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WO2018156852A1 - Système de mise en place de greffe d'endoprothèse présentant une gaine rétrécie et procédé d'utilisation - Google Patents

Système de mise en place de greffe d'endoprothèse présentant une gaine rétrécie et procédé d'utilisation Download PDF

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Publication number
WO2018156852A1
WO2018156852A1 PCT/US2018/019354 US2018019354W WO2018156852A1 WO 2018156852 A1 WO2018156852 A1 WO 2018156852A1 US 2018019354 W US2018019354 W US 2018019354W WO 2018156852 A1 WO2018156852 A1 WO 2018156852A1
Authority
WO
WIPO (PCT)
Prior art keywords
flexible sheath
stent graft
openings
delivery system
proximal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2018/019354
Other languages
English (en)
Inventor
Timothy Lostetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bolton Medical Inc
Original Assignee
Bolton Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bolton Medical Inc filed Critical Bolton Medical Inc
Priority to EP18709881.9A priority Critical patent/EP3534848B1/fr
Priority to JP2019523067A priority patent/JP7112393B2/ja
Priority to ES18709881T priority patent/ES2954897T3/es
Priority to CN201880004187.9A priority patent/CN109890331B/zh
Publication of WO2018156852A1 publication Critical patent/WO2018156852A1/fr
Priority to US16/391,995 priority patent/US11413177B2/en
Anticipated expiration legal-status Critical
Priority to US17/883,019 priority patent/US12083030B2/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/97—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2/07—Stent-grafts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09—Guide wires
    • A61M25/09041—Mechanisms for insertion of guide wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06—Blood vessels
    • A61F2002/061—Blood vessels provided with means for allowing access to secondary lumens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2002/823—Stents, different from stent-grafts, adapted to cover an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2002/9534—Instruments specially adapted for placement or removal of stents or stent-grafts for repositioning of stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
    • A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
    • A61F2/966—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
    • A61F2002/9665—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod with additional retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0014—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof using shape memory or superelastic materials, e.g. nitinol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable

Definitions

  • Fenestrated endovascular aortic repair is a minimally invasive procedure to treat aortic aneurysms that span blood vessels arising from the aorta that supply blood to vital organs including the kidneys, intestine and liver.
  • Endovascular grafts employed in FEVAR define fenestrations for insertion of branch prostheses that serve as passageways for blood flow through arterial branches to vital organs following implantation of the endovascular graft.
  • the present invention relates to a stent graft delivery system and a method for its use in treating and repairing arterial vascular damage, such as vascular damage associated with aortic aneurysms in regions of the aorta having arterial branches that supply blood to vital organs and tissues, including abdominal aortic aneurysms and thoracoabdominal aortic aneurysms, such as juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms.
  • arterial vascular damage such as vascular damage associated with aortic aneurysms in regions of the aorta having arterial branches that supply blood to vital organs and tissues, including abdominal aortic aneurysms and thoracoabdominal aortic aneurysms, such as juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms.
  • a stent graft delivery system of the invention includes a handle, a guidewire catheter, an outer catheter, a flexible sheath, and a ligature.
  • the guidewire catheter extends distally from the handle and includes a distal end and a proximal end, and defines a longitudinal axis, the guidewire catheter being movable relative to the handle.
  • the outer catheter is fixed to and extends distally from the handle and about the guidewire catheter.
  • the flexible sheath extends between the guidewire catheter and the outer catheter and is longitudinally movable relative to the guidewire catheter and the outer catheter.
  • the flexible sheath includes openings, whereby an arrangement of the openings will cause the flexible sheath to have a luminal configuration having a constricted radial diameter.
  • the ligature extends through the openings that causes the openings to conform to the arrangement, thereby configuring the flexible sheath to conform to the constricted radial diameter of the luminal configuration, the ligature being proximally retracted from the openings to thereby release the flexible sheath from the constricted radial diameter.
  • the invention is a method for delivering a stent graft to an aneurysm site of a patient, including the steps of directing the stent graft to an aneurysm site of the patient, the stent graft being radially constricted, at least in part, by a flexible sheath that includes openings conforming to an arrangement along a longitudinal axis of a guidewire catheter to which the stent graft is releasably fixed. The openings are released from the arrangement, whereby the stent graft is released from radial constriction, thereby delivering a stent graft to the aneurysm site.
  • the stent graft delivery systems and methods of the invention have several advantages.
  • the surgeon is provided with increased flexibility in the placement of the stent graft by enabling rotation or repositioning of the stent graft after it has been partially deployed while remaining in the flexible sheath, such as by only partially releasing at least one ligature extending through openings in the flexible sheath.
  • the flexible sheath can also include a fenestration that is aligned with the fenestration of the stent graft, whereby the fenestration can be better aligned with a branch artery and, optionally, the proximal end of a branch prosthesis can be directed through the fenestration of the stent graft while the stent graft is radially constrained by the flexible sheath.
  • removal of the ligature releases the flexible sheath from the arrangement of openings and therefore allows the stent graft to radially expand.
  • a stent graft can be deployed at a surgical site with more accuracy, less risk of injury to the vasculature of the subject, and without significant risk of distorting the intended shape of the stent graft when implanted at the surgical site.
  • FIG. 1 A is a side view of a flexible sheath of one embodiment of a stent graft delivery system of the invention, including a wire holding openings in the flexible sheath in an arrangement that causes the flexible sheath to have a luminal configuration and a constricted radial diameter, and wherein the flexible sheath defines a fenestration in the luminal configuration that is aligned with a fenestration in a stent graft radially constricted within the flexible sheath.
  • FIG. IB is a plan view of the flexible sheath and stent graft represented in FIG. 1A.
  • FIG. 2A is a perspective view of a flexible sheath of a stent graft stent graft delivery system of the invention having openings that, when in an arrangement by a ligature, cause the flexible sheath to have a luminal configuration having a constricted radial diameter.
  • FIG. 2B is a perspective view of the embodiment shown in FIG. 2A following retraction of the ligature and consequent release of the openings of the flexible sheath from the arrangement.
  • FIG. 3 A is a perspective view of another embodiment of a flexible sheath of the stent graft delivery system of the invention, wherein the openings of the flexible sheath are suture loops that, when in an arrangement, cause the flexible sheath to have a luminal configuration having a constricted radial diameter, and wherein the arrangement of openings by a ligature causes scalloped edges of the flexible sheath to define a fenestration in the luminal configuration.
  • FIG. 3B is a perspective view of the embodiment shown in FIG. 3 A following retraction of the ligature and consequent release of the openings from the arrangement.
  • FIG. 4A is a side view of an embodiment of the stent graft delivery system of the invention, wherein a stent graft is captured by the stent graft delivery system and is radially constricted by a flexible sheath of the stent graft delivery system while openings in the flexible sheath are held in an arrangement that causes the flexible sheath to assume a luminal configuration having a constricted radial diameter, and wherein the flexible sheath defines a fenestration that is aligned with a fenestration in the stent graft.
  • FIG. 4B is a side view of the stent graft delivery system shown in FIG.
  • FIG. 4A depicting radial expansion of the stent graft, while still captured by the stent graft stent graft delivery system at a proximal end, but following proximal retraction of a ligature, to release the openings of the flexible sheath from the radially constricted arrangement.
  • FIG. 4C is a side view of the stent graft delivery system shown in FIGs. 4A and 4B following proximal retraction of the flexible sheath to expose the stent graft during delivery to an aneurysm site.
  • FIG. 4C(i) is a detail of the apex capture assembly of the stent graft delivery system shown in FIG. 4C.
  • FIG. 4C(ii) is another detail of the apex capture assembly of the stent graft delivery system shown in FIG. 4C.
  • FIG. 4D is a side view of the stent graft delivery system shown in FIGs. 4A through 4C following release of a proximal bare stent of the stent graft from an apex capture assembly of the stent graft delivery system and prior to complete retraction of the stent graft delivery system from the stent graft.
  • FIG. 4D(i) is an apex capture assembly of the stent graft delivery system shown in FIG. 4D.
  • FIG. 5 is an exploded view of a stent graft delivery system of the invention.
  • FIG. 6A is a side view of the stent graft delivery system shown in FIG. 5 when assembled, and containing a stent graft (not shown) loaded within an introducer sheath of the stent graft delivery system and having been advanced to an aneurysm to be treated by one embodiment of a method of the invention.
  • FIG. 6B is a side view of the stent graft delivery system shown in FIG. 6A after retraction of the introducer sheath to thereby expose the stent graft contained therein.
  • FIG. 6C is a side view of the stent graft delivery system shown in FIGs. 6A and 6B following retraction of a wire that releases the stent graft from a radially constricted position within a flexible sheath of the stent graft delivery system of the invention.
  • FIG. 6D is a side view of the stent graft delivery system shown in FIGs. 6A through 6C, following retraction of the flexible sheath from the stent graft still captured by an apex capture assembly of the stent graft delivery system of the invention.
  • FIG. 6E is a side view of the stent graft delivery system shown in FIGs. 6A through 6D, following release of the stent graft from the apex capture assembly of the stent graft delivery system of the invention.
  • FIG. 6F is a side view of the stent graft delivery system shown in FIGs. 6A through 6E, following retraction of the stent graft delivery system from within the stent graft.
  • FIG. 6G is a side view of the stent graft delivery system shown in FIGs. 6A through 6F following retraction of the stent graft delivery system from within the stent graft, thereby completing implantation of the stent graft at the aneurysm by one embodiment of the invention.
  • FIG. 7 A is a side view of an embodiment of the stent graft delivery system of the invention, wherein a stent graft having a bare stent is radially constricted by a flexible sheath of the stent graft delivery system.
  • FIG. 7B is a side view of the stent graft delivery system shown in FIG. 7A following retraction of the flexible sheath.
  • FIG. 8 is a side view of a vascular prosthesis implanted at an aneurysm in a patient employing a stent graft delivery system of the invention, and branch prostheses implanted through respective fenestrations of the vascular prosthesis and into arterial branches of the aorta.
  • the invention is generally directed to stent graft delivery systems for use in treating and repairing aortic vascular damage, such as vascular damage associated with an aortic aneurysm in regions of the aorta having arterial branches to vital organs and tissues, such as juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms.
  • aortic vascular damage such as vascular damage associated with an aortic aneurysm in regions of the aorta having arterial branches to vital organs and tissues, such as juxtarenal aortic aneurysms and short-neck abdominal aortic aneurysms.
  • proximal means that portion of the prosthesis or component of the prosthesis that is relatively close to the heart of the patient and “distal” means that portion of the prosthesis or component of the prosthesis that is relatively far from the heart of the patient.
  • longitudinal axis as that term is defined herein, means an axis along a lengthwise direction of a body that also passes through a center of gravity of the body.
  • proximal means closer to the clinician using the delivery system.
  • distal means, further away from the clinician using the delivery system.
  • proximate means “close to,” as opposed to the meanings ascribed to “proximal” or “distal” described above with respect to either the prosthesis or a delivery system.
  • a stent graft delivery system of the invention includes a flexible sheath, as shown in FIGs. 1 A and IB.
  • flexible sheath 10 is held in a luminal configuration by an arrangement of openings 12 that causes flexible sheath 10 to have a constricted radial diameter D.
  • the arrangement of openings 12 is maintained by wire 14 that extends through openings 12.
  • Wire 14 extends generally parallel to flexible sheath 10. It is to be understood, however, that openings 12 could be arranged in any pattern that causes flexible sheath 10 to assume a luminal configuration.
  • FIG. 1 A When openings are so arranged, regardless, stent graft 16 is maintained in a radially constricted position.
  • flexible sheath 10 when openings 12 are arranged to cause flexible sheath 10 to have a luminal configuration having constricted diameter D, flexible sheath 10 defines fenestration 18 that exposes fenestration 20 of stent graft 16 radially constricted therein.
  • FIG. IB is a view of the embodiment shown in FIG. 1 A, rotated 90° about longitudinal axis 13, showing wire 14 extending through openings 12 and spanning fenestration 18 of flexible sheath 10 while stent graft 16 is radially constricted within flexible sheath 10.
  • a suitable material for use in ligature is a wire that includes at least one member of the group consisting of a shape memory alloy, stainless steel, or a polymer, such as nylon.
  • the shape memory alloy is Nitinol.
  • ligature is a suitable thread such as is known in the art and employed to form sutures.
  • FIG. 2A is a perspective view of another embodiment of a flexible sheath component 22 of the stent graft delivery system of the invention, wherein openings are slits 24 defined by flexible sheath 22 and are longitudinally aligned by wire 26 in a linear arrangement to thereby cause flexible sheath 22 to have a luminal configuration of constricted radial diameter D.
  • FIG. 2B is a perspective view of flexible sheath 22 shown in FIG. 2A, following retraction of wire 26, thereby releasing slits 24 from the linear arrangement that causes flexible sheath to have a constricted radial diameter D.
  • FIG. 3 A another embodiment of a stent graft delivery system of the invention that includes a flexible sheath 28, wherein the openings of flexible sheath 28 are suture loops 30 that, when in an arrangement, cause flexible sheath 28 to have a luminal configuration having a constricted radial diameter D.
  • the arrangement of suture loops 30 is a longitudinal alignment of suture loops by wire 32 that forms seam 36.
  • flexible sheath 28 defines fenestration 34.
  • FIG. 3B is a perspective view of the embodiment shown in FIG. 3 A, following retraction of wire 32 from suture loops 30, whereby suture loops 30 are released from the arrangement causing flexible sheath 28 to have a luminal configuration.
  • seam 36 of FIG. 3A includes edges 38.
  • Scalloped edges 38 as shown in FIG. 3B, define fenestration 34 represented in FIG. 3A, when loops 30 of flexible sheath 28 are arranged to cause flexible sheath 28 to assume a luminal configuration having constricted radial diameter D.
  • openings can be, for example, slits in the material of the flexible sheath, as shown in FIGs. 2A and 2B
  • the openings can also be suture loops fixed to flexible sheath, such as shown in FIGs. 3A and 3B.
  • openings can have some other configuration, such as combinations of suture loops and slits.
  • the arrangement of openings that cause flexible sheath to have a luminal configuration of constricted radial diameter D need not be linear, so long as the arrangement is maintained with sufficient strength to sufficiently radially constrict a stent graft for delivery to an aneurysm site of a patient.
  • FIG. 4A through 4D represent successive steps in the release of a stent graft according to one embodiment of a method of the invention.
  • flexible sheath 40 radially constricts stent graft 42 by a linear arrangement of openings 44 maintained by wire 46.
  • Stent graft 42 includes fenestration 51 and bare stent 48 at proximal end 50 of stent graft 42 that is captured by apex capture assembly 52.
  • radially self-expansion of stent graft 42 can be effected by employing radially self-expanding stents, such as shown in the art.
  • radially self-expanding stents can include struts that are joined at opposite ends to define proximal and distal apices, and can be fabricated of Nitinol, or some other shape memory alloy.
  • stents are not radially self-expanding, they can be radially expanded by, for example, employing a balloon catheter, such as is known in the art.
  • Openings 44 previously aligned along 46 wire move as a consequence of radial expansion of stent graft 42, thereby separating edges of seam 74.
  • Retraction of flexible sheath 40 from stent graft 42 as shown in FIG. 4C completes exposure of stent graft 42.
  • Proximal apices 68 of bare stent 48 are released by actuation of apex capture assembly 52, as can be seen in FIG. 4D, wherein proximal apex capture component 60 and nose cone 76 are separated from distal apex capture component 54 by proximal retraction of apex capture catheter 70, as can be seen in the transition from detailed views shown in FIGs. 4C(i) and 4C(ii) to FIG. 4D(i).
  • apex capture assembly 52 includes distal apex capture component 54 fixed to distal end 56 of guidewire catheter 58, and proximal apex capture component 60 defines tines 62, whereby distal apex capture component 54 and proximal apex capture component 60 together define a capture opening 64 that captures bare stent 48 at proximal apices 68 to thereby releasably secure and at least partially constrain proximal end 50 of stent graft 42.
  • Apex capture catheter 70 of apex capture assembly 52 extends about guidewire catheter 58 and has a distal end 72 to which proximal apex capture component 60 is fixed. Bare stent 48 is thereby released from the stent graft delivery system.
  • FIG. 5 is an exploded view of one embodiment of a stent graft delivery system 80 of the invention.
  • guidewire catheter 82 includes proximal end 84 and distal end 86.
  • Nose cone 90 is fixed to distal end 86 of guidewire catheter 82.
  • Flexible sheath 92 is secured to pushrod 94 and flexible sheath handle 96.
  • Pushrod 94 includes proximal end 98, to which flexible sheath handle 96 is fixed, and distal end 100, to which flexible sheath 92 is fixed.
  • Wire 102 extends through openings 104 of flexible sheath 92 and extends from flexible sheath 92 along pushrod 94 to flexible sheath handle 96.
  • Flexible sheath 92 when wire 102 extends through openings 104, causes openings 104 to have an arrangement wherein flexible sheath 92 is in a luminal configuration and has constricted diameter D.
  • scalloped edges as shown in FIGs. 3B, and 4B through 4D form a seam, as shown in FIGs. 3 A and 4A, and define fenestration 106.
  • Introducer sheath 110 includes proximal end 112 and distal end 114.
  • Distal handle 116 is fixed to proximal end 112 of introducer sheath 110, and releasably fixed to guidewire catheter 82.
  • FIGs. 6A-6F represent successive stages of a method of the invention employing the assembled stent graft delivery system of FIG. 5 and loaded with stent graft prosthesis 120, such as that shown in FIGs. 4A-4D.
  • FIG. 6A is a side view in assembled form of stent graft delivery system 80 of FIG. 5, within which a stent graft (not shown) has been loaded and delivered to an aneurysm site 122 of a patient.
  • Distal handle 116 and introducer sheath 110 are then retracted without being fixed to guidewire catheter 82, as shown in FIG.
  • stent graft 120 can be delivered to aneurysm 122 by directing introducer sheath to a position distal to aneurysm 122, followed by fixing flexible sheath handle 96 to guidewire catheter 82, and advancing both in a distal direction, indicated by arrow 119, whereby stent graft 120 is advanced from introducer sheath 110 to thereby span aneurysm 122.
  • At least guidewire catheter 82, pushrod 94 and flexible sheath 92 are axially rotated about longitudinal axis 124 to thereby align fenestration 126 of stent graft 120 and fenestration 106 of flexible sheath 92 with arterial branch 128.
  • Branch prosthesis 130 can then be implanted in fenestration 126 of stent graft prosthesis 120 and arterial branch 128 without significant interference by flexible sheath 92.
  • Wire 102 is retracted from openings 104 of flexible sheath 92, as shown in FIG.
  • FIG. 6D thereby releasing openings 104 from the arrangement, in this case a linear arrangement, that causes flexible sheath 92 to have a luminal configuration of constricted radial diameter D'.
  • Flexible sheath handle 96 thereafter is retracted, thereby retracting pushrod 94, causing flexible sheath 92 to be separated from stent graft 120, as shown in FIG. 6E.
  • Stent graft 120 is then released from stent graft delivery system 80 of the invention, such as by releasing bare stent 132 of stent graft prosthesis 120 from apex capture assembly 134, as shown in FIG. 6F.
  • Distal handle is then fixed to guidewire 82, and retracted in proximal direction 117, whereby the remainder of stent graft delivery system 80 of the invention is retracted from stent graft 120, thereby completing treatment of the aortic aneurysm, as shown in FIG. 6G.
  • branch prosthesis can be conducted by the same or a similar stent graft delivery system as that of the invention. It is also understood that branch prosthesis can be implanted after release of openings of the flexible sheath from the arrangement constraining the stent graft.
  • the invention is a method for delivering a stent graft to an aneurysm site of a patient.
  • stent graft 140 which includes no bare stent is directed to an aneurysm site (not shown) of a patient
  • introducer sheath 152 is retracted from flexible sheath 142 and radially constricted stent graft 140.
  • Stent graft 140 being radially constricted, at least in part, by a flexible sheath 142 that includes openings 144 conforming to an arrangement that causes the flexible sheath 142 to have a luminal configuration having a constricted radial diameter D, as shown in FIG. 7A. Openings 144 are released from the arrangement, whereby stent graft 140 is released from constraint, as shown in FIG. 7B, opening seam 152 of scalloped edge 154, thereby causing stent graft 140 to radially expand in diameter to D'. Stent graft 140 is thereby delivered to the aneurysm.
  • fenestration 150 of stent graft 140 is rotated to align fenestration with an arterial branch, as shown in FIG. 8, which shows one embodiment of an implanted stent graft 152 at aneurysm site 180 by use of a stent graft stent graft delivery system and method of the invention.
  • branch prostheses 154, 156,158,160 can be directed through fenestrations
  • leg stent graft prostheses 182, 184 extend from distal end 186 of stent graft 180.
  • the distal end of the vascular repair device of the invention can be bifurcated and additional prostheses can be implanted into the distal end of the bifurcated vascular prosthesis.
  • Vascular prostheses implanted by the stent graft systems and methods of the invention can be implanted, for example, by transfemoral access.
  • Additional branch prostheses that are directed into the vascular prostheses of the invention can be implanted, for example, by supraaortic vessel access (e.g., through the brachial artery), or by transfemoral access, or access from some other branch or branch of major blood vessels, including peripheral blood vessels.
  • PCT/US2017/025844; PCT/US2017/025849; PCT/US2017/025912; PCT/US2017/034223 and PCT/US2017/046062, are also incorporated by reference in their entirety.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Prostheses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

La présente invention concerne un système de mise en place et un procédé d'implantation d'une greffe d'endoprothèse comprenant une gaine souple qui définit des ouvertures réparties longitudinalement et dans lequel l'alignement substantiel des ouvertures le long d'un axe longitudinal d'un cathéter guide fil rétrécit radialement la gaine souple. La gaine souple comprend au moins une fenestration. Une ligature s'étend à travers les ouvertures de la gaine souple et amène les ouvertures à s'aligner sensiblement, rétrécissant ainsi la gaine souple. La ligature est rétractable de manière proximale depuis les ouvertures pour libérer ainsi la gaine souple d'une configuration radialement rétrécie.
PCT/US2018/019354 2017-02-24 2018-02-23 Système de mise en place de greffe d'endoprothèse présentant une gaine rétrécie et procédé d'utilisation Ceased WO2018156852A1 (fr)

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EP18709881.9A EP3534848B1 (fr) 2017-02-24 2018-02-23 Système de mise en place de greffe d'endoprothèse présentant une gaine rétrécie
JP2019523067A JP7112393B2 (ja) 2017-02-24 2018-02-23 シースが収縮されたステントグラフト送達システムおよび使用方法
ES18709881T ES2954897T3 (es) 2017-02-24 2018-02-23 Sistema de colocación de injerto de stent con envoltura restringida
CN201880004187.9A CN109890331B (zh) 2017-02-24 2018-02-23 具有收缩护套的支架移植物递送系统和使用方法
US16/391,995 US11413177B2 (en) 2017-02-24 2019-04-23 Stent graft delivery system with constricted sheath and method of use
US17/883,019 US12083030B2 (en) 2017-02-24 2022-08-08 Stent graft delivery system with constricted sheath and method of use

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US201762463051P 2017-02-24 2017-02-24
US62/463,051 2017-02-24

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CN109890331B (zh) 2022-07-12
ES2954897T3 (es) 2023-11-27
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US20250009539A1 (en) 2025-01-09
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EP3534848B1 (fr) 2023-06-28
US20190247213A1 (en) 2019-08-15
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US11413177B2 (en) 2022-08-16

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