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WO2008156124A1 - Procédé de séparation d'un monomère d'immunoglobuline - Google Patents

Procédé de séparation d'un monomère d'immunoglobuline Download PDF

Info

Publication number
WO2008156124A1
WO2008156124A1 PCT/JP2008/061164 JP2008061164W WO2008156124A1 WO 2008156124 A1 WO2008156124 A1 WO 2008156124A1 JP 2008061164 W JP2008061164 W JP 2008061164W WO 2008156124 A1 WO2008156124 A1 WO 2008156124A1
Authority
WO
WIPO (PCT)
Prior art keywords
immunoglobulin
monomer
ultrafiltration membrane
immunoglobulin monomer
passing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/061164
Other languages
English (en)
Japanese (ja)
Inventor
Fumihiko Yamaguchi
Hitoshi Mizomoto
Shinya Hamasaki
Takena Mochizuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Corp, Asahi Chemical Industry Co Ltd filed Critical Asahi Kasei Corp
Priority to US12/665,651 priority Critical patent/US8741600B2/en
Priority to JP2009520521A priority patent/JP5099930B2/ja
Publication of WO2008156124A1 publication Critical patent/WO2008156124A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/22—Controlling or regulating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/261—Polyethylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/26—Polyalkenes
    • B01D71/262—Polypropylene
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/32—Polyalkenyl halides containing fluorine atoms
    • B01D71/34—Polyvinylidene fluoride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B01D71/42—Polymers of nitriles, e.g. polyacrylonitrile
    • B01D71/421—Polyacrylonitrile
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/52—Polyethers
    • B01D71/521—Aliphatic polyethers
    • B01D71/5211—Polyethylene glycol or polyethyleneoxide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/66—Polymers having sulfur in the main chain, with or without nitrogen, oxygen or carbon only
    • B01D71/68—Polysulfones; Polyethersulfones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
    • C08L71/10—Polyethers derived from hydroxy compounds or from their metallic derivatives from phenols
    • C08L71/12—Polyphenylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L81/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing sulfur with or without nitrogen, oxygen or carbon only; Compositions of polysulfones; Compositions of derivatives of such polymers
    • C08L81/06—Polysulfones; Polyethersulfones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/14—Pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/16—Flow or flux control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L25/00—Compositions of, homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an aromatic carbocyclic ring; Compositions of derivatives of such polymers
    • C08L25/02—Homopolymers or copolymers of hydrocarbons
    • C08L25/04—Homopolymers or copolymers of styrene
    • C08L25/08—Copolymers of styrene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
    • C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

L'objectif de l'invention est de créer un procédé permettant la séparation d'un monomère d'immunoglobuline avec un degré de précision élevé en soumettant une solution d'immunoglobuline comprenant au moins le monomère d'immunoglobuline et un agrégat de celui-ci à une filtration tangentielle à travers une membrane d'ultrafiltration; et un module de membrane d'ultrafiltration et un appareil de filtration tangentielle destinés à être utilisés dans ledit procédé. A cet effet, le procédé selon l'invention permet de séparer un monomère d'immunoglobuline en soumettant une solution d'immunoglobuline comprenant au moins le monomère d'immunoglobuline et un agrégat de celui-ci et ayant une concentration d'immunoglobuline de 1 à 150 g/l à la filtration tangentielle à travers une membrane d'ultrafiltration ayant un poids moléculaire de coupure non inférieur à 100000 et inférieur à 500000. De cette manière, le monomère d'immunoglobuline peut être transmis à un taux de passage de 80 % ou plus et avec des performances de fractionnement telles que le rapport du taux de passage d'un dimère d'immunoglobuline passant à travers la membrane d'ultrafiltration sur le taux de passage du monomère d'immunoglobuline passant à travers la membrane d'ultrafiltration soit égal à 0,2 ou moins.
PCT/JP2008/061164 2007-06-19 2008-06-18 Procédé de séparation d'un monomère d'immunoglobuline Ceased WO2008156124A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/665,651 US8741600B2 (en) 2007-06-19 2008-06-18 Method for separation of immunoglobulin monomers
JP2009520521A JP5099930B2 (ja) 2007-06-19 2008-06-18 免疫グロブリン１量体の分離方法

Applications Claiming Priority (30)

Application Number Priority Date Filing Date Title
JP2007161048 2007-06-19
JP2007-161048 2007-06-19
JP2008021079 2008-01-31
JP2008-021068 2008-01-31
JP2008-021080 2008-01-31
JP2008021080 2008-01-31
JP2008021068 2008-01-31
JP2008-021079 2008-01-31
JP2008022346 2008-02-01
JP2008-022363 2008-02-01
JP2008-022473 2008-02-01
JP2008-022471 2008-02-01
JP2008-022349 2008-02-01
JP2008-022346 2008-02-01
JP2008022358 2008-02-01
JP2008022473 2008-02-01
JP2008022471 2008-02-01
JP2008022472 2008-02-01
JP2008022349 2008-02-01
JP2008022363 2008-02-01
JP2008-022358 2008-02-01
JP2008-022472 2008-02-01
JP2008-042381 2008-02-25
JP2008042381 2008-02-25
JP2008-042380 2008-02-25
JP2008042380 2008-02-25
JP2008053148 2008-03-04
JP2008-053148 2008-03-04
JP2008066676 2008-03-14
JP2008-066676 2008-03-14

Publications (1)

Publication Number Publication Date
WO2008156124A1 true WO2008156124A1 (fr) 2008-12-24

Family

ID=40156283

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061164 Ceased WO2008156124A1 (fr) 2007-06-19 2008-06-18 Procédé de séparation d'un monomère d'immunoglobuline

Country Status (2)

Country Link
JP (1) JP5099930B2 (fr)
WO (1) WO2008156124A1 (fr)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009141965A1 (fr) * 2008-05-22 2009-11-26 旭化成メディカル株式会社 Procédé de filtration
WO2010109920A1 (fr) * 2009-03-27 2010-09-30 旭化成メディカル株式会社 Procédé pour éliminer des virus dans une solution d'anticorps monoclonal à haute concentration
WO2011111679A1 (fr) * 2010-03-09 2011-09-15 東洋紡績株式会社 Membrane capillaire poreuse destinée au traitement d'un liquide contenant des protéines
JP2012006989A (ja) * 2010-06-22 2012-01-12 Nok Corp 繊維強化多孔質膜の製造法
JP2012006988A (ja) * 2010-06-22 2012-01-12 Nok Corp 繊維強化ポリフッ化ビニリデン系多孔質膜の製造法
EP2377599A4 (fr) * 2008-12-25 2013-05-01 Toyo Boseki Membrane à fibre creuse poreuse et membrane à fibre creuse poreuse pour traiter un liquide contenant des protéines
WO2013077341A1 (fr) * 2011-11-21 2013-05-30 東レ株式会社 Procédé de production de cellulase et appareil permettant la mise en œuvre dudit procédé
JP2013534540A (ja) * 2010-07-19 2013-09-05 ラボラトワール、フランセ、デュ、フラクショヌマン、エ、デ、ビオテクノロジ 濃縮ヒト免疫グロブリン組成物
JP2014526371A (ja) * 2011-09-01 2014-10-06 中外製薬株式会社 限外ろ過によって高度に濃縮された抗体を含む組成物を調製するための方法
WO2014181796A1 (fr) 2013-05-07 2014-11-13 株式会社日立製作所 Dispositif de purification, et procédé de purification
WO2016031834A1 (fr) * 2014-08-25 2016-03-03 旭化成メディカル株式会社 Membrane poreuse
JP2017515664A (ja) * 2014-05-01 2017-06-15 サビック グローバル テクノロジーズ ベスローテン フェンノートシャップ 多孔性非対称ポリフェニレンエーテル膜ならびに関連する分離モジュールおよび方法
JP2018011530A (ja) * 2016-07-19 2018-01-25 株式会社日立製作所 分離装置、培養装置および分離方法
JP2020513308A (ja) * 2016-12-09 2020-05-14 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング 改善された分離効率を有する中空糸膜、および改善された分離効率を有する中空糸膜の生成
JP2022522961A (ja) * 2019-01-18 2022-04-21 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング フッ素含有中空繊維膜を含む透析器
WO2022118943A1 (fr) * 2020-12-04 2022-06-09 旭化成メディカル株式会社 Membrane poreuse à fibres creuses et procédé de test d'intégrité

Citations (5)

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Publication number Priority date Publication date Assignee Title
JPS5659716A (en) * 1979-10-22 1981-05-23 Toyo Soda Mfg Co Ltd Separating method of gamma-globulin aggregate with membrane
JPH10265406A (ja) * 1997-03-19 1998-10-06 Green Cross Corp:The 免疫グロブリン製剤
WO2002013859A1 (fr) * 2000-08-10 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Methode permettant d'inhiber la coagulation ou la turbidite d'une solution contenant des anticorps
JP2003012693A (ja) * 2000-11-03 2003-01-15 Millipore Corp 蛋白質溶液から蛋白質凝集体及びウイルスを除去する方法
WO2007018284A1 (fr) * 2005-08-09 2007-02-15 Asahi Kasei Kabushiki Kaisha Membrane de séparation destinée au traitement d'un liquide et comprenant un polymère d'éther aromatique qui est hydrophilisé par un agent hydrophilisant

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5659716A (en) * 1979-10-22 1981-05-23 Toyo Soda Mfg Co Ltd Separating method of gamma-globulin aggregate with membrane
JPH10265406A (ja) * 1997-03-19 1998-10-06 Green Cross Corp:The 免疫グロブリン製剤
WO2002013859A1 (fr) * 2000-08-10 2002-02-21 Chugai Seiyaku Kabushiki Kaisha Methode permettant d'inhiber la coagulation ou la turbidite d'une solution contenant des anticorps
JP2003012693A (ja) * 2000-11-03 2003-01-15 Millipore Corp 蛋白質溶液から蛋白質凝集体及びウイルスを除去する方法
WO2007018284A1 (fr) * 2005-08-09 2007-02-15 Asahi Kasei Kabushiki Kaisha Membrane de séparation destinée au traitement d'un liquide et comprenant un polymère d'éther aromatique qui est hydrophilisé par un agent hydrophilisant

Non-Patent Citations (1)

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Title
LITZEN A. ET AL.: "Separation and quantitation of monoclonal antibody aggregates by asymmetrical flow field-flow fractionation and comparison to gel permeation chromatography", ANAL. BIOCHEM., vol. 212, no. 2, 1993, pages 469 - 480, XP024763578 *

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5403827B2 (ja) * 2008-05-22 2014-01-29 旭化成メディカル株式会社 濾過方法
US9272245B2 (en) 2008-05-22 2016-03-01 Asahi Kasei Medical Co., Ltd. Filtration method
WO2009141965A1 (fr) * 2008-05-22 2009-11-26 旭化成メディカル株式会社 Procédé de filtration
EP2377599A4 (fr) * 2008-12-25 2013-05-01 Toyo Boseki Membrane à fibre creuse poreuse et membrane à fibre creuse poreuse pour traiter un liquide contenant des protéines
US9795932B2 (en) 2008-12-25 2017-10-24 Toyo Boseki Kabushiki Kaisha Porous hollow fiber membrane and a porous hollow fiber membrane for the treatment of a protein-containing liquid
WO2010109920A1 (fr) * 2009-03-27 2010-09-30 旭化成メディカル株式会社 Procédé pour éliminer des virus dans une solution d'anticorps monoclonal à haute concentration
US9056896B2 (en) 2009-03-27 2015-06-16 Asahi Kasei Medical Co., Ltd. Method for removing viruses from high concentration monoclonal antibody solution
EP2412817B1 (fr) 2009-03-27 2016-05-04 Asahi Kasei Medical Co., Ltd. Procédé pour éliminer des virus dans une solution d'anticorps monoclonal à haute concentration
AU2011225316B2 (en) * 2010-03-09 2014-04-17 Toyobo Co., Ltd. Porous, hollow fiber membrane for liquid treatment containing protein
US9492794B2 (en) 2010-03-09 2016-11-15 Toyobo Boseki Kabushiki Kaisha Porous hollow fiber membrane for treatment of protein-containing liquid
JP5754654B2 (ja) * 2010-03-09 2015-07-29 東洋紡株式会社 タンパク質含有液処理用多孔質中空糸膜
WO2011111679A1 (fr) * 2010-03-09 2011-09-15 東洋紡績株式会社 Membrane capillaire poreuse destinée au traitement d'un liquide contenant des protéines
JP2012006988A (ja) * 2010-06-22 2012-01-12 Nok Corp 繊維強化ポリフッ化ビニリデン系多孔質膜の製造法
JP2012006989A (ja) * 2010-06-22 2012-01-12 Nok Corp 繊維強化多孔質膜の製造法
JP2013534540A (ja) * 2010-07-19 2013-09-05 ラボラトワール、フランセ、デュ、フラクショヌマン、エ、デ、ビオテクノロジ 濃縮ヒト免疫グロブリン組成物
US9630988B2 (en) 2011-09-01 2017-04-25 Chugai Seiyaku Kabushiki Kaisha Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
US12209109B2 (en) 2011-09-01 2025-01-28 Chugai Seiyaku Kabushiki Kaisha Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
JP2014526371A (ja) * 2011-09-01 2014-10-06 中外製薬株式会社 限外ろ過によって高度に濃縮された抗体を含む組成物を調製するための方法
US10590164B2 (en) 2011-09-01 2020-03-17 Chugai Seiyaku Kabushiki Kaisha Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
AU2012341519B2 (en) * 2011-11-21 2018-04-19 Toray Industries, Inc. Method for producing cellulase, and apparatus for said method
US11253818B2 (en) 2011-11-21 2022-02-22 Toray Industries, Inc. Method for producing cellulase and apparatus for said method
WO2013077341A1 (fr) * 2011-11-21 2013-05-30 東レ株式会社 Procédé de production de cellulase et appareil permettant la mise en œuvre dudit procédé
WO2014181796A1 (fr) 2013-05-07 2014-11-13 株式会社日立製作所 Dispositif de purification, et procédé de purification
US9981205B2 (en) 2013-05-07 2018-05-29 Hitachi, Ltd. Purification device, and purification method
JP2017515664A (ja) * 2014-05-01 2017-06-15 サビック グローバル テクノロジーズ ベスローテン フェンノートシャップ 多孔性非対称ポリフェニレンエーテル膜ならびに関連する分離モジュールおよび方法
JP2017515662A (ja) * 2014-05-01 2017-06-15 サビック グローバル テクノロジーズ ベスローテン フェンノートシャップ 多孔性非対称ポリフェニレンエーテル膜ならびに関連する分離モジュールおよび方法
WO2016031834A1 (fr) * 2014-08-25 2016-03-03 旭化成メディカル株式会社 Membrane poreuse
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JP2022522961A (ja) * 2019-01-18 2022-04-21 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング フッ素含有中空繊維膜を含む透析器
JP7467481B2 (ja) 2019-01-18 2024-04-15 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング フッ素含有中空繊維膜を含む透析器
JP7600265B2 (ja) 2020-12-04 2024-12-16 旭化成メディカル株式会社 多孔質中空糸膜及び完全性試験方法
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