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WO2019083306A1 - Appareil de spectroscopie - Google Patents

Appareil de spectroscopie

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Publication number
WO2019083306A1
WO2019083306A1 PCT/KR2018/012754 KR2018012754W WO2019083306A1 WO 2019083306 A1 WO2019083306 A1 WO 2019083306A1 KR 2018012754 W KR2018012754 W KR 2018012754W WO 2019083306 A1 WO2019083306 A1 WO 2019083306A1
Authority
WO
WIPO (PCT)
Prior art keywords
pqr
spectrocopy
light
laser
lasers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/012754
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English (en)
Korean (ko)
Inventor
권오대
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yhk Co Ltd
Original Assignee
Yhk Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yhk Co Ltd filed Critical Yhk Co Ltd
Publication of WO2019083306A1 publication Critical patent/WO2019083306A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N2021/3129—Determining multicomponents by multiwavelength light

Definitions

  • An embodiment of the present invention relates to an apparatus for spectroscopy diagnosis / spectroscopy analysis, and more particularly to a spectroscopy apparatus using a photonic quantum ring (PQR) laser .
  • PQR photonic quantum ring
  • fMRI Magnetic Resonance Imaging
  • fNIRS functional neurometry
  • conventional MRI equipment is heavy, fNIRS imaging technology does not require massive magnetic field conditions.
  • light from an array of light sources such as LED (Light Emitting Diode) or VCSEL (Vertical Cavity Surface Emitting Laser) is exposed to the cortex of the brain and its reflection / (PD), and is recorded as an image.
  • LED Light Emitting Diode
  • VCSEL Very Cavity Surface Emitting Laser
  • fNIRS technology takes extremely short measurement / diagnosis time of several msec to several tens of msec and negligible power consumption Not only will it require, but it will also make affordable diagnostic costs possible.
  • fNIRS imaging technology has been used for brain imaging diagnosis of Parkinson's disease patients.
  • a CW-operated LED as a light source
  • obtaining fNIRS images by detecting light with ordinary PD elements enables cortical analysis to be performed up to a few centimeters of the brain, The reflected light reflects changes in the concentration of oxygen contained in hemoglobin in blood vessels passing through this cortical area.
  • a general fNIRS imaging technique uses a near-infrared or infrared LED as a light source to read the concentration profile of oxygenated hemoglobin (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb) Of the brain.
  • a GaAs-based LED light source utilizes the fact that light absorption of deoxy-Hb is stronger than that of oxy-Hb in the near infrared region of 750 to 800 nm and that the intensity of light absorption spectrum is opposite in the region of 900 to 1000 nm, The state of the patient can be detected from the concentration distribution of Hb.
  • a spectroscopy apparatus includes a light source including a plurality of photonic quantum ring (PQR) lasers, and a light detector configured to detect light emitted from the upper light source and generate an observation signal
  • PQR photonic quantum ring
  • Each of the plurality of PQR lasers emitting a multi-wavelength light wherein the upper light detector comprises a plurality of light detecting subunits, And are detected by different ones of the detection sub-units.
  • Embodiments of the present invention provide an improved technique for diagnosing patients with brain diseases.
  • the fNIRS technique can be extended to suit dynamic analysis, detailed analysis, time-of-day analysis, local analysis, etc. of oxygen saturation of hemoglobin.
  • Embodiments of the present invention enable spectroscopy diagnosis / spectroscopy analysis that utilizes various kinds of data such as the concentration of ions other than oxygen saturation.
  • Figure 1 illustrates an fNIRS diagnostic device that may be used to diagnose a patient's brain condition in accordance with an embodiment of the present invention.
  • Figures 2a and 2b depict an exemplary PQR laser with a circular plane and another exemplary PQR laser with a radial plane, respectively, in a perspective view.
  • FIG 3 shows a spectrum of light emitted from an exemplary PQR laser and detected at a predetermined viewing angle.
  • FIG. 4 shows a spectrum of light emitted from an exemplary columnar GaAs semiconductor PQR laser and detected at a predetermined viewing angle.
  • Figure 1 illustrates an fNIRS diagnostic device 100 that may be used to diagnose the condition of the brain of a patient 180 in accordance with an embodiment of the present invention.
  • the exemplary fNIRS diagnostic apparatus 100 may be configured in a two-dimensional band form as shown. However, the scope of the embodiment is not limited thereto. In another embodiment, the fNIRS diagnostic device 100 may be linear or helmet type.
  • the fNIRS diagnostic apparatus 100 includes a light source 110.
  • the light source 110 may be an array of Photonic Quantum Ring (PQR) lasers.
  • PQR Photonic Quantum Ring
  • the PQR laser of the light source 110 may be placed along the lateral midline on the surface of the fNIRS diagnostic device 100.
  • each PQR laser may have a circular side edge as shown in FIG. 2A or a side edge of a radial (e.g., petal) shape as shown in FIG. 2B.
  • Such a PQR laser may be in the form of a chip (e.g., a 1K chip on the order of 1mm x 1mm or a lower integrated chip on a smaller scale).
  • the PQR laser has a reflective layer disposed above and below a multi-quantum well (MQW) active layer to constrain the photon in the vertical direction and to cause a total internal reflection (TIR) along the lateral boundary of the PQR laser To constrain the photon in the horizontal direction and to perform a TIR multi-wavelength mode oscillation of a three-dimensional "whispering cave mode (WCM) resonator.
  • MQW multi-quantum well
  • TIR total internal reflection
  • WCM whispering cave mode
  • the Rayleigh region defined along the edge of the MQW active layer plane (for example, a disk) is different from the VCSEL light source in that the VCSEL light source performs one-dimensional surface oscillation in the central portion of the columnar semiconductor mesa.
  • a toroid resonator is formed to oscillate a helix standing wave.
  • the carrier of the MQW active layer is aligned with a concentric quantum wire momentarily (e.g., within a few pico seconds) due to the photonic quantum corral effect (PQCE) of the spiral standing wave
  • PQCE photonic quantum corral effect
  • photons are generated through electron-hole recombination, usually with three to seven stranded concentric quantum lines arranged on the rim of the quantum well active layer plane of the mesa having a diameter phi of 10 mu m to 30 mu m.
  • the PQR laser has inherent characteristics such as a minimal threshold current, temperature stability, and the like.
  • a concave TIR condition of a mesa type is established in the radial convex portion
  • a convex TIR condition of a hole type is established in the radial concave portion
  • PQR lasers exhibit multi-mode oscillation spectra, which have oscillating spectra according to their radiation angle (or viewing angle) with respect to the normal of the plane of the PQR laser (either with circular side edges or with radial side edges)
  • the envelope is a blue transition.
  • light from a PQR laser can be scattered around like a rainbow with concentric ringlets of different frequencies (ie multi-wavelengths). 3 shows that light emitted from an exemplary PQR laser with a diameter 15 of the side edge is detected at a position tilted from the normal of the predetermined radial surface of the PQR laser by viewing angles?
  • the wavelength of the oscillation mode of the PQR laser depends on the resonance condition of such a PQR laser, but the envelope of the spectrum representing the intensity of the light depends on the angle at which the light is detected.
  • Light emitted from this exemplary light source 110 may be exposed to the brain of the patient 180 and such light may be absorbed and scattered by oxy-Hb and deoxy-Hb.
  • the fNIRS diagnostic apparatus 100 further includes a photodetector 120.
  • a photodetector 120 may be any type of photodetector that is exposed to the patient 180 from the light source 110 and reflected or transmitted, for example, light that has passed through tissue, such as the cortex of the patient 180, And to generate / output an fNIRS observation signal (e.g., photocurrent).
  • the photodetector 120 may include a band pass filter (which may be referred to hereinbelow as a "color filter” (CF)) by which one or more bands of light may be selected May be an array of the light detecting subunits.
  • CF color filter
  • the CF of the light detecting subunit may be a grating structure such as a diffraction grating element or a grating layer.
  • the CF of the photodetection subunit may be a multi-layered film, for example a multi-layered dielectric film.
  • the photodetection subunit of the photodetector 120 may be spaced apart from the light source 110 on the surface of the fNIRS diagnostic device 100 and laterally disposed above and below the light source 110.
  • the scope of the embodiment is not limited to this arrangement.
  • the light source 110 includes a plurality of PQR lasers (e.g., an embodiment in which a light source 110 including an array of PQR lasers is applied as shown in Fig. 1)
  • the light of different frequencies e.g., f 1 , f 2 , f 3 , f 4 , ..., f n
  • each PQR laser e.g., X 1
  • the optical detection subunit which may include a CF-PD combination.
  • the PQR laser e.g., X 1 and then the PQR laser (e.g., X 2) different frequencies radiated in (, for example, f 1, f 2, f 3 , f 4, ..., f n) of the light of the (E.g., Y 2 , Y 3 , Y 4 , Y 5 , ..., Y n + 1 ) that may be shifted by one position (which may include a CF-PD combination) .
  • This repeated structure of the PQR laser can be obtained by obtaining a time-dependent detection value or an observation signal, providing a respective driving input signal having a different time difference to the individual PQR lasers, , Driving the individual PQR lasers with such drive signals, detecting light of different time differences as different optical detection subunits, performing color coding, and the like.
  • the exemplary fNIRS diagnostic device 100 provides an improved technique for diagnosing patients with brain disease, by employing a PQR rainbow light source instead of a conventional LED.
  • This fNIRS diagnostic device 100 can be tailored to suit the dynamic, detailed, hourly, and local analysis of oxygen saturation of hemoglobin using multi-wavelength radial oscillation.
  • the fNIRS diagnostic apparatus 100 can be adapted for spectroscopy diagnosis utilizing various kinds of data such as the concentration of ions other than oxygen saturation.
  • a spectroscopy diagnostic device such as the fNIRS diagnostic device 100 may be used to perform various analysis functions.
  • fNIRS image when the fNIRS image is configured with the output signal of the fNIRS diagnostic apparatus 100 to investigate the oxygen saturation of the hemoglobin and diagnose the patient, continuous driving of the light source 110 and wide frequency modulation (for example, kHz (Eg, frequency modulation from 1 GHz to GHz), thus allowing more detailed hemodynamic measurements for analysis and various signal processing, eg, dynamically configuring fNIRS images (ie, composing moving images from fNIRS output signals) fNIRS images can be composed of subdivided images, fNIRS images can be configured by time, and so on.
  • kHz frequency modulation from 1 GHz to GHz
  • a first wavelength region (hereinafter, referred to as a " near-infrared region ”) having a wavelength of about 750 nm, 780 nm, 820 nm, Visible light region ”) having a wavelength of about 620 nm, 680 nm, 700 nm (e.g., about 600 nm to 700 nm, such as reddish yellow light)
  • a third wavelength region (hereinafter, also referred to as an " infrared region ”) having a wavelength of about 920 nm, 950 nm, 980 nm, and the like (for example, about 900 nm to 1000 nm) may be used for spectroscopy diagnosis
  • the amount of change in the ion concentration other than the oxygen saturation of hemoglobin can be measured.
  • the apparatus for such spectroscopy diagnosis may be configured in the same manner as the fNIRS diagnostic apparatus 100 described above.
  • the spectroscopy diagnostic apparatus may be configured in the same manner as the fNIRS diagnostic apparatus 100,
  • a suitable PQR laser chip e.g., capable of emitting light in a different wavelength region
  • the ion whose concentration is to be measured by the wavelength of the PQR laser chip and /
  • replacing the PQR laser of the fNIRS diagnostic apparatus 100 with the laser beam can be used not only for enhanced spectroscopy diagnosis for a patient but also for a variety of other spectroscopic analyzes.
  • each PQR laser of the spectroscopy diagnostic apparatus can be configured to emit light having a wavelength in one wavelength region (e.g., near-infrared region, infrared region, or visible light region).
  • the PQR laser of the spectroscopy diagnostic apparatus is a GaAs-based semiconductor chip, and can handle the near infrared region.
  • the PQR laser of the spectroscopy diagnostic apparatus is an InGaAs-based semiconductor chip, which can deal with the infrared region.
  • the light source of the spectroscopy diagnostic device may comprise a plurality of PQR lasers, each array comprising a PQR laser emitting light in a different wavelength range.
  • the spectroscopy diagnostic apparatus comprises three PQR laser arrays (e.g., a first array of PQR lasers emitting light having wavelengths in the near-infrared region, a second array of PQR lasers emitting light having wavelengths in the infrared region, And a third array of PQR lasers emitting light having wavelengths within the visible light region).
  • light of different frequencies emitted by each PQR laser in each array included in the light source for example, different frequencies emitted from each PQR laser (e.g., X1,1 ) in the first array each of the PQR laser (e.g., X 2,1 in the light, and the second array of (e.g., f 1,1, f 1,2, f 1,3, f 1,4, ..., f 1, n) (E.g., f 2,1 , f 2,2 , f 2,3 , f 2,4 , ..., f 2, n ) radiated from each of the PQR lasers
  • the light of different frequencies (e.g., f 3,1 , f 3,2 , f 3,3 , f 3,4 , ..., f 3, n ) radiated at different frequencies (e.g., X 3,1 ) (which may include a combination CF-PD) detection sub-unit may be determined by the (e.
  • each second PQR laser (2,2 X) different frequencies e.g., f 2,1 emitted from the array , f 2 , 2 , f 2 , 3 , f 2 , 4 , ..., f 2, n and the different frequencies emitted by each PQR laser (e.g., X 3, 2 ) (e.
  • f 3,1, f 3,2, f 3,3, f 3,4, ..., f 3, n) of the light is different from the extruded light detecting sub-unit (CF-PD combination one position (For example, Y 2 , Y 3 , Y 4 , Y 5 , ..., Y n + 1 ).
  • CF-PD combination one position For example, Y 2 , Y 3 , Y 4 , Y 5 , ..., Y n + 1 .
  • a spectroscopy diagnostic device in accordance with an embodiment of the present invention may be configured to perform the same functions as a computing device that is configured to operate for control of such diagnostic devices and / Device 190).
  • a spectroscopy diagnostic device e.g., fNIRS diagnostic device 100
  • a predetermined connection e.g., connection 185
  • a cable e.g., Ethernet cable
  • a wireless connection such as a wireless local area network (WLAN), Bluetooth, or the like.
  • WLAN wireless local area network
  • the computing device (e.g., computing device 190) coupled with the exemplary spectrocopy diagnostic device may be any suitable type of computing device, such as a desktop computer, a notebook computer, a tablet, a smartphone, and the like.
  • a computing device may include one or more processors and a computer-readable storage medium (e.g., volatile memory, non-volatile memory and / or storage device) readable by the processor.
  • Computer-readable storage media may store computer-executable instructions.
  • the processor may execute instructions stored on the computer readable storage medium.
  • Such an instruction when executed by a processor, may cause a computing device to perform a method of using a spectroscopy diagnostic device (e.g., fNIRS diagnostic device 100) for diagnosis of a patient, such as a spectroscopy diagnostic device (E.g., an instruction to drive the light source of such a diagnostic apparatus), a spectroscopy diagnostic apparatus (e.g., the fNIRS diagnostic apparatus 100) for controlling the fNIRS diagnostic apparatus 100 (e.g., fNIRS diagnostic apparatus 100) (E.g., an instruction to generate an fNIRS image from an fNIRS observation signal, an instruction to filter noise of an fNIRS observation signal).
  • a spectroscopy diagnostic device e.g., fNIRS diagnostic device 100
  • a spectroscopy diagnostic apparatus e.g., the fNIRS diagnostic apparatus 100
  • fNIRS diagnostic apparatus 100 for controlling the fNIRS diagnostic apparatus 100
  • an instruction to generate an fNIRS image from an fNIRS observation signal
  • the computing device may be an input device (e.g., a pointing device such as a mouse, a keyboard, a touch sensitive input device, a voice input device such as a microphone), an output device (e.g., a display device, a printer, a speaker and / Or an interface device that supports communication with at least one external device, input device, and / or output device.
  • an input device e.g., a pointing device such as a mouse, a keyboard, a touch sensitive input device, a voice input device such as a microphone
  • an output device e.g., a display device, a printer, a speaker and / Or an interface device that supports communication with at least one external device, input device, and / or output device.
  • Example 1 includes a spectroscopy apparatus for spectroscopy diagnosis or spectroscopy analysis, which comprises a light source including a plurality of photonic quantum ring (PQR) lasers, and a light source And a photodetector configured to detect and generate an observed signal.
  • a spectroscopy apparatus for spectroscopy diagnosis or spectroscopy analysis which comprises a light source including a plurality of photonic quantum ring (PQR) lasers, and a light source And a photodetector configured to detect and generate an observed signal.
  • PQR photonic quantum ring
  • Example 2 includes the object of Example 1, wherein each of the plurality of PQR lasers emits multi-wavelength light, and the upper light detector includes a plurality of light detecting subunits.
  • Example 3 includes the object of Example 2, wherein the plurality of light detecting subunits are arranged on the upper spectroscopic apparatus sub-unit so that different wavelength components of the upper-most wavelength light are detected by different ones of the above- .
  • Example 4 includes an object of any of Examples 1 to 3, wherein the upper light detecting subunit includes a color filter (CF) and a photodiode (PD).
  • the upper light detecting subunit includes a color filter (CF) and a photodiode (PD).
  • Example 5 includes the object of Example 4, wherein the upper CF comprises a lattice structure.
  • Example 6 includes the object of Example 4, wherein the upper CF comprises a multilayer film.
  • Example 7 includes an object of any of Examples 1 to 6, wherein the PQR laser has a circular side edge.
  • Example 8 includes an object of any of Examples 1 to 6, wherein the PQR laser has a radial side edge.
  • Example 9 comprises an object of any of Examples 1 to 8 wherein the upper light source comprises a plurality of arrangements of PQR lasers and each arrangement is arranged to emit light having wavelengths in different wavelength regions of a plurality of wavelength regions And at least one PQR laser among the plurality of PQR lasers configured.
  • the upper light source comprises a plurality of arrangements of PQR lasers and each arrangement is arranged to emit light having wavelengths in different wavelength regions of a plurality of wavelength regions And at least one PQR laser among the plurality of PQR lasers configured.
  • Example 10 includes an object of any of Examples 1 to 8 wherein the PQR laser is configured to emit light of a wavelength for use in functional Near-Infrared Spectroscopy (fNIRS) diagnostics.
  • fNIRS Near-Infrared Spectroscopy
  • Example 11 includes an object of any of Examples 1 to 8, wherein the PQR laser comprises a GaAs-based semiconductor chip.
  • Example 12 includes an object of any of Examples 1 to 8, wherein the PQR laser comprises an InGaAs-based semiconductor chip.
  • Example 13 includes an object of any of Examples 1 to 12, wherein each of the plurality of PQR lasers is configured to be provided with a drive input signal having a different time difference.
  • Example 14 includes an object of any of Examples 1 to 13 wherein the upper spectroscopy device is coupled to a computing device configured to generate or process a spectroscopic image in accordance with the upper observation signal.

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Abstract

La présente invention concerne un appareil de spectroscopie. Un appareil de spectroscopie comprend une source de lumière comprenant : de multiples lasers photoniques à anneau quantique ; et un détecteur de lumière configuré pour générer un signal d'observation en détectant la lumière provenant de la source de lumière. Selon l'invention : chacun des lasers photoniques à anneau quantique émet des rayons de lumière ayant de multiples longueurs d'onde ; le détecteur de lumière comprend de multiples sous-unités de détection de lumière ; et différentes composantes de longueur d'onde des rayons lumineux ayant de multiples longueurs d'onde sont détectées par différentes sous-unités de détection de lumière parmi les multiples sous-unités de détection de lumière.
PCT/KR2018/012754 2017-10-26 2018-10-25 Appareil de spectroscopie Ceased WO2019083306A1 (fr)

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KR1020170140085A KR20190046368A (ko) 2017-10-26 2017-10-26 스펙트로스코피 장치
KR10-2017-0140085 2017-10-26

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007313343A (ja) * 1998-10-13 2007-12-06 Somanetics Corp 多チャンネル無侵襲組織オキシメータ
JP2009148388A (ja) * 2007-12-20 2009-07-09 Shimadzu Corp 光計測装置
US20130034863A1 (en) * 2009-01-23 2013-02-07 Philadelphia Health And Education Corporation Apparatus and Methods for Detecting Inflammation Using Quantum Dots
KR20160018134A (ko) * 2014-08-08 2016-02-17 최상식 사용자의 상태를 관리하는 머리착용형 장치 및 사용자의 상태를 관리하는 방법
JP2017038878A (ja) * 2015-08-21 2017-02-23 株式会社日立製作所 生体光計測装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007313343A (ja) * 1998-10-13 2007-12-06 Somanetics Corp 多チャンネル無侵襲組織オキシメータ
JP2009148388A (ja) * 2007-12-20 2009-07-09 Shimadzu Corp 光計測装置
US20130034863A1 (en) * 2009-01-23 2013-02-07 Philadelphia Health And Education Corporation Apparatus and Methods for Detecting Inflammation Using Quantum Dots
KR20160018134A (ko) * 2014-08-08 2016-02-17 최상식 사용자의 상태를 관리하는 머리착용형 장치 및 사용자의 상태를 관리하는 방법
JP2017038878A (ja) * 2015-08-21 2017-02-23 株式会社日立製作所 生体光計測装置

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