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WO2018008622A1 - Sonde d'irradiation de lumière et son procédé de fabrication - Google Patents

Sonde d'irradiation de lumière et son procédé de fabrication Download PDF

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Publication number
WO2018008622A1
WO2018008622A1 PCT/JP2017/024445 JP2017024445W WO2018008622A1 WO 2018008622 A1 WO2018008622 A1 WO 2018008622A1 JP 2017024445 W JP2017024445 W JP 2017024445W WO 2018008622 A1 WO2018008622 A1 WO 2018008622A1
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WO
WIPO (PCT)
Prior art keywords
optical fiber
light
light diffuser
transparent tube
tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2017/024445
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English (en)
Japanese (ja)
Inventor
荒井　恒憲
恵美悠 小川
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Keio University
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Keio University
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Filing date
Publication date
Application filed by Keio University filed Critical Keio University
Publication of WO2018008622A1 publication Critical patent/WO2018008622A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/26—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes using light guides
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/02—Optical fibres with cladding with or without a coating

Definitions

  • the present invention relates to a light irradiation probe used for photodynamic therapy and the like and a method for manufacturing the same.
  • Photodynamic therapy (also referred to as PDT or photochemical treatment) is used for cancer treatment, tachyarrhythmia treatment, and the like.
  • Photodynamic therapy is a method of injecting a photosensitizer (photosensitizer) into a living body and irradiating light such as laser light with a wavelength in the target living tissue to generate active oxygen from the photosensitizer.
  • This is a technique for treating lesions such as cancer and infectious diseases.
  • a photosensitive substance is administered by intravenous injection, etc., and after selectively absorbing and accumulating in the cancer tissue, the accumulated cancer tissue is irradiated with light such as laser light of a specific wavelength.
  • a photochemical reaction is caused to generate active oxygen and radicals in the target tissue, and necrosis of cancer cells is attempted to treat diseases such as cancer.
  • laser light is irradiated onto tissues inside a living body by inserting a catheter including an optical fiber that transmits light into a luminal organ such as a digestive organ or a blood vessel, It is carried out by bringing it close to a living tissue.
  • a laser beam irradiation probe provided with such an optical fiber, one that emits laser beam only from the tip of the fiber and performs pinpoint irradiation has been the mainstream.
  • a laser beam irradiation probe that emits laser light only from the tip of the fiber, if the irradiation area of the laser beam is narrow and the volume of the lesion to be treated is large, the point irradiated with the pinpoint is connected. It was necessary to obtain a linear or planar treatment area.
  • a concave groove structure is provided on the peripheral side surface of the tip portion of the fiber constituting the core so that the laser light transmitted through the fiber is diffused from the peripheral side surface of the tip portion in a direction bent with respect to the optical axis direction of the core.
  • a laser beam diffusion irradiation probe is proposed (for example, Patent Document 1).
  • Patent Document 1 since the laser light is diffused from the peripheral side surface of the tip portion in a direction that bends with respect to the optical axis direction of the core, it is possible to irradiate the range in which the laser light is diffused and Is large, for example, even when the volume of a lesion such as a tumor to be treated is large, the laser beam can be irradiated more uniformly.
  • the laser beam irradiation probe of Patent Document 1 is formed by coating a core glass with a diameter of 0.5 mm with a jacket with a diameter of 2 mm, for example, passing through a lumen having a diameter of about 1 to 2 mm of an endoscope or a catheter.
  • the outer diameter was too large to be used.
  • the laser beam irradiation probe of Patent Document 1 is made of glass, the core and the clad are easily broken when used as a laser beam irradiation probe with a small diameter, and a practical laser beam irradiation probe with a small diameter is manufactured. I could't.
  • a laser beam irradiation probe having a diameter of 0.9 mm or less including the outer cover is not known.
  • the present invention has been made in view of the above problems, and an object of the present invention is to provide a small-diameter light that can be used by being inserted into a lumen of an endoscope or a catheter or a thin luminal organ of a living body.
  • An object is to provide an irradiation probe and a manufacturing method thereof.
  • Another object of the present invention is to provide a light irradiation probe having a small diameter in which heat generation in a light diffuser during photodynamic treatment is suppressed and a method for producing the same.
  • the above-described problem is a light irradiation probe comprising: a plastic optical fiber that transmits light from a light source; and a light diffuser continuously provided at the tip of the optical fiber.
  • a transparent tube covering the light diffuser and the optical fiber, and a gap is formed between the inner surface of the transparent tube and the outer surface of the light diffuser and the optical fiber, Is fixed in the longitudinal direction of the optical fiber with respect to the transparent tube on the end side on the light diffuser side, and is positioned and fixed at a position closer to the central axis than the outer periphery of the transparent tube.
  • the tip of the light diffuser is disposed at a position closer to the central axis than the outer periphery of the transparent tube, and is not fixed to the transparent tube.
  • proximal means the outside of the living body, that is, the practitioner side in a state where the light irradiation probe is inserted into the living body
  • distal means the distal end side of the portion inserted into the living body. That is, it refers to the tissue to be treated or diagnosed.
  • the end portion side of the optical fiber on the light diffuser side is the end portion side on the distal side of the optical fiber.
  • the tip side of the light diffuser is the distal side of the light diffuser.
  • a gap is formed between the inner surface of the transparent tube and the outer surface of the light diffuser and the optical fiber, even when the temperature of the transparent tube rises, the gap exhibits a heat insulating effect.
  • the temperature of the light diffuser and the optical fiber can be prevented from rising.
  • a thin plastic optical fiber is very soft and easily stretched by a tensile force in the longitudinal direction to change the characteristics of light irradiation. In the present invention, the surroundings of the light diffuser and the optical fiber are changed.
  • the gap is a gap, it is possible to suppress an external force from being applied to the light diffuser and the optical fiber, and to suppress a change in the light irradiation characteristics of the light diffuser. Furthermore, since the optical fiber made of a small-diameter plastic is very soft, it is difficult to pass through the transparent tube, but a gap is provided between the inner surface of the transparent tube and the light diffuser and the outer surface of the optical fiber. The process of inserting the optical fiber through the transparent tube is facilitated.
  • the average distance between the inner surface of the transparent tube and the outer surface of the light diffuser and the optical fiber is preferably 50 ⁇ m or more.
  • the said edge part side by the side of the said light diffuser of the said optical fiber is good to be fixed by the fastening member which winds up the said light irradiation probe.
  • the end portion of the optical fiber on the light diffuser side is fixed by the winding member, it is possible to easily fix the proximal side of the light diffuser in the longitudinal direction of the optical fiber. . Further, it is possible to easily position and fix at a position closer to the central axis than the outer periphery of the transparent tube without strictly adjusting the radial fixing position.
  • a cap having a depression on the inner surface may be fixed to the distal end of the transparent tube, and the distal end side of the light diffusing body may be disposed inside the depression.
  • the distal end side of the light diffuser distal side can be arranged at a position closer to the central axis than the outer periphery of the transparent tube without being fixed to the transparent tube with a simple configuration.
  • the outer diameter of the light irradiation probe is preferably 900 ⁇ m or less.
  • the light irradiation probe of the present invention is inserted into lumens having a diameter of 2 mm or less, such as endoscope forceps ports, suction ports, and air flow / water flow lumens of endoscopes and catheters.
  • a conventionally known light irradiation probe having a diameter of about 1 mm cannot be inserted into a lumen having a diameter of more than 1 mm, such as an air flow lumen of a respiratory endoscope, but the light irradiation probe of the present invention.
  • the outer diameter is 900 ⁇ m or less, it can be inserted. Furthermore, it can be used for a narrow part in a living body.
  • the object includes a plastic optical fiber that transmits light from a light source, and a light diffuser that is continuously provided at the tip of the optical fiber.
  • a method of manufacturing a light irradiation probe comprising: connecting a wire to a tip of the optical fiber opposite to the light diffuser; inserting the wire from one end of a transparent tube; and from the other end of the transparent tube Pulling out, storing the optical fiber and the light diffuser in the transparent tube, and arranging the tip of the light diffuser at a position aligned with the other end of the transparent tube; and the light irradiation probe, A step of tightening by a tightening member on an end side of the optical fiber on the light diffuser side, and a cap having the recess on an inner surface so that the tip of the light diffuser is located inside the recess. It is carried out and fixing the one end of the transparent tube, sequentially, is solved by.
  • the step of connecting a wire to the tip of the optical fiber opposite to the light diffuser the wire is inserted from one end of the transparent tube, and pulled out from the other end of the transparent tube, the optical fiber
  • the optical fiber can be inserted into the transparent tube.
  • the step of tightening the light irradiation probe by a tightening member on the end side of the optical fiber on the light diffuser side, and the tip of the light diffuser is positioned inside the recess.
  • the proximal side of the light diffuser is fixed and the distal tip is a free end or a simple support end, so that there is no tension on the light diffuser and it is closer to the central axis side than the outer periphery in the transparent tube. It is possible to form a gap around the light diffuser by positioning at the position.
  • the gap since a gap is formed between the inner surface of the transparent tube and the outer surface of the light diffuser and the optical fiber, the gap exhibits a heat insulating effect even when the temperature of the transparent tube rises. And it can control that the temperature of a light diffuser and an optical fiber rises. As a result, it is possible to protect the light diffuser and the optical fiber from heat generation by suppressing the temperature rise of the plastic light diffuser and the optical fiber having a low melting point and low heat resistance.
  • a thin plastic optical fiber is very soft and easily stretched by a tensile force in the longitudinal direction to change the characteristics of light irradiation. In the present invention, the surroundings of the light diffuser and the optical fiber are changed.
  • the gap is a gap, it is possible to suppress an external force from being applied to the light diffuser and the optical fiber, and to suppress a change in the light irradiation characteristics of the light diffuser. Furthermore, since the optical fiber made of a small-diameter plastic is very soft, it is difficult to pass through the transparent tube, but a gap is provided between the inner surface of the transparent tube and the light diffuser and the outer surface of the optical fiber. The process of inserting the optical fiber through the transparent tube is facilitated.
  • FIG. 2 is a cross-sectional view taken along the line AA in FIG. It is a graph which shows the result of the confirmation test of the temperature rise inhibitory effect of the light irradiation probe which concerns on one Example of this invention.
  • the light irradiation probe 1 includes a long optical fiber cable 2, a light diffuser 3 that is continuously provided integrally with the tip of the optical fiber cable 2, and a light A tube 4 (corresponding to a transparent tube) through which the fiber cable 2 and the light diffuser 3 are inserted, and a cap 5 provided at the tip of the tube 4 are main components.
  • the optical fiber cable 2 is configured by covering a long cylindrical core 21 with a cladding 22.
  • the core 21 is made of polymethyl methacrylate, polystyrene, polycarbonate or the like
  • the cladding 22 is made of a fluorinated polymer or the like and has a diameter of 200 ⁇ m or more and 300 ⁇ m or less, preferably 230 ⁇ m or more and 300 ⁇ m or less, more preferably
  • the optical fiber cable 2 is made of a plastic optical fiber that is resistant to bending, and is made of a plastic optical fiber having a diameter of 250 ⁇ m or more and 275 ⁇ m or less.
  • the operability of the catheter or endoscope is used, and the light irradiation probe 1 itself is operated. Sex is not necessary. However, operability may be imparted to the light irradiation probe 1, or the light irradiation probe 1 may be formed from a shape memory material.
  • the light diffuser 3 is formed by removing the clad 22 and exposing the core 21 from the tip of the optical fiber cable 2 to a predetermined length L.
  • the light diffuser 3 is formed integrally with the core 21 and is formed by sandblasting the core 21, and the emitted light to the side having an angle with respect to the length direction of the light diffuser 3 is made uniform. Yes.
  • the configuration of the light diffuser 3 is not limited to this, and the light diffuser 3 is formed by providing a hollow portion at the center and providing a light reflecting mirror on the inner surface, or providing a notch on the inner surface.
  • the emitted light to the side may be made uniform.
  • the length of the light diffuser 3 serving as a light emitting region is 5 mm to 50 mm.
  • the light diffuser 3 is not limited to the one shown in FIG.
  • the light diffusing body 3 can be broadly divided into a case where the light diffusing body 3 is formed by extending the core 21 of the optical fiber cable 2 and a case where a light diffusing body 3 separate from the core 21 is provided. And can be used as the light diffuser 3 of the present embodiment.
  • the core 21 may or may not constitute the diffusing material itself.
  • a transmission light leakage method (a method in which a small scratch is applied to the cladding 22 and a part of the core 21 is exposed, a method in which leakage is formed by bending, etc.) and a method using a diffusing substance are roughly classified.
  • Transmission light leakage methods include scratch processing (sand blasting, stamping, solvent processing, etc.), fiber bragg grating (FBG), and microbending.
  • a method using a diffusing material a method of putting a diffusing material in the core 21 / cladding 22, removing the cladding 22, exposing the core 21, and putting the diffusing material in a coating (not shown) that covers the core 21.
  • Sand blasting is a method of spraying fine particles, and therefore applies to a method using this diffusing substance.
  • the latter case where the light diffuser 3 separate from the core 21 is provided is the case where an optical element different from the core 21 is used as the light diffuser 3.
  • an optical element such as a polyhedral prism, a SELFOC (registered trademark) lens (a gradient index lens) is used.
  • the tube 4 is made of a soft tube made of a fluororesin that has optical transparency, has a high melting point of 200 ° C. or higher, and is difficult to melt and tear even when the temperature rises in vivo.
  • a fluororesin is preferably used, and in particular, a fluorinated carbon resin such as polytetrafluoroethylene (PTFE) is preferably used.
  • FIG. 2 is a cross-sectional view taken along the line AA in FIG. FIG. 2 shows the relationship between the diameter of the tube 4 and the core 21 or the light diffuser 3 and the clad 22.
  • the outer diameter of the tube 4 of this embodiment is 900 ⁇ m or less, preferably 600 ⁇ m or more and 850 ⁇ m or less, more preferably 700 ⁇ m or more and 810 ⁇ m or less.
  • the diameter of the core 21 and the light diffuser 3 is 250 to 300 ⁇ m, and the cladding
  • the thickness of 22 is 10 ⁇ m or less, preferably 3 to 7 ⁇ m.
  • the tube 4, the core 21, the cladding 22, and the light diffuser 3 are arranged substantially coaxially, and a cylindrical gap 6 is formed between the outer surface of the cladding 22 or the light diffuser 3 and the inner surface of the tube 4.
  • the gap 6 has an average of the entire circumference of at least 50 ⁇ m or more, preferably 75 ⁇ m or more, and more preferably 100 ⁇ m or more.
  • the light diffuser 3 is physically tensioned by contacting with the heat insulating material. , The light diffuser 3 is partially expanded. As a result, the light irradiation characteristics of the light diffuser 3 vary depending on the location and become non-uniform.
  • the gap 6 that is an air layer, no physical pressure is applied to the light diffuser 3, The light irradiation probe 1 having uniform characteristics can be achieved.
  • the gap 6 has a substantially cylindrical shape surrounding the light diffuser 3 when no external force is applied to the light irradiation probe 1.
  • the light irradiation probe 1 bends in various directions and angles in various lumens such as endoscopes and catheters and in living body lumens.
  • the body 3 may temporarily contact the inner wall of the tube 4, the light diffuser 3 may not be in contact with the inner wall of the tube 4 at all times. This is because the surface contact does not occur unless the contact is always made, and the transfer of heat from the tube 4 side to the light diffuser 3 is not problematic.
  • a cap 5 is fixed to the distal end of the tube 4 so as to close the opening of the distal end of the tube 4.
  • the cap 5 is formed with a cylindrical recess 5h having a diameter slightly larger than the surface of the distal end tip 3e of the light diffuser 3 on one cylindrical bottom surface.
  • the cap 5 is made of a soft material made of the same fluororesin as that of the tube 4, and is welded and fixed so as to close the opening at the tip of the tube 4 by heating the cap 5.
  • the cap 5 is made of a transparent body for applications that require forward irradiation from the distal tip 3e of the light diffuser 3, and forward from the distal tip 3e of the light diffuser 3. When irradiation is unnecessary, it is configured using a cloudy material.
  • the distal tip 3e of the light diffuser 3 is disposed in the internal space of the recess 5h.
  • the tip 3 e is a free end or a simple support end, and is not fixed to the recess 5 h of the cap 5.
  • the tip 3e is located in a space formed by the inner surface of the recess 5h.
  • the tube 4 is wound in the direction of reducing the diameter of the tube 4 by an annular winding member 7 on the proximal side of the light diffuser 3.
  • the winding member 7 is wound around the outer periphery of the tube 4, and the tube 4 and the optical fiber cable 2 are fixed to each other so as not to be displaced in the longitudinal direction.
  • the winding member 7 is preferably formed from a material that also functions as an X-ray opaque marker, such as platinum (Pt). In addition, it is preferable to install the X-ray opaque marker on the outer periphery of the cap 5.
  • the optical fiber cable 2 is positioned at a predetermined position on the central axis side from the outer periphery of the tube 4, that is, on the central axis side in the region surrounded by the outer periphery of the tube 4. And is positioned near the center. As a position in the vicinity of the center of the tube 4, it is possible to set it to a position where it can be substantially identified with the center of the tube 4.
  • the tube 4 having flexibility When the winding member 7 is tightened, the tube 4 having flexibility may be twisted. In such a case, the tube 4 is not the center of the tube 4 but can be substantially equated with the center of the tube 4. It will be fixed in position. In the present specification, the term “a position that can be substantially identified with the center of the tube 4” is used as a meaning including the center of the tube 4.
  • the length from the position where the optical fiber cable 2 is wound by the winding member 7 to the tip 3e of the optical fiber cable 2 and the light diffuser 3 is, for example, When the length is sufficiently long, such as 8 mm or more, the tip 3e side that is a free end or a simple support end hangs down due to gravity, and abuts on any part of the inner surface forming the recess 5h on the side surface near the tip 3e. However, when the length of the optical fiber cable 2 and the light diffuser 3 from the position where the optical fiber cable 2 is wound by the winding member 7 to the tip 3e is short, or when the rigidity of the light diffuser 3 is high, etc.
  • the tip 3e does not hang down, and the side surface in the vicinity of the tip 3e of the light diffuser 3 is not in contact with the inner surface of the recess 5h, but is held in the vicinity of the center with a gap between the inner surface of the recess 5h. Can be.
  • the manufacturing method of the light irradiation probe 1 of this embodiment is demonstrated.
  • the cladding 22 is removed from the distal end portion of the plastic optical fiber cable 2 having a diameter of 300 ⁇ m or less over a predetermined length L to form a light diffuser 3 as shown in FIG.
  • a wire (not shown) is connected to the tip of the optical diffuser 3 opposite to the proximal side of the optical fiber cable 2 with an adhesive or an adhesive tape.
  • the optical fiber cable 2 is inserted into a soft tube 4 made of light-transmitting fluororesin.
  • the tube 4 has an inner diameter such that an average gap of 50 ⁇ m or more is provided between the outer periphery of the optical fiber cable 2 and the outer diameter is 900 ⁇ m or less.
  • the tip 3 e of the light diffuser 3 on the distal side of the optical fiber cable 2 is arranged so as to be aligned with the end of the tube 4.
  • the periphery of the tube 4 is tightened with a tightening member 7, and the optical fiber cable 2 and the tube 4 are mutually connected.
  • the wire is removed from the optical fiber cable 2 by cutting at the proximal end of the optical fiber cable 2.
  • the cap 5 is welded and fixed to the tip of the tube 4 so that the tip 3 e of the light diffuser 3 is disposed in the space of the recess 5 h on the inner surface of the cap 5.
  • the distal end 3e on the distal side of the light diffuser 3 is not fixed to the recess 5h, but is a free end or a simple support end.
  • the simple support end means a simple support end where the position of the optical fiber cable 2 wound by the winding member 7 is a fulcrum of simple support. Since the position of the optical fiber cable 2 wound by the winding member 7 becomes a fixed point for simple support, a moment is generated. However, since the tip 3e is a free end or a simple support end, no moment is generated. Thus, the light irradiation probe 1 is completed.
  • the light diffuser 3 hangs down in accordance with the gravity just by inserting the optical fiber cable 2 into the tube 4 and abuts the inner surface of the tube 4 on the lower side.
  • the light diffuser 3 and the inner surface of the tube 4 are in surface contact.
  • the gap 6 between the tube 4 and the entire periphery of the light diffuser 3 cannot be maintained. Therefore, in the present embodiment, the distal end 3e on the distal side of the light diffuser 3 is disposed in the space of the recess 5h provided at the radial center of the tube 4, and at the proximal side of the light diffuser 3.
  • the ultra-thin plastic optical fiber cable 2 having a diameter of 300 ⁇ m or less is highly flexible and has a property of expanding and contracting depending on the presence or absence of a tensile force applied in the longitudinal direction. Therefore, when the plastic optical fiber cable 2 is fixed to the tube 4 side at a plurality of locations in the length direction, the portion sandwiched between the fixed locations is stretched or twisted as the tube 4 moves. As a result, the light irradiation characteristics of the light diffuser 3 change. Therefore, in the present embodiment, the distal end 3e and the concave portion 5h on the distal side of the light diffuser 3 are not fixed, and the fixing portion between the plastic optical fiber cable 2 and the tube 4 is fixed to the proximal side of the light diffuser 3. The light diffuser 3 is prevented from expanding and contracting by using only one portion of the winding member 7.
  • the core 21 and the clad 22 are each made of PMMA (polymethyl methacrylate resin), and the clad 22 has a thickness of about 5 ⁇ m and a diameter of 250 ⁇ m from the tip of the optical fiber cable 2 (manufactured by Nissei Electric Co., Ltd.) to a predetermined length L.
  • An optical fiber cable 2 from which the cladding 22 was removed was produced.
  • a transparent, soft tube 4 manufactured by Nissei Electric Co., Ltd.
  • the probe 1 was produced with a diffusion length of 50 mm, and the light irradiation probe 1 of Example 1 was obtained.
  • Cylindrical® Diffuser manufactured by Medlight was used as the light irradiation probe of Comparative Example 1.
  • the light irradiation probe of Comparative Example 1 has a plastic optical fiber covered with a tube, and has a diameter of 0.98 mm, a core diameter of 500 ⁇ m, a diffusion length of 50 mm, and a minimum bending radius of 10 mm.
  • the tube covering the fiber was not transparent but clouded. There was no gap between the tube and the fiber, and the tube and the fiber were in close contact. Therefore, neither the fixing mechanism in the longitudinal direction nor the radial direction of the fiber by the concave portion 5h of the cap 5 and the winding member 7 in FIG.
  • the light irradiation probes of Example 1 and Comparative Example 1 are placed in the air, the input power to the light irradiation probe is 500 mW, the irradiation time is 500 seconds, irradiation is performed from each light irradiation probe, and light is irradiated using a thermography camera.
  • the probe surface temperature was measured.
  • the distance between the light irradiation probe and the thermographic camera was about 15 cm, and the ambient temperature was 22 ° C., which is room temperature.
  • the measurement results are shown in FIG.
  • the maximum temperature rise at the irradiation time of 500 seconds was 5.6 ° C. with the light irradiation probe of Comparative Example 1, whereas it was 1.94 ° C. with the light irradiation probe of Example 1.
  • the advantage was low.
  • the light irradiation probe of Example 1 it turned out that the temperature rise of the light irradiation probe by the light radiation from a light diffuser is suppressed.

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Abstract

La présente invention concerne une sonde d'irradiation de lumière de faible diamètre pouvant être insérée et utilisée dans une lumière d'endoscope ou de cathéter ou un organe creux mince, et un procédé pour sa fabrication. Une sonde d'irradiation de lumière 1 est pourvue d'une fibre optique en plastique 2 pour transmettre de la lumière provenant d'une source de lumière, et d'un diffuseur de lumière 3 disposé en continu avec une extrémité distale de la fibre optique 2. Un tube transparent 4 pour recouvrir le diffuseur de lumière 3 et la fibre optique 2 est disposé, et un espacement 6 est formé entre une surface interne du tube transparent 4 et une surface externe du diffuseur de lumière 3 et de la fibre optique 2. Sur un côté de partie d'extrémité de la fibre optique 2 vers le diffuseur de lumière 3, la fibre optique 2 est fixée au tube transparent 4 dans la direction de la longueur de la fibre optique 2, et est fixée en position à une position plus proche d'un axe central que la périphérie externe du tube transparent 4. Un côté d'extrémité distale du diffuseur de lumière 3 est disposé à une position plus proche de l'axe central que la périphérie externe du tube transparent 4, et n'est pas fixé au tube transparent 4.
PCT/JP2017/024445 2016-07-04 2017-07-04 Sonde d'irradiation de lumière et son procédé de fabrication Ceased WO2018008622A1 (fr)

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JP2016132738A JP2018000624A (ja) 2016-07-04 2016-07-04 光照射プローブ及びその製造方法
JP2016-132738 2016-07-04

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WO2018008622A1 true WO2018008622A1 (fr) 2018-01-11

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020069379A (ja) * 2018-10-25 2020-05-07 住友電気工業株式会社 医療用レーザライトガイド

Citations (5)

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JP7210377B2 (ja) 2018-10-25 2023-01-23 タツタ電線株式会社 医療用レーザライトガイド

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