[go: up one dir, main page]

WO2019070086A3 - Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication - Google Patents

Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication Download PDF

Info

Publication number
WO2019070086A3
WO2019070086A3 PCT/KP2018/000048 KP2018000048W WO2019070086A3 WO 2019070086 A3 WO2019070086 A3 WO 2019070086A3 KP 2018000048 W KP2018000048 W KP 2018000048W WO 2019070086 A3 WO2019070086 A3 WO 2019070086A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
haemoglobin
manufacturing
swine
oxygen carrying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KP2018/000048
Other languages
English (en)
Other versions
WO2019070086A2 (fr
Inventor
Won Nam Yun
Chol Hui HAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rim Chang Ho
Original Assignee
Rim Chang Ho
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rim Chang Ho filed Critical Rim Chang Ho
Publication of WO2019070086A2 publication Critical patent/WO2019070086A2/fr
Publication of WO2019070086A3 publication Critical patent/WO2019070086A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne un substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc. La présente invention concerne un procédé de fabrication d'un substitut sanguin transportant de l'oxygène à partir de sang de porc. Ledit procédé comprend un processus d'élimination de la protéine plasmatique du sang de porc, un processus de séparation de l'hémoglobine, un processus de purification de l'hémoglobine avec une résine d'échange de cation fortement acide , un processus de polymérisation d'hémoglobine avec du glutaraldéhyde, un processus d'ultrafiltration de polymère d'hémoglobine, un processus d'inactivation de virus dans un polymère d'hémoglobine et un processus d'emballage.
PCT/KP2018/000048 2017-09-20 2018-11-20 Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication Ceased WO2019070086A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KP201720003509 2017-09-20
KP201720003509 2017-09-20

Publications (2)

Publication Number Publication Date
WO2019070086A2 WO2019070086A2 (fr) 2019-04-11
WO2019070086A3 true WO2019070086A3 (fr) 2019-06-13

Family

ID=65994508

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KP2018/000048 Ceased WO2019070086A2 (fr) 2017-09-20 2018-11-20 Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication

Country Status (1)

Country Link
WO (1) WO2019070086A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113509488B (zh) * 2021-06-29 2022-05-20 西安交通大学 一种携氧仿生纳米解毒剂及其制备方法和应用
CN119367518A (zh) * 2024-10-28 2025-01-28 广州蕊特生物科技有限公司 一种人造血液及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301144A (en) * 1979-07-11 1981-11-17 Ajinomoto Company, Incorporated Blood substitute containing modified hemoglobin
WO2007136555A2 (fr) * 2006-05-09 2007-11-29 The United States Of America As Represented By The Secretary Of The Navy Substitut sanguin plurifonctionnel
EP2322207A2 (fr) * 2008-03-18 2011-05-18 Nauchno Proizvodstennaya Kompaniya "MEDBIOFARM" Substitut sanguin à fonction de transport d oxygène, composition pharmaceutique et variantes
CN107137699A (zh) * 2017-06-15 2017-09-08 中国医学科学院输血研究所 一种天然血红蛋白类血液代用品的脱氧方法和制备工艺

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301144A (en) * 1979-07-11 1981-11-17 Ajinomoto Company, Incorporated Blood substitute containing modified hemoglobin
WO2007136555A2 (fr) * 2006-05-09 2007-11-29 The United States Of America As Represented By The Secretary Of The Navy Substitut sanguin plurifonctionnel
EP2322207A2 (fr) * 2008-03-18 2011-05-18 Nauchno Proizvodstennaya Kompaniya "MEDBIOFARM" Substitut sanguin à fonction de transport d oxygène, composition pharmaceutique et variantes
CN107137699A (zh) * 2017-06-15 2017-09-08 中国医学科学院输血研究所 一种天然血红蛋白类血液代用品的脱氧方法和制备工艺

Also Published As

Publication number Publication date
WO2019070086A2 (fr) 2019-04-11

Similar Documents

Publication Publication Date Title
PH12020500199A1 (en) Process for efficient purification of neutral human milk oligosaccharides (hmos) from microbial fermentation
WO2008002492A3 (fr) Procédés pour le traitement thermique du lait
WO2009063291A8 (fr) Procédé de stérilisation par filtration à l'état dilué pour des biopolymères viscoélastiques
FI3801037T3 (fi) Yksinkertainen menetelmä sialylaktooinin puhdistamiseen
NZ595765A (en) Isolation and purification of components of whey
EP2612747A3 (fr) Dispositif de fabrication en couche d'objets tridimensionnels
HK1252568A1 (zh) 一种治疗方法
WO2019070086A3 (fr) Substitut sanguin transportant de l'oxygène obtenu à partir de sang de porc et son procédé de fabrication
EP2570129A3 (fr) Appareil de préparation de sérum
WO2008156124A1 (fr) Procédé de séparation d'un monomère d'immunoglobuline
WO2017048673A8 (fr) Appareil, systèmes et procédés de stockage, traitement et/ou traitement de composants du sang
WO2011106233A3 (fr) Procédés de dialyse assistés par vibration
MX2019007316A (es) Eliminacion de acidos nucleicos y fragmentos de los mismos de un material de biomasa.
MY147456A (en) Method of removing abnormal prion protein from blood products
WO2009085109A3 (fr) Systèmes et procédés pour éliminer les particules entraînées de courants de gaz, et systèmes de réacteur mettant en œuvre lesdits systèmes et procédés
ATE532577T1 (de) Membranen mit verbesserter leistung
EP2186534B8 (fr) Procédé de filtrage de liquide
EP4169677A4 (fr) Système de fabrication de produit moulé stratifié, procédé de fabrication de produit moulé stratifié et programme de fabrication de produit moulé stratifié
BR0206286A (pt) processo e dispositivo para separação de produtos de fermentação de baixa molecularidade de misturas de materiais
WO2022219431A3 (fr) Procédé, appareil et système pour la production, la séparation et la purification de radio-isotopes
EP1679117A3 (fr) Sytème d'adsorption pour éliminer les virus et les composés viraux de fluides, en particulier du sang et du plasma sanguin
CN110614763B (zh) 一种透析器外壳电晕处理工艺
MX387912B (es) Método optimizado para descontaminar la produccion de polímeros de glucosa y los hidrolizados de polímero de glucosa.
WO2006061160A3 (fr) Copolymeres sequences de terephtalate de polyethylene et de polyamide constitue de meta-xylylene diamine et d'acide adipique
AU2018321131A1 (en) Method for virus filtration of von Willebrand Factor

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18865128

Country of ref document: EP

Kind code of ref document: A2

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 23/09/2020)

122 Ep: pct application non-entry in european phase

Ref document number: 18865128

Country of ref document: EP

Kind code of ref document: A2