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WO2018123873A1 - Composition pour favoriser la transpiration - Google Patents

Composition pour favoriser la transpiration Download PDF

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Publication number
WO2018123873A1
WO2018123873A1 PCT/JP2017/046151 JP2017046151W WO2018123873A1 WO 2018123873 A1 WO2018123873 A1 WO 2018123873A1 JP 2017046151 W JP2017046151 W JP 2017046151W WO 2018123873 A1 WO2018123873 A1 WO 2018123873A1
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WO
WIPO (PCT)
Prior art keywords
composition
sweating
promoting
vitamin
milk protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2017/046151
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English (en)
Japanese (ja)
Inventor
明佳 府川
伊藤　健太郎
山口　真
健人 山地
英喜 谷口
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Meiji Co Ltd
Original Assignee
Meiji Co Ltd
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Filing date
Publication date
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Priority to JP2018559154A priority Critical patent/JPWO2018123873A1/ja
Publication of WO2018123873A1 publication Critical patent/WO2018123873A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/19—Dairy proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Definitions

  • the present invention relates to a composition for promoting sweating in a hot environment such as summer.
  • Patent Document 1 As measures against heat stroke, in addition to devising the living environment and clothes, intake of diligent water and salt is recommended as a hydration during exercise, for example, a function that can replenish water and mineral components lost due to sweating during exercise As a typical beverage, a soft drink containing a specific sugar content and sodium has been reported (Patent Document 1).
  • composition for promoting sweating that can promote sweating even in non-exercise in a hot environment and that can be eaten easily.
  • Non-patent Document 1 Effects on heat acclimatization when taking dietary interventions that adjust the ingredients of the meal and enhance protein and vitamin B in the whole meal without giving exercise load.
  • objective evaluation items such as the depth body temperature increase rate and ⁇ sweating results indicate that the intervention diet group and the control diet group There was no difference between them, and adaptability of the body in a hot environment was not confirmed.
  • what kind of protein is not prescribed
  • regulated as the protein of this literature no composition for promoting sweating that can effectively promote sweating even in a hot environment even during non-exercises has been reported.
  • the present inventors now promote sweating when ingesting a milk protein, preferably a composition comprising milk protein and vitamins B and / or vitamin C, even in a hot environment, even when not exercising. Unexpectedly, we found a new composition for promoting sweating. Further, this composition for promoting sweating was free from bitterness, and could be added to a normal meal and consumed easily. The present invention is based on these findings.
  • an object of the present invention is to provide a composition for promoting sweating that can promote sweating in a hot environment.
  • a composition for promoting sweating in a hot environment comprising milk protein as an active ingredient.
  • the composition for promoting sweating according to (1) further comprising vitamin Bs.
  • the composition for promoting sweating according to (1) or (2) further comprising vitamin C.
  • the composition for promoting sweating according to any one of (1) to (3) which is used during non-exercise.
  • the composition for promoting sweating according to any one of (1) to (4) wherein the daily intake is 0.5 g or more / kg body weight as the amount of milk protein.
  • Sweating promotion according to any one of (1) to (6) comprising a unit packaging form per serving, wherein the unit packaging form contains 30 g or more of milk protein as a single meal intake Composition.
  • the composition for promoting sweating according to any one of (1) to (7) which is used for preventing non-working heat stroke.
  • a method for promoting sweating in a hot environment comprising allowing a subject in need thereof to take an effective amount of a composition comprising milk protein.
  • the composition comprises at least one selected from the group consisting of vitamin Bs and vitamin C.
  • the composition for promoting sweating of the present invention realizes an action capable of promoting sweating in a hot environment even when not exercising, and can be eaten easily. Therefore, the composition for promoting sweating of the present invention can be expected to have a body temperature regulating effect by promoting sweating even when not exercising, and is therefore advantageous in that it can provide a composition for preventing non-working heat stroke. is there.
  • FIG. 1 is a graph showing the amount of change in the average increase in deep body temperature in a hot environment between a group that has taken a composition for promoting sweating and a group that has not taken it.
  • FIG. 2 is a graph showing the average amount of sweat perspiration (mg / cm 2 ) in a hot environment between a group that has taken a composition for promoting sweating and a group that has not taken it.
  • composition for promoting sweating of the present invention comprises milk protein as an active ingredient.
  • An active ingredient means an ingredient required for exerting an effect of promoting sweating of an intake subject in a hot environment.
  • Heat environment refers to a hot environment that affects the body, such as summer heat.
  • a high temperature and high humidity environment such as indoors where the temperature is around 38 ° C. and the humidity is around 60.0%, and the heat index ((WBGT (wet bulb black temperature) Wet Globe Temperature)) is 25 in daily life.
  • WBGT wet bulb black temperature
  • Heat stroke is a general term for organ damage caused by deficiencies in the body's water and electrolytes (such as sodium and potassium) and hyperthermia itself, which occurs in a hot environment. Heat stroke is divided into exertional heat stroke and non-working heat stroke. being classified.
  • Non-working heat stroke is a heat stroke in daily life, such as onset in a midsummer car with long baths, saunas, and air conditioners, or on extremely hot and tropical nights every day. It is a symptom that gradually worsens over several days, and is likely to affect older people, infants, and infants mainly indoors.
  • the hot environment is a non-exercise hot environment.
  • the subject ingesting the composition for promoting sweating of the present invention is not particularly limited as long as it has a sweat gland that requires body temperature adjustment by promoting sweating in a hot environment.
  • the target includes not only humans but also animals other than humans (for example, domestic animals such as horses and cows, pets such as dogs and cats, appreciation animals kept in zoos, etc.).
  • the composition for promoting sweating of the present invention can promote sweating even when not exercising.
  • “when not exercising” refers to a state where there is no sudden increase in body temperature due to energy conversion of carbohydrates, lipids, and proteins due to exercise, and daily life such as long baths, saunas, and air conditioners are exhausted. Includes exposure to midsummer cars, hot days, and tropical nights.
  • the sweating promoting effect means that the composition for promoting sweating of the present invention promotes sweating even in a hot environment even when not exercising.
  • the sweating promoting effect can be confirmed by measuring the amount of sweating as shown in Example 1 to be described later. Specifically, in the adaptability test in a hot environment where no exercise load is applied, the start of sauna load is started. After 20 minutes, it can be determined that the sweating average increase when ingested is higher than that when the composition for promoting perspiration of the present invention is not ingested. See Example 1).
  • milk protein used in the present invention is not particularly limited as long as it is a milk-derived protein.
  • whey protein whey protein
  • casein protein whey protein degradation product
  • casein protein degradation product peptide
  • examples include those containing a non-protein nitrogen component at a specific concentration (content), and preferably a whey protein in terms of good solubility.
  • “Milk protein” is a mixture of whey protein, casein protein, whey protein degradation product, casein protein degradation product, peptide, or non-protein nitrogen component that has been separately separated and purified to a specific concentration. May contain whey protein, casein protein, whey proteolysate, casein proteolysate, peptide, or non-protein nitrogen component at a specific concentration, which may or may not be separately separated or purified You may use a raw material (material), food-drinks, etc. At this time, the “milk protein” used in the present invention does not require a separation step or purification step of whey protein, casein protein, whey protein degradation product, casein protein degradation product, peptide, or non-protein nitrogen component.
  • the main ingredients are foods and foods that contain whey protein, casein protein, whey protein degradation product, casein protein degradation product, or peptide and non-protein nitrogen components. Accordingly, it is preferable to use separately purified whey protein, casein protein, whey protein degradation product, casein protein degradation product, or peptide and non-protein nitrogen components so as to have a specific concentration.
  • Whey proteins separated and purified separately from casein protein include, for example, whey stock solutions (sweet whey, acid whey, etc.), concentrates, dried products (whey powder), frozen products, etc. A reducing solution or the like can be used. Furthermore, desalted whey, whey protein concentrate (WPC), whey protein purified product (WPI), ⁇ -lactalbumin ( ⁇ -La), ⁇ -lactoglobulin ( ⁇ -Lg), immunoglobulin, lactoferrin, etc., and These reducing solutions can be used. As the whey protein degradation product, a hydrolyzate of whey protein separated and purified separately from the above casein protein, a reduced solution thereof, and the like can be used.
  • Casein protein separated and purified separately from whey protein includes, for example, casein isolate (natural cheese such as fresh cheese, sodium caseinate, calcium caseinate), its concentrate, its dried product, its Frozen products and the like, and reducing solutions thereof can be used. Furthermore, purified products such as ⁇ -casein, ⁇ -casein, and ITA-casein, and reducing solutions thereof can be used. In addition, as a casein protein degradation product, a hydrolyzate of casein protein separated and purified separately from the whey protein, a reduced solution thereof, and the like can be used.
  • raw materials and foods and drinks that already contain whey protein and casein protein at specific concentrations include, for example, raw milk, pasteurized milk (such as milk), skim milk, component-adjusted milk, processed milk, and dairy products (concentrated milk).
  • powdered milk, condensed milk, fermented milk (yogurt, natural cheese, etc.), lactic acid bacteria beverages, processed cheeses, ice creams, creams), milk protein concentrate (MPC), its concentrate, its dried product, its frozen product, A hydrolyzate thereof, a reducing solution thereof or the like can be used. At this time, you may obtain and use a commercial item for these, and may prepare and use it for themselves.
  • the composition for promoting sweating of the present invention contains milk protein as an active ingredient, the composition is better absorbed into the body than general proteins, and increases blood flow and retains water for a long time. Therefore, even if the intake period is short, a high sweating promoting effect can be obtained.
  • the composition for promoting sweating of the present invention may further contain vitamins B and / or vitamin C.
  • Vitamin B used in the present invention includes eight types of vitamins B1, B2, B6, B12, niacin, pantothenic acid, folic acid and biotin. These may be used alone or in combination of two or more.
  • the vitamin Bs are preferably vitamins B1, B2, B6, B12, niacin, pantothenic acid and folic acid, more preferably vitamins B1, B2, B6 and niacin. Vitamin Bs can assist milk protein metabolism by being taken with milk protein.
  • the total amount of vitamin B is desirably added so that the ratio of vitamin B: milk protein amount is from 1: 30000 to 1: 1000, preferably from 2: 30000 to 2: Add to 1000.
  • the vitamin B is vitamin B1 and / or vitamin B2
  • the vitamin B1 and / or vitamin B2: milk protein amount ratio is 1: 30000 to 1: 1000. Is added so as to be 2: 30000-2: 1000.
  • Vitamin C used in the present invention is a kind of water-soluble vitamin, and chemically refers to L-ascorbic acid. Vitamin C can promote protein synthesis. Vitamin C may be natural or synthesized.
  • Vitamin C is preferably added so that the ratio of vitamin C: milk protein to the milk protein content is 1: 3000, more preferably 1: 300, and even more preferably 1:30. Add to.
  • the composition for promoting sweating of the present invention comprises milk protein, vitamin Bs, and vitamin C as active ingredients.
  • the composition for promoting sweating of the present invention comprises milk protein, one or more vitamin Bs selected from vitamin B1, vitamin B2, niacin, vitamin B6, folic acid and pantothenic acid, and vitamins. C as an active ingredient.
  • the composition for promoting sweating of the present invention is effective in milk protein, at least one vitamin B selected from vitamin B1, vitamin B2, niacin, and vitamin B6, and vitamin C. Comprising as an ingredient.
  • the composition for promoting sweating of the present invention comprises milk protein, one or more vitamin Bs selected from vitamin B1 and vitamin B2, and vitamin C as active ingredients.
  • the composition for promoting sweating of the present invention may contain other components as long as the effect of promoting sweating is not hindered.
  • other components include sodium, potassium, iron, calcium, and magnesium.
  • the composition for promoting perspiration of the present invention may contain a protein other than milk protein and an amino acid.
  • the method (or method of administration) for ingesting the composition for promoting sweating of the present invention to a subject can be appropriately selected from oral ingestion (or oral administration), enteral administration, gastric fistula and the like depending on the subject and application. Although it can, it is preferably taken orally (or orally).
  • composition for promoting sweating according to the present invention can prevent perspiration from being greatly changed even in a hot environment by promoting sweating. That is, the composition for promoting sweating of the present invention can also be used as a composition for regulating body temperature in a hot environment.
  • the composition for promoting sweating of the present invention can regulate the deep body temperature by promoting sweating, and thus can prevent and alleviate heat stroke. That is, the composition for promoting sweating of the present invention can be used as a prophylactic and / or therapeutic agent for heat stroke, and preferably as a prophylactic and / or therapeutic agent for non-working heat stroke.
  • the composition for promoting sweating of the present invention can promote sweating, a detox effect for beauty purposes such as elimination of swelling in a sauna or bath can be obtained. That is, the composition for promoting sweating of the present invention can also be used as a composition for promoting detox and a composition for improving swelling.
  • “detox” means the action of excreting toxins from the body. That is, it means that harmful substances and toxins gradually accumulated in the body by ingesting a trace amount from the environment such as food and air are discharged outside the body by sweating, defecation and urination.
  • composition for promoting sweating of the present invention may be in any form as long as the effect is exerted, for example, solid (powder, granule, capsule, block, etc.), liquid, gel , Paste, paste and the like.
  • the composition for promoting sweating of the present invention is in a solid form in that it can improve storage stability and portability.
  • the composition for promoting sweating of the present invention contains milk protein, and the daily intake is 0.5 g or more / kg body weight as the protein amount of milk protein. Ingested, preferably 0.5 to 10 g / kg body weight, more preferably 0.5 to 8 g / kg body weight, still more preferably 0.5 to 6 g / kg body weight. According to another preferred embodiment of the present invention, the composition for promoting sweating of the present invention is ingested so that the protein content of milk protein is preferably 0.5 g / kg body weight or more per serving.
  • the representative weight of the subject is estimated to be 60 kg.
  • the composition for promoting sweating of the present invention comprises milk protein and vitamins B and / or vitamin C, and the daily intake is 5 g or more as the amount of milk protein.
  • / Kg body weight is desirable, preferably 5 to 10 g / kg body weight, more preferably 5 to 8 g / kg body weight, still more preferably 5 to 6 g / kg body weight.
  • the composition for promoting sweating of the present invention comprises milk protein and vitamins B and / or vitamin C, and the daily intake is the amount of milk protein.
  • the body weight is 0.5 g or more / kg body weight, preferably 0.5 to 10 g / kg body weight, more preferably 0.5 to 8 g / kg body weight, further preferably 0.5 to Ingested to reach 6 g / kg body weight.
  • the composition for promoting sweating of the present invention comprises milk protein and vitamins B and / or vitamin C, and the protein content of the milk protein is per serving, Preferably, it is taken so as to be 0.5 g or more / kg body weight, more preferably 0.5 to 1.6 g / kg body weight, still more preferably 0.5 to 1.2 g / kg body weight, more preferably Ingested so as to be 0.5 to 1 g / kg body weight, more preferably 0.5 to 0.7 g / kg body weight.
  • vitamin Bs are desirably ingested so as to be 0.0015 mg / kg body weight or more, preferably 0.0015 to 2 mg / kg body weight, more preferably 0.015 to 1 mg / kg body weight, More preferably, it is taken to be 0.03 to 0.7 mg / kg body weight, and vitamin C is desirably taken to be 0.15 mg or more / kg body weight, preferably 0.8 to 50 mg. / Kg body weight, more preferably 1.5 to 35 mg / kg body weight, still more preferably 8 to 25 mg / kg body weight.
  • the representative weight of the subject is estimated to be 60 kg.
  • the composition for promoting sweating of the present invention comprises a unit packaging form per serving, and the amount of milk protein as a meal intake is included in the unit packaging form. And adjusted to 30 g or more, preferably 30 to 100 g, more preferably 30 to 80 g, still more preferably 30 to 60 g, still more preferably 30 to 40 g.
  • “Contains a unit packaging form per meal” is a form in which the intake per meal is determined in advance, for example, as a food that can be ingested in a specific amount, not only general foods but also health supplements , Health functional foods, supplements, beverages (drinks, etc.).
  • unit packaging form per meal for example, in the case of powdery, granular, capsule, block-like solid food, liquid beverage, gel-like, paste-like, paste-like jelly, Forms that can specify a specific amount (dose) in packaging containers such as metal cans, glass bottles (such as bottles), plastic containers (such as plastic bottles), packs, pouches, film containers, paper boxes, etc., or intake per serving (usage) , Dose) can be specified on a packaging container or a homepage, and the specific amount can be specified.
  • dose in packaging containers such as metal cans, glass bottles (such as bottles), plastic containers (such as plastic bottles), packs, pouches, film containers, paper boxes, etc., or intake per serving (usage) , Dose) can be specified on a packaging container or a homepage, and the specific amount can be specified.
  • the composition for promoting sweating of the present invention further comprises vitamin Bs and / or vitamin C in a unit package form per serving, in which case the vitamin Bs Is preferably adjusted to 0.1 mg or more, and preferably 0.1 to 100 mg, more preferably 1 to 50 mg, and even more preferably 2 to 40 mg.
  • the intake per serving is preferably adjusted to 10 mg or more, preferably 50 to 3000 mg, more preferably 100 to 2000 mg, and still more preferably 500 to 1500 mg.
  • the protein amount is 30 to 100 g of milk protein, preferably
  • the composition containing the milk protein and vitamins B and / or vitamin C is used as a volume (dose) per serving, for example, in a form (filled) in a film container.
  • the amount of protein (30 to 100 g of milk protein, preferably a composition containing the milk protein and vitamins B and / or vitamin C) may be displayed on a packaging container or homepage. And the form put into the packaging container etc. of a large capacity
  • the period during which the composition for promoting sweating of the present invention is ingested is preferably before exposure to a hot environment, preferably 3 days before exposure, more preferably 5 days before exposure, and even more preferably 7 days before exposure.
  • the longer the intake period the better the blood flow in the body can be increased, and as a result, the sweating promoting effect is enhanced.
  • the composition for promoting sweating of the present invention can be used alone as it is, but as long as the function of promoting sweating is exhibited, various oral intakes such as foods and pharmaceuticals can be used.
  • a composition having a sweating promoting effect for example, a pharmaceutical composition or a food composition
  • the composition for promoting sweating of the present invention does not impair the taste even when added to a meal, it can be easily ingested by adding it to a normal meal or a drink.
  • the food composition of the present invention in the food composition of the present invention, as other components, for example, water, carbohydrates, lipids, vitamins, minerals, organic acids, organic bases, fruit juices, and flavors Etc. can be used. These other components may be used in combination of two or more thereof, or a synthetic product thereof and / or a food containing a large amount thereof may be used.
  • the sugar is not particularly limited as long as it is used as a food composition.
  • sugar processed starch (in addition to text phosphorus, soluble starch, British starch, oxidized starch, starch ester, starch ether, etc.), And dietary fiber.
  • the lipid is not particularly limited as long as it is used as a food composition.
  • animal oils such as lard, fish oil and the like, fractionated oils, hydrogenated oils and transesterified oils; and palm oil , Vegetable oils such as safflower oil, corn oil, rapeseed oil, coconut oil, fractionated oils thereof, hydrogenated oils, and transesterified oils.
  • the minerals are not particularly limited as long as they are used as food compositions, and examples thereof include calcium, potassium, magnesium, sodium, copper, iron, copper, phosphorus, manganese, and selenium.
  • the organic acid is not particularly limited as long as it is used as a food composition, and examples thereof include malic acid, citric acid, lactic acid, and tartaric acid.
  • the organic base is not particularly limited as long as it is used as a food composition, and examples thereof include histidine.
  • the fruit juice is not particularly limited as long as it is used as a food composition, and examples thereof include grape, orange, mango, grapefruit, blueberry, strawberry, cassis, apple, and pineapple.
  • a food for promoting sweating comprising milk protein, preferably milk protein and vitamins B and / or vitamin C as active ingredients.
  • the form of “food” is not particularly limited as long as it can be taken orally, such as a solution, a suspension, an emulsion, a powder, and a solid molded product.
  • instant foods such as retort foods, canned foods, microwave foods, instant soups, freeze-dried foods; coffee drinks, tea drinks, powdered drinks, concentrated drinks; bread, pasta, noodles, cake mixes, bread crumbs, etc.
  • Flour products Flour products; cookies, biscuits, cakes, snacks, crackers, chocolates, desserts and other confectionery; cooking mixes, curry and stew ingredients; milk beverages, fermented milk (such as yogurt), lactic acid bacteria beverages, Examples include dairy products such as natural cheese, processed cheeses, creams and ice creams; processed agricultural products such as cereals; frozen foods; and liquid foods. By taking such a form, it can be taken without feeling a psychological disorder.
  • Foods include health foods, functional labeling foods, dietary supplements, foods for specified health use, foods for the sick, infant formulas, milk powder for pregnant and lactating women, and promotion of sweating in hot environments It also includes those classified as foods with a label indicating that they are used for the purpose.
  • a drug for promoting sweating comprising milk protein, preferably milk protein and vitamin Bs and / or vitamin C as active ingredients.
  • the “medicament” (pharmaceutical composition) is prepared as an oral preparation or a parenteral preparation according to a conventional method using additives that are acceptable for formulation.
  • the pharmaceutical is an oral preparation, it should be in the form of a solid preparation such as a tablet, powder, fine granule, granule, capsule, pill or sustained release, or a liquid preparation such as a solution, suspension or emulsion. Can take.
  • a pharmaceutical when a pharmaceutical is a parenteral formulation, it can take the form of an injection or a suppository.
  • an oral preparation is preferable for a pharmaceutical product.
  • additives that are acceptable for formulation include, for example, excipients, stabilizers, preservatives, wetting agents, emulsifiers, lubricants, sweeteners, coloring agents, fragrances, buffers, antioxidants. Agents, pH adjusters and the like.
  • the pharmaceutical agent of the present invention can be used for the treatment or prevention of diseases requiring the promotion of sweating, specifically heat stroke (preferably non-working heat stroke).
  • the composition for promoting sweating of the present invention is an effective amount of a composition comprising milk protein, preferably milk protein and vitamins B and / or vitamin C, and any orally acceptable.
  • a composition for promoting sweating comprising blending an effective amount of a milk protein, preferably a milk protein and a composition comprising vitamin Bs and / or vitamin C.
  • a manufacturing method is provided.
  • an effective amount of a composition comprising milk protein, preferably milk protein and vitamins B and / or vitamin C, is ingested by a subject in a hot environment in need thereof.
  • a method of promoting perspiration comprising the step of:
  • the method for promoting sweating excludes medical practice for humans.
  • the “medical action for humans” means an action that requires a doctor or the like to ingest (administer) a medicine to a human.
  • the subject is preferably a healthy person.
  • the method for promoting sweating of the present invention may be used for improving a disease or a condition associated with a decrease in sweating function in a subject. Therefore, the method for promoting sweating of the present invention is preferably a method for ameliorating a disease or condition associated with reduced sweat function, more preferably a method for improving heat stroke, and more preferably a method for improving non-working heat stroke.
  • “amelioration” includes not only treating an established disease or condition, but also preventing a disease or condition that may be established in the future.
  • the method for promoting sweating of the present invention can be carried out according to the description of the composition for promoting sweating in the present specification.
  • milk protein is ingested (administered) so that the protein content per meal is preferably 0.5 g / kg body weight or more, More preferably, it is 0.5 to 1.6 g / kg body weight, more preferably 0.5 to 1.2 g / kg body weight, more preferably 0.5 to 1 g / kg body weight, still more preferably 0.5 to 0. It can be ingested (administered) to a weight of 7 g / kg.
  • the typical weight of the subject is estimated to be about 60 kg.
  • the milk protein in the method for promoting sweating of the present invention, can be ingested so that the protein content is 30 g or more per meal, specifically, 30 to 100 g. It can be ingested so that it is preferably 30 to 80 g, more preferably 30 to 60 g, and still more preferably 30 to 40 g.
  • the use of milk protein to promote sweating is for consumption with vitamins B and / or vitamin C.
  • the use of the invention is a non-therapeutic use.
  • the use of milk protein for the production of a composition for promoting sweating is provided.
  • the use is for consumption with vitamins B and / or vitamin C.
  • the use is for the production of a sweat promoting food or medicament.
  • a milk protein for promoting sweating is provided.
  • the milk protein is used with vitamins B and / or vitamin C.
  • Example 1 Adaptability test in a hot environment
  • a composition for promoting sweating consisting of the composition shown in the following table (and daily intake).
  • the adaptability of the body at a sauna room temperature of 38 ° C. and a humidity of 60% was examined.
  • vitamin B those containing vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid and pantothenic acid as constituent components were used.
  • Ingestion of the composition for promoting sweating was performed by adding it to a normal meal. Specifically, the following method was used.
  • Subjects The subjects were 10 healthy male university students with written consent. Statistical software Stat Flex ver. 6 (Artec Co., Ltd.), 5 of the subjects were the stage I intervention group and the remaining 5 were the stage II intervention group.
  • the study design was a prospective intervention study and a crossover study.
  • Stage I subjects ingested a diet (test food) supplemented with a sweat-promoting composition in the Stage I intervention group, and the sweating-promoting composition in the Stage II intervention group. Not ingested (continue normal diet).
  • stage II the stage I intervention group did not take the composition for promoting sweating (continued normal diet), and the stage II intervention group had the composition for promoting sweating added (Test food) was ingested.
  • water and salt intake were not restricted. Alcohol consumption was prohibited.
  • the far-infrared sauna load test was conducted a total of 4 times before and after the period I (first 7 days) and before and after the period II.
  • the intake energy added per day when taking the test food is 139 kcal.
  • Evaluation item Evaluation was performed at the time of 5 minutes, 10 minutes, 20 minutes, and 30 minutes after the start of sauna loading.
  • deep body temperature was measured using a body temperature monitor (Terumo Corporation, CM-210).
  • a heat flow compensation probe was used to measure the deep body temperature.
  • a deep body temperature probe was attached to the forehead with tape and a band.
  • As an average amount of increase in deep body temperature the average value of the deep body temperature for 3 minutes before entering the sauna is used as a reference value, and the average of the deep body temperature for 30 seconds at the time of 5 minutes, 10 minutes, 20 minutes, and 30 minutes after starting the sauna load The difference between the reference values was determined.
  • the amount of sweat (mg / cm 2 / min) was measured using a sweat meter (Techno Science Co., Ltd., TPL3520).
  • the sensor head was attached to the inside of the left forearm near the elbow with tape.
  • the average increase in perspiration (mg / cm 2 ) is the average of perspiration for 3 minutes before entering the sauna, and it is 30 minutes each at 5 minutes, 10 minutes, 20 minutes and 30 minutes after the start of sauna loading. The difference between the average amount of sweating and the reference value was determined.
  • a room temperature was set using a far-infrared sauna, natural spa, relaxing for one person (Kobe Medicare).
  • the sauna room temperature was set to 38 ° C.
  • a humidifier (SIS Corporation, PIA HYBRID humidifier) was used as the humidity in the sauna room.
  • the humidity in the sauna room was set to be around 60.0%.
  • the exposure time in the hot environment was 30 minutes, which is within the safety standards for using far-infrared saunas.
  • all subjects while entering the sauna, all subjects wore commercial clothing of the same material.
  • Figure 1 shows the results of changes in the average increase in deep body temperature before and after the intervention.
  • the amount of change in the average increase in deep body temperature is 0.04 ⁇ 0.02 ° C. at 5 minutes after the start of sauna loading, and 0 at 10 minutes 0.08 ⁇ 0.03 ° C., 0.18 ⁇ 0.02 ° C. at 20 minutes, 0.20 ⁇ 0.02 ° C. at 30 minutes, and increased with time.
  • the sweat intake composition intake group intervention
  • ⁇ 0.01 ⁇ 0.04 ° C. at 5 minutes after the start of sauna loading ⁇ 0.09 ⁇ 0.05 ° C. at 20 minutes, 20 minutes It changed to 0.05 ⁇ 0.04 ° C. at the time point of ⁇ 0.06 ⁇ 0.05 ° C. at the time point of 30 minutes and hardly increased. Therefore, it was shown that the increase in deep body temperature was suppressed by ingestion of the composition for promoting sweating in a hot environment.
  • Example 2 Change in taste due to addition of composition for promoting sweating
  • the composition for promoting sweating used in Example 1 is added to meals (for example, soup, miso soup, stew) and beverages (for example, cafe au lait, milk tea) The effect on taste was confirmed.
  • the taste was compared between a meal or beverage to which the composition for promoting sweating per day was added and a non-added meal or beverage.
  • the tastes were almost the same as those of the non-added foods and beverages.

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Abstract

L'invention concerne une composition pour favoriser la transpiration, au moyen de laquelle il est possible de favoriser la transpiration même pendant des périodes de non-exercice dans un environnement chaud. Plus spécifiquement, cette composition pour favoriser la transpiration contient une protéine du lait comme principe actif.
PCT/JP2017/046151 2016-12-28 2017-12-22 Composition pour favoriser la transpiration Ceased WO2018123873A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138026A1 (fr) 2018-12-28 2020-07-02 株式会社林原 Agent d'atténuation de stress thermique

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004137268A (ja) * 2002-09-27 2004-05-13 Univ Shinshu 血漿量増加促進剤
JP2009235050A (ja) * 2008-03-06 2009-10-15 Ss Pharmaceut Co Ltd 医薬
WO2015037719A1 (fr) * 2013-09-12 2015-03-19 株式会社明治 Agent de maintien de l'hydratation corporelle

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004137268A (ja) * 2002-09-27 2004-05-13 Univ Shinshu 血漿量増加促進剤
JP2009235050A (ja) * 2008-03-06 2009-10-15 Ss Pharmaceut Co Ltd 医薬
WO2015037719A1 (fr) * 2013-09-12 2015-03-19 株式会社明治 Agent de maintien de l'hydratation corporelle

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Title
"Countermeasure against heat-stroke is performed according to a period, in thirdth", GERIATRIC MEDICINE, vol. 52, no. 5, 2014, pages 519 - 525, ISSN: 0387-1088 *
TANIGUCHI HIDEKI ET AL.: "Effect on Acclimation to intense heat by ingesting protein and Vitamin B group- enriched food : Meal intervention study using blind test for 7 days with respect to female volunteer college students", JAPANESE PHARMACOLOGY & THERAPEUTICS, vol. 44, no. 1, 2016, pages 73 - 83, ISSN: 0386-3603 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138026A1 (fr) 2018-12-28 2020-07-02 株式会社林原 Agent d'atténuation de stress thermique

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