing the inside of the stomach, a light source for sterilizing inflammation, A plurality of pH sensors for measuring the hydrogen ion concentration outside the housing, a storage unit storing the inflammation lesion information, and a control unit for controlling the light source unit and the photographing unit.
  • the storage unit and the control unit may be located inside the housing or outside the body.
  • the control unit detects the position of the housing and the infecting site using the information on the hydrogen ion concentration received from the plurality of pH sensors, and controls the light source unit to irradiate sterilizing light to the infected site.
  • control unit detects the inflammation site using the image taken by the imaging unit and the inflammation lesion information stored in the storage unit, and controls the light source unit so that the inflammation treatment light is irradiated to the inflammation site.
  • control unit controls the irradiation time or amount of light to control the total cumulative value of the light energy exposed at the same site.
  • FIG. 1 is an exemplary view showing a medical capsule device according to a first embodiment of the present invention.
  • the medical capsule device 100 includes a housing 110, a light source 120, a substrate 130, and a power source 140.
  • the power supply unit 140 stores power and supplies power to the light source unit 120.
  • the power supply unit 140 is a battery.
  • the light source unit 120 emits light.
  • the light source unit 120 may emit ultraviolet rays.
  • the ultraviolet rays emitted from the light source unit 120 are ultraviolet rays for sterilization that sterilize the infectious agent.
  • the infectious agent is a hospital microorganism that spreads to humans and animals such as bacteria and viruses to cause infection.
  • Ultraviolet rays can be ultraviolet rays of a certain wavelength band if the infectious source can be sterilized.
  • the light source unit 120 may emit visible light. If the visible light has the effect of alleviating the inflammation, it can be the visible light of a certain wavelength band.
  • the substrate 130 is connected to the power supply unit 140 so that the power of the power supply unit 140 is supplied to the light source unit 120.
  • the power supply unit 140 may be directly connected to the light source unit 120 to supply power. In this case, the substrate 130 may be omitted.
  • the housing 110 is formed to surround the internal components of the medical capsule device 100 such as the light source unit 120, the substrate 130, and the power source unit 140.
  • the housing 110 thus formed protects the internal constituent parts of the medical capsule device 100 until the medical capsule device 100 is discharged after being moved inside the organ of the human body through the oral cavity. Further, the housing 110 can prevent the internal constituent parts of the medical capsule device 100 from affecting organs of the human body.
  • the housing 110 is formed of an acid-resistant material to protect the internal components of the medical capsule device 100.
  • the housing 110 is composed of a body 111 and a window 115.
  • the body 111 is formed so as to surround the internal constituent parts of the medical capsule device 100.
  • the body 111 and the window 115 are formed of an acid-resistant material.
  • the window 115 is formed of a material through which ultraviolet rays are transmitted. That is, ultraviolet rays emitted from the light source unit 120 are irradiated to the inside of the stomach through the window 115.
  • the medical capsule apparatus 100 thus formed is formed to have a small size so as to be movable into the human body through the oral cavity.
  • the medical capsule device 100 can move into the stomach and emit ultraviolet rays inside the stomach.
  • the ultraviolet rays emitted from the inside of the stomach sterilize the infection source inside the stomach.
  • the medical capsule device 100 can sterilize Helicobacter pylori, an infection caused by ultraviolet rays, in the gastric mucosa. Therefore, the medical capsule device 100 can treat a disease caused by Helicobacter pylori.
  • the medical capsule device 100 may emit visible light within the stomach. Visible light emitted from inside the stomach can relieve and cure the inflammation inside the stomach.
  • the medical capsule device 100 emits ultraviolet rays or visible rays inside the stomach.
  • the medical capsule device 100 can control the time of light emission according to the capacity of the power source unit 140.
  • the power source unit 140 When the power source unit 140 is installed in the medical capsule apparatus 100, light emission is started. When the power source unit 140 is exhausted, the light emission can be stopped. Accordingly, the power supply unit 140 may be formed to have a capacity enough to sufficiently sterilize the infectious source inside the stomach or to allow the release of light to be sustained for a period of time necessary to alleviate or cure the inflammation.
  • the medical capsule device 100 may further include a switch.
  • the switch may start or stop the light emission of the medical capsule device 100.
  • the switch may electrically connect or disconnect the light source unit 120 and the power source unit 140 so that the power source unit 120 is powered or the power source is interrupted.
  • the medical capsule device 100 can remove an infectious agent such as Helicobacter pylori without antibiotics when emitting ultraviolet rays. Therefore, when the medical capsule device 100 that emits ultraviolet rays is used, it is possible to solve the side effect problem caused by the conventional antibiotic.
  • the medical capsule device 100 when the medical capsule device 100 emits visible light, the inflammation in the body organs such as the stomach can be directly treated. Therefore, by using the medical capsule device 100 that emits visible light, direct and rapid inflammation treatment is possible.
  • Fig. 1 illustrates a medical capsule apparatus 100 according to the first embodiment.
  • description of the same configuration as that of the medical capsule device 100 according to the first embodiment will be omitted.
  • the description omitted in the other embodiments refers to the description of the medical capsule apparatus 100 according to the first embodiment of FIG.
  • FIG. 2 is an exemplary view showing a medical capsule apparatus according to a second embodiment of the present invention.
  • the medical capsule device 200 includes a housing 210, a light source 120 for emitting ultraviolet rays, a substrate 130, and a power source 140.
  • the medical capsule device 200 includes a plurality of light source units 120.
  • the plurality of light source portions 120 are disposed on both sides of the substrate 130.
  • the medical capsule device 200 emits ultraviolet rays in the upper and lower directions of the substrate 130.
  • the plurality of light source units 120 may be disposed on both the upper and lower surfaces of the substrate 130 as well as on both sides. In this case, the medical capsule device 200 may emit ultraviolet rays in all directions of the substrate 130.
  • the housing 210 may be formed of a material through which ultraviolet rays are transmitted. Therefore, the medical capsule device 200 can emit ultraviolet rays to the outside in any direction.
  • the medical capsule device 200 can simultaneously emit ultraviolet rays in various directions, not in one direction. Therefore, infectious agents living in various parts of the stomach can be sterilized by simultaneously irradiating ultraviolet rays.
  • FIG 3 is an exemplary view showing a medical capsule device according to a third embodiment of the present invention.
  • the medical capsule device 300 includes a housing 110, a first light source 310, a second light source 320, a substrate 130, and a power source 140 .
  • the first light source 310 emits ultraviolet rays.
  • the ultraviolet rays emitted from the first light source 310 are ultraviolet rays of a wavelength band capable of sterilizing the infectious agent.
  • the second light source 320 emits visible light.
  • the visible light emitted from the second light source 320 is a visible light of a wavelength range having an effect of alleviating inflammation or alleviating pain.
  • inflammation may occur in the stomach wall due to stimulation or infection caused by the infectious agent.
  • Helicobacter pylori can cause inflammation of the stomach wall and, furthermore, gastric ulcers.
  • the medical capsule device 300 of the present embodiment includes both a first light source 310 for sterilizing an infectious source and a second light source 320 for relieving inflammation and pain. Accordingly, the medical capsule device 300 can simultaneously perform sterilization of the infectious source living in the stomach wall, inflammation, and pain relief.
  • the medical capsule device 300 may be formed of a material through which the ultraviolet rays and the visible rays are transmitted through the entire housing 110.
  • the medical capsule device 300 includes a plurality of first light sources 310 and a plurality of second light sources 320.
  • the first light source 310 and the second light source 320 are disposed on at least both sides of the substrate 130, . Accordingly, the medical capsule device 300 can sterilize and treat inflammation at various sites at the same time.
  • an antibody is formed on the housing 110 as in the third embodiment, and sterilization and inflammation of a specific site can be performed.
  • FIG. 4 is a view illustrating an example of a medical capsule device according to a fourth embodiment of the present invention.
  • the medical capsule device 400 includes a housing 110, a light source unit 120 that emits ultraviolet rays, a substrate 130, a power source unit 140, and a timer 410 .
  • the timer 410 allows the light source unit 120 to emit ultraviolet rays for a predetermined ultraviolet emission time.
  • the ultraviolet emission time may be a time calculated so that the medical capsule device 400 emits ultraviolet rays while staying inside the stomach.
  • the timer 410 may control the power supply unit 140 to start supplying power to the light source unit 120 at a preset time. In addition, the timer 410 can control the power supply unit 140 to stop the power supply to the light source unit 120 after a predetermined time has elapsed.
  • the timer 410 may control only one of the power source unit 140 starting or stopping power supply to the light source unit 120 at a preset time.
  • the timer 410 controls at least one of the power source unit 140, the substrate 130, and the light source unit 120 so that the power supply to the light source unit 120 can be started and stopped.
  • the medical capsule device 400 of the present embodiment can control the timer 410 to emit ultraviolet rays only when necessary. That is, the timer 410 can be used to emit ultraviolet rays only during the time that the medical capsule device 400 stays in the stomach. Therefore, the medical capsule device 400 can prevent unnecessary consumption of power. Or the size of the medical capsule device 400 can be reduced by reducing the capacity of the power source unit 140.
  • the medical capsule device 400 may include a light source that is formed of a material through which ultraviolet light and visible light are transmitted, or that emits visible light, or may include a plurality of light sources.
  • FIG. 5 is an exemplary view showing a medical capsule device according to a fifth embodiment of the present invention.
  • the medical capsule device 500 includes a housing 110, a light source 120 that emits ultraviolet rays, a substrate 130, a power source 140, and a sensor 510 .
  • the sensor 510 is disposed in the housing 110 to sense the external environment of the medical capsule device 500. In addition, the sensor 510 generates a sensing signal according to the sensed external environment.
  • the medical capsule device 500 may emit ultraviolet rays or stop ultraviolet emission according to a sensing signal generated by the sensor 510.
  • the sensor 510 senses when the medical capsule device 500 is positioned inside the camouflage.
  • gastrin an acidic substance
  • gastric fluid gastric fluid and hormone secreted from the stomach. Accordingly, when the sensor 510 senses an acidic substance or a gastrin, it can determine that the medical capsule device 500 is located inside the camouflage, and generate a detection signal to inform it.
  • the sensor 510 transmits a detection signal to the substrate 130 or the power source unit 140.
  • the substrate 130 or the power supply 140 receiving the sensing signal operates to supply power to the light source 120. That is, when the sensor 510 generates the detection signal, the power of the power source unit 140 is supplied to the light source unit 120.
  • the sensor 510 senses when the medical capsule device 500 is out of the stomach.
  • the medical capsule device 500 which has entered the body through the oral cavity, moves from the stomach to the large intestine. There are basic bacteria in the large intestine. Therefore, when the sensor senses a basic substance, it can determine that the medical capsule device 500 is located at a position other than the camouflage, and generate a sensing signal to inform it.
  • the sensor 510 transmits a detection signal to the substrate 130 or the power source unit 140.
  • the substrate 130 or the power supply 140 receiving the sensing signal stops supplying power to the light source 120.
  • the medical capsule device 500 including the sensor 510 stops emitting ultraviolet rays when it is out of the stomach.
  • the medical capsule device 500 detects when the user enters the stomach or when the user goes out of the stomach. Accordingly, when the medical capsule device 500 enters the stomach, it can emit ultraviolet rays and sterilize the infectious source living in the stomach. Or the medical capsule device 500 may sterilize the infectious agent with ultraviolet light inside the stomach and stop the ultraviolet radiation emission when the stomach is released. Accordingly, the medical capsule device 500 can prevent the ultraviolet ray from being emitted throughout the movement through the inside of the body through the sensor 510. Accordingly, it is possible to reduce the size of the power source unit 140 and the size of the medical capsule device 500. [
  • FIG. 6 is an exemplary view showing a medical capsule device according to a sixth embodiment of the present invention.
  • the medical capsule device 600 includes a housing 110, a light source 120 for emitting ultraviolet rays, a substrate 130, a power source 140, a first sensor 610, And a second sensor 620.
  • the first sensor 610 detects the medical capsule device 600 when it is positioned inside the camouflage. That is, when the first sensor 610 senses an acidic substance or a gastrin, the first sensor 610 determines that the medical capsule device 600 is located inside the stomach, and generates a first sensing signal to inform it.
  • the second sensor 620 senses when the medical capsule device 600 is out of the stomach. That is, when the second sensor 620 senses a basic substance, it determines that the medical capsule device 600 is out of the stomach and is located in the large intestine, and generates a second sensing signal.
  • the medical capsule device 600 of this embodiment starts to emit ultraviolet light when the first sensor 610 generates the first sensing signal and stops the ultraviolet light emission when the second sensor 620 generates the second sensing signal do. That is, the medical capsule device 600 emits ultraviolet rays only inside the stomach by the first sensor 610 and the second sensor 620. Therefore, since the medical capsule device 600 is sterilized only in the stomach, it is possible to prevent the beneficial bacteria from being sterilized while moving inside the other organs.
  • the medical capsule devices 500 and 600 have not been described in the fifth and sixth embodiments, the antibody, the light source that emits visible light, and the structure of the housing described in other embodiments can be applied.
  • FIG. 7 is an exemplary view showing a medical capsule device according to a seventh embodiment of the present invention.
  • the medical capsule device 700 includes a housing 110, a light source unit 120 that emits ultraviolet rays, a substrate 130, a power source unit 140, and a photographing unit 710 can do.
  • the photographing unit 710 photographs the outside of the housing 110. That is, the photographing unit 710 photographs the inside of the stomach when the medical capsule unit 700 sterilizes the infectious source of the stomach.
  • the medical capsule apparatus 700 can photograph an image or a photograph inside the camouflage by the photographing unit 710 and transmit it to the outside. Therefore, from the outside, the medical capsule device 700 can confirm the state of gastrointestinal condition or sterilization of the infectious source from the image or photograph inside the stomach.
  • the photographing unit 710 can photograph an image or a photograph of a long-term inside while moving the organ, as well as the camouflage, and transmit it to the outside. Therefore, it is possible to check the presence or absence of abnormality in other organs while the medical capsule apparatus 700 is moving in other organs.
  • the photographing unit 710 is connected to the power supply unit 140 and includes components necessary for photographing a substrate, an ultra-small camera, and a lens.
  • the photographing unit 710 can photograph the outside of the medical capsule unit 700 through the window 115.
  • the window 115 transmits ultraviolet rays, and is formed of a material that is both acid resistant and transparent.
  • the photographing portion 710 may be disposed at a position different from that shown in Fig. At this time, a separate window may be formed in the housing 111 so that the photographing unit 710 can take an image of the outside of the medical capsule unit 700.
  • the medical capsule device 700 may include a plurality of photographing portions 710.
  • the medical capsule device 700 includes an illumination unit that emits light for photographing and a communication unit that transmits an image or a photograph to the outside, so that detailed description will be omitted.
  • the medical capsule device 700 is not described in the seventh embodiment, the antibody, the light source that emits visible light, the structure of the housing, and the sensor described in other embodiments may be applied. If the medical capsule apparatus 700 includes a sensor, it is also possible to control the operation of the photographing section 710 by the sensor.
  • FIG. 8 is an exemplary view showing a medical capsule device according to an eighth embodiment of the present invention.
  • the medical capsule device 800 includes a housing 110, a first light source 310 that emits ultraviolet rays, a substrate 130, a power source 140, and a first antibody 850 < / RTI >
  • the first antibody 850 binds to an antigen of a specific infectious source existing inside the stomach.
  • the infectious agent may be Helicobacter pylori.
  • the long chain portion 851 of the first antibody 850 is attached to the housing 110.
  • the antigen binding site 852 of the first antibody 850 binds to the antigen of the infectious agent.
  • the medical capsule apparatus 800 also moves to a site where a specific infectious agent is inhabited.
  • the first antibody 850 is attached to the housing 110 such that the antigen binding site 852 protrudes in the direction in which the ultraviolet rays are directed. That is, the antigen-binding site 852 faces the upper direction of the window 115 of the housing 110.
  • ultraviolet light can be irradiated to the infectious agent.
  • the structure of the first antibody 850 is changed depending on the object to be sterilized. That is, the structure of the first antibody 850 is formed with a structure that binds to the antigen of the infectious agent to be sterilized.
  • the medical capsule device 800 according to the eighth embodiment can intensively irradiate ultraviolet rays to the site where the infectious source habitually uses the binding of the antigen and the first antibody. Therefore, by using the medical capsule device 800 of the present embodiment, it is possible to solve the problem that the active ingredient does not sufficiently reach the Helicobacter pylori when antibiotics are conventionally used.
  • the medical capsule device 800 is capable of changing the first antibody 850 according to a specific infectious agent, it is possible to sterilize a specific infectious agent.
  • the medical capsule device 800 may further include a sensor.
  • the sensor can perform the same function as the sensor described in the previous embodiment.
  • the sensor may be connected to the first antibody 850.
  • the sensor may control the first light source 310 or the power source unit 140 so that the first light source 310 emits ultraviolet light when the first antibody 850 binds to a specific antigen.
  • the sensor may control the first light source 310 or the power source unit 140 so that the first light source 310 stops the ultraviolet emission when the first antibody 850 is separated from the antigen in a state where the first antibody 850 is bound to the antigen.
  • the housing 110 can be any of the housings of the first or second embodiment.
  • the first light source 310 may be plural as in the second embodiment.
  • the medical capsule device 800 may include a housing 110 formed of a material through which ultraviolet rays are transmitted and a plurality of first light sources 310. At this time, the medical capsule device 800 can intensively irradiate ultraviolet rays at a location where a specific infectious source resides, and sterilize by irradiating ultraviolet rays to infectious sources living in other areas.
  • FIG. 9 is an exemplary view showing a medical capsule device according to a ninth embodiment of the present invention.
  • the medical capsule device 900 includes a housing 110, a second light source 920 that emits visible light, a substrate 130, a power source 140, and a second antibody 950).
  • the second antibody 950 is attached to the housing 110 by a long chain portion 951 such that the antigen binding portion 952 protrudes in the direction in which the visible light is directed.
  • the second antibody 950 is associated with an antigen of an inflammatory factor.
  • the medical capsule device 900 also moves to the site where the inflammation has occurred. Since the antigen-binding site 952 is oriented toward the upper side of the window 115 of the housing 110, when the second antibody 950 and the antigen are combined, the visible light can be emitted toward the site where the inflammation is formed.
  • the medical capsule device 900 can intensively irradiate visible light to the site of inflammation using the second antibody 950 which reacts with the antigen of the inflammatory factor. Therefore, the medical capsule device 900 can intensively treat the inflammation generated inside the stomach.
  • the medical capsule device 900 can control the second light source 920 to emit visible light or stop visible light emission by applying the sensor described in the eighth embodiment.
  • FIG. 10 is an exemplary view showing a medical capsule device according to a tenth embodiment of the present invention.
  • the medical capsule device 1000 includes a housing 210, a first light source 310 for emitting ultraviolet rays, a second light source 320 for emitting visible light, a substrate 130 A power supply unit 140, a first antibody 850, a second antibody 950, a third sensor 1010 and a fourth sensor 1020.
  • the first light source 310 and the second light source 320 are arranged to face in different directions.
  • the first light source 310 is disposed on one side of the substrate 130
  • the second light source 320 is disposed on the other side of the substrate 130.
  • the housing 210 may be formed of a material through which ultraviolet rays and visible rays are transmitted as a whole.
  • First antibody 850 is an antibody that binds to the antigen of the infectious agent.
  • the first antibody 850 is attached to the housing 210 by the long chain portion 851 so that the antigen binding portion 852 protrudes in the direction in which ultraviolet rays are directed.
  • the second antibody 950 is an antibody that binds to an antigen of an inflammatory factor.
  • the second antibody 950 is attached to the housing 210 by the long chain portion 951 so that the antigen binding portion 952 protrudes in the direction in which the visible light is directed.
  • the medical capsule device 1000 may be such that the first antibody 850 is bound to the antigen of the infectious agent or the second antibody 950 is bound to the antigen of the inflammatory factor.
  • the third sensor 1010 detects whether the first antibody 850 binds to an external antigen.
  • the third sensor 1010 may cause ultraviolet light to be emitted from the first light source 310 when the first antibody 850 binds to the antigen of the infectious source. Therefore, ultraviolet rays emitted from the first light source 310 can be irradiated to the infectious source.
  • the fourth sensor 1020 detects whether the second antibody 950 binds to an antigen of an inflammatory factor.
  • the fourth sensor 1020 may cause visible light to be emitted from the second light source 320 when the second antibody 950 is coupled with an antigen of an inflammatory factor. Therefore, the visible light emitted from the second light source 320 can be irradiated with inflammation.
  • the medical capsule apparatus 1000 uses the first antibody 850 and the second antibody 950 to detect ultraviolet rays depending on whether there is an infectious source or inflammation at a position where the medical capsule apparatus 1000 moves Or irradiate visible light.
  • the medical capsule device 1000 can be selected by sterilizing the infectious agent or treating inflammation according to circumstances.
  • sterilization of the infectious agent or treatment of inflammation is intensively performed at necessary sites, not omni-directional, so that effective treatment is possible.
  • the first light source 310 and the second light source 320 are arranged to face in different directions, but they may be arranged to face in the same direction.
  • the first antibody 850 and the second antibody 950 are aligned such that the antigen-binding site 852 of the first antibody 850 and the antigen-binding site 952 of the second antibody 950 are oriented in the same direction Can be attached to the housing 210 side by side.
  • the housing 210 is formed of a material through which ultraviolet rays and visible rays are transmitted as a whole.
  • the window 210 is formed of a material that can transmit the respective light beams to the portion facing the ultraviolet ray and the portion facing the visible ray.
  • 11 to 13 are views illustrating an example of a medical capsule device according to an eleventh embodiment of the present invention.
  • 11 is a perspective view of the medical capsule device according to the eleventh embodiment.
  • 12 is a side view of the medical capsule device according to the eleventh embodiment.
  • 13 is a block diagram of the medical capsule device according to the eleventh embodiment.
  • the medical capsule device 1100 includes a plurality of photographing portions 1120, a plurality of light source portions 1130, a supporting portion 1150, a plurality of pH sensors 1140, And a housing 1110.
  • the photographing unit 1120 photographs the outside of the housing 1110 which is the outside of the medical capsule apparatus 1100.
  • the photographing part 1120 starts the photographing and acquires an image of the inside of the camouflage.
  • the photographing unit 1120 can photograph the inside of the camouflage continuously at a predetermined time interval while the medical capsule apparatus 1100 is located inside the camouflage.
  • the photographing unit 1120 includes components necessary for photographing a substrate, a micro camera, a lens, and the like.
  • the medical capsule device 1100 includes a plurality of photographing portions 1120, and uses the images of the inside of the stomach obtained by the photographing portion 1120 to determine an inflammation site.
  • the medical capsule device 1100 may further include an illumination light source 1135 for emitting white light.
  • the illuminating light source 1135 is a light source for acquiring an accurate image when the photographing unit 1120 photographs. Therefore, the illumination light source 1135 is disposed adjacent to the photographing unit 1120.
  • the illumination light source 1135 may be provided as a separate package or a separate module separate from the light source 1130. However, the present invention is not limited thereto. As another example, the illumination light source 1135 may be provided in one module or one package with other light sources of the light source 1130. [ Alternatively, the illumination light source 1135 may be provided as one package or one module with the photographing unit 1120.
  • the light source unit 1130 includes a light source 1131 for treating inflammation and a light source 1132 for sterilizing.
  • the light source 1131 for treating inflammation emits light for treating inflammation.
  • the light for treating inflammation is light including at least one of UVA and UVB.
  • the sterilizing light source 1132 emits sterilizing light.
  • the sterilizing light source 1132 includes a light source 1133 for a porphyrin target.
  • the light source 1133 for the porphyrin target emits light for the porphyrin target which is activated when the porphyrin material absorbs.
  • the light for the porphyrin target may include at least one of red light and blue light.
  • a porphyrin substance is a substance that is produced during the metabolic process of bacteria and is a substance existing in Helicobacter pylori and acne bacteria (1P.acne).
  • a porphyrin material absorbs light for a porphyrin target, it generates active oxygen.
  • the produced active oxygen inhibits the growth of bacteria or destroys bacteria.
  • the sterilizing light source 1132 includes only the light source 1133 for the porphyrin target, and can emit light including any one of red light and blue light. Or sterilizing light source 1132 may emit UVC as well as red and blue light. UVC destroys bacterial gene function, inhibiting the growth of bacteria or destroying bacteria.
  • the supporting portion 1150 allows the components located inside the housing 1110 to be fixed at a predetermined position.
  • the supporting portion 1150 is in the form of a quadrangular prism, and the photographing portion 1120 and the light source portion 1130 are disposed on each side of the supporting portion 1150. Therefore, the photographing unit 1120 can photograph the inside of the camouflage in various directions, so that it is possible to photograph all the inside of the camouflage. Also, since the light source 1130 can emit light in various directions, it is possible to irradiate light to all parts of the stomach.
  • the supporting portion 1150 may be formed of any material to which the light source 1130 and the photographing portion 1120 can be fixed.
  • the support part 1150 may be made of metal to perform heat dissipation of the light source part 1130 and the photographing part 1120.
  • the supporting portion 1150 may be formed of a substrate on which wiring for transmitting electrical signals to the light source portion 1130 and the photographing portion 1120 is formed.
  • the supporting part 1150 is formed to have an inner space and other parts such as a control part (not shown), a power supply part (not shown) and a storage part (not shown) may be disposed in the inner space of the supporting part 1150 .
  • the photographing unit 1120 has a structure protruding from one surface of the supporting unit 1150. Such a structure can widen the viewing angle of the photographing unit 1120 and shorten the distance from the mucous membrane of the stomach.
  • the structure of the medical capsule device 1100 of the present invention is not limited thereto. It is also possible that at least a part of the photographing part 1120 is inserted into the support part 1150 if the viewing angle of the photographing part 1120 and the distance from the mucous membrane of the camouflage are sufficient. In this case, the size of the housing 1110 of the medical capsule device 1100 can be reduced.
  • the housing 1110 protects the components disposed therein from the external environment. That is, the housing 1110 protects the internal components of the medical capsule device 1100 until the medical capsule device 1100 is discharged after being moved inside the organ of the body through the mouth. Also, the housing 1110 can prevent the internal constituent parts of the medical capsule device 1100 from affecting organs of the human body. According to the present embodiment, the photographing unit 1120, the light source unit 1130, and the supporting unit 1150 are disposed inside the housing 1110.
  • the housing 1110 is formed of an acid-resistant material to protect the internal components of the medical capsule device 1100. Further, the housing 1110 is formed of a material having transparency to such an extent that the photographing portion 1120 disposed therein can acquire an image of the exterior of the housing 1110. The housing 1110 is formed of a light-transmissive material so that the light of the light source unit 1130 disposed therein is emitted to the outside of the housing 1110.
  • the housing 1110 may be formed of a transparent material that faces the photographing unit 1120 but not the entire area of the housing 1110.
  • a portion of the housing 1110 facing the light source unit 1130 may be formed of a light transmitting material.
  • the plurality of pH sensors 1140 are disposed on the outer wall of the housing 1110 to measure the hydrogen ion concentration outside the medical capsule device 1100.
  • the medical capsule device 1100 is used to determine the position of the medical capsule device 1100 and the site of infection of the stomach from the hydrogen ion concentration measured by the plurality of pH sensors 1140.
  • the plurality of pH sensors 1140, the plurality of light source units 1130 and the plurality of photographing units 1120 can measure hydrogen ion concentration through all directions of the medical capsule apparatus 1100, So that photographing and light emission are performed.
  • the plurality of pH sensors 1140 and the plurality of light source units 1130 are disposed at positions corresponding to each other. For example, as shown in FIGS. 11 and 12, at least one light source portion 1130 is located in a lower region of each pH sensor 1140.
  • the medical capsule device 1100 allows sterilizing light to be emitted from at least one light source part 1130 disposed at a position corresponding to the pH sensor 1140 that senses the infection among the plurality of pH sensors 1140, To be irradiated with light.
  • the light source unit 1130 corresponding to each pH sensor 1140 is at least one light source unit 1130 located near each pH sensor 1140.
  • the number of the light source units 1130 and the light source units 1130 at positions corresponding to the respective pH sensors 1140 can be set in advance.
  • a plurality of photographing units 1120 and a plurality of light source units 1130 are also arranged at positions corresponding to each other.
  • each photographing portion 1120 is disposed on each surface of the support portion 1150 and is disposed to be located between the plurality of light source portions 1130. Therefore, at least one light source unit 1130 corresponding to the photographing unit 1120 and the photographing unit 1120 faces the same direction.
  • the medical capsule apparatus 1100 allows light for treating inflammation to be emitted from the light source unit 1130 disposed at a position corresponding to the photographing unit 1120 that senses inflammation among a plurality of the photographing units 1120, Investigate.
  • the medical capsule device 1100 may further include a power source unit.
  • the power supply unit supplies power necessary for all the components included in the medical capsule device 1100 to operate.
  • the medical capsule apparatus 1100 includes a plurality of pH sensors 1140, a plurality of photographing units 1120, a plurality of light source units 1130, a storage unit 1160, and a control unit 1170.
  • the plurality of pH sensors 1140 measure the hydrogen ion concentration outside the medical capsule device 1100.
  • the plurality of photographing units 1120 photographs the outside of the medical capsule apparatus 1100 to acquire images.
  • the plurality of light source portions 1130 emit light for treating inflammation and light for sterilizing.
  • Inflammatory lesion information is stored in the storage unit 1160.
  • Inflammatory lesion information is information about a lesion appearing at the site of inflammation when inflammation occurs in the gastrointestinal tract.
  • the inflammatory lesion information may include information on the color and morphology of the gastric mucosa appearing at the site of inflammation.
  • the control unit 1170 determines the position of the medical capsule device 1100 and controls the light source unit 1130 using the information received from the pH sensor 1140, the photographing unit 1120 and the storage unit 1160.
  • the control unit 1170 may be a module for processing all the information of the pH sensor 1140, the photographing unit 1120, and the storage unit 1160.
  • the control unit 1170 may be collectively referred to as a circuit that is included in each of the pH sensor 1140, the photographing unit 1120, and the storage unit 1160 and controls each component.
  • the controller 1170 detects the position of the medical capsule device 1100 and the infecting site using information on the hydrogen ion concentration received from the plurality of pH sensors 1140. At this time, the control unit 1170 controls the light source unit 1130 to irradiate sterilization light to the detected infection site.
  • the control unit 1170 detects the inflammation site using the images taken by the plurality of radiography units 1120 and the inflammatory lesion information stored in the storage unit 1160. At this time, the control unit 1170 controls the light source unit 1130 to irradiate the inflammation site to the detected inflammation site.
  • the control unit 1170 controls the light source unit 1130 to emit light only when the medical capsule apparatus 1100 is located inside the stomach.
  • the inside of the stomach has hydrogen ion concentration below pH 4.0 by the gastric juice.
  • the duodenum associated with the stomach has a hydrogen ion concentration above pH 4.0.
  • the controller 1170 determines that the medical capsule device 1100 has entered the inside of the stomach.
  • the controller 1170 determines that the medical capsule device 1100 has not entered the inside of the stomach before all the pH sensors 1140 simultaneously measure the hydrogen ion concentration below the pH 4.0.
  • the control unit 1170 determines that the medical capsule apparatus 1100 is located at a place other than the inside of the stomach when all the pH sensors 1140 measure hydrogen ion concentrations exceeding pH 4.0 for the first time at the same time. For example, if all the pH sensors 1140 simultaneously measure the hydrogen ion concentrations below pH 4.0 for the first time and then all the pH sensors 1140 simultaneously measure the hydrogen ion concentrations above pH 4.0 for the first time, Determines that the medical capsule device 1100 has passed through the stomach and has entered the duodenum.
  • the control unit 1170 controls the plurality of photographing units 1120 to photograph the inside of the camouflage. At this time, the plurality of photographing units 1120 capture an image of the inside of the camouflage at predetermined time intervals.
  • the control unit 1170 compares the image of the inside of the camouflage acquired by the photographing unit 1120 with the inflammatory lesion information of the storage unit 1160. If the acquired image matches the inflammatory lesion information with a predetermined numerical value or more, the control unit 1170 determines that the region corresponding to the image is an inflammatory site. For example, if the obtained image matches at least 80% of the color or shape stored in the inflammatory lesion information, the control unit 1170 determines that the region corresponding to the image is an inflammatory site in which inflammation occurs.
  • control unit 1170 When the control unit 1170 detects an inflammation site, the control unit 1170 controls the at least one light source unit 1130 disposed at a position corresponding to the imaging unit 1120 that has taken the inflammation site to emit light for treating inflammation. Therefore, the medical capsule device 1100 can treat the inflammation site by irradiating the inflammation site with the light for treating the inflammation.
  • control unit 1170 compares the image obtained by the photographing unit 1120 with the image obtained in the past to determine whether the inflammation site is the same site. The control unit 1170 judges that the same irritation site is present if the image of the currently acquired irritation site and the image of the irritation site acquired in the past are equal to or greater than predetermined values. The control unit 1170 controls the light source unit 1130 so as not to irradiate light for treating inflammation to the inflammation site determined to be the same site. If the same area is irradiated with the light for treating inflammation of the ultraviolet wavelength band, the normal mucous membrane around the inflammation site may be damaged. Accordingly, the control unit 1170 can prevent the inflammation treatment light from being irradiated to the same site in a redundant manner, thereby preventing the stomach from being damaged.
  • the area infected by the infectious agent has a higher hydrogen ion concentration than the normal mucous membrane.
  • the hydrogen ion concentration at the site of infection is pH 4.0.
  • the control unit 1170 controls the at least one light source unit 1130 disposed at the position corresponding to the pH sensor 1140 to emit sterilizing light. Therefore, the medical capsule device 1100 can sterilize the infectious source by irradiating sterilizing light to the infected site.
  • the medical capsule device 1100 can remove the infectious agent such as Halicobacter pylori without antibiotics by directly irradiating sterilizing light to the infected site. Therefore, the medical capsule device 1100 can prevent side effects caused by antibiotics.
  • the medical capsule device 1100 can directly treat the inflammation inside the stomach by directly irradiating inflammation to the inflammation site.
  • the medical capsule device 1100 is capable of treating a rapid inflammation.
  • FIG. 14 to 17 are illustrations showing various embodiments of the support portion of the medical capsule device.
  • Figs. 14-17 illustrate cross-sections of a support positioned within the housing 1110 of the medical capsule device.
  • Figs. 14 to 17 are for explaining various embodiments of the structure of the support portion, and other constituent parts of the medical capsule device are omitted from the drawings.
  • the support portion 1151 of the medical capsule device has a triangular cross-section.
  • the support portion 1151 may have a triangular columnar structure.
  • a light source unit (not shown) and a photographing unit 1120 may be disposed on all sides of the support unit 1151.
  • the support portion 1152 of the medical capsule device has a circular section.
  • the support portion 1152 may have a cylindrical structure.
  • the light source unit (not shown) may be distributed over the entire outer surface of the support unit 1152.
  • the support portion 1153 of the medical capsule device has a structure in which all the corners have a size in contact with the inner surface of the housing 1110. [ The supporting portion 1153 having such a structure can be fixed so as not to move inside the housing 1110 without a separate fixing member.
  • the medical capsule device includes a fixing portion 1155 for fixing the support portion 1154 so as not to move in the interior of the housing 1110. As shown in Fig. One end of the fixing portion 1155 is fixed to the inner surface of the housing 1110 and the other end is fixed to the supporting portion 1154. [ Although one fixing portion 1155 is shown in Fig. 17, the number of fixing portions 1155 can be changed. In addition, the fixing portion 1155 may be formed of a light transmitting material to prevent the light efficiency of the medical capsule device from being reduced.
  • the support portions 1150, 151, and 152 are shown to have a smaller cross-sectional size than the cross-sectional size of the housing 1110.
  • the support portions 1150 151 and 152 may rotate inside the housing 1110 or move in various directions depending on the movement of the medical capsule device.
  • the entire inside of the camouflage can also be photographed with one photographing section 1120 as shown in FIG. 16 by using the movements of the supporting sections 1150, 151 and 152. That is, when the support parts 1150, 151 and 152 move inside the housing 1110, the entire inside of the camouflage can be photographed with only a small number of the photographing parts 1120 than the embodiment in which the support part is fixed to the housing.
  • the medical capsule device performs inflammation treatment in real time while photographing the inside of the stomach. Therefore, the medical capsule device in which the supporting portions 1153 and 154 are fixed to the housing 1110 can take the entire inside of the gastrointestinal tract for a short time, thereby shortening the inflammation treatment time. Thus, the medical capsule device can treat all inflammation sites for a certain period of staying in the stomach.
  • the supporting portion can rotate at a fixed speed at a fixed portion of the photographing portion.
  • the photographing part moves along the periphery of the outer surface of the support part.
  • the medical capsule device can photograph all directions with a smaller number of photographing portions than when the supporting portion is fixed inside the housing.
  • FIG. 18 is a block diagram of a medical capsule device according to a twelfth embodiment of the present invention.
  • the medical capsule device 1200 includes a plurality of photographing portions 1120, a plurality of light source portions 1130, a plurality of pH sensors 1140, a housing 1110, a control portion 1170 A storage unit 1160, a first wireless communication unit 1220, and a second wireless communication unit 1230.
  • the photographing part 1120 and the light source part 1130 are fixed to the support part and are located inside the housing 1110 and the pH sensor 1140 is located outside the housing.
  • the medical capsule device 1200 of the twelfth embodiment has the storage part 1160 and the control part 1170 inside the housing 1110 in the medical capsule device of the eleventh embodiment (100 of Figs. 11 to 13)
  • the portion 1160 is located outside the body.
  • the storage unit 1160 and the second wireless communication unit 1230 may be components of the electronic device 1210 located outside the body.
  • the electronic device 1210 may be a device capable of data storage and wireless communication.
  • the storage unit 1160 and the second wireless communication unit 1230 form independent electronic devices, and may be electrically connected to each other.
  • the medical capsule device 1200 of the present embodiment includes a component portion disposed in the housing 1110 located inside the body and a storage portion 1160 located outside the body to receive the first wireless communication portion 1220 and the second wireless communication portion 1230 It is possible to perform wireless communication.
  • the first wireless communication unit 1220 is disposed inside the housing 1110 and the second wireless communication unit 1230 is connected to the storage unit 1160 from outside the body.
  • the first wireless communication unit 1220 transmits a signal requesting the inflammatory lesion information through wireless communication 2 wireless communication unit 1230, as shown in FIG.
  • the second wireless communication unit 1230 transmits the received signal to the storage unit 1160 and the storage unit 1160 transmits the requested inflammation lesion information to the second wireless communication unit 1230.
  • the second wireless communication unit 1230 transmits the irritation lesion information received from the storage unit 1160 to the first wireless communication unit 1220 through wireless communication and the first wireless communication unit 1220 transmits the received irritation lesion information to the control unit 1170).
  • the controller 1170 can compare the irritation lesion information received by the wireless communication with the image obtained by the photographing unit 1120 to determine the inflammation site.
  • FIG. 19 is a block diagram of a medical capsule device according to a thirteenth embodiment of the present invention.
  • the storage unit 1160, the control unit 1170, and the second wireless communication unit 1230 are disposed outside the body.
  • the control unit 1170 can control the light source unit 1130 and the photographing unit 1120 by wireless communication.
  • the storage unit 1160, the control unit 1170, and the second wireless communication unit 1230 may be components of the electronic device 1310 located outside the body.
  • the storage unit 1160, the controller 1170, and the second wireless communication unit 1230 may be devices capable of data storage, data processing, and wireless communication such as a computer, a mobile, and the like.
  • the medical capsule apparatus 1300 of this embodiment transmits the image photographed by the photographing unit 1120 and the hydrogen ion concentration detected by the pH sensor 1140 to the second wireless communication unit 1230 through the first wireless communication unit 1220 do.
  • the second wireless communication unit 1230 transmits the received image and the hydrogen ion concentration to the controller 1170.
  • the control unit 1170 compares the image received from the second wireless communication unit 1230 with the inflammatory lesion information stored in the storage unit 1160 to determine an inflammatory site.
  • the controller 1170 uses the hydrogen ion concentration received from the second wireless communication unit 1230 to determine an infected area.
  • the control unit 1170 transmits the control signal to the first wireless communication unit 1220 through the second wireless communication unit 1230 after determining the infected area and the infected area.
  • control signal is a signal for controlling at least one of the light source unit 1130 and the photographing unit 1120.
  • the control signal received by the first wireless communication unit 1220 is transmitted to the light source unit 1130 and the photographing unit 1120, the light source unit 1130 and the photographing unit 1120 operate according to a control signal.
  • the medical capsule device (200 of FIG. 18) according to the twelfth embodiment and the medical capsule device 1300 according to the thirteenth embodiment are arranged such that the size of the housing 1110 can be reduced have.
  • the reduction of the size of the housing 1110 can reduce the burden on the user to be treated with the medical capsule device.
  • the control unit 1170 or the storage unit 1160 is disposed outside the body, restrictions on the capacity and size of the control unit 1170 or the storage unit 1160 are reduced. Accordingly, the control unit 1170 or the storage unit 1160 can have a high capacity and a high processing capacity. As a result, the medical capsule apparatus can improve the efficiency of treatment by quickly and accurately discriminating the treatment site.
  • the medical capsule device 1200 according to the twelfth embodiment and the medical capsule device 1300 according to the thirteenth embodiment can be configured such that the image of the inside of the camouflage photographed by the photographing part 1120 is transmitted to the outside And may be stored in the storage unit 1160. Also, although not shown, the inside of the camouflage can be directly checked in real time through a display device connected to the storage unit 1160. Further, whenever the medical capsule device is used, the photograph of the inside of the stored camouflage can be used to confirm the progress of the treatment.
  • 20 is a block diagram of a medical capsule device according to a fourteenth embodiment of the present invention.
  • 21 is a block diagram of a medical capsule device according to a fifteenth embodiment of the present invention.
  • UVC ultraviolet ray
  • the ultraviolet ray has a maximum light energy of 3 mJ / cm 2 per day for the human body.
  • the blue light which is a visible light, has a sterilizing power of 99.9% at a light energy of 20 mJ / cm 2 and a sterilizing power of 90% at a light intensity of 5.3 mJ / cm 2.
  • maximum light energy can be preset for each light type for safe and effective treatment.
  • the maximum light energy is a total cumulative value of light energy irradiated to the same site.
  • the maximum light energy may be 3 mJ / cm2 for UVA, UVB and UVC, and the blue light and the red light for visible light may be 5 mJ / cm2. Therefore, the medical capsule device can be set in advance so that light is irradiated to the same site at a maximum light energy or less for each light type.
  • the medical capsule device 1400 includes a time control unit 1410.
  • Both the light source for treating inflammation and the light source for sterilization of the light source 1130 are predetermined in terms of the amount of light per unit time.
  • the medical capsule apparatus 1400 of the fourteenth embodiment controls the total energy of light irradiated to the same site in such a manner as to control the light irradiation time of the light source unit 1130 that emits light of a constant light quantity per unit time. That is, in the medical capsule device 1400 of the fourteenth embodiment, the total light amount irradiated to the same site does not exceed the maximum light energy in such a manner that the light irradiation time is controlled.
  • the time control unit 1410 stores preset time information. At this time, the time information is the maximum light irradiation time for the same part set for each kind of light source or type of light. The time control unit 1410 prevents the time for irradiating the light irradiated to the same site to exceed the stored maximum light irradiation time depending on the type of light source or the type of light.
  • the plurality of photographing units 1120 photographs the inside of the camouflage at predetermined time intervals.
  • the control unit 1170 detects the inflammation site in real time using the inflammation lesion information stored in the storage unit 1160 and the images taken by the plurality of photographing units 1120. [ The control unit 1170 controls the light source unit 1130 corresponding to the photographing unit 1120 that photographs the inflammation site to irradiate the inflammation site with the inflammation treatment light. At this time, the control unit 1170 controls the light source unit 1130 so that the inflammation treatment light is not irradiated to the inflammation site upon receiving the inflammation treatment interruption signal from the time control unit 1410.
  • the controller 1170 detects the infection site using the hydrogen ion concentration measured by the plurality of pH sensors 1140.
  • the control unit 1170 controls the light source unit 1130 corresponding to the pH sensor 1140 that detects the infected area so that the sterilizing light is irradiated to the infected area.
  • the control unit 1170 receives the infectious treatment stop signal from the time control unit 1410, and controls the light source unit 1130 so that the sterilizing light is not irradiated to the infection site.
  • the time control unit 1410 compares the current image where the inflammation site is detected and the previously captured image when the control unit 1170 detects the inflammation site.
  • the time control unit 1410 compares the current image with the previous image to check whether the currently detected irritation site has been detected by the control unit 1170 in advance.
  • the time control unit 1410 checks the number of times that the detected inflammation site has been detected before. That is, the time controller 1410 can confirm the number of times the same inflammation site is detected by checking the number of images having the inflammation site that is currently detected.
  • the time control unit 1410 transmits an inflammation treatment interruption signal to the control unit 1170 if the detected inflammation site is detected more than a predetermined number of times.
  • the time controller 1410 compares the current image captured by the photographing unit 1120 corresponding to the pH sensor 1140 with the previously captured image when the controller 1170 detects an infected area.
  • the photographing unit 1120 corresponding to the corresponding pH sensor 1140 also photographs the same region around the infected site. Accordingly, the time control unit 1410 can check whether the currently detected infected area has been previously detected by comparing the current image with the previous image
  • the time control unit 1410 checks the number of times of detection of the currently detected infection site, and transmits an infection treatment stop signal to the control unit 1170 if the detected number of times is more than a predetermined number.
  • the time control unit 1410 controls the light irradiation time for the same site as the number of times the same inflammation site or infection site is detected.
  • the medical capsule apparatus 1400 of this embodiment controls the light irradiation time for the same site as the same number of times the same inflammation site is detected so that the total light amount irradiated to the same site is prevented from exceeding the preset maximum light energy .
  • the light irradiation time is controlled using the photographing speed of the photographing unit 1120, but the light irradiation time can be controlled in various ways other than this method.
  • control unit 1170 for controlling the light source unit 1130 and the time control unit 1410 for controlling the light irradiation time are described as separate components. However, it is also possible for one component to perform the functions of the controller 1170 and the time controller 1410. For example, the control unit 1170 may perform the functions of the time control unit 1410.
  • the medical capsule device 1500 includes a speed sensor 1510 and a light amount control unit 1520.
  • the light source for treating inflammation and the light source for sterilizing the light source 1130 may be light emitting diodes.
  • the light intensity of light emitting diodes varies depending on the magnitude of current.
  • the medical capsule device 1500 according to the fifteenth embodiment controls the light amount per unit time emitted from the light source part 1130 so that the total light amount irradiated to the same part for a predetermined time does not exceed the maximum light energy.
  • the housing 1110 moves by the movement of the stomach or along the movement of the stomach fluid.
  • the speed sensor 1510 thus measures the speed of the housing 1110 moving within the stomach.
  • the speed sensor 1510 can measure the speed of the housing 1110 at predetermined time intervals. Further, the speed sensor 1510 can measure the speed of the housing 1110 whenever the controller 1170 detects an infected area or an infected area.
  • the light amount controller 1520 stores information on the maximum light energy for the same predetermined area. At this time, the information about the maximum light energy can be set for each kind of light source or light.
  • the light amount controller 1520 controls the light intensity of the light source 1130 using the speed measured by the speed sensor 1510.
  • the light amount control unit 1520 calculates the time taken to move the light source by using an arbitrary distance using the speed of the housing 1110. That is, the light amount control unit 1520 calculates the estimated time required to pass through the infected area or the infected area detected by the control unit 1170 using the speed of the housing 1110. Also, the light amount controller 1520 calculates the intensity of the light to such an extent that the light energy exposed to the inflamed site or the infected site does not exceed the preset maximum light energy for the calculated estimated time.
  • the light amount controller 1520 controls the light source 1130 so that light for treating inflammation or light for sterilizing is emitted at the intensity of the calculated light.
  • the medical capsule device 1500 of this embodiment can control the speed of the housing 1110 and the intensity of the light of the light source part 1130 to prevent light from being irradiated to the same part in a degree exceeding the preset maximum light energy .
  • control unit 1170 and the light amount control unit 1520 are described as separate components, but it is also possible that one configuration unit performs the functions of the control unit 1170 and the light amount control unit 1520.
  • control unit 1170 can perform the functions of the light amount control unit 1520.
  • the medical capsule device can directly treat inflammation and infection by using various light in the organ. At this time, the medical capsule device controls the maximum light energy irradiated to the same site, thereby enabling safe and effective treatment to the human body.

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  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un dispositif de capsule médicale. Un dispositif de capsule médicale selon un mode de réalisation de la présente invention comprend : un boîtier, dont au moins une partie est constituée d'un matériau transmettant la lumière ; une pluralité d'unités de source de lumière agencées à l'intérieur du boîtier et comprenant des sources de lumière de stérilisation ; une pluralité de capteurs de pH pour mesurer une concentration d'ions d'hydrogène à l'extérieur du boîtier ; et une unité de commande pour commander les unités de source de lumière.
PCT/KR2018/013541 2017-11-08 2018-11-08 Dispositif de capsule médicale Ceased WO2019093787A2 (fr)

Priority Applications (1)

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CN201880009168.5A CN110234399B (zh) 2017-11-08 2018-11-08 医疗用胶囊装置

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KR1020170147749A KR20190052241A (ko) 2017-11-08 2017-11-08 의료용 캡슐 장치
KR10-2017-0147749 2017-11-08
US201862756385P 2018-11-06 2018-11-06
US62/756,385 2018-11-06

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110433403A (zh) * 2019-08-26 2019-11-12 林军 胃肠led矩阵光源杀菌灭毒系统
CN110433402A (zh) * 2019-08-26 2019-11-12 林军 Led矩阵光源抑制和杀灭癌细胞系统
WO2020178819A1 (fr) * 2019-03-04 2020-09-10 Photopill Medical Ltd. Méthode et dispositif de manipulation de microbiote intestinal
WO2021151166A1 (fr) 2020-01-31 2021-08-05 Cosmoaesthetics Pty Ltd Dispositif thérapeutique ingérable pour le traitement de la gastrite
CN113491496A (zh) * 2021-07-05 2021-10-12 上海交通大学 一种胃肠道幽门螺旋杆菌诊疗系统
CN117357808A (zh) * 2023-11-13 2024-01-09 中国人民解放军总医院第二医学中心 一种用于体内紫外线疗法的胶囊

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WO2002055984A2 (fr) * 2001-01-16 2002-07-18 Given Imaging Ltd. Systeme et methode permettant de determiner des conditions de lumieres corporelles in vivo
JP4744026B2 (ja) * 2001-07-30 2011-08-10 オリンパス株式会社 カプセル内視鏡およびカプセル内視鏡システム
JP4716922B2 (ja) * 2006-05-23 2011-07-06 オリンパスメディカルシステムズ株式会社 カプセル型医療装置およびこれを用いた薬剤導入システム
KR100893761B1 (ko) * 2008-07-31 2009-04-20 박만수 캡슐형 광 치료장치
KR20110055974A (ko) * 2009-11-20 2011-05-26 전자부품연구원 캡슐 내시경 및 그의 구동방법
WO2016049602A1 (fr) * 2014-09-25 2016-03-31 Progenity, Inc. Dispositif de pilules électromécaniques avec capacités de localisation

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020178819A1 (fr) * 2019-03-04 2020-09-10 Photopill Medical Ltd. Méthode et dispositif de manipulation de microbiote intestinal
CN110433403A (zh) * 2019-08-26 2019-11-12 林军 胃肠led矩阵光源杀菌灭毒系统
CN110433402A (zh) * 2019-08-26 2019-11-12 林军 Led矩阵光源抑制和杀灭癌细胞系统
WO2021151166A1 (fr) 2020-01-31 2021-08-05 Cosmoaesthetics Pty Ltd Dispositif thérapeutique ingérable pour le traitement de la gastrite
JP2023513476A (ja) * 2020-01-31 2023-03-31 コスモイースセティクス ピーティーワイ リミテッド 胃炎の処置のための摂取可能な治療デバイス
EP4096779A4 (fr) * 2020-01-31 2024-01-31 Cosmoaesthetics Pty Ltd Dispositif thérapeutique ingérable pour le traitement de la gastrite
JP7682554B2 (ja) 2020-01-31 2025-05-26 コスモイースセティクス ピーティーワイ リミテッド 胃炎の処置のための摂取可能な治療デバイス
CN113491496A (zh) * 2021-07-05 2021-10-12 上海交通大学 一种胃肠道幽门螺旋杆菌诊疗系统
CN117357808A (zh) * 2023-11-13 2024-01-09 中国人民解放军总医院第二医学中心 一种用于体内紫外线疗法的胶囊
CN117357808B (zh) * 2023-11-13 2024-09-20 中国人民解放军总医院第二医学中心 一种用于体内紫外线疗法的胶囊

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