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WO2019092752A3 - Novel salt of lenalidomide and polymorphic forms thereof - Google Patents

Novel salt of lenalidomide and polymorphic forms thereof Download PDF

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Publication number
WO2019092752A3
WO2019092752A3 PCT/IN2018/050741 IN2018050741W WO2019092752A3 WO 2019092752 A3 WO2019092752 A3 WO 2019092752A3 IN 2018050741 W IN2018050741 W IN 2018050741W WO 2019092752 A3 WO2019092752 A3 WO 2019092752A3
Authority
WO
WIPO (PCT)
Prior art keywords
lenalidomide
polymorphic forms
novel salt
discloses
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2018/050741
Other languages
French (fr)
Other versions
WO2019092752A2 (en
Inventor
Venkata Rama Rao Alla
Chandrashekar Ramarao
Mukesh Padmakar SHEWALKAR
Sampath AMUDALA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avra Laboratories Pvt Ltd
Original Assignee
Avra Laboratories Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avra Laboratories Pvt Ltd filed Critical Avra Laboratories Pvt Ltd
Publication of WO2019092752A2 publication Critical patent/WO2019092752A2/en
Publication of WO2019092752A3 publication Critical patent/WO2019092752A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention discloses a novel pharmaceutical salt of Lenalidomide. More particularly, the invention discloses crystalline Trifluroacetic acid salt of Lenalidomide; polymorphic forms thereof and process for preparation thereof. The invention further discloses pharmaceutical composition comprising crystalline Trifluroacetic acid salt of Lenalidomide in association with one or more pharmaceutical excipients.
PCT/IN2018/050741 2017-11-13 2018-11-13 Novel salt of lenalidomide and polymorphic forms thereof Ceased WO2019092752A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201741040454 2017-11-13
IN201741040454 2017-11-13
IN201841006631 2018-02-21
IN201841006631 2018-02-21

Publications (2)

Publication Number Publication Date
WO2019092752A2 WO2019092752A2 (en) 2019-05-16
WO2019092752A3 true WO2019092752A3 (en) 2019-06-13

Family

ID=66437672

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2018/050741 Ceased WO2019092752A2 (en) 2017-11-13 2018-11-13 Novel salt of lenalidomide and polymorphic forms thereof

Country Status (1)

Country Link
WO (1) WO2019092752A2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110021567A1 (en) * 2008-03-11 2011-01-27 Dr. Reddy's Laboratories Ltd. Preparation of lenalidomide
US20110060010A1 (en) * 2008-03-13 2011-03-10 Tianjin Hemay Bio-Tech Co., Ltd Salts of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione and derivatives thereof, or polymorphs of salts, process for preparing same and use thereof
WO2011050962A1 (en) * 2009-10-29 2011-05-05 Ratiopharm Gmbh Acid addition salts of lenalidomide
US20120190711A1 (en) * 2009-08-12 2012-07-26 Jacobus Theodorus Henricus Van Eupen Lenalidomide salts

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110021567A1 (en) * 2008-03-11 2011-01-27 Dr. Reddy's Laboratories Ltd. Preparation of lenalidomide
US20110060010A1 (en) * 2008-03-13 2011-03-10 Tianjin Hemay Bio-Tech Co., Ltd Salts of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)piperidine-2,6-dione and derivatives thereof, or polymorphs of salts, process for preparing same and use thereof
US20120190711A1 (en) * 2009-08-12 2012-07-26 Jacobus Theodorus Henricus Van Eupen Lenalidomide salts
WO2011050962A1 (en) * 2009-10-29 2011-05-05 Ratiopharm Gmbh Acid addition salts of lenalidomide

Also Published As

Publication number Publication date
WO2019092752A2 (en) 2019-05-16

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