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WO2017197907A1 - Système de préparation aseptique de médicaments - Google Patents

Système de préparation aseptique de médicaments Download PDF

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Publication number
WO2017197907A1
WO2017197907A1 PCT/CN2017/000362 CN2017000362W WO2017197907A1 WO 2017197907 A1 WO2017197907 A1 WO 2017197907A1 CN 2017000362 W CN2017000362 W CN 2017000362W WO 2017197907 A1 WO2017197907 A1 WO 2017197907A1
Authority
WO
WIPO (PCT)
Prior art keywords
air
solvent
dispensing system
unit
gas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2017/000362
Other languages
English (en)
Chinese (zh)
Inventor
张巍
张劲东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201610329493.2A external-priority patent/CN105796340B/zh
Priority claimed from CN201620781461.1U external-priority patent/CN206273281U/zh
Priority claimed from CN201620781398.1U external-priority patent/CN206261831U/zh
Priority claimed from CN201620781400.5U external-priority patent/CN206275831U/zh
Priority claimed from CN201620781399.6U external-priority patent/CN206261832U/zh
Priority claimed from CN201720052251.3U external-priority patent/CN208710520U/zh
Application filed by Individual filed Critical Individual
Publication of WO2017197907A1 publication Critical patent/WO2017197907A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests

Definitions

  • the invention relates to the technical field of medical instruments, in particular to an aseptic dispensing system.
  • the most common way of clinical infusion dispensing is by manual dispensing.
  • the nurse needs to manually mix the liquid medicine, powder and the like in the ampoule with other liquids, and then inject the mixture into the infusion bottle or the patient. .
  • the nurse continuously operates the dispensing device to absorb liquid and inject liquid.
  • the labor intensity is high, the efficiency is low, and the manual operation is easy to make mistakes.
  • the nurse's hand cannot contact the dispensing pusher of the dispensing device, and the operation difficulty is difficult. Big, it is inevitable that there are mistakes, increasing the risk of drug contamination.
  • the technical solution adopted by the present invention is to provide an aseptic dispensing system, comprising: a solvent-dissolving unit for providing a cavity for mixing the medicament;
  • a power unit for powering the solvent unit A power unit for powering the solvent unit.
  • the aseptic dispensing system further comprises a first hand-held component and a sterilization unit, the hand-held component being detachably coupled to the power unit, the sterilization unit for filtering impurities and bacteria in the air .
  • the power unit includes a pipeline group and a first air pump, the first air pump is in communication with the pipeline group, the pipeline group includes at least four pipelines, and the pipeline group includes electromagnetic
  • the solenoid valve group includes at least four solenoid valves, and the number of solenoid valves in the solenoid valve group corresponds to the number of pipelines in the pipeline group.
  • the aseptic dispensing system further comprises a sterile unit for constructing a sterile environment, the sterile unit comprising a dispensing push rod and a set of rods, the dispensing push rod being located in the set rod Internally, and the dispensing push rod and the sleeve rod are relatively movable, the solvent-dissolving unit is in sealing connection with the aseptic unit; the power unit is an actuating portion for driving the dispensing push rod Move forward or backward.
  • a sterile unit for constructing a sterile environment
  • the sterile unit comprising a dispensing push rod and a set of rods, the dispensing push rod being located in the set rod Internally, and the dispensing push rod and the sleeve rod are relatively movable, the solvent-dissolving unit is in sealing connection with the aseptic unit; the power unit is an actuating portion for driving the dispensing push rod Move forward or backward.
  • the aseptic dispensing system further includes a first clean laminar flow device, a purifying device, and a second air pump, the purifying device having one end in communication with the first clean laminar flow device and the other end and the second air pump Connected.
  • the aseptic dispensing system further comprises a second hand-held component, a sterilization device, a second clean laminar flow device, a first magnet and a second magnet; a piston is built in the solvent-dissolving unit, the rubber plug a first magnet is disposed therein; one end of the second hand-held component is detachably connected to the solvent-dissolving unit, the other end is in communication with the power unit, and the second hand-held component is internally provided with a second magnet;
  • the second clean laminar flow device is in communication with the power unit, and the sterilization device is in communication with the power unit.
  • the sterilization device comprises a first sterilization device and a second sterilization device
  • the first sterilization device is disposed inside the second hand-held component
  • the second clean laminar flow device passes through the
  • the second sterilization device is in communication with the pneumatic unit
  • the second magnet is an electromagnet
  • the aseptic dispensing system further includes a first purifying device, a second purifying device, and a third clean laminar flow device, the first purifying device having one end connected to the solvent-dissolving unit; and the second purifying device One end is in communication with the third clean laminar flow device, the other end is in communication with the power unit, a piston is built in the solvent body, a third magnet is disposed inside the piston, and the first purification device is internally provided The fourth magnet.
  • the aseptic dispensing system further comprises a first purifying device, a second purifying device and a fourth clean laminar flow device, the power unit comprising a third air pump and a fourth air pump, the first purifying device having one end The drug dissolution unit is connected, and the other end is in communication with the third air pump; the second purification device has one end communicating with the fourth clean laminar flow device, and the other end is in communication with the fourth air pump, and the piston is built in the The drug dissolver body.
  • the power unit is a gas source output device, comprising:
  • a purifying device for outputting a gentle, small flow of clean air.
  • the present invention provides an aseptic dispensing system in which the power unit is capable of powering a drug dissolution unit, facilitating operation by a user, and improving the efficiency of dissolution of the drug;
  • the solvent-dissolving unit and the first hand-held component are connected by a detachable connection, which is easy to disassemble and convenient to use; the solvent-dissolving unit has low manufacturing cost and is suitable for mass production and popularization.
  • FIG. 1 is a schematic structural view of an aseptic dispensing system according to a first embodiment of the present invention
  • FIG. 2 is a schematic structural view of an aseptic dispensing system according to a second embodiment of the present invention.
  • Figure 3 is a cross-sectional view showing the first hand-held component and the drug-dissolving unit in the second embodiment of the present invention
  • FIG. 4 is a schematic diagram of connection of a control unit in Embodiment 2 of the present invention.
  • Figure 5 is a cross-sectional view showing the first hand-held component and the drug dissolution unit in the third embodiment of the present invention.
  • Figure 6 is a schematic view 1 of the aseptic dispensing system of the present embodiment
  • Figure 7 is a schematic view 2 of the aseptic dispensing system of the present embodiment.
  • Figure 8 is a schematic view 3 of the aseptic dispensing system of the present embodiment.
  • Figure 9 is a schematic view 4 of the aseptic dispensing system of the present embodiment.
  • Figure 10 is a schematic view showing the structure of the aseptic dispensing system in the present embodiment.
  • Figure 11 is a schematic view showing the internal structure of the second hand-held component in the embodiment.
  • Figure 12 is a schematic diagram showing the function of the control unit in the embodiment.
  • Figure 13 is a schematic view showing the structure of the drug dissolver body of the present invention.
  • Figure 14 is a schematic view showing the structure of a solvent dissolver of the aseptic dispensing system of the present embodiment
  • Figure 15 is a schematic view showing the structure of a solvent dissolver of the aseptic dispensing system of the present embodiment
  • Figure 16 is a front elevational view of the gas source output device
  • Figure 17 is a rear elevational view of the gas source output device
  • Figure 18 is a schematic view showing the internal structure of the front side of the gas source output device
  • Figure 19 is a schematic view showing the internal structure of the back side of the air source output device
  • Figure 20 is a schematic diagram of a fan of a gas source output device
  • Figure 21 is a schematic view of the gas flow of the present invention.
  • Figure 22 is an overall appearance view of the fifteenth embodiment
  • Figure 23 is a schematic view showing the flow of gas in the sixteenth embodiment
  • Figure 24 is a schematic view showing the flow of gas in the seventeenth embodiment
  • Figure 25 is a schematic view showing the flow of gas in the eighteenth embodiment
  • Figure 26 is a schematic structural view of Embodiment 19;
  • Figure 27 is a schematic view showing the structure of Embodiment 20.
  • the present invention provides an aseptic dispensing system comprising: a drug dissolution unit for providing a cavity for mixing a medicament; and a power unit for powering the drug dissolution unit.
  • the solvent-dissolving unit has low manufacturing cost and is suitable for mass production and popularization; the power unit can provide power for the drug-dissolving unit, is convenient for the user to operate, and improves the efficiency of the drug-dissolving.
  • the present invention provides an aseptic dispensing system comprising: a drug dissolution unit for providing a cavity for mixing a medicament; a power unit for powering the drug dissolution unit; and a first hand held component for connecting to the a solvent unit and the power unit; a sterilization unit for filtering impurities and bacteria in the air.
  • FIG. 1 is a schematic structural view of the aseptic dispensing system of the first embodiment.
  • the drug dissolution unit 1 is connected to the first hand-held component 3 via a first quick interface 2, and the power unit 4 is connected to the first hand-held component 3 via a second quick interface 5.
  • the sterilization unit 6 is built in the first hand held part 3.
  • the solvent-dissolving unit comprises a drug dissolver body 11, an injection needle 12, a needle holder 13 and a first piston 14.
  • One end of the drug dissolver body 11 is connected to the injection needle 12 through a needle holder 13, and the other end of the drug dissolver body 11 is provided.
  • the first piston 14 is built in the solvent body 11 at the first pair of interfaces 15 that connect the first quick interface 2.
  • the needle holder 13 is a hollow column that is outwardly convex relative to the body of the dissolver for supporting the injection needle 12, and the injection needle 12 is fixed in the needle holder 13 by a fixing unit, the fixing The unit may be an elastomer having a sealing function such as a rubber soft body or a resin soft body.
  • the inner surface of the drug dissolver body 11 has a cylindrical shape, and the first piston 14 is a cylindrical rubber soft body, and the outer diameter of the first piston 14 is the same as the inner diameter of the solvent body 11.
  • the first piston 14 moves axially within the solvent body 11.
  • the first piston 14 separates the interior of the solvent body 11 into a solvent chamber 16 and a solvent chamber, and the solvent chamber 16 and the solvent chamber 17 are completely hermetically sealed.
  • the first hand-held component 3 includes a housing 31 and a second piston 32.
  • One end of the housing 31 is provided with a first quick interface 2, and the other end of the housing 31 is provided with a second quick interface 5.
  • the second piston 32 is built in the housing 31.
  • the material used to make the second piston 32 is a high temperature resistant and biosafety silicone rubber.
  • the inner surface of the casing 31 has a cylindrical shape
  • the second piston 32 is a cylindrical rubber soft body
  • the outer diameter of the second piston 32 is the same as the inner diameter of the casing 31.
  • the second piston 32 moves axially within the housing 31.
  • the sterilization unit 6 includes a sterilization device 61, and the sterilization device 61 is installed inside the casing 31.
  • the sterilization device 61 comprises at least one of polypropylene, diatomaceous earth, glass fiber, mixed cellulose ester, polyvinylidene fluoride, polytetrafluoroethylene, polyether oxime, nylon, cellulose ester, and modified cellulose.
  • the filtration pore size of the sterilization device 61 does not exceed 0.22 micrometers.
  • the sterilization device 61 and the second piston 32 collectively divide the housing 31 into a first air chamber 33, a second air chamber 34, and a third air chamber 35, and the first air chamber 33 is located at the Between the second piston 32 and the second quick interface 5, the second air chamber 34 is located between the second piston 32 and the sterilization device 61, and the third air chamber 35 is located at the sterilization device 61 is between the first fast interface 2.
  • the first air chamber 33 and the second air chamber 34 are completely hermetically sealed, and the second air chamber 34 and the third air chamber 35 are in communication with each other through the sterilization device 61.
  • the gas pressures in the solvent chamber, the second chamber 34, and the third chamber 35 are the same.
  • the power unit 4 includes a first air pump 41 and a gas pump switch 42, and the first air pump 41 is provided with a second pair of interfaces 43 for connecting the second quick interface 5.
  • the first air pump 41 is in communication with the first air chamber 33 through the second quick interface 5 .
  • the air pump switch 42 is provided with a standby gear position, an inflation gear position and an exhaust gear position.
  • the operation of the first air pump 41 provides two modes of operation, the mode of operation including a pressurization process and a depressurization process.
  • the pressurization process is:
  • the air pump switch 42 is adjusted to the inflating gear position, and the first air pump 41 pumps air into the first air chamber 33 to increase the air pressure in the first air chamber 33.
  • the air pressure in the first air chamber 33 is higher than the second air chamber 33
  • the air chamber 34 is in the air chamber 34, the high pressure gas in the first air chamber 33 pushes the second piston 32 to move away from the first air pump 41, and the gas in the second air chamber 34 gradually flows into the third air chamber 35 through the sterilization device 61. Therefore, the air in the third air chamber 35 is filtered sterile air.
  • the third air chamber 35 communicates with the solvent chamber 17 through the first quick interface 2, the gas in the third air chamber 35 gradually flows into the solvent chamber 17 of the solvent, and the gas pressure in the air chamber 17 of the solvent is higher than that.
  • the pressure in the drug chamber 16 causes the high pressure gas in the solvent chamber 17 to urge the first piston 14 toward the needle holder 13.
  • the air pump decompression process is:
  • the air pump switch 42 is adjusted to the exhaust gear position, the first air pump 41 pumps the air in the first air chamber 33, the air pressure in the first air chamber 33 is lowered, and the air pressure in the first air chamber 33 is low.
  • the high pressure gas in the second air chamber 34 pushes the second piston 32 to move toward the first air pump 41, so that the gas in the third air chamber 35 gradually flows into the second air chamber 34, and then dissolves.
  • the gas in the drug chamber 17 flows into the third air chamber 35.
  • the air pressure in the solvent chamber 17 is lower than the pressure in the solvent chamber 16, the first piston 14 moves away from the needle holder 13. .
  • the working principle of the aseptic dispensing system is:
  • the second pair of interfaces 43 are connected to the second quick interface 5, and then the first pair of interfaces 15 are connected to the first quick interface.
  • the air pump switch 42 is adjusted to the inflated gear position, and the first increase is performed.
  • the air in the solvent chamber 16 is completely discharged.
  • the injection needle 12 is inserted into the liquid medicine bottle, and then the air pump switch 42 is adjusted to the exhaust gear position, and execution is performed.
  • the drug solution flows into the drug dissolution chamber 16, and then the liquid drug bottle is removed, and the injection needle 12 is inserted into the lyophilized powder drug bottle, thereby performing a second pressurization process to make the drug solution chamber 16
  • the medicine liquid flows into the lyophilized powder medicine bottle, and after the medicine liquid and the lyophilized powder are thoroughly mixed, the second decompression process is performed, and the mixture of the lyophilized powder and the medicine liquid is extracted into the solvent cavity. Complete the dissolution.
  • the air in the solvent chamber 17 is always kept as sterile air after filtration, preventing the interior of the solvent body 11 from being contaminated, and making the solvent-dissolving process safer.
  • the present embodiment provides an aseptic dispensing system comprising: a drug dissolution unit for providing a cavity for mixing a medicament; a power unit for powering the drug dissolution unit; and a first hand-held component for connecting The solvent unit and the power unit; a sterilization unit for filtering impurities and bacteria in the air; and a control unit for controlling the power unit.
  • FIG. 2 is a schematic view showing the structure of the aseptic dispensing system in the second embodiment.
  • the solvent-dissolving unit 101 is screwed to the first hand-held component 102, the sterilization unit is connected to the power unit 103, and the power unit 103 is connected to the first hand-held component 102 through a gas pipe 104.
  • the control unit 105 is connected to the first hand-held component 102 and the power unit 103 by wires, and the control unit 105 is used to control the power unit 103.
  • the drug dissolution unit 101 includes a drug dissolver body 111, an injection needle 112, a needle holder 113, and a first piston 114.
  • the front end of the drug solution body 111 is connected to the injection needle 112 through the needle holder 113.
  • the tail end of the dissolver body 111 is screwed to the first hand-held component 102, and the first piston 114 is built in the solvent body 111.
  • the needle holder 113 is a hollow column that is outwardly convex relative to the drug sol body for supporting the injection needle 112.
  • the injection needle 112 is fixed in the needle holder 113 by a fixing unit.
  • the fixing unit may be an elastomer having a sealing function such as a rubber soft body or a resin soft body.
  • the inner surface of the solvent body 111 is cylindrical, the first piston 114 is a cylindrical rubber soft body, and the outer diameter of the first piston 114 is the same as the inner diameter of the solvent body 111.
  • the first piston 114 moves axially within the solvent body 111.
  • the first piston 114 separates the interior of the solvent body 111 into a solvent chamber 116 and a solvent chamber 117, and the solvent chamber 116 and the solvent chamber 117 are completely hermetically sealed.
  • the first hand-held component 102 includes a handle 121 and a handle base 122.
  • One end of the handle 121 is connected to the handle base 122 by a first thread 123, and the other end of the handle 121 is connected to the air tube 104 via a pneumatic joint 124.
  • the handle 121 further includes a push button 125 and a suction button 126, and the push button 125 and the suction button 126 control the power unit 103 through the control unit 105.
  • the handle base 122 is internally provided with a second thread 127 for fixing the tail end of the solvent body 111 to the handle seat 122.
  • the handle base 122 further includes a sealing pad 128, and the sealing pad 128 is disposed between the solvent body 111 and the handle seat 122 for securing the solvent body 111 and the The airtightness of the connection between the handle seats 122.
  • the handle 121 is an internal hollow structure.
  • the power unit 103 includes a connection tee 130, a first pipeline 131, a second pipeline 132, a third pipeline 133, a fourth pipeline 134, an air pump 135, a gas pump intake tee 136, and a gas pump exhaust tee. 137.
  • the first line 131 includes a first solenoid valve 1311, a first line front section 1312, and a first line rear section 1313.
  • the first pipeline front section 1312 and the first pipeline rear section 1313 are connected by the first solenoid valve 1311.
  • the second conduit 132 includes a second solenoid valve 1321, a second conduit front section 1322, and a second conduit rear section 1323.
  • the second pipeline front section 1322 and the second pipeline rear section 1323 are connected by a second electromagnetic valve 1321.
  • the third conduit 133 includes a third solenoid valve 1331, a third conduit front section 1332, and a third conduit rear section 1333.
  • the third pipeline front section 1332 and the third pipeline rear section 1333 are connected by a third solenoid valve 1331.
  • the fourth conduit 134 includes a fourth solenoid valve 1341, a fourth conduit front section 1342, and a fourth conduit rear section 1343.
  • the fourth pipeline front section 1342 and the fourth pipeline rear section 1343 are connected by a
  • the air pump 135 includes a gas pump intake port 1351 and a gas pump exhaust port 1352.
  • the three ports of the air pump intake tee 136 are respectively connected to the air pump inlet 1351, the first pipeline rear section 1313 and the second pipeline rear section 1323.
  • the three ports of the air pump exhaust tee 137 are respectively connected to the air pump exhaust port 1352, the third pipeline rear section 1333 and the fourth pipeline rear section 1343.
  • the three ports connecting the three-way 130 are connected to the air pipe 104, the second pipe front section 1322, and the third pipe front section 1332, respectively.
  • the sterilization unit is a filter, and the filter is disposed on the air inlet 141 and the air outlet 142, that is, under the action of the filter, the air inlet 141 and the air outlet 142 have both intake air and air outlet. Filtering the function of sterilization, the air inlet 141 is connected to the first pipeline front section 1312, and the exhaust port 142 and the fourth pipeline front section 1342 connection.
  • the filter disposed on the air inlet 141 and the exhaust port 142 includes at least polypropylene, diatomaceous earth, glass fiber, mixed cellulose ester, polyvinylidene fluoride, polytetrafluoroethylene, polyethersulfone, One of nylon, cellulose ester, and modified cellulose.
  • the filter apertures of the filters on the inlet 141 and the outlet 142 are each no more than 0.22 microns.
  • the sterilization unit causes the gas entering the air pump 135 and the interior of the solvent chamber 117 to be sterile air.
  • control unit is connected to the air pump 135, the push button 125, the suction button 126, the first solenoid valve 1311, the second solenoid valve 1321, and the third.
  • the solenoid valve 1331 is connected to the fourth solenoid valve 1341.
  • the first control logic executed by the control unit 105 is that after the push button 125 is pressed separately, the first solenoid valve 1311 and the third solenoid valve 1331 are opened, the second solenoid valve 1321 and the fourth solenoid valve 1341 are closed, and the air pump 135 is closed. start working.
  • the first control logic is executed to sequentially pass air through the air inlet 141, the first pipeline front section 1312, the first solenoid valve 1311, the first pipeline rear section 1313, the air pump intake tee 136, and the air pump inlet 1351.
  • the cavity 117 when the pressure in the solvent chamber 117 is greater than the solvent chamber 116, the high pressure gas in the solvent chamber 117 pushes the first piston 114 to move away from the handle 121.
  • the second control logic executed by the control unit 105 is that after the suction button 126 is separately pressed, the first electromagnetic valve 1311 and the third electromagnetic valve 1331 are closed, and the second electromagnetic valve 1321 and the fourth electromagnetic valve 1341 are opened.
  • the air pump 135 starts working.
  • the second control logic is executed to sequentially pass the gas in the solvent chamber 117 through the inside of the handle 121, the air tube 104, the connection tee 130, the second line front section 1322, the second solenoid valve 1321, and the second line.
  • the tail end of the solvent body 111 is fixedly connected with the handle base 122, and then the push button 125 is pressed to execute the first control logic to discharge all the air in the solvent chamber 116.
  • the push button 125 is released, and the injection needle 112 is inserted into the liquid drug bottle, and then the suction button 126 is pressed to execute the second control logic, after the drug solution flows into the drug solution chamber 116.
  • Release the push button 126 remove the liquid medicament bottle, insert the needle 112 into the lyophilized powder bottle, and press the push button 125 to execute the first control logic to allow the drug solution into the drug solution chamber 116 to flow into the drug solution.
  • the suction button 126 is pressed to execute the second control logic, and the mixture of the lyophilized powder and the medicine liquid is extracted into the solvent cavity to complete the dissolution medicine. .
  • the air in the solvent chamber 117 is always kept as sterile air after filtration, preventing the interior of the solvent body 111 from being contaminated, and making the solvent-dissolving process more secure.
  • the present embodiment provides an aseptic dispensing system that differs from the second embodiment in that a sterilization unit is built in the first hand-held component 202, that is, the air inlet 141 and the air outlet 142 are only It has an intake and exhaust function, and its hand held component 102 also includes a second piston 223.
  • the second piston 223 is built in the handle 221 .
  • the material used to make the second piston 223 is a high temperature resistant and biosafety silicone rubber.
  • the inner surface of the handle 121 has a cylindrical shape
  • the second piston 223 is a cylindrical rubber soft body
  • the outer diameter of the second piston 223 is the same as the inner diameter of the handle 121.
  • the second piston 223 moves axially within the handle 121.
  • the sterilization unit is built in the handle 121.
  • the sterilization unit is a filter 206, and the filter 206 comprises at least polypropylene, diatomaceous earth, glass fiber, mixed cellulose ester, polyvinylidene fluoride, polytetrafluoroethylene, polyether oxime, nylon, cellulose ester, improved In one of the celluloses, the filter 206 has a filtration pore size of no more than 0.22 microns.
  • the filter 206 and the second piston 223 collectively divide the handle 121 into a first air chamber 2211, a a second air chamber 2212, a third air chamber 2211, the first air chamber 2211 is located between the second piston 223 and the pneumatic joint 124, and the second air chamber 2212 is located at the second piston 223 and the filter Between the 206, the third air chamber 2213 is located between the filter 206 and the handle base 122.
  • the first air chamber 2211 and the second air chamber 2212 are completely hermetically sealed, and the second air chamber 2212 and the third air chamber 2213 are in communication with each other through the filter 206.
  • the gas pressures in the solvent chamber 117, the second chamber 2212, and the third chamber 2213 are the same.
  • the air is sequentially flowed through the air inlet 141, the first pipeline front section 1312, the first solenoid valve 1311, the first pipeline rear section 1313, the air pump intake tee 136, and the air pump inlet 1351.
  • the air pressure in the first air chamber 2211 is increased.
  • the air pressure in the first air chamber 2211 is higher than the second air chamber 2212, the high pressure gas in the first air chamber 2211 pushes the second piston 223 to move away from the air pump 135.
  • the movement of the second piston 223 causes the gas in the second air chamber 2212 to gradually flow into the third air chamber 2213 through the filter 206, so that the air in the third air chamber 2213 is filtered sterile air. Since the third air chamber 2213 communicates with the solvent chamber 117 through the handle seat 122, the gas in the third air chamber 2213 gradually flows into the solvent chamber 117, and the gas pressure in the solvent chamber 117 is higher than that in the solvent chamber 117. During the pressure within the drug chamber 116, the high pressure gas within the solvent chamber 117 will urge the first piston 114 toward the needle holder 113.
  • the air pump 135 starts to operate, so that the gas in the first air chamber 2211 sequentially flows through the air pipe 104, the connection tee 130, the second pipeline front section 1322, the second solenoid valve 1321, and the second pipeline.
  • the gas in the second air chamber 2212 pushes the second piston 223 toward the air pump 135.
  • the gas in the third air chamber 2213 is gradually flowed into the second air chamber 2212, and then the gas in the solvent chamber 117 flows into the third air chamber 2213.
  • the gas pressure in the solvent chamber 117 is lower than the solvent chamber
  • the first piston 114 moves away from the needle holder 113.
  • a sterile unit for constructing a sterile environment, the sterile unit comprising a dispensing push rod and a set of rods, the dispensing push rod being located in the set rod;
  • the solvent unit is in a sealed connection with the sterile unit.
  • the aseptic dispensing system also includes a first clean laminar flow device, a purification device, and a second air pump.
  • the sterile unit includes a dispensing push rod and a set of rods, the dispensing push rod is located in the set rod; the sterile unit may be a disposable component, and in order to prevent bacteria from entering the solvent-dissolving unit, a set of rods is disposed outside the dispensing pusher connected to the solvent-dissolving unit, so that the dispensing push rod is in a sterile environment; the dispensing push rod is fixed inside the sleeve by a fixing member, the fixing member The fixed form can be fixed at both ends or screwed. Among them, the dispensing pusher is the front pusher 410.
  • the drug dissolution unit includes a drug dissolver body 11 and a rubber stopper 21 having a cavity formed by a gap between the drug dissolver body 11 and the rubber stopper 21
  • the size of the cavity may vary depending on the relative position of the dissolver body 11 and the rubber stopper 21.
  • the power unit is an actuating portion, and the actuating portion comprises: a push rod motor 310, a push rod gear 311, a rotating support ring 312 and an external thread push rod 313.
  • the push rod motor 310 is used to power the actuating portion, and the push rod motor 310 as a power mechanism may be a step linear motor, a permanent magnet linear motor, and any other type of linear motor; the push rod gear 311 Connected to the push rod motor 310, the push rod gear 311 is used to transmit the power provided by the push rod motor 310 to a subsequent unit; the rotating support ring 312 has a toothed structure on the outside, the rotating support ring The outer toothed structure of the 312 meshes with the teeth of the push rod gear 311, and the inner side of the rotating support ring 312 is internally provided Threaded, the rotating support ring 312 is fixed by the outer structure, so that the rotating support ring 312 can only pivot under the driving of the push rod gear 311, and can not perform translation in all directions, the external thread pushing A rod 313 is placed inside the rotating support ring 312, and an external thread of the externally threaded push rod 313 cooperates with an internal thread of the rotating support ring 312.
  • the push rod motor 310 rotates to drive the push rod gear 311 connected thereto to rotate, and the push rod gear 311 rotates to further rotate the rotating support ring 312 engaged with the rotating support ring 312 only in the push rod gear.
  • the rotation of the shaft 311 is not able to perform translation in all directions, and the rotation of the rotation support ring 312 will drive the external thread push rod 313 to move in the axial direction.
  • the joint portion includes: a gear set, a head rotating electric machine 413, a parallel rail 414 and a support ring 415;
  • the gear set includes a first gear 411 and a second gear 412;
  • the joint portion is driven by the external thread push rod 313, and the end portion of the external thread push rod 313 is connected to one side of the first gear 411, and the first gear 411 is moved in the axial direction along with the external thread push rod 313.
  • the first gear 411 is movably connected with the externally-threaded push rod 313, that is, the first gear 411 is rotatable relative to the externally-threaded push rod 313; the other side of the first gear 411 is connected to one end of the front-stage push rod 410, first The gear 411 drives the front push rod 410 to rotate and rotate coaxially.
  • the other end of the front push rod 410 is provided with an internal thread, and the rubber plug 21 is provided with an externally threaded joint 210 corresponding to the internal thread on the front push rod 410.
  • the support ring 4 is disposed outside the front stage push rod 410.
  • the head rotating electric machine 413 is configured to provide a rotating torque to the front stage push rod 410 to screw the front stage push rod 410 with the externally threaded joint 210 on the rubber plug 21, the head rotation
  • the motor 413 is coupled to the second gear 412, the second gear 412 is meshed with the first gear 411; the head rotating motor 413 is slidable along the parallel rail 414 when the front section push rod When the shaft 410 is translated in the axial direction, the head rotating electric machine 413 slides synchronously along the parallel rails 414.
  • the externally-threaded push rod 313 When the externally-threaded push rod 313 is moved in the axial direction by the rotation support ring 312, the externally-threaded push rod 313 drives the front-stage push rod 410 to move, and at the same time, the actuating portion drives the
  • the head rotating electric machine 413 slides synchronously with the front stage push rod 410 along the parallel rail 414; in the initial state, the front stage push rod 410 is at the distal end position of the solvent body 11 at this time, The front push rod 410 does not protrude into the interior of the solvent body 11.
  • the rubber plug 21 is located at the foremost end of the solvent body 11, and the front push rod is driven by the external thread push rod 313. 410 gradually extends into the interior of the solvent body 11.
  • the head rotating motor 413 When the front push rod 410 is in contact with the external threaded joint 210 on the rubber plug 21, the head rotating motor 413 is activated, thereby driving the The second gear 412 rotates, the second gear 412 rotates to drive the first gear 411 meshing with the first gear 411, the first gear 411 drives the front push rod 410 to rotate, and the front push rod 410 rotates Rotating around the axis to advance the internal thread of the front push rod 410 Male connector 210 screwed, said front case pusher 41 021 combined with the plug.
  • the push rod motor 310 is reversely rotated, so that the push rod motor 310 drives the push rod gear 311 to rotate in the reverse direction, and the rotating support ring 312 that meshes with the push rod gear 311 rotates in the reverse direction, thereby causing the externally threaded push rod 313 to
  • the internal thread of the rotating support ring 312 is driven in the opposite direction, and the externally-threaded push rod 313 drives the first gear 411 to move in the opposite direction.
  • the first gear 411 drives the front-stage push rod 410 toward the far-dissolving body 11 .
  • the direction movement, the front push rod 410 drives the rubber plug 21 combined with it to move away from the solvent body 11 , and then completes the suction process through the needle disposed at the front of the dissolver body 11; the solvent body 11 can be connected to a needle.
  • the first clean laminar flow device 514 is disposed above the side of the push rod 34 that is adjacent to the first gear 411.
  • An annular air outlet is disposed on the first clean laminar flow device 514, and the first clean laminar flow device 514 is in communication with the purifying device 516 through the air tube 515.
  • the purifying device 516 is provided with an air filter 517, and the air filter 517 is used for filtering from the second The gas of the air pump 518, the second air pump 518 is in communication with the purification device 516 via a conduit.
  • the second air pump 518 pumps air into the purification device 516, and the air is filtered by the air filter 517 in the purification device 516 to form sterile air, which in turn flows through the air tube 515 and the first clean. Laminar flow device 514.
  • the filtered sterile air is discharged through an annular vent on the first clean laminar flow device 514, and the sterile air forms a positive pressure at the annular vent.
  • the sterile air forming a positive pressure surrounds the solvent body 11 and the needle to form a gas shield laminar flow, and the gas shield laminar flow can avoid the dissolver body 11 Contact with the air with bacteria to enhance the safety of the dispensing.
  • the present invention provides an aseptic dispensing system that differs from the fourth embodiment in that the front end push rod 410 is provided with an external thread at one end, and the rubber end 21 is provided with the front end push rod 410. Corresponding internal threaded joint; the front push rod 410 rotates about the axis while advancing, and the external thread of the front push rod 410 is screwed with the female threaded joint of the rubber plug 21, thereby The front stage push rod 410 is combined with the rubber plug 21.
  • An aseptic dispensing system provided by this embodiment is different from Embodiment 5 in that the aseptic dispensing system is further provided with a plurality of photoelectric position sensors, and a photoelectric block that can move along with the joint portion.
  • the sheet 610 through the cooperation of the photoelectric position sensor and the photoelectric blocking piece 610, can realize the opening and closing of the circuit to control the rotation of the push rod motor 310 and the head rotating electric machine 413; as shown in FIG.
  • the photoelectric blocking piece 610 is induced by the first photoelectric position sensor 510, the front stage push rod 410 is at a farthest position from the solvent body 11 , and the front stage push rod 410 does not protrude into the solvent.
  • the rubber plug 21 is located at the foremost end of the solvent body 11; as shown in FIG. 7 , the front push rod 410 is gradually extended by the actuating portion.
  • the front stage push rod 410 is in contact with the tail end of the male threaded joint 210 disposed on the rubber plug 21 , At this time, the head rotating electric motor 413 is activated, thereby driving The front pusher 410 rotates; as shown in FIG.
  • the pusher motor 310 continues to push the front pusher 410 forward, while the head rotary motor 413 drives the front pusher 410 to rotate, the front push The rod 410 rotates about the axis while advancing, and the external thread of the front push rod 410 is screwed with the female threaded joint of the rubber plug 21, so that the front push rod 410 is combined with the rubber plug 21,
  • the photoelectric blocking piece 610 is sensed by the fourth photoelectric position sensor 513
  • the front stage push rod 410 is screwed and fixed to the external threaded joint 210, and the front stage push rod 410 reaches the foremost position of the stroke; As shown in FIG.
  • the sterile dispensing system provided in this embodiment is different from the embodiment 6 in that the aseptic dispensing system further comprises:
  • a main control circuit configured to receive a signal transmitted by the photoelectric blocking piece 610 and the photoelectric position sensor, and control start and stop of the head rotating electric machine 413 and the push rod motor 310;
  • a status indicator light for displaying the working status of the aseptic dispensing system, prompting the medical personnel to perform reasonable operations.
  • An aseptic dispensing system provided in this embodiment is different from the embodiment 7 in that, in actual use, in order to ensure that the dispensing system is in a sterile state and avoid doping of different agents, the solvent body 11
  • Both the rubber plug 21 can be designed as a detachable disposable component, which can also be designed as a detachable disposable component.
  • the portion of the sterile dispensing system that is easily contaminated can be made into a disposable structure, such as the solvent body 11 and the glue, in a form in which the front pusher 410 is screwed into the rubber plug 21
  • the plug 21; the non-contaminated portion is used for multiple times, such as the front push rod 410; other parts that are not in contact with the liquid medicine are used for a long period of time and are periodically disinfected.
  • the degree of waste of the disposable component can be saved, and only the solvent body 11 and the rubber plug 21 need to be replaced after each use, without The front pusher 410 is replaced each time, thereby reducing medical waste and protecting the environment.
  • An aseptic dispensing system provided in this embodiment is different from the embodiment 8 in that the dispensing pusher is a non-detachable component; the dispensing pusher is fixedly connected to the actuating portion, and the dispensing pusher External setting The sleeve is sealingly coupled to the actuation portion to ensure that the sterile unit is in a sterile environment at all times.
  • FIG. 10 is a schematic structural view of the aseptic dispensing system of the present invention.
  • FIG. 11 is a schematic view showing the internal structure of the second hand-held component in the present invention.
  • FIG. 12 is a schematic view showing the function of the control unit in the present invention. .
  • the present invention provides an aseptic dispensing system comprising: a drug dissolution unit for providing a cavity for mixing a medicament; and a second clean laminar flow device for placing the drug dissolution unit in a sterile environment; a power unit for powering the solvent-dissolving unit and providing a positive pressure gas for the second clean laminar flow device; a second hand-held component for connecting the solvent-dissolving unit and the power unit; and a control unit For controlling the power unit; the sterilization device, the sterilization device includes a first sterilization device 407 and a second sterilization device 9.
  • the solvent-dissolving unit includes a drug dissolver body 11 that is screwed to the second hand-held component 40, the power unit is an air pump 7, and the second hand-held component 40 is in communication with the air pump 7 through the first air pipe 602.
  • the control unit 8 is electrically connected to the second hand-held component 40 and the air pump 7, respectively.
  • the drug dissolution unit further includes an injection needle 22, a needle holder 110 and a rubber stopper 21, and the front end of the drug solution body 11 is connected to the injection needle 22 through the needle holder 110, and the tail end of the drug dissolver body 11 and the first
  • the two hand-held members 40 are screwed together, and the rubber stopper 21 is built in the solvent body 11.
  • the needle holder 110 is a hollow column that is outwardly convex relative to the body of the drug solution for supporting the injection needle 22.
  • the injection needle 22 is fixed in the needle holder 110 by a fixing unit, and the fixing unit can be a rubber soft body.
  • An elastomer having a sealing function such as a resin soft body.
  • the inner surface of the drug dissolver body 11 has a cylindrical shape, one end of the rubber plug 21 is a cylindrical rubber soft body, and the other end is provided with a first magnet, the first magnet is a permanent magnet 2101, the outer diameter of the rubber plug 21 and the solvent body 11 inner diameter is the same.
  • the rubber stopper 21 moves axially within the dissolver body 11.
  • the rubber plug 21 separates the inside of the solvent body 11 into a solvent cavity 120 and a solvent cavity 140, and the solvent cavity 120 and the solvent cavity 140 are completely sealed.
  • the second hand held component 40 includes a handle base 405 and a handle 406. One end of the handle 406 is coupled to the handle base 405 by a first thread 50, and the other end of the handle 406 is coupled to the first air tube 602 by a pneumatic joint 403.
  • the first button and the second button are further disposed on the handle 406.
  • the first button is a push button 401
  • the second button is a suction button 402
  • the push button 401 and the suction button 402 are electrically connected to the control unit 8.
  • the handle seat 405 is internally provided with a second thread 404 for securing the trailing end of the solvent body 11 to the handle seat 405.
  • the handle base further includes a sealing rubber pad 502 disposed between the drug dissolver body 11 and the handle seat 405 for ensuring the airtightness of the connection between the drug dissolver body 11 and the handle seat 405.
  • the handle 406 is an internal hollow structure.
  • a first sterilization device 407 and a second magnet are also disposed inside the handle 406.
  • the sterilization material used in the first sterilization device 407 includes at least polypropylene, diatomaceous earth, glass fiber, mixed cellulose ester, polyvinylidene fluoride, polytetrafluoroethylene, polyether oxime, nylon, cellulose ester, One or more of the modified cellulose, the filtration pore size of the first sterilization device 407 does not exceed 0.22 ⁇ m.
  • the second magnet is an electromagnet 408 that is electrically connected to the control unit 8.
  • the second clean laminar flow device 501 is disposed on the second hand-held component 40.
  • the second clean laminar flow device 501 is provided with an annular air outlet, and the second clean laminar flow device 501 is connected to the air pump 7 through the second air pipe 601.
  • the second air pipe A second sterilization device 9 and a second electromagnetic valve 603 are also disposed on the 601.
  • the sterilization material used in the second sterilization device 9 includes at least polypropylene, diatomaceous earth, glass fiber, mixed cellulose ester, polyvinylidene fluoride, polytetrafluoroethylene, polyether oxime, nylon, cellulose ester.
  • One or more of the modified cellulose, the filtration pore size of the second sterilization device 9 is not more than 0.22 ⁇ m, and the second sterilization device 9 is for filtering the gas from the air pump 7.
  • the second solenoid valve 603 is electrically connected to the control unit 8.
  • the second hand-held component 40 is in communication with the air pump 7 through the first air tube 602.
  • the first air tube 602 is provided with a first electromagnetic valve 604, and the first electromagnetic valve 604 is electrically connected to the control unit 8.
  • the control unit 8 is electrically connected to the first electromagnetic valve 604, the second electromagnetic valve 603, the air pump 7, the electromagnet 408, the push button 401, and the suction button 402, respectively.
  • the tail end of the dissolver body 11 is fixedly coupled with the handle base 405, and then the push button 401 is pressed.
  • the control unit 8 controls the first solenoid valve 604 and the second solenoid valve 603 to be opened, and the control unit 8 controls The air pump 7 starts to operate, and the air pump 7 starts pumping gas into the first air tube 602 and the second air tube 601.
  • the gas entering the second gas pipe 601 passes through the second electromagnetic valve 603 and the second sterilization device 9, and finally passes through the second
  • the annular air outlet on the clean laminar flow device 501 is discharged, and the gas flowing through the second sterilization device 9 is filtered to become a sterile gas, so that the gas discharged from the annular air outlet on the second clean laminar flow device 501 is none.
  • the sterile air forms a positive pressure at the annular vent.
  • the sterile air forming a positive pressure surrounds the solvent body 11 and the drug taker 2 to form a gas shield laminar flow, and the gas shield laminar flow can prevent the solvent body 11 and the injection needle 22 from contacting the air with bacteria, enhancing The safety of dispensing.
  • the gas entering the first gas pipe 602 flows through the first electromagnetic valve 604 and the first sterilization device 407, and then flows into the solvent chamber 140, so that the gas pressure in the solvent chamber 140 is raised.
  • the gas pressure in the solvent chamber 140 is greater than the pressure in the solvent chamber 12
  • the high pressure gas in the solvent chamber 140 pushes the rubber stopper 21 to move away from the air pump 7, and the rubber plug 21 moves away from the air pump 7
  • the directional movement discharges all the air in the solvent chamber 120.
  • the injection needle 22 is inserted into the liquid medicine bottle, and then the suction button 402 is pressed.
  • control unit 8 controls the first The second solenoid valve 603 is opened, the first electromagnetic valve 604 is closed, the air pump 7 starts to pump the gas into the second gas pipe 601, and the gas entering the second gas pipe 601 passes through the second electromagnetic valve 603 and the second sterilization device 9, and finally passes through the first The annular air outlet on the second clean laminar flow device 501 is discharged.
  • the control unit 8 controls the electromagnet 408 to be energized, and the energized electromagnet 408 generates an electromagnetic field which causes an attractive force between the electromagnet 408 and the permanent magnet 2101 in the rubber stopper 21, and under the action of the magnetic force, the rubber stopper 21 moves toward the electromagnet 408, thereby causing the liquid medicine in the liquid medicine bottle to flow into the drug solution chamber 120, then removing the liquid medicine bottle, inserting the injection needle 22 into the freeze-dried powder freeze-dried powder medicine bottle, and then pressing The button 401 is pushed, at which time the control unit 8 controls the first solenoid valve 604 and the second solenoid valve 603 to be opened, and the air pump 7 pumps the gas into the first gas pipe 602 and the second gas pipe 601.
  • the gas entering the second gas pipe 601 is sequentially passed through the second electromagnetic valve 603 and the second sterilization device 9, and finally discharged through the annular air outlet on the second clean laminar flow device 501.
  • the gas entering the first gas pipe 602 flows through the first electromagnetic valve 604 and the first sterilization device 407, and then flows into the solvent chamber 140, so that the gas pressure in the solvent chamber 140 is raised.
  • the high pressure gas in the solvent chamber 140 pushes the rubber stopper 21 to move away from the air pump 7, so that the solvent is dissolved in the solvent chamber 120.
  • the liquid flows into the lyophilized powder medicament bottle.
  • the suction button 402 is pressed.
  • the control unit 8 controls the second solenoid valve 603 to open, the first solenoid valve 604 is closed, and the air pump 7 starts.
  • the gas is pumped into the second gas pipe 601, and the gas entering the second gas pipe 601 is sequentially passed through the second electromagnetic valve 603 and the second sterilization device 9, and finally discharged through the annular air outlet on the second clean laminar flow device 501.
  • control unit 8 controls the electromagnet 408 to be energized, and the energized electromagnet 408 generates an electromagnetic field which causes an attractive force between the electromagnet 408 and the permanent magnet 2101 in the rubber stopper 21, and under the action of the magnetic force, the rubber stopper 21 moves toward the electromagnet 408, and the mixture of the lyophilized powder and the medical solution is drawn into the dissolution chamber 120 to complete the dissolution.
  • the air in the solvent chamber 12 is always kept as sterile air after filtration, preventing the interior of the body 11 from being contaminated, making the dissolution process safer, and at the same time, the second clean layer
  • the positive pressure of the sterile gas is always output at the annular outlet of the flow device 501, so that the gas shield laminar flow is always present, so that the dissolver body 11, the injection needle 22 and the medicament bottle are in a sterile environment.
  • An aseptic dispensing system provided in this embodiment is different from the embodiment 8 in that the sterilization device includes only a third sterilization device, and the third sterilization device passes through the air tube and the first electromagnetic valve respectively. 604 is in communication with the second solenoid valve 603, and the other end of the third sterilization device is coupled to the power unit.
  • FIG. 13 is a schematic view showing the structure of the drug dissolver body of the present invention.
  • Fig. 14 it is a schematic structural view of a solvent dissolver of the aseptic dispensing system of the present embodiment.
  • the present embodiment provides an aseptic dispensing system comprising a drug dissolver body 11 having a first connecting portion 118 at one end and a second connecting portion 119 at the other end.
  • the first connecting portion 118 is connected to the first cleaning device 51 by a screw connection or a snap connection or a claw hook connection or a screw connection or a magnetic connection.
  • the second connecting portion 119 is connected to the injection needle 22 by a screw connection or a snap connection or a claw hook connection or a screw connection or a magnetic connection.
  • the rubber stopper 21 is built in the solvent body 11.
  • a first magnet is disposed inside the rubber plug 21, and the first magnet is a permanent magnet 2101, and the rubber plug 21 moves axially within the solvent body 11.
  • the rubber stopper 21 divides the drug dissolver body 11 into a first cavity 150 and a second cavity 160.
  • the shape of the drug dissolver body 11 is a cylinder or an elliptical cylinder or a rectangular parallelepiped or a triangular prism.
  • the first purification device 51 communicates with the outside air through the pipe port 52, and the first purification device 51 is further provided inside.
  • the gas line 53 is provided with a pipe port 52 at one end and a second chamber 160 at the other end.
  • the gas line 53 is provided with a first air filter 53 for filtering The outside air entering the gas line 53 through the duct opening 52.
  • the first air filter 53 causes the air entering the second chamber 160 to become sterile air.
  • a seal ring 54 is provided at the junction of the first purification device 51 and the first connection portion 118.
  • the cross-sectional area of the end of the gas line 53 communicating with the solvent body 11 is smaller than the cross-sectional area of the rubber plug 21, which has the advantage of preventing the rubber stopper 21 from coming out of the solvent body 11 and entering the gas line 53.
  • the second cleaning device 51 is fixedly mounted with a second magnet, and the second magnet is an electromagnet 55 for driving the permanent magnet 2101 to move, thereby driving the rubber stopper 21 to move.
  • the electromagnet 55 is not energized, the position of the permanent magnet 2101 remains unchanged.
  • the electromagnet 55 is energized in the forward direction, a repulsive force is generated between the electromagnet 55 and the permanent magnet 2101.
  • the electromagnet 55 is reversely energized, the electromagnet 55 and An attractive force is generated between the permanent magnets 2101.
  • the aseptic dispensing system provided in this embodiment further includes a third clean laminar flow device 10, the third clean laminar flow device 10 is set on the first purifying device 51, and the third clean laminar flow device 10 is provided with an annular air outlet.
  • the third clean laminar flow device 10 is in communication with the second purifying device 56 through the air tube 58 , the second air filter 57 is built in the second purifying device 56 , and the second air filter 57 is used to filter the gas from the third air pump 59 .
  • the third air pump 59 is in communication with the second purification device 56 via a conduit.
  • the third air pump 59 is activated, and the third air pump 59 pumps air into the second purifying device 56, and the air is filtered through the second air filter 57, and then sequentially flows through the air tube 58 and the third clean laminar flow device 10.
  • the sterile air is discharged through the annular air outlet on the third clean laminar flow device 10, and the sterile air forms a positive pressure at the annular air outlet.
  • the sterile air forming a positive pressure surrounds the solvent body 11 and the injection needle 22 to form a gas shield laminar flow, and the gas shield laminar flow can prevent the solvent body 11 and the injection needle 22 from coming into contact with the air with bacteria, thereby enhancing The safety of dispensing.
  • the solvent body 11 is hermetically connected to the first purification device 51.
  • the electromagnet 55 is energized in the forward direction, and the electromagnetic field generated by the electromagnet 55 drives the permanent magnet 2101 to move toward the injection needle 22, and the outside air passes through the pipeline.
  • the port 52 enters the gas line 53 and is filtered by the first air filter 53 to become sterile air, which in turn enters the second chamber 160.
  • the permanent magnet 2101 discharges the air in the first cavity 150 during the movement toward the injection needle 22.
  • the injection needle 22 When the air in the first cavity 150 is completely discharged, the injection needle 22 is inserted into the liquid medicament bottle, and then The electromagnet 55 is energized in the reverse direction, and the electromagnetic field generated by the electromagnet 55 is reversely energized to drive the permanent magnet 2101 to move away from the injection needle 22, thereby moving the rubber stopper 21 toward the first purification device 51 to inhale the liquid.
  • the control electromagnet 55 is energized in the forward direction, and the electromagnetic field generated by the electromagnet 55 is energized to drive the permanent magnet 2101 to move toward the injection needle 22.
  • the chemical solution in the first cavity 150 is caused to flow into the lyophilized powder drug bottle, and after the drug solution and the lyophilized powder are sufficiently mixed, the electromagnet 55 is reversely energized, and the electromagnetic field generated by the electromagnet 55 is reversely energized to drive the permanent
  • the magnet 2101 moves in a direction away from the injection needle 22, thereby moving the rubber stopper 21 toward the first purification device 51, and further extracting the mixture of the lyophilized powder and the medical solution into the first cavity 150 to complete the dispensing.
  • the third air pump 59 is always in operation so that the gas barrier laminar flow is always present to ensure that the drug injector body 11, the injection needle 22 and the medicament bottle are in a sterile environment.
  • FIG. 13 it is a schematic structural view of the main body of the drug solution of the present invention, as shown in FIG. 15, which is a schematic structural view of the drug dissolver of the aseptic dispensing system of the present embodiment.
  • the present embodiment provides an aseptic dispensing system comprising a drug dissolver body 11 having a first connecting portion 118 at one end and a second connecting portion 119 at the other end.
  • the first connecting portion 118 is connected to the first cleaning device 51 by a screw connection or a snap connection or a claw hook connection or a screw connection or a magnetic connection.
  • the second connecting portion 119 is connected to the injection needle 22 by a screw connection or a snap connection or a claw hook connection or a screw connection or a magnetic connection.
  • the rubber stopper 21 is built in the solvent body 11.
  • the rubber stopper 21 moves axially within the dissolver body 11.
  • the rubber plug 21 divides the solvent body 11 into a first cavity 150 and a second cavity 160.
  • the material used to make the rubber plug 21 is a high temperature resistant and biosafety silicone rubber.
  • the shape of the drug dissolver body 11 is a cylinder or an elliptical cylinder or a rectangular parallelepiped or a triangular prism.
  • the first purifying device 51 is in communication with the third air pump 60 through the joint 52.
  • the first purifying device 51 is further provided with a gas line 53.
  • One end of the gas line 53 communicates with the joint 52, and the other end communicates with the second chamber 160.
  • the gas tube The path 53 is provided with a first air filter 53 for filtering the gas from the third air pump 60, and the first air filter 53 causes the air from the third air pump 60 to become sterile air.
  • a seal ring 54 is provided at the junction of the first purification device 51 and the first connection portion 118.
  • the cross-sectional area of the end of the gas line 53 communicating with the solvent body 11 is smaller than the cross-sectional area of the rubber plug 21, which has the advantage of preventing the rubber stopper 21 from coming out of the solvent body 11 and entering the gas line 53.
  • the aseptic dispensing system provided in this embodiment further includes a fourth clean laminar flow device 100, the fourth clean laminar flow device 100 is set on the first purifying device 51, and the fourth clean laminar flow device 100 is provided with an annular air outlet.
  • the fourth clean laminar flow device 100 communicates with the second purifying device 56 through the air tube 17, the second air filter 57 is built in the second purifying device 56, and the second air filter 57 is used to filter the gas from the fourth air pump 59.
  • the fourth air pump 59 is in communication with the second purification device 56 through a conduit.
  • the fourth air pump 59 Before the start of dispensing, the fourth air pump 59 is activated, and the fourth air pump 59 pumps air into the second purifying device 56, and the air is filtered through the second air filter 57, and then sequentially flows through the air tube 17 and the fourth clean laminar flow device 100.
  • the sterile air is discharged through the annular air outlet on the fourth clean laminar flow device 100, and the sterile air forms a positive pressure at the annular air outlet.
  • the sterile air forming a positive pressure surrounds the solvent body 11 and the injection needle 22 to form a gas shield laminar flow, and the gas shield laminar flow can prevent the solvent body 11 and the injection needle 22 from coming into contact with the air with bacteria, thereby enhancing The safety of dispensing.
  • the solvent body 11 is hermetically connected to the first purification device 51.
  • the third air pump 60 presses air into the gas line 53. Since the gas line 53 communicates with the second chamber 160, the second chamber The gas pressure in 160 rises. When the gas pressure in the second chamber 160 is higher than the first chamber 150, the high pressure gas in the second chamber 160 pushes the piston to move toward the injection needle 22. The air in the first cavity 150 is completely discharged. When the air in the first cavity 150 is completely discharged, the injection needle 22 is inserted into the liquid medicine bottle, and then the gas in the second cavity 160 is passed through the third air pump 60.
  • the rubber stopper 21 moves toward the first cleaning device 51 to suck the liquid into the first cavity 150. Then, the liquid medicine bottle is removed, and the injection needle 22 is inserted into the lyophilized powder medicine bottle, and the third air pump 60 is controlled to press air into the gas line 53.
  • the air pressure in the second chamber 160 is higher than the first chamber At 150 o'clock, the high pressure gas in the second cavity 160 pushes the piston to move closer to the injection needle 22, so that the liquid medicine in the first cavity 150 flows into the lyophilized powder medicine bottle, and the drug solution is thoroughly mixed with the lyophilized powder.
  • the gas in the second cavity 160 is sucked out by the third air pump 60.
  • the rubber plug 21 moves toward the first cleaning device 51. Further, the mixture of the lyophilized powder and the drug solution is drawn into the first cavity 150 to complete the dispensing.
  • the air flowing into the second chamber 160 is purified as sterile air, preventing the interior of the solvent body 11 from being contaminated.
  • the dispensing process is safer.
  • the fourth air pump 59 is always in operation, so that the gas barrier laminar flow is always present to ensure that the drug solution body 11, the injection needle 22 and the medicament bottle are in a sterile environment.
  • the air source output device is a box structure, and the inside is divided into an upper box and a lower box by a heat insulating layer 70 to form two relatively sealed environments, and the heat insulating layer is insulated. Efficacy, to prevent unnecessary damage to the equipment caused by a large amount of heat generated by the operation of the air pump, power supply and other equipment.
  • a main working pump 79 is disposed inside the lower casing, and the main working pump 79 is equipped with a filtering device for removing oil and water to ensure the cleanliness and high performance working condition of the equipment.
  • a switch 71 is provided on the upper casing for generating a small current.
  • the side of the main working pump is provided with a triggering device 81, which receives stimulation from a small current and generates a large current, thereby controlling the on/off of the circuit of the gas source output device.
  • the electric device only has one button main pipe as the switch, and the push is opened, but this simple switch causes the working current flowing into the device to be large and not safe enough. As shown in FIG.
  • the trigger device is a relay, and after the switch 71 is pressed, the generated small current stimulates the relay 24 to make its line A certain voltage is applied to both ends of the ring, a certain current flows through the coil, thereby generating an electromagnetic effect, and the armature is attracted to the iron core against the action of the spring under the attraction of the electromagnetic force, thereby driving the movable contact and the static contact of the armature.
  • the switch is closed, the switch 71 is turned off, the switch of the relay is turned off, the electromagnetic attraction is also lost, and the armature returns to the original position under the reaction force of the spring, so that the movable contact and the movable contact The static contact is released and the circuit is disconnected.
  • the combination of the switch and the relay is to control the large current with a small current, so that the current through the device will have a buffer, which will not become sharply larger or smaller, which greatly ensures the safety of the device.
  • the front of the main working pump 79 is a voltage regulator 80 for outputting a stable voltage supply to the gas source output device to prevent sparks from occurring due to voltage instability, damage to the circuit, and the like.
  • the voltage regulator 80 includes a voltage regulating circuit, a control circuit and a servo motor. When the input voltage or load changes, the control circuit samples, compares, and amplifies, and then drives the servo motor to rotate, so that the position of the voltage brush of the voltage regulator is changed through automatic Adjust the turns ratio of the coil to keep the output voltage stable.
  • Below the main working pump 79 are provided four damping pads 87 for mitigating the vibration of the main working pump 79 and ensuring the overall stability of the gas source output device.
  • the main working pump 79, the relay 24, and the voltage regulator 80 are all high-power devices, a large amount of heat is generated during operation, so two fans 84 are disposed on the back of the lower casing for heat dissipation, and the air inlet of the fan 84 is at the lower portion. On the back side of the box body, the air outlet is on both sides.
  • This structural design is beneficial to the internal air circulation and has the best heat dissipation effect.
  • the air inlet of the fan 84 is provided with an inefficient filter, the filter material is 100% synthetic fiber, and the inefficient filter can filter out impurities such as larger particles and hair in the air to prevent it from entering the air source output device. , causing damage to its internal equipment and causing environmental pollution.
  • the heat insulation layer 70 is provided with an intermediate effect filter 3131.
  • the air inlet is below the heat insulation layer, and the air filtered by the inefficient filter in the lower box is extracted, and the equipment is effectively removed under a higher temperature environment. Water vapor and oil vapor, to avoid condensation of water into water vapor after cooling, affecting the overall cleanliness and normal use of equipment.
  • the medium efficiency filter 3131 utilizes the inertia and diffusion of the particles, electrostatic action and chemical filtration to filter the air, and has a stable structure and a good purification function.
  • the intake of the main working pump 79 is extracted through the intermediate effect filter 3131, and the outlet of the main working pump 79 is disposed in the upper casing. The main working pump is always in the state of starting. On the one hand, if it is started when it is used, there will be a delay. On the other hand, when the switch is started, an electric spark will be generated, the service life will be reduced, and the use cost will be increased.
  • a support structure 82 is provided between the bottom of the lower case and the heat insulating layer 70 for supporting the heat insulating layer 70.
  • the support structure is at least one post 261, the upper end of which is screwed to the heat insulating layer, and the lower end is screwed to the bottom of the lower case.
  • the column saves space and facilitates the heat dissipation of the main working pump, relay and voltage regulator, greatly improving the safety of the working of the gas source output device.
  • the pillar is preferably made of sheet metal, because it has good rigidity, is not easy to be broken and deformed, and can play a good supporting role. In addition, the pillar of sheet metal can effectively resist the vibration generated by the work of air pump, relay and other equipment. Greatly improve the overall stability of the gas source output device.
  • the position of the pillar is not limited to the four vertices of the heat insulation layer in FIG. 18, and may be other positions between the bottom of the lower tank and the heat insulation layer, for example, the middle point of each side of the bottom of the lower tank body and the like for facilitating the installation of the pillar.
  • a plurality of columns can be arranged between the bottom of the lower tank and the heat insulation layer.
  • the air in the upper tank is extracted by the main working pump 79 through the intermediate effect filter 3131, so it is relatively clean.
  • the upper tank is provided with a purifying device. Compared with the main working pump, the purifying device is used for outputting a smooth and gentle flow of clean air, and the main working pump is used for outputting a large flow of clean air, which can be used as a power source.
  • the upper casing is further provided with a second electromagnetic valve 73, a third electromagnetic valve 74, and the purifying sub-assembly comprises: a purging pump and a first electromagnetic valve, and the three electromagnetic valves are sequentially arranged on the thermal insulation layer 70.
  • the purifying pump extracts the air inside the upper tank, and the purified air is output to the air source output device through the hose.
  • the first solenoid valve is a two-way solenoid valve disposed on the gas pipeline of the purification pump for controlling the opening and closing of the air passage.
  • the second solenoid valve 73 and the third solenoid valve 74 are three-way solenoid valves disposed on the gas pipeline of the main working pump 79 for controlling the opening and closing of the air passages in different gas transmission directions, and the air passages of the second electromagnetic valve are located.
  • the direction of gas transmission is: from the inside to the outside
  • the gas direction of the airway where the third solenoid valve is located is: from the outside to the inside.
  • the lower end of the purifying device is a circuit board 78, and the air source output device is connected by Bluetooth.
  • the circuit board 78 is used to integrate the uploaded data function, and can upload information such as the number of times of use.
  • sensors can be installed at various positions of the gas source output device, and the working state of the system can be judged by the data of the sensor, which is convenient for maintenance.
  • the upper casing has a small air outlet on the casing for discharging excess gas due to the main working pump 79 Constantly transporting gas to the upper tank will cause the internal air pressure to rise, so the air outlet is used to balance the air pressure.
  • the back casing of the upper casing is provided with a hook 77, which can be used for holding the air source output device or hanging it on a wall or the like to facilitate the user's work.
  • the output port 76 of the air source output device is disposed on the side of the upper box, and the output port 76 includes a gas path output port.
  • the gas source output device can be wired or wirelessly communicated with the outside world. If wired communication, the output port further includes a circuit output. Port for circuit connection. The setting of the output port on the side does not affect the overall aesthetics, and also avoids the cleaning dead angle, which brings inconvenience to the cleaning work.
  • the working principle of the gas source output device is:
  • FIG. 21 it is a schematic diagram of gas flow in the gas source output device.
  • the main working pump 79 is always in the working state.
  • the second electromagnetic valve 73 and the third electromagnetic valve 74 are both closed, the air flows along the intermediate effect filter 31, B1, B2, the air inlet, the air outlet, A2, A1.
  • the purging pump extracts the air in the upper tank, the first solenoid valve controls the opening and closing of the air passage, the air passes through the tee, and finally outputs from the output port 76, and the output air is a smooth and gentle small flow clean air;
  • the valve When the valve is opened, the air flows along the intermediate effect filter 31, B1, B2, the air inlet, the air outlet, A2, A3, C2, C3, and finally outputs from the output port 76, and the output is a large flow of clean air, which can be used as a
  • the third electromagnetic valve 74 is opened, the air is input from the output port 76, flows along the C3, C2, B3, B2, the air inlet, the air outlet, the A2, the A1, and the air is drawn into the air source output device.
  • the main working pump 79 and the purifying sub-device as two different gas source output terminals, can provide a small flow, smooth clean air, and can provide a large flow, clean air that can be used as a power source, and the user can It is very practical for its selection. In addition, it can be replaced separately when it is renewed, it is convenient and effective to use, and it is not too expensive.
  • the present invention provides an aseptic dispensing system.
  • the output port 76 is connected with a handle 86, and the other end of the handle is detachably filled with a solvent dissolver 85.
  • the source output device delivers clean air through the handle 86.
  • a high-efficiency filter is provided in the handle to purify the air from the air source output device in order to ensure that the solvent is injected into the solvent.
  • the handle is provided with a detecting device, which is a photoelectric sensor, and a light shielding strip is arranged on the solvent dissolver, and the photoelectric sensor is used together with the light shielding tape to detect whether the solvent dissolver has been installed to the designated position.
  • a detecting device detects that the solvent dissolver is not installed on the handle, the first electromagnetic valve is opened, the purifying pump works, the front end of the handle keeps the small power clean air blowing, and the front end of the handle is replaced with a clean and sterile environment to prevent the bacteria from being dissolved. Drugs, drugs cause pollution.
  • the first solenoid valve is opened and the purge pump is stopped.
  • the dispensing operation of the aseptic dispensing system is started, and the air from the main working pump is used as the driving force for the rubber stopper movement in the dissolver.
  • the operator holds the handle and controls the operation through the relevant buttons on the handle.
  • the handle is provided with two buttons of "forward” and “reverse” for controlling the on and off of the second solenoid valve 73 and the third solenoid valve 74, respectively.
  • the "forward” button is pressed, the second solenoid valve 73 is opened, and the air flows along the intermediate effect filter 31, B1, B2, the air inlet, the air outlet, A2, A3, C2, C3, and the air is output from the air source.
  • the drug dissolver is injected through the handle and the high-efficiency filter in the handle to push the rubber plug forward, and the liquid medicine in the solvent dissolver is pushed out.
  • the front end of the rubber plug is clean and sterile air, and the back end is also Aseptic air;
  • the third solenoid valve 74 is opened, air is drawn in from the outside of the air source output device, and enters the air source output device via the handle and the high efficiency filter in the handle, and along the C3, C2 , B3, B2, air inlet, air outlet, A2, A1 flow.
  • the aseptic dispensing system through the gas source output device, as well as the high-efficiency filter to replace the air at the front end of the handle, can ensure that the cavity of the solvent dissolver always maintains a sterile environment throughout the dispensing process, greatly ensuring the patient's Medication safety.
  • the purifying sub-device is a fourth electromagnetic valve disposed on the gas pipeline of the main working pump for controlling the clean air of the small working airflow output by the main working pump.
  • the fourth solenoid valve differs from the second solenoid valve in that the fourth solenoid valve has higher precision and can control a small flow of air.
  • FIG. 23 it is a schematic diagram of the gas flow of the present embodiment.
  • the main working pump 79 is always in operation.
  • the fourth solenoid valve When the fourth solenoid valve is opened, the second solenoid valve and the third solenoid valve are closed, the air flows along the intermediate effect filter 31, B1, B2, the air inlet, the air outlet, D1, D2, and the air passes through the tee, and finally The output port 76 outputs, the output air is a smooth and gentle small flow clean air; when the second electromagnetic valve is opened, the air along the intermediate effect filter 31, B1, B2, air inlet, air outlet, A2, A3, C2 C3 flows, and finally outputs from the output port 76.
  • the output is a large flow of clean air, which can be used as a power source; when the third solenoid valve 74 is opened, air is input from the output port 76 along C3, C2, B3, and B2. The air inlet, the air outlet, the A2 and the A1 flow, and the air is pumped to the air source output device.
  • the purifying device is a gas cylinder, and the inside is filled with clean air, and the output of the small air purifying air is controlled by the switch of the gas cylinder.
  • the purifying device uses a gas cylinder with low price and convenient use.
  • the gas cylinder itself does not have the function of self-purification, so it is necessary to replace the new gas cylinder regularly to ensure that the output of the gas source output device is clean. air.
  • FIG. 24 it is a schematic diagram of gas flow in the present embodiment.
  • the gas cylinder switch When the gas cylinder switch is turned on, the clean air inside the gas cylinder is passed through the tee, and finally outputted by the output port 76, and the output air is a smooth and gentle small flow clean air; the main working pump 79 is always in working state, when the first When the two solenoid valves are opened, the air flows along the intermediate effect filters 31, B1, B2, the air inlets, the air outlets, A2, A3, C2, and C3, and finally outputs from the output port 76, and the output is a large flow of clean air.
  • the third solenoid valve 74 As a power source; when the third solenoid valve 74 is opened, air is input from the output port 76, flows along C3, C2, B3, B2, the air inlet, the air outlet, A2, A1, and the air is drawn to the air source.
  • the third solenoid valve 74 As a power source; when the third solenoid valve 74 is
  • the purifying device is a gas cylinder
  • the gas inside is from the main working pump 79
  • the gas cylinder is internally provided with a pressure control unit for detecting and balancing the gas cylinder.
  • Internal air pressure When the gas cylinder switch is opened and the gas cylinder is exhausted through the tee, the pressure control unit controls the gas cylinder to pump from the upper tank; when the gas cylinder switch is closed, the gas cylinder also stops pumping inward. Gas to maintain the air pressure balance inside the cylinder.
  • the technical solution provided by the embodiment does not need to replace the gas cylinder regularly, and is provided with a pressure control unit, which has the advantages of convenience and high efficiency.
  • FIG. 25 it is a schematic diagram of the gas flow of the present embodiment.
  • the main working pump 79 is always in the working state.
  • the air flows along the intermediate effect filter 31, B1, B2, the air inlet, the air outlet, A2, A1. , the air is discharged into the upper tank.
  • the switch of the gas cylinder is opened, the air in the bottle passes through the tee, and finally is outputted from the output port 76, and the output air is a smooth, gentle, small-flow clean air, and the gas cylinder is operated from the upper part by the pressure control unit.
  • the tank is pumped to maintain the air pressure balance inside the cylinder.
  • the air flows along the intermediate effect filter 31, B1, B2, the air inlet, the air outlet, A2, A3, C2, C3, and finally outputs from the output port 76, and the output is a large flow of clean air. It can be used as a power source; when the third solenoid valve 74 is opened, air is input from the output port 76, and flows along the C3, C2, B3, B2, the air inlet, the air outlet, the A2, and the A1, and the air is taken in.
  • the source output device is filtered, transported to the upper tank, and discharged as needed.
  • the main working pump 79 and the purifying sub-device as two different gas source output terminals, can provide a small flow, smooth clean air, and can provide a large flow, clean air that can be used as a power source, and the user can It is very practical for its selection. In addition, it can be replaced separately when it is renewed, it is convenient and effective to use, and it is not too expensive.
  • the embodiment is different from the above embodiment in that, as shown in FIG. 26, the support structure is a support plate 262, and the upper end and the lower end are provided with protrusions, and the bottom of the lower box body and the connection between the heat insulation layer and the support plate are provided.
  • the groove when connected, the protrusion is trapped in the groove.
  • the support plate is detachable structure, easy to replace, convenient and practical.
  • the support plate is provided with hollowing and reinforcing ribs. In addition to saving raw materials, the hollow design has a good heat dissipation effect.
  • the reinforcing ribs can effectively increase the strength and rigidity of the support frame, and avoid the uneven force caused by the support frame. Deformation to improve the overall stability of the device.
  • the material of the support plate is preferably sheet metal, because it has good rigidity, is not easy to be broken and deformed, and can play a good supporting role.
  • the support plate of sheet metal can effectively resist the vibration generated by the operation of air pump, relay and other equipment, and greatly improve the overall stability of the air source output device.
  • FIG. 27 is a schematic structural view of the embodiment.
  • the supporting structure between the heat insulating layer and the lower box body is: four columns are set at four vertices of the heat insulating layer, the upper end of the column is screwed with the heat insulating layer, and the lower end is screwed with the bottom of the lower box body.
  • a reinforcing rib is welded between each two adjacent columns, which serves as a reinforcement.
  • the rib is made of stainless steel material, which has the characteristics of resistance to weak corrosive medium such as steam and water. It is effective against the high temperature steam generated by the working of various equipments. The stainless steel material is not easy to be damaged, and can be used for a long time, and has high cost performance.
  • the position of the rib is not limited to the diagonal line shown in Fig. 25, and may be provided at a corner and the like where reinforcement is required.
  • the trigger device 81 used in conjunction with the switch 71 is a device for driving a triode with a single chip, and a small current from the switch is used as a base input current of the triode, and the common emitter is amplified based on the triode.
  • the technical solution provided by this embodiment has the advantages of low power consumption, high speed, and long service life.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système de préparation aseptique de médicaments, comprenant : une unité de dissolution de médicaments (1, 101) utilisée pour fournir une cavité pour mélanger des médicaments ; et une unité d'alimentation (2, 103) utilisée pour fournir de l'énergie à l'unité de dissolution de médicaments (1, 101).
PCT/CN2017/000362 2016-05-18 2017-05-18 Système de préparation aseptique de médicaments Ceased WO2017197907A1 (fr)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
CN201610329493.2 2016-05-18
CN201610329493.2A CN105796340B (zh) 2016-05-18 2016-05-18 一种无菌配药系统
CN201620781461.1U CN206273281U (zh) 2016-07-22 2016-07-22 一种无菌配药系统
CN201620781398.1U CN206261831U (zh) 2016-07-22 2016-07-22 一种无菌配药系统
CN201620781400.5U CN206275831U (zh) 2016-07-22 2016-07-22 一种无菌配药系统
CN201620781399.6 2016-07-22
CN201620781399.6U CN206261832U (zh) 2016-07-22 2016-07-22 一种无菌配药系统
CN201620781398.1 2016-07-22
CN201620781461.1 2016-07-22
CN201620781400.5 2016-07-22
CN201720052251.3U CN208710520U (zh) 2017-01-17 2017-01-17 一种气源输出装置及具有该装置的无菌配药系统
CN201720052251.3 2017-01-17

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WO2017197907A1 true WO2017197907A1 (fr) 2017-11-23

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CN110314088A (zh) * 2019-06-12 2019-10-11 陈大为 电磁式配药器
CN111135083A (zh) * 2020-01-17 2020-05-12 哈尔滨鼓润生物技术有限公司 一种配药机
CN114306799A (zh) * 2022-03-10 2022-04-12 济南鑫贝西生物技术有限公司 一种水平流配药洁净工作台

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CN102973377A (zh) * 2012-12-14 2013-03-20 丁恒生 医用临床输液无菌自动配药工作台
WO2015091985A1 (fr) * 2013-12-20 2015-06-25 Ge Healthcare Limited Procédés et systèmes pour vider un contenant à déchets
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CN108992347A (zh) * 2018-08-10 2018-12-14 吴鹏 一种气体隔离式超净、定量配药方法及配药系统
CN110314088A (zh) * 2019-06-12 2019-10-11 陈大为 电磁式配药器
CN111135083A (zh) * 2020-01-17 2020-05-12 哈尔滨鼓润生物技术有限公司 一种配药机
CN111135083B (zh) * 2020-01-17 2022-04-01 安婷 一种配药机
CN114306799A (zh) * 2022-03-10 2022-04-12 济南鑫贝西生物技术有限公司 一种水平流配药洁净工作台

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