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WO2017179763A1 - Biodispositif portable et son procédé de fabrication - Google Patents

Biodispositif portable et son procédé de fabrication Download PDF

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Publication number
WO2017179763A1
WO2017179763A1 PCT/KR2016/006474 KR2016006474W WO2017179763A1 WO 2017179763 A1 WO2017179763 A1 WO 2017179763A1 KR 2016006474 W KR2016006474 W KR 2016006474W WO 2017179763 A1 WO2017179763 A1 WO 2017179763A1
Authority
WO
WIPO (PCT)
Prior art keywords
substrate
biological tissue
insulating layer
wiring layer
wearable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2016/006474
Other languages
English (en)
Korean (ko)
Inventor
권용준
최헌진
홍민호
나주관
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agency for Defence Development
Original Assignee
Agency for Defence Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency for Defence Development filed Critical Agency for Defence Development
Publication of WO2017179763A1 publication Critical patent/WO2017179763A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/685—Microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes

Definitions

  • the present invention relates to a wearable biological device for sensing an electrical signal inside a living tissue and a method of manufacturing the same.
  • bio devices widely known to the general public have a function of detecting physical changes such as temperature or pressure by attaching them to the outside of the body and enclosing them in a band form, and bio devices that detect ions and biological factors occurring in the body are widely used. It is unknown.
  • bio-elements have been developed to detect the cell signal described above finely, one of which is a microneedle is inserted into the human tissue or microscopic extracellular matrix and the other is the human body of the same site It is inserted into tissue and diagnosed through cellular signals sensed by ions and biological factors present therein.
  • One object of the present invention is to provide a wearable bioelement and a method for manufacturing the same, which can effectively detect ions and biological factors constituting biological tissues in the body without undergoing an incision procedure.
  • the wearable biological device of the present invention the substrate located outside the biological tissue; At least one pillar portion extending in one direction on the substrate and having a needle-shaped end portion to be inserted into the biological tissue; And a conductive material so as to sense an electrical signal inside the biological tissue from the outside of the biological tissue, and formed on the end portion and the substrate provided at the pillar portion to electrically connect between the end portion and the substrate.
  • a wearable biodevice comprising a wiring layer.
  • the wearable bio device is made of an insulator so as to block an electrical signal of the biological tissue in contact with a region other than the end portion, and is formed to surround the remaining region of the wiring layer except for the end portion and the substrate. It may further include an insulating layer.
  • the wearable biological device may include an insulating material and further include a second insulating layer formed to surround the substrate and the pillar, and the wiring layer may be disposed between the first insulating layer and the second insulating layer.
  • the first insulating layer and the second insulating layer may be formed of any one selected from the group consisting of silica (SiO 2), aluminum oxide (Al 2 O 3), and parylene.
  • the cross section of the pillar portion may be formed in a circular or quadrangular shape, and the diameter or the length of one side of the pillar portion may be formed to 20 micrometers or more and 400 micrometers or less.
  • the height of the pillar portion may be formed to 50 micrometers or more and 1000 micrometers or less.
  • An angle formed by the end portion may be formed to 10 degrees or more and 20 degrees or less.
  • the pillar portion is composed of first and second pillars arranged on the substrate, and the wiring layer includes first and second wirings formed on the first and second pillars, respectively, and the first and second wirings. Each may be configured to detect different kinds of electrical signals from inside the biological tissue.
  • the pillar portion is composed of first and second pillars arranged on the substrate, and the wiring layer includes first and second wirings formed on the first and second pillars, respectively, and the first and second wirings.
  • the first and second wires may be configured to detect electrical signals of the same type from inside the biological tissue.
  • the pillar portion is composed of first and second pillars having first and second ends, respectively, and is arranged on the substrate, and the wiring layer includes first and second wirings formed on the first and second pillars, respectively.
  • the first and second pillars may be formed to have different heights so that the first and second ends are positioned at different portions in the biological tissue.
  • a method of manufacturing a wearable biological device Disclosed is a method of manufacturing a wearable biological device.
  • the method of manufacturing the wearable biodevice further includes depositing a second insulating layer formed of an insulator on the pillar part and the substrate after the second step, wherein the third step comprises depositing the wiring layer on the second layer.
  • An insulating layer may be formed between the end portion of the substrate and the substrate.
  • a substrate positioned outside the biological tissue a pillar portion formed on the substrate and having a needle-shaped end portion, and made of a conductive material and formed on the substrate and the end portion of the pillar portion,
  • a wiring layer is electrically connected between the end portion and the substrate. Accordingly, the wiring layer formed on the substrate located outside the biological tissue can effectively detect the ions and biological factors constituting the biological tissue in the body without undergoing an incision procedure, and reduce the physical and economic burden on the subject.
  • the advantage is that early screening of the disease can be made more popular.
  • the pillar portion is provided with a plurality of first and second pillars are arranged on the substrate, the wiring layer has a first and second wiring formed on the first and second pillars, respectively.
  • FIG. 1 is a perspective view showing a wearable biological device according to an embodiment of the present invention.
  • FIG. 2 is a diagram conceptually illustrating a cross section of the wearable biodevice illustrated in FIG. 1.
  • FIG. 3 is a flowchart illustrating a method of manufacturing a wearable biodevice according to another exemplary embodiment of the present invention.
  • FIG. 4 is a diagram illustrating a manufacturing process according to the method of manufacturing the wearable biodevice shown in FIG. 3 step by step.
  • FIG. 1 is a perspective view illustrating a wearable biodevice 100 according to an exemplary embodiment of the present invention
  • FIG. 2 is a view conceptually illustrating a cross section of the wearable biodevice 100 illustrated in FIG. 1.
  • the wearable bio device 100 includes a substrate 110, a pillar 120, and a wiring layer 130.
  • the substrate 110 may be formed in a flat plate shape and may provide a space for arranging at least one pillar 120 to be described later.
  • the substrate 110 is located outside the living tissue, and the living tissue mainly refers to skin tissue of the human body, but may refer to a specific organ located in the body.
  • the substrate 110 may be formed to be elastically deformable so that the surface facing the living tissue is in close contact.
  • the pillar portion 120 extends in one direction on the substrate 110 and has a needle-shaped end portion 121, and may be formed to be inserted into the biological tissue, and on the substrate 110. At least one may be formed.
  • the pillar portion 120 may be formed to have a cylindrical or square column shape to have a circular or rectangular cross section, and the diameter or the length of one side of the pillar portion 120 is 20 micrometers or more and 400 micrometers or less. Can be, The height of the pillar portion 120 may be formed to 50 micrometers or more and 1000 micrometers or less.
  • the skin tissue of the human body is composed of the stratum corneum of 10 ⁇ m to 20 ⁇ m, the epidermal layer of 70 ⁇ m to 120 ⁇ m, the dermal layer in which the blood vessel is located has a thickness of 500 ⁇ m to 3,000 ⁇ m.
  • the pillar portion 120 of the present invention can invade to the depth where the dermis layer is located.
  • the height of the pillar portion 120 is formed to be at least 50 micrometers or more, the depth of the outer wall of the organ 50 ⁇ m thickness of the organ that does not perform a normal function when the internal organs are exposed to the air by incision to diagnose the inevitable disease Invasion is possible.
  • the angle formed by the end portion 121 of the pillar part 120 may be formed to 10 degrees or more and 20 degrees or less. Note that, In the micro unit, the force acting on the volume (gravity and inertia) that dominated the phenomenon in the macro unit is relatively small, and the force acting on the surface area (friction and surface tension) which was negligible in the macro unit dominates the phenomenon. Accordingly, the pillar portion 120 of the present invention has an advantage that it can effectively invade the skin tissue or internal organs having a large surface tension.
  • the wiring layer 130 is made of a conductive material, and is formed on the end 121 and the substrate 110 provided in the pillar part 110 to be electrically connected between the end 121 and the substrate 110.
  • the conductive material may be made of any one material of Au, Ag, Cu, Pt.
  • the electrical signal inside the biological tissue from the outside of the biological tissue through the wiring layer 130 formed on the substrate 110 positioned outside the biological tissue without undergoing an incision for example
  • the wearable biological device 100 may further include a first insulating layer 140.
  • the first insulating layer 140 is made of an insulator so as to block an electrical signal of the body tissue in contact with the remaining area except the end 121 provided in the pillar part 120, as shown in FIGS. 1 and 2.
  • the substrate may be formed to surround the remaining area of the wiring layer 130 except for the end portion 121 and the portion of the substrate 110.
  • the pillar portion 120 except for the end 121 in the inside or outside of the biological tissue and the other portion of the substrate 110 except for the portion of the substrate 110 is the first insulating layer 140 The electrical signal transmission of the body tissue through the wiring layer 130 is blocked.
  • the first insulating layer 140 may be formed of any one selected from the group consisting of silica (SiO 2), aluminum oxide (Al 2 O 3), and parylene.
  • the wearable biological device 100 may further include a second insulating layer 150.
  • the second insulating layer 150 may be made of an insulating material, and may be formed to surround the substrate 110 and the pillar part 120.
  • the wiring layer 130 may be disposed between the first insulating layer 140 and the second insulating layer 150. Accordingly, the wiring layer 130 is configured in such a manner that the outer surface of the wiring layer 130 is entirely covered by the insulator by the first insulating layer 140 and the second insulating layer 150, thereby forming the end 121 of the pillar part 120. It has the advantage that it can effectively detect only the electrical signal of the biological tissue through.
  • the second insulating layer 150 may be formed of any one selected from the group consisting of silica (SiO 2), aluminum oxide (Al 2 O 3), and parylene, like the first insulating layer 140.
  • the pillar part 120 may include the first pillar 120a and the second pillar 120b and may be arranged on the substrate 110.
  • the wiring layer 130 may include a first wiring 130a and a second wiring 130b formed to correspond to the first pillar 120a and the second pillar 120b, respectively.
  • the first and second wires 130a and 130b may be configured to detect different types of electrical signals from inside the biological tissue, respectively.
  • the first wire 130a may be configured to acquire an electrical signal related to cholera from inside the living tissue or the internal organs
  • the second wire 130b may be configured to acquire an electrical signal related to diabetes.
  • first and second wirings 130a and 130b may be configured to cross-check the electrical signal detected through the first and second wirings 130a and 130b. It can be configured to sense the same kind of electrical signals from inside.
  • the electronic device may be configured to acquire an electrical signal related to diabetes through the first wiring 130a and the second wiring 130b.
  • first wire 130a and the second wire 130b exposed on the substrate 110 may be configured to meet each other at one point and be exposed to the outside. That is, an electrical signal may be acquired through each end of the first pillar 120a and the second pillar 120b through one point of the wiring layer 130 exposed on the substrate 110.
  • the electrical signal to the internal organs or internal organs can be detected by dividing the signal into a plurality of areas. Reduces the physical pain of the, there is an advantage that can ensure a sufficient cross-sectional area of the contact portion with the end 121 for the detection of the electrical signal.
  • the pillar portion 120 is provided with a plurality of first and second pillars (120a, 120b) arranged on the substrate 110, the wiring layer 130 is the first and second pillars First and second wirings 130a and 130b are formed on the 120a and 120b, respectively. Accordingly, the same or different types of electrical signals may be detected from the same or different biological tissues through the first and second wirings 130a and 130b and the first and second wirings 130a and 130b may be used. Cross-check of the detected electrical signals is possible, and several types of electrical signals can be detected at the same time, further reducing the time required for inspection.
  • the pillar portion is composed of the first and second pillars (120a, 120b) having a first and a second end (not shown), respectively, is arranged on the substrate 110, the wiring layer 130 is the first First and second wires 130a and 130b formed on the first and second pillars 120a and 120b, respectively, wherein the first and second ends are located at different portions within the biological tissue.
  • the first and second pillars 120a and 120b may be formed to have different heights.
  • FIG. 3 is a flowchart illustrating a method of manufacturing a wearable biodevice according to another embodiment of the present invention
  • FIG. 4 is a step-by-step view illustrating a manufacturing process according to the method of manufacturing the wearable biodevice shown in FIG. 3.
  • At least one pillar portion 120 extending in one direction as shown in FIG. 3A is formed on a substrate 110. Needle end (121) of the pillar portion 120, so that the pillar portion 120 can be inserted into the biological tissue as shown in (b) of FIG.
  • the third step (S130) to form a wiring layer 130 between the end 121 and the substrate 110 to electrically connect between the end 121 is provided and the substrate 110 located outside the biological tissue (S130) ) And a first insulating layer 140 made of an insulator on the wiring layer 130 as shown in FIG.
  • the pillar 120 may be processed by a deep reactive ion etching (DRIE) process.
  • the processing of the end 121 may be performed by polishing using an ion beam.
  • DRIE deep reactive ion etching
  • the fourth step (S140) may be performed to deposit the first insulating layer 140 by an insulator such as silica (SiO 2) or parylene by chemical vapor deposition (CVD).
  • the fifth step S150 may be performed by etching a portion of the first insulating layer 140 by laser or plasma.
  • the method of manufacturing the wearable biological device as shown in FIG. 3C, after the second step S120, the pillar part 120 and the second insulating layer 150 made of an insulator are formed.
  • the method further includes a step (S160) of depositing on the substrate 110, wherein the third step (S130) is the end portion 121 and the second insulating layer 150 is deposited on the wiring layer 130 and the It may be made to form between the substrate (110).
  • the second insulating layer 150 may be formed of an insulating material such as silica (SiO 2) or parylene.
  • Embodiments of the present invention by providing a wearable bio-device and a method of manufacturing the same having a substrate having a columnar structure having a needle-shaped end portion on one surface to effectively perform the examination of the biological tissue in the body without the incision procedure It can be applied to various industries.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

La présente invention concerne un biodispositif portable comprenant : un substrat situé à l'extérieur d'un tissu biologique ; au moins une partie de pilier s'étendant dans une direction sur le substrat, et formée de façon à être insérée dans le tissu biologique en ayant une partie d'extrémité en forme d'aiguille ; et une couche de câblage constituée d'un matériau conducteur de façon à détecter un signal électrique à l'intérieur du tissu biologique depuis l'extérieur du tissu biologique, et formée sur la partie d'extrémité, disposée dans la partie de pilier, et sur le substrat de façon à connecter électriquement la partie d'extrémité et le substrat.
PCT/KR2016/006474 2016-04-11 2016-06-17 Biodispositif portable et son procédé de fabrication Ceased WO2017179763A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020160044250A KR101887073B1 (ko) 2016-04-11 2016-04-11 웨어러블 생체소자 및 그 제조 방법
KR10-2016-0044250 2016-04-11

Publications (1)

Publication Number Publication Date
WO2017179763A1 true WO2017179763A1 (fr) 2017-10-19

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PCT/KR2016/006474 Ceased WO2017179763A1 (fr) 2016-04-11 2016-06-17 Biodispositif portable et son procédé de fabrication

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WO (1) WO2017179763A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102505313B1 (ko) * 2021-09-23 2023-03-06 주식회사 알비티 패시브 레이어를 포함하는 마이크로 니들 바이오 센서 제조 방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200418215Y1 (ko) * 2006-03-25 2006-06-09 양태유 사혈침 기구
US20060264716A1 (en) * 2005-04-25 2006-11-23 Dennis Zander Microneedle with glucose sensor and methods thereof
JP2007534343A (ja) * 2003-03-13 2007-11-29 ボストン　サイエンティフィック　リミテッド 表面電極の多重モード動作
KR20130091917A (ko) * 2012-02-09 2013-08-20 광주과학기술원 하이브리드형 미세전극 배열체 및 그것의 제조 방법
JP2014073293A (ja) * 2012-10-05 2014-04-24 O Well Corp 生体用微小神経電極針体及び生体用微小神経電極針体の製造方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007534343A (ja) * 2003-03-13 2007-11-29 ボストン　サイエンティフィック　リミテッド 表面電極の多重モード動作
US20060264716A1 (en) * 2005-04-25 2006-11-23 Dennis Zander Microneedle with glucose sensor and methods thereof
KR200418215Y1 (ko) * 2006-03-25 2006-06-09 양태유 사혈침 기구
KR20130091917A (ko) * 2012-02-09 2013-08-20 광주과학기술원 하이브리드형 미세전극 배열체 및 그것의 제조 방법
JP2014073293A (ja) * 2012-10-05 2014-04-24 O Well Corp 生体用微小神経電極針体及び生体用微小神経電極針体の製造方法

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Publication number Publication date
KR101887073B1 (ko) 2018-08-09
KR20170116458A (ko) 2017-10-19

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