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WO2018186611A3 - Bioink and preparation method therefor - Google Patents

Bioink and preparation method therefor Download PDF

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Publication number
WO2018186611A3
WO2018186611A3 PCT/KR2018/003353 KR2018003353W WO2018186611A3 WO 2018186611 A3 WO2018186611 A3 WO 2018186611A3 KR 2018003353 W KR2018003353 W KR 2018003353W WO 2018186611 A3 WO2018186611 A3 WO 2018186611A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
bioink
method therefor
prepared
mechanical properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2018/003353
Other languages
French (fr)
Korean (ko)
Other versions
WO2018186611A2 (en
Inventor
박찬흠
김순희
이정민
연응규
이영진
서예빈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Industry Academic Cooperation Foundation of Hallym University
Original Assignee
Industry Academic Cooperation Foundation of Hallym University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry Academic Cooperation Foundation of Hallym University filed Critical Industry Academic Cooperation Foundation of Hallym University
Publication of WO2018186611A2 publication Critical patent/WO2018186611A2/en
Publication of WO2018186611A3 publication Critical patent/WO2018186611A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/10—Printing inks based on artificial resins
    • C09D11/106—Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/04—Homopolymers or copolymers of esters
    • C09D133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C09D133/10—Homopolymers or copolymers of methacrylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Macromonomer-Based Addition Polymer (AREA)

Abstract

The present invention relates to a bioink which is prepared from silk fibroin, a natural protein fiber, and from which biological tissues having improved cytocompatibility and outstanding mechanical properties can be prepared by means of a 3D printer, and a preparation method therefor. By 3D printing, the present invention can prepare a biological tissue having mechanical properties such as moisture absorbency, volume expansion rate, compressive strength, tensile strength, etc. In addition, the preparation of a bioink including silk fibroin as a base skeleton allows for the construction of a biostructure which causes almost no immune response in the body and thus is superb in biocompatibility.
PCT/KR2018/003353 2017-04-04 2018-03-22 Bioink and preparation method therefor Ceased WO2018186611A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0043518 2017-04-04
KR1020170043518A KR101983741B1 (en) 2017-04-04 2017-04-04 Bio-ink and manufacturing method thereof

Publications (2)

Publication Number Publication Date
WO2018186611A2 WO2018186611A2 (en) 2018-10-11
WO2018186611A3 true WO2018186611A3 (en) 2019-01-10

Family

ID=63712162

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/003353 Ceased WO2018186611A2 (en) 2017-04-04 2018-03-22 Bioink and preparation method therefor

Country Status (2)

Country Link
KR (1) KR101983741B1 (en)
WO (1) WO2018186611A2 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102124579B1 (en) 2018-12-04 2020-06-18 한국생산기술연구원 Bio-ink composition for minimizing cell necrosis and method for manufacturing a biostructure using the same
KR102188574B1 (en) 2019-03-12 2020-12-08 울산과학기술원 Ink for bioprinting and hydrogel formed from the same
KR102211477B1 (en) * 2019-08-30 2021-02-03 충남대학교산학협력단 Bioink for 3d bioprinting and process for preparing the same
KR102180865B1 (en) 2019-09-30 2020-11-19 한림대학교 산학협력단 Photocurable bioink with electroconductivity and a preparation thereof
CN111454614B (en) * 2020-05-28 2022-05-24 苏州大学 3D biological printing ink and preparation method and application thereof
CN113956506B (en) * 2020-07-03 2023-07-21 中国科学院苏州纳米技术与纳米仿生研究所 A kind of double network hydrogel and its preparation method and application
CN112111072A (en) * 2020-09-17 2020-12-22 南京工业大学 3D-printable polylysine antibacterial hydrogel and preparation method and application thereof
KR102462953B1 (en) * 2020-12-03 2022-11-02 아주대학교산학협력단 Photo-crosslinked hyaluronic acid bioink for bioprinting, method for manufacturing the same, and printing biostructure for controlling physical properties using the same
CN112516330B (en) * 2020-12-15 2023-08-04 上海交通大学医学院附属第九人民医院 Method for coupling grafting of silk fibroin and parathyroid hormone and application thereof
KR102415399B1 (en) 2021-03-24 2022-07-01 한림대학교 산학협력단 A bio dlp 3d printer containing magnetically linked reservoir for multi cell or material printing
CN113713179B (en) * 2021-09-06 2022-08-02 山东大学 High comprehensive performance photocurable bio-3D printing composite hydrogel and its preparation method and application
KR102841005B1 (en) 2022-07-22 2025-08-01 한림대학교 산학협력단 A photo-curable bioink to fabricate ultra-strong, electroconductive, and biocompatible hydrogel for regenerative medicine and preparation method thereof
WO2024144269A1 (en) * 2022-12-27 2024-07-04 한국재료연구원 Bioink comprising functional peptide
KR20240167117A (en) 2023-05-19 2024-11-26 한림대학교 산학협력단 Manufacturing method of fluorescent bio-ink and bio-ink including fluorescent silk fibroin manufcatured thereof
CN116726247B (en) * 2023-06-15 2025-10-28 浙江大学 Preparation method and application of 3D printing strong silk fibroin scaffold material
CN116925396A (en) * 2023-07-19 2023-10-24 西湖大学 Silk protein-based ink and its application in 3D printing to prepare tissue engineering scaffolds
KR20250093878A (en) 2023-12-18 2025-06-25 국립순천대학교산학협력단 Silk Fibroin-Based Thermosensitive Bioink for 3D Bioprinting

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3005667B2 (en) * 1996-11-06 2000-01-31 農林水産省蚕糸・昆虫農業技術研究所長 Modified silk protein, method for producing the same, and osteosynthetic material
KR20110012204A (en) * 2009-07-30 2011-02-09 (주)라이브에이비씨 Method and system for providing language service using geographical association
US20150376248A1 (en) * 2013-02-06 2015-12-31 Virginia Commonwealth University Photoactive silk protein and fabrication of silk protein structures using photolithography
KR20170001444A (en) * 2015-06-26 2017-01-04 아주대학교산학협력단 The method for preparing bio-ink and its application on 3D printing

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8153591B2 (en) 2003-08-26 2012-04-10 Gel-Del Technologies, Inc. Protein biomaterials and biocoacervates and methods of making and using thereof
KR101176793B1 (en) * 2010-05-03 2012-09-07 대한민국(농촌진흥청장) Bone cement composition containing silk fibroin hydrolysates and polymethylmetacrylate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3005667B2 (en) * 1996-11-06 2000-01-31 農林水産省蚕糸・昆虫農業技術研究所長 Modified silk protein, method for producing the same, and osteosynthetic material
KR20110012204A (en) * 2009-07-30 2011-02-09 (주)라이브에이비씨 Method and system for providing language service using geographical association
US20150376248A1 (en) * 2013-02-06 2015-12-31 Virginia Commonwealth University Photoactive silk protein and fabrication of silk protein structures using photolithography
KR20170001444A (en) * 2015-06-26 2017-01-04 아주대학교산학협력단 The method for preparing bio-ink and its application on 3D printing

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FURUZONO, T. ET AL.: "Chemical Modificaiton of Silk Fibroin with 2-meihyacryloyl Oxyethyl Phosphorylcholine. II. Graft-polymerization onto Fabric through 2-methyacryloyloxyethyl Isocyanate and Interaction between Fabric and Platelets", BIOMATERIALS, vol. 21, no. 4, 2000, pages 327 - 333, XP004184114 *
KUNDU, JOYDIP ET AL.: "Silk Fibroin/poly(vinyl alcohol) Photocrosslinked Hydrogels for Delivery of Macromolecular Drugs", ACTA BIOMATERIALIA, vol. 8, no. 5, 2012, pages 1720 - 1729, XP028476144 *

Also Published As

Publication number Publication date
KR101983741B1 (en) 2019-09-10
WO2018186611A2 (en) 2018-10-11
KR20180112436A (en) 2018-10-12

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