[go: up one dir, main page]

WO2018133329A1 - Filtre, manche, et système de distribution de médicament aseptique - Google Patents

Filtre, manche, et système de distribution de médicament aseptique Download PDF

Info

Publication number
WO2018133329A1
WO2018133329A1 PCT/CN2017/090319 CN2017090319W WO2018133329A1 WO 2018133329 A1 WO2018133329 A1 WO 2018133329A1 CN 2017090319 W CN2017090319 W CN 2017090319W WO 2018133329 A1 WO2018133329 A1 WO 2018133329A1
Authority
WO
WIPO (PCT)
Prior art keywords
filter
handle
dissolver
air
housing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2017/090319
Other languages
English (en)
Chinese (zh)
Inventor
张巍
张劲东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2018133329A1 publication Critical patent/WO2018133329A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/10—Particle separators, e.g. dust precipitators, using filter plates, sheets or pads having plane surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/42—Auxiliary equipment or operation thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
    • B01D46/54—Particle separators, e.g. dust precipitators, using ultra-fine filter sheets or diaphragms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams

Definitions

  • the invention relates to the field of dispensing equipment, in particular to a filter and a handle and a sterile dispensing system.
  • hospital dispensing mainly relies on manual operation, and most of them are carried out in an open space. Such operations can easily cause various gases and bacteria in the air to enter the drug, causing drug contamination.
  • the most common method for clinical infusion dispensing is manual dispensing.
  • the nurse needs to manually use a syringe to inject the liquid medicine, powder, etc. in the bottle with other liquids, and then inject the mixture into the infusion bottle or the patient.
  • the nurse continuously operates the dispensing device to perform the work of pumping the liquid, which is labor intensive, inefficient, and more importantly, the traditional dispensing device is easy to bring bacteria into the dispensing system due to exposure to the air.
  • the dispensing device has poor airtightness and cannot achieve a sterile effect, which is likely to cause contamination of the drug.
  • the technical solution adopted by the present invention is to provide a filter including an upper case, a lower case, and a filter film, the upper case is fixedly connected to the lower case, and the filter film is disposed at the In the cavity between the lower case and the upper case, the upper case is provided with a plurality of small holes for increasing the outgas area and providing a uniform, slow, non-intersecting gas.
  • the lower shell and the upper shell are provided with reinforcing ribs for improving the overall strength and clamping the filter membrane.
  • the upper shell surface is flat to avoid eddy currents and dead angles to ensure a sterile environment.
  • the filter further includes a positioning member disposed between the lower case and the upper case for clamping the filter film.
  • the method further includes a housing, a sealing fixture and a connecting member, the sealing fixture being disposed inside the housing and sealingly and fixedly connected with the filter for ensuring an internal air passage of the handle Airtight; the connecting member is connected at one end to the filter in the housing, and the other end is connected to the air tube outside the housing.
  • the housing comprises a housing and a control unit, and the control unit is disposed on the housing for controlling the air source output device to blow and pump air to the handle.
  • it further comprises a detecting unit disposed on the outer casing for detecting position information of the mounting solvent and transmitting to the air source output device.
  • the connecting member is a quick connector for facilitating quick insertion and removal and ensuring airtightness at the joint.
  • it further comprises a solvent dissolver and a gas source output device, wherein the handle is connected to the gas source output device through a power line and a gas pipe, and the drug dissolver is detachably mounted on the handle.
  • the solvent dissolver is provided with a strip for matching the detecting unit on the handle to complete the position detection of the solvent dissolver.
  • the invention has the beneficial effects that the invention provides a filter and a handle and a sterile dispensing system, and the filter structure of the invention is simple and reasonable, the filtering is efficient, and the device can provide uniform, slow, non-crossing, Large area of clean air, replacing the front end of the filter with a clean and sterile environment to achieve a local level of cleanliness;
  • the handle with the above filter of the invention has good sealing performance, easy disassembly and assembly, convenient replacement, and the ability to filter The front end is replaced by a clean and sterile environment, and is safe and reliable;
  • the aseptic dispensing system with the above handle of the invention further comprises a solvent dissolver and a gas source output device, and the aseptic preparation is completed by the cooperation of the three, the filtration efficiency is high, and the filtration is high.
  • the process is safe, sterilized, and the filtering effect is good, the labor intensity is reduced, and the applicability is wide.
  • FIG. 1 is a schematic structural view of a filter according to Embodiment 1 of the present invention.
  • FIG. 2 is a schematic exploded view of a handle according to a third embodiment of the present invention.
  • FIG. 3 is a schematic exploded view of a handle according to Embodiment 4 of the present invention.
  • FIG. 4 is a schematic view showing the assembly structure of the sealing fixture and the filter of the fifth embodiment
  • FIG. 5 is a schematic exploded view of a handle according to Embodiment 7 of the present invention.
  • Figure 6 is a schematic view showing the structure of an aseptic dispensing system of the present invention.
  • Fig. 7 is a schematic view showing the flow of gas in the gas source output device of the aseptic dispensing system of the present embodiment.
  • a schematic structural view of a filter provided by the present invention includes a top case, a lower case and a filter film 82.
  • the upper case is fixedly connected to the lower case, and the filter film 82 is disposed on the lower case and Inside the cavity between the upper shells.
  • the upper and lower casings are also referred to as a filter upper casing 81 and a filter lower casing 83.
  • the filter lower case 83 has a tapered shape, and a reinforcing rib is evenly disposed on the inner wall thereof for improving the strength of the filter lower case 83. And the filter upper case 81 cooperates to hold the filter film 82, and the clean air enters through the small opening of the tapered filter lower case 83.
  • the filtering upper casing 81 is a circular buckle structure matched with the large opening of the filtering lower casing 83, and is fastened to the filtering lower casing 83; the filtering upper casing 81 is provided with a certain number of small diameter holes as the air outlet, which can make The airflow area is increased, and the air outlets are evenly distributed, which can provide a large area of clean gas which is relatively slow, uniform, non-intersecting, and free of turbulence and no turbulence.
  • the diameter of the upper shell of the filter is 2.5 cm, which can produce a gas with a diameter of 2.5 cm.
  • the beam is used to replace the front end of the gas outlet with a clean environment to achieve a local aseptic effect;
  • the surface of the filter upper shell 81 is flat, that is, the upper shell 81 is filtered, and the surfaces except the gas outlet holes are all in the same plane, and there is no convexity. Lifting or grooved to avoid eddy currents and dead angles, to prevent adhesion by contaminants, thereby ensuring a sterile environment;
  • the filter upper casing 81 is provided with reinforcing ribs on the side of the filter lower casing 83 for improving the strength of the filtering upper casing 81, and
  • the filter case 82 is clamped to cooperate with the filter case 83.
  • the arrangement of the reinforcing ribs on the filter improves the overall strength, and also clamps the intermediate filter film 82 to prevent the film from being broken and improves the filtration efficiency.
  • the number of the reinforcing ribs of the filter upper case 81 is two, and one or more may be provided.
  • the number of the reinforcing ribs of the lower filter case 83 is six, and of course, less or more than six may be provided, and different numbers may be flexibly set. Reinforce the ribs to meet different requirements under different designs.
  • the reinforcing ribs on the filtering upper casing 81 and the filtering lower casing 83 are all in a single shape. Of course, other shapes with a curvature or an angle may also be used, that is, the shape of the reinforcing ribs may also be specifically determined according to actual needs. set up.
  • the filter membrane 82 is disposed between the filter upper shell 81 and the filter lower shell 83.
  • the filter membrane 82 of the present invention adopts a 0.24 mm pore size polytetrafluoroethylene filter membrane, which is generally used and low in cost, and has a pore size.
  • the size is the threshold for sterile filtration and works well for filtering gases.
  • the lower casing 83 When blowing the filter, the lower casing 83 is filtered as an air inlet, and the upper casing 81 is filtered as an air outlet.
  • the gas enters from the small opening of the lower casing 83 and is filtered by the filtration membrane 82 to become a clean gas.
  • the small holes of the shell 81 are blown out, and the gas bundle blown from the filter upper shell 81 can be up to 2.5 cm in diameter, the gas output area is increased, and the air flow is slow, uniform, and does not cross each other, and there is no turbulent flow and no turbulence, which can be filtered.
  • the area at the front end of the upper casing 81 is replaced with a clean and sterile environment to achieve a local level of cleanliness.
  • the filter structure of the invention is simple and reasonable, and the filter upper casing 81 adopts a circular buckle cover with small holes, which reduces the resistance of the gas flowing through the filter, and can provide uniform, slow, non-crossing and large area. Clean air, to achieve the local clean and sterile effect at the front end of the filter, and the filtration efficiency is high and the effect is good.
  • the filter of this embodiment is different from the first embodiment in that the filter of the embodiment further includes a positioning member.
  • the positioning member is disposed between the filter upper case 81 and the filter lower case 83 for holding the filter film 82.
  • the positioning member of the embodiment is a circular structure having the same diameter as the filter film 82.
  • the surface of the positioning member is provided with an air outlet hole corresponding to the filter upper case 81, and is disposed between the filter upper case 81 and the filter lower case 83.
  • the cavity is disposed coaxially with the filter film 82, and its thickness is adapted to the cavity margin between the filter upper case 81 and the filter lower case 83 to serve as a clamping function for the filter film 82.
  • the gas enters from the small opening of the filtering lower casing 83, and the gas passes through the filtering film 82 through the positioning member. After being filtered by the filtration membrane 82, it becomes a clean gas, and is blown out from each small hole of the filtration upper casing 81, and the diameter of the gas bundle blown from the filtration upper casing 81 can be up to 2.5 cm, the gas output area is increased, and the gas flow is slow and uniform. They do not cross each other, and there is no turbulent flow, and the area of the front end of the filter upper casing 81 can be replaced with a clean and sterile environment to achieve a local level of cleanliness.
  • FIG. 2 it is a schematic exploded view of a handle of the present embodiment.
  • the handle of the embodiment includes the filter 8 of the first embodiment or the second embodiment, and further includes a housing, a sealing fixture and a connection. Pieces.
  • the sealing fixture is disposed inside the casing and is sealingly and fixedly connected with the filter for ensuring the airtightness of the air passage inside the handle; one end of the connecting member is connected to the filter in the casing, and the other end is connected to the air pipe outside the casing.
  • the housing includes a housing and a control unit, and the control unit is disposed on the housing for controlling the air source output device to blow and pump air to the handle.
  • the outer cover includes an upper cover, a cover 2 and a bottom case 3. The cover 2 and the bottom case 3 are connected by a lock to facilitate disassembly; the upper cover is disposed on the inner side of the front end of the bottom case 3, and the two are used as a front end part of the handle for Fixing the drug dissolver, the front end part of the handle is protruding for the user to hold, and the protruding form can be designed differently according to the optimal effect of the actual situation to obtain a better user experience; the outer side of the upper cover and the inner side of the bottom case 3
  • the arc is the same, the inner arc of the upper cover is the same as the outer arc of the solvent dissolver, so that when the solvent dissolver is installed, the solvent dissolver and the inner side of the upper cover can be completely fitted, so that the solvent dissolver and the handle are more stable
  • the upper cover is provided with a groove, and when the solvent dissolver is mounted on the handle, the side flap of the solvent dissolver is stuck in the groove, and the solvent dissolver and the handle are coaxial, and then the drug is dissolved.
  • the device is rotated 90 degrees, and the solvent dissolver is engaged with the handle.
  • the control unit is a button, and the button is disposed on the bottom case 3, and the number of the buttons is at least two, and is used for controlling the airway output device to blow and pump air to the handle.
  • the seal fixture includes a filter head 5, a movable plug 6 and a filter tail 9.
  • the movable plug 6 is engaged with the filter upper casing 81 of the filter, the shape of the filter tail 9 is adapted to the filter 8, and the filter is set in the filter In the tail 9 of the machine, the filter head 5 is directly buckled on the tail 9 of the filter.
  • the solvent dissolver is mounted on the handle, when the tail of the dissolver reaches the position of the filter head 5, the tail of the dissolver is fixed to the movable plug 6, the dissolver is rotated 90 degrees, and the tail of the dissolver is The movable plug 6 rotates, and the movable plug 6 does not rotate together with the tail of the dissolver to complete the installation and fixation of the dissolver and the handle.
  • the connecting piece is a double-headed gas pipe joint 10, one end of the double-headed gas pipe joint 10 is connected to the filter through the connecting filter tail 9 and the other end is connected to the closed gas pipe, and the double-headed gas pipe joint 10 is a quick joint, which has the advantages of being easy to insert and remove, and sealed. Good sex.
  • the handle of the embodiment is connected by a gas pipe and a power line and a gas source output device, and before the solvent dissolver is installed to the handle of the embodiment, the gas source output device supplies a small power source to the handle, and the small power source enters the filter through the gas pipe.
  • the lower casing 83 is filtered through the filtration membrane 82 to obtain a clean and sterile gas.
  • the filtered gas is filtered through the upper casing 81 and blown out from the small pores of the filtration upper casing 81 to obtain a uniform, slow, non-crossing, large area.
  • the clean air can replace the area of the front end of the filter upper casing 81 into a clean and sterile environment to achieve a local level of cleanliness; when the solvent dissolver is mounted to the handle, the front end of the handle is kept for a small power source, and the handle is held. Replace the front end area with a clean and sterile environment, attach the solvent dissolver to the inside of the front end of the handle, hold the squeeze solvent applicator against the handle, and push it toward the filter.
  • a handle of the embodiment is different from the third embodiment in that the seal fixing member of the handle of the embodiment further includes an O-ring. 7.
  • An O-ring 7 is provided between the filter and the movable plug 6 for preventing hard grinding and for buffering.
  • the movable plug 6 is fastened on the filter upper casing 81 of the filter, and an O-ring 7 is disposed between the movable plug 6 and the filter.
  • the intermediate diameter of the O-ring 7 is consistent with the solvent dissolver and is set to 2 cm. Used to prevent hard grinding and buffering, thereby increasing the service life of the movable plug 6,
  • FIG. 4 a schematic view of the assembly structure of the seal fixing member and the filter of the present embodiment, the handle of the present embodiment is different from the fourth embodiment in the sealed seal fixing member of the embodiment.
  • Filter The machine head 5 is directly snapped onto the filter tail 9 so that the filter head 5, the movable plug 6, the O-ring 7, the filter and the filter tail 9 are assembled to be integrated, disassembled and replaced. Air circuit components.
  • the fixed connection of the filter head 5 and the filter tail 9 is a snap connection, which has achieved a fast and stable fixed connection and ensures airtightness.
  • the connection between the filter head 5 and the filter can also be Plug and unplug connections, threaded connections, and more.
  • the sealing fixture and the filter are assembled into a pneumatic circuit assembly that can be disassembled and replaced integrally.
  • the components of the pneumatic circuit assembly can be assembled separately and assembled, and assembled into an integrated replacement piece.
  • the replacement frequency is once a day. This allows for quick installation and removal of the pneumatic components to ensure a sterile environment and air tightness, and to increase work efficiency and simplify work steps.
  • a handle of this embodiment is different from the third embodiment in that the movable plug 6 in the seal fixing member of the present embodiment is buckled on the filter.
  • the solvent dissolver is mounted on the handle, when the tail of the dissolver reaches the position of the filter head 5, the tail of the dissolver is fixed to the movable plug 6, and the dissolver is rotated by 90 degrees, and the movable plug 6 follows The tail of the solvent dissolves together to better seal the tail of the dissolver with the sealing fixture in the handle, further enhancing the airtightness.
  • a schematic diagram of an exploded structure of a handle of the present embodiment is different from the third embodiment in that the handle of the embodiment further includes a detecting unit.
  • the detecting unit is disposed on the outer casing for detecting position information of the installed solvent dissolver and transmitting the information to the air source output device.
  • the detecting unit comprises a light transmitting lens 11 and a photoelectric sensor, and the light transmitting lens 11 is disposed at a position on the upper cover at a distance from the air path component for causing the photoelectric sensor located inside thereof to read the strip disposed at the corresponding position of the solvent dissolver.
  • the distance from the strip on the solvent applicator to the rear end of the drug dissolver is the same as the distance between the light-transmitting lens 11 and the air path component.
  • the strip on the drug dissolver is covered.
  • the light transmissive lens 11 triggers the photoelectric sensor, and the photoelectric sensor sends a signal to the control gas path output device, and the control gas path output device stops supplying the small power gas source.
  • the setting of the detecting unit can accurately detect whether the solvent dissolver is installed to the designated position, determine the relevant solenoid valve in the gas source output device after the solvent dissolver is installed to the designated position, and stop providing small power to the handle.
  • the gas source began to supply a large power source, which simplifies the work steps, speeds up the dispensing process, and improves work efficiency.
  • the aseptic dispensing system of the present invention comprises the handle of the above embodiment, which further comprises a solvent dissolver and a gas source output device.
  • the handle is connected to the air source output device through a power line and a gas pipe, and the solvent dissolver is detachably mounted on the handle.
  • the gas source output device delivers clean air to the solvent dissolver through the handle to drive the melter rubber plug movement, and the filter in the handle purifies the air from the gas source output device to ensure injection into the solvent dissolver. It is clean and sterile air.
  • the drug dissolver has a needle, a cylinder and a rubber plug, the rubber plug is disposed inside the cylinder, and the strip is provided with a strip for use with the detecting unit in the handle to detect whether the solvent is already It is mounted on the handle, wherein the strip is designed in a semicircular shape on the melter, or may be a circular surround melter, or may be a semicircular strip, a corrugated strip or the like.
  • the solvent dissolver When the solvent dissolver is not in use, that is, in the initial position, the end of the dissolver is kept in the same plane as the rubber plug, and there is no dead angle to ensure that the small power source can blow the end of the dissolver and the rubber plug to the sterilized, and then Ensure that the solvent chamber is clean and sterile when in use.
  • FIG. 7 a schematic diagram of the gas flow in the gas source output device of the aseptic dispensing system of the present embodiment
  • the main working pump 21 is always in the working state, and when the second electromagnetic valve 13 and the third electromagnetic valve 14 are both When the state is off, the air flows along the intermediate effect filter, B1, B2, the air inlet, the air outlet, A2, A1, and the purifying pump extracts the air in the upper tank, and the first solenoid valve controls the connection in the pipeline with the purifying pump.
  • Air flow air is output through the three-way, and finally output from the output port 16, the output air is a smooth, gentle small flow of clean air, that is, a small power source;
  • the second solenoid valve is opened, the air along the intermediate effect filter , B1, B2, air inlet, air outlet, A2, A3, C2, C3 flow, and finally output from the output port 16, the output is a large flow of clean air, can be used as a power source, that is, a large power source;
  • the third solenoid valve 14 When the third solenoid valve 14 is opened, air is input from the output port 16, and flows along C3, C2, B3, B2, the air inlet, the air outlet, A2, and A1, and the air is pumped to the air source output device, filtered and transported to the upper portion.
  • the main working pump 21 and the purifying sub-device as two different gas source output terminals, can provide a small flow, smooth clean air, and can provide a large flow, clean air that can be used as a power source, and the user can It is very practical for its selection. In addition, it can be replaced separately when it is renewed, it is convenient and effective to use, and it is not too expensive.
  • the dispensing of the sterile dispensing system begins, and the air from the main working pump acts as the power for the rubber plug movement in the drug dissolver.
  • the operator holds the handle and controls the operation through the relevant buttons on the handle.
  • the handle is provided with at least two buttons for controlling the forward and reverse buttons of the rubber plug, which are respectively used for controlling the opening and closing of the second solenoid valve 13 and the third solenoid valve 14.
  • the button for controlling the advancement of the rubber stopper is pressed, the second electromagnetic valve 13 is opened, and the air flows along the intermediate effect filter, B1, B2, the air inlet, the air outlet, A2, A3, C2, C3, and the air is output from the air source.
  • the device After the device is output, via the handle and the handle a high-efficiency filter, injecting a solvent dissolver, pushing the rubber plug forward, pushing the liquid medicine in the solvent dissolver, the front end of the rubber plug is clean and sterile air, and the rear end is also sterile air; when pressed
  • the button of the rubber back is controlled, the third electromagnetic valve 14 is opened, and the air is sucked from the outside of the air source output device, and enters the air source output device via the handle and the high efficiency filter in the handle, and along the C3, C2. B3, B2, air inlet, air outlet, A2, A1 flow.
  • a negative pressure zone is formed at the tail of the drug dissolver to attract the rubber stopper to be withdrawn, and the drug solution in the vial can be drawn into the drug dissolver. Repeat this several times using the button to control the rubber stopper to repeat the movement until the solution is dissolved.
  • the aseptic dispensing system can ensure that the aseptic environment is always maintained in the cavity of the drug dissolver during the entire dispensing process, thereby greatly ensuring the patient.
  • the medication is safe.
  • the aseptic dispensing step of the present invention comprises:
  • Step S6 inserting the needle of the solvent dissolver into the medicine bottle, controlling the rubber stopper in the solvent dissolver to move away from the needle, and pumping the liquid medicine in the medicine bottle into the solvent dissolver And withdrawing the needle;
  • Step S7 inserting the needle of the solvent into a new vial, and if the new vial is a medicinal solution, controlling the rubber stopper in the medicinal device to move away from the needle, The liquid medicine in the medicine bottle is drawn into the solvent dissolver and the needle is withdrawn; if the new medicine bottle is a powder, the rubber plug is controlled to move in a direction close to the needle, and the liquid medicine is Push the vial and mix it out;
  • Step S8 The previous step is repeated until the liquid medicines in all the vials are drawn into the drug dissolver.
  • the rubber stopper in the solvent dissolver is spaced apart from the front end of the cartridge body to counter the negative pressure in the bottle.
  • the handle control air source output device extracts the air at the rear end of the rubber plug in the cylinder body to form a negative pressure environment, so that the rubber plug moves away from the needle; the handle controls the air source output device to output air to the rubber plug rear end of the cylinder body, Form a positive pressure environment and move the rubber plug in a direction close to the needle.
  • Step S5 mounting the solvent dissolver on the handle.
  • the method includes:
  • Step S1 the gas source output device outputs a small power source to the handle, and the small power source passes through the filter in the handle, and replaces the front end region of the handle with a clean and sterile environment;
  • Step S2 attaching the solvent dissolver to the inner side of the front end of the handle and pushing it backward until the rear end of the solvent dissolver enters the aseptic environment at the front end of the handle;
  • Step S3 the solvent dissolver is installed backward on the handle, and the air source output device is controlled to stop providing a small power source to the handle.
  • step S1 the rubber stopper in the solvent dissolver is located at the end of the solvent dissolver, and the end of the solvent dissolver is in the same plane as the rubber plug to ensure that the small power gas source can end the solvent dissolver
  • the rubber stopper is sterilized, thereby ensuring that the medicinal device is clean and sterilized when it is in use.
  • step S2 after the back end of the solvent enters the aseptic environment at the front end of the handle, the installation is continued for 1-2 seconds, and then the installation is continued to ensure that the small power source blows the back end of the solvent to the sterility. Clean and sterile environment at the back end of the dissolver and the front end of the handle.
  • step S3 when the solvent dissolver is pushed to the groove position of the front end of the handle, the solvent dissolver is inserted into the front end groove of the handle, and the solvent dissolver is rotated to achieve the The solvent dissolver is engaged with the handle.
  • the snap-on installation is quick and sealed.
  • the invention provides a filter and a handle and an aseptic dispensing system.
  • the filter structure of the invention is simple and reasonable in structure, high in filtering, and can provide uniform, slow, non-crossing, large area of clean air, and replace the filter front end with The clean and sterile environment reaches a local level of cleanliness;
  • the handle with the above filter of the invention has good sealing property, easy disassembly and assembly, and is convenient to replace, and can replace the filter front end with a clean and sterile environment, and is safe and reliable;
  • the aseptic dispensing system with the above handle of the invention further comprises a solvent dissolver and a gas source output device, and the aseptic preparation is completed by the cooperation of the three, the filtering efficiency is high, the filtering process is safe and sterile, the filtering effect is good, and the filtering is reduced. Labor intensity, wide applicability.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un filtre (8), un manche et un système de distribution de médicament aseptique. Le filtre (8) comprend un boîtier supérieur (81), un boîtier inférieur (83) et un film de filtre (82); le boîtier supérieur est pourvu de plusieurs orifices pour augmenter la zone de sortie, fournissant même, des courants d'air, lents, et ne se croisant pas. Un manche ayant le filtre décrit (8), comprend en outre un boîtier, un élément de fixation d'étanchéité, un connecteur, une unité de commande et une unité de détection. L'invention concerne un système de distribution de médicament aseptique ayant le manche décrit, comprenant en outre un dispositif de dissolution de médicament et un dispositif de sortie de source d'air, un processus de distribution de médicament aseptique étant assuré grâce à la coopération des trois.
PCT/CN2017/090319 2017-01-17 2017-06-27 Filtre, manche, et système de distribution de médicament aseptique Ceased WO2018133329A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201720069258.6U CN206700982U (zh) 2017-01-17 2017-01-17 一种过滤器及手柄和无菌配药系统
CN201720069258.6 2017-01-17

Publications (1)

Publication Number Publication Date
WO2018133329A1 true WO2018133329A1 (fr) 2018-07-26

Family

ID=60472389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2017/090319 Ceased WO2018133329A1 (fr) 2017-01-17 2017-06-27 Filtre, manche, et système de distribution de médicament aseptique

Country Status (2)

Country Link
CN (1) CN206700982U (fr)
WO (1) WO2018133329A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108652968A (zh) * 2018-07-20 2018-10-16 山东艾博康生物科技有限公司 一种智能测位的溶药器和手柄组合体
CN110064260B (zh) * 2019-04-08 2024-03-19 江苏联环医疗科技有限公司 一种与过滤器配合的具有泄压功能的手柄

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN203677542U (zh) * 2013-12-17 2014-07-02 上海康德莱企业发展集团股份有限公司 一种取药过滤器
CN105796340A (zh) * 2016-05-18 2016-07-27 张巍 一种无菌配药系统
CN106726566A (zh) * 2017-01-17 2017-05-31 哈尔滨鼓润生物技术有限公司 一种溶药器及手柄和无菌配药系统
CN106821751A (zh) * 2017-01-17 2017-06-13 哈尔滨鼓润生物技术有限公司 一种无菌配药系统及无菌配药方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN203677542U (zh) * 2013-12-17 2014-07-02 上海康德莱企业发展集团股份有限公司 一种取药过滤器
CN105796340A (zh) * 2016-05-18 2016-07-27 张巍 一种无菌配药系统
CN106726566A (zh) * 2017-01-17 2017-05-31 哈尔滨鼓润生物技术有限公司 一种溶药器及手柄和无菌配药系统
CN106821751A (zh) * 2017-01-17 2017-06-13 哈尔滨鼓润生物技术有限公司 一种无菌配药系统及无菌配药方法

Also Published As

Publication number Publication date
CN206700982U (zh) 2017-12-05

Similar Documents

Publication Publication Date Title
WO2018133327A1 (fr) Système de distribution de médicament stérile et procédé de distribution de médicament stérile
ES2725607T3 (es) Cámara y sistema de recogida de huevos para IVF
RU2526261C2 (ru) Устройство управления перемещением текучей среды и способ отбора проб текучей среды пациента
CN106176220B (zh) 一种无菌配药系统
CN206424054U (zh) 一次性电子内窥镜手柄
WO2018133329A1 (fr) Filtre, manche, et système de distribution de médicament aseptique
CN216294812U (zh) 一种全封闭式吸痰管冲洗装置
WO2017197907A1 (fr) Système de préparation aseptique de médicaments
CN108652968A (zh) 一种智能测位的溶药器和手柄组合体
TWM463586U (zh) 腹膜透析用管路對接操作倉
CN208974762U (zh) 分段式吸痰管
CN206273281U (zh) 一种无菌配药系统
CN222549242U (zh) 一种密闭式肺泡灌洗液采集运输套件
CN211357150U (zh) 一种输液泵配置连接管
CN211611270U (zh) 一种肛肠科用体外给药治疗器
CN223323841U (zh) 疫苗生产用血清采集器
CN204815285U (zh) 旋塞式密闭吸痰管接口组件
CN219835618U (zh) Ecmo环路抽血装置
CN204319386U (zh) 一种活性炭加注系统及活性炭自动加注式洗胃装置
CN209695160U (zh) 一种腔镜器械
CN218889978U (zh) 一种用于动物实验的改良枪型手动负压吸引装置
CN113134127B (zh) 一种麻醉科浓度调节式麻醉装置
CN219729019U (zh) 一种具有搅拌功能的一次性生物工艺袋
CN215652930U (zh) 一种具有改良型负压引流结构的引流袋
WO2015154303A1 (fr) Contact de commutation de pression positive utilisé à des fins médicales

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 17893087

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 17893087

Country of ref document: EP

Kind code of ref document: A1