WO2016207914A3 - Methods for preparing oltipraz - Google Patents
Methods for preparing oltipraz Download PDFInfo
- Publication number
- WO2016207914A3 WO2016207914A3 PCT/IN2016/050197 IN2016050197W WO2016207914A3 WO 2016207914 A3 WO2016207914 A3 WO 2016207914A3 IN 2016050197 W IN2016050197 W IN 2016050197W WO 2016207914 A3 WO2016207914 A3 WO 2016207914A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methods
- oltipraz
- preparing
- preparing oltipraz
- result
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides improved methods of synthesizing oltipraz, which result in higher overall yield and better purity of the desired product.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020187002139A KR20180022838A (en) | 2015-06-25 | 2016-06-24 | Method for making orthoplazes |
| CA2989228A CA2989228A1 (en) | 2015-06-25 | 2016-06-24 | Methods for preparing oltipraz |
| AU2016283082A AU2016283082B2 (en) | 2015-06-25 | 2016-06-24 | Methods for preparing oltipraz |
| JP2017565999A JP6773693B2 (en) | 2015-06-25 | 2016-06-24 | How to prepare Orchipraz |
| EP16813869.1A EP3313835A4 (en) | 2015-06-25 | 2016-06-24 | PROCESS FOR THE PREPARATION OF OLTIPRAZ |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1891DE2015 | 2015-06-25 | ||
| IN1891/DEL/2015 | 2015-06-25 | ||
| US14/823,256 US20160376259A1 (en) | 2015-06-25 | 2015-08-11 | Methods for Preparing Oltipraz |
| US14/823,256 | 2015-08-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2016207914A2 WO2016207914A2 (en) | 2016-12-29 |
| WO2016207914A3 true WO2016207914A3 (en) | 2017-02-02 |
Family
ID=57585057
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2016/050197 Ceased WO2016207914A2 (en) | 2015-06-25 | 2016-06-24 | Methods for preparing oltipraz |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2016207914A2 (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017322544B2 (en) | 2016-09-12 | 2022-06-02 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3H-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same |
| WO2018047013A1 (en) | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1, 2-dithiole-3-thione, and methods of making and using same |
| WO2018047002A1 (en) | 2016-09-12 | 2018-03-15 | St Ip Holding Ag | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1.2-dithiole-3-thione, taste-modified formulations, and methods of making and using same |
| EP3509642A1 (en) | 2016-09-12 | 2019-07-17 | ST IP Holding AG | Formulations of 4-methyl-5-(pyrazin-2-yl)-3h-1, 2-dithiole-3-thione, and methods of making and using same |
| EP3762104A2 (en) | 2018-03-07 | 2021-01-13 | ST IP Holding AG | Combination compositions and therapies comprising 4-methyl-5-(pyrazin-2-yl)-3h-1,2-dithiole-3-thione, and methods of making and using same |
| SG11202102653WA (en) | 2018-09-18 | 2021-04-29 | St Ip Holding Ag | Rotomeric isomers of 4-alkyl-5-heteroaryl-3h-1,2- dithiole-3-thiones |
| TW202200144A (en) | 2020-03-16 | 2022-01-01 | 瑞士商Ｓｔ知識產權控股公司 | Rotomeric isomers of 4-alkyl-5-heteroaryl-3h-1,2-dithiole-3-thiones |
| US11135220B1 (en) | 2020-04-08 | 2021-10-05 | St Ip Holding Ag | Methods of treating viral infections with formulated compositions comprising 4-methyl-5-(pyrazin-2-yl)-3H-1,2-dithiole-3-thione |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110450A (en) * | 1976-02-10 | 1978-08-29 | Rhone-Poulenc Industries | 1,2-dithiole derivatives |
| US20040053989A1 (en) * | 1999-07-29 | 2004-03-18 | Patrick Prendergast | Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement |
| US20060106079A1 (en) * | 2002-11-26 | 2006-05-18 | Cj Corporation | Method for preparing oltipraz |
-
2016
- 2016-06-24 WO PCT/IN2016/050197 patent/WO2016207914A2/en not_active Ceased
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4110450A (en) * | 1976-02-10 | 1978-08-29 | Rhone-Poulenc Industries | 1,2-dithiole derivatives |
| US20040053989A1 (en) * | 1999-07-29 | 2004-03-18 | Patrick Prendergast | Dithiolthione compounds for the treatment of neurological disorders and for memory enhancement |
| US20060106079A1 (en) * | 2002-11-26 | 2006-05-18 | Cj Corporation | Method for preparing oltipraz |
Non-Patent Citations (1)
| Title |
|---|
| See also references of EP3313835A4 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016207914A2 (en) | 2016-12-29 |
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