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WO2017138017A1 - Procédé de préparation d'un dérivé de benzazépine-2-one - Google Patents

Procédé de préparation d'un dérivé de benzazépine-2-one Download PDF

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Publication number
WO2017138017A1
WO2017138017A1 PCT/IN2017/000031 IN2017000031W WO2017138017A1 WO 2017138017 A1 WO2017138017 A1 WO 2017138017A1 IN 2017000031 W IN2017000031 W IN 2017000031W WO 2017138017 A1 WO2017138017 A1 WO 2017138017A1
Authority
WO
WIPO (PCT)
Prior art keywords
formula
acid
benzazepine
compound
dimethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2017/000031
Other languages
English (en)
Inventor
Gajendra Singh
Vani Singh
Atipriya Attri
Lalit Wadhwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IND-SWIFT LABORATORIES Ltd
Original Assignee
IND-SWIFT LABORATORIES Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IND-SWIFT LABORATORIES Ltd filed Critical IND-SWIFT LABORATORIES Ltd
Publication of WO2017138017A1 publication Critical patent/WO2017138017A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un procédé rentable, respectueux de l'environnement et industriellement viable, pour la préparation de 7,8-diméthoxy-1,3-dihydro-2H-3-benzazépine-2-one, un intermédiaire utilisé dans la préparation de l'ivabradine, sans utiliser d'intermédiaire de chlorure d'acide ni d'agent de condensation.
PCT/IN2017/000031 2016-02-10 2017-02-09 Procédé de préparation d'un dérivé de benzazépine-2-one Ceased WO2017138017A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201611004745 2016-02-10
IN201611004745 2016-02-10

Publications (1)

Publication Number Publication Date
WO2017138017A1 true WO2017138017A1 (fr) 2017-08-17

Family

ID=59563730

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2017/000031 Ceased WO2017138017A1 (fr) 2016-02-10 2017-02-09 Procédé de préparation d'un dérivé de benzazépine-2-one

Country Status (1)

Country Link
WO (1) WO2017138017A1 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0534859B1 (fr) * 1991-09-27 1994-11-17 Adir Et Compagnie 3-Benzazépin-zones substituées par un groupe benzocyclobutyl- ou indanyl-alkyl-amino-alkyle, utiles dans le traitement des affections cardiovasculaires
WO2010072409A1 (fr) * 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Procédé pour la préparation d'ivabradine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0534859B1 (fr) * 1991-09-27 1994-11-17 Adir Et Compagnie 3-Benzazépin-zones substituées par un groupe benzocyclobutyl- ou indanyl-alkyl-amino-alkyle, utiles dans le traitement des affections cardiovasculaires
WO2010072409A1 (fr) * 2008-12-22 2010-07-01 Krka, D. D., Novo Mesto Procédé pour la préparation d'ivabradine

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