WO2017179763A1 - Wearable biodevice and manufacturing method therefor - Google Patents

Abstract

Disclosed is a wearable biodevice comprising: a substrate located on the outside of a biological tissue; at least one pillar part extending in one direction on the substrate, and formed so as to be inserted into the biological tissue by having a needle-shaped end portion; and a wiring layer made of a conductive material so as to sense an electrical signal inside the biological tissue from the outside of the biological tissue, and formed on the end portion, provided in the pillar part, and on the substrate so as to electrically connect the end portion and the substrate.

Description

Wearable biological device and manufacturing method thereof

The present invention relates to a wearable biological device for sensing an electrical signal inside a living tissue and a method of manufacturing the same.

The importance of continuous health monitoring technology is more important than ever to promote national health welfare in an aging society, and finding ways to prevent disease through early diagnosis as well as treatment is a very important social issue. .

As one of methods for solving such a problem, a method of using a biodevice has been attracting attention, and such a method has been actively adopted medically.

Prevention through early diagnosis using the above-mentioned biodevices is generally attached to the membrane portion of the tissue after incision and detects cell signaling through a portion or an extracellular matrix. In other words, the blood is extracted and diagnosed according to the long-term test results.

Until now, the bio devices widely known to the general public have a function of detecting physical changes such as temperature or pressure by attaching them to the outside of the body and enclosing them in a band form, and bio devices that detect ions and biological factors occurring in the body are widely used. It is unknown.

On the other hand, bio-elements have been developed to detect the cell signal described above finely, one of which is a microneedle is inserted into the human tissue or microscopic extracellular matrix and the other is the human body of the same site It is inserted into tissue and diagnosed through cellular signals sensed by ions and biological factors present therein.

However, such bio-devices cannot be analyzed in real time, and thus, since the tissues of the subjects to be removed must be removed and analyzed in an ex vivo state, there is a problem that early diagnosis is difficult. In addition, depending on which part of the human tissue may require an incision, the stage of treatment is increased to increase the labor time of the personnel in charge, as well as the pain of the patient due to the incision and the resulting wound remains physical pain, Mental pain must be felt, and economic losses are not yet popularized for a large reason.

One object of the present invention is to provide a wearable bioelement and a method for manufacturing the same, which can effectively detect ions and biological factors constituting biological tissues in the body without undergoing an incision procedure.

In order to achieve the above object of the present invention, the wearable biological device of the present invention, the substrate located outside the biological tissue; At least one pillar portion extending in one direction on the substrate and having a needle-shaped end portion to be inserted into the biological tissue; And a conductive material so as to sense an electrical signal inside the biological tissue from the outside of the biological tissue, and formed on the end portion and the substrate provided at the pillar portion to electrically connect between the end portion and the substrate. Disclosed is a wearable biodevice comprising a wiring layer.

The wearable bio device is made of an insulator so as to block an electrical signal of the biological tissue in contact with a region other than the end portion, and is formed to surround the remaining region of the wiring layer except for the end portion and the substrate. It may further include an insulating layer.

The wearable biological device may include an insulating material and further include a second insulating layer formed to surround the substrate and the pillar, and the wiring layer may be disposed between the first insulating layer and the second insulating layer. .

The first insulating layer and the second insulating layer may be formed of any one selected from the group consisting of silica (SiO 2), aluminum oxide (Al 2 O 3), and parylene.

The cross section of the pillar portion may be formed in a circular or quadrangular shape, and the diameter or the length of one side of the pillar portion may be formed to 20 micrometers or more and 400 micrometers or less.

The height of the pillar portion may be formed to 50 micrometers or more and 1000 micrometers or less.

An angle formed by the end portion may be formed to 10 degrees or more and 20 degrees or less.

The pillar portion is composed of first and second pillars arranged on the substrate, and the wiring layer includes first and second wirings formed on the first and second pillars, respectively, and the first and second wirings. Each may be configured to detect different kinds of electrical signals from inside the biological tissue.

The pillar portion is composed of first and second pillars arranged on the substrate, and the wiring layer includes first and second wirings formed on the first and second pillars, respectively, and the first and second wirings. In order to cross-check the electrical signal detected through the first and second wires, the first and second wires may be configured to detect electrical signals of the same type from inside the biological tissue.

The pillar portion is composed of first and second pillars having first and second ends, respectively, and is arranged on the substrate, and the wiring layer includes first and second wirings formed on the first and second pillars, respectively. The first and second pillars may be formed to have different heights so that the first and second ends are positioned at different portions in the biological tissue.

In addition, the present invention, the first step of forming at least one pillar portion extending in one direction on the substrate; A second step of processing an end portion of the pillar portion into a needle shape so that the pillar portion can be inserted into the biological tissue; A wiring layer formed between the end portion and the substrate to electrically connect the end portion and the substrate positioned outside the biological tissue to enable sensing of an electrical signal inside the biological tissue outside of the biological tissue. Three steps; Depositing a first insulating layer made of an insulator on the wiring layer; And a fifth step of exposing the wiring layer to the outside by removing the first insulating layer formed on the end portion and the portion of the substrate so as to block an electrical signal of the biological tissue in contact with a region other than the end portion. Disclosed is a method of manufacturing a wearable biological device.

The method of manufacturing the wearable biodevice further includes depositing a second insulating layer formed of an insulator on the pillar part and the substrate after the second step, wherein the third step comprises depositing the wiring layer on the second layer. An insulating layer may be formed between the end portion of the substrate and the substrate.

According to the present invention, a substrate positioned outside the biological tissue, a pillar portion formed on the substrate and having a needle-shaped end portion, and made of a conductive material and formed on the substrate and the end portion of the pillar portion, A wiring layer is electrically connected between the end portion and the substrate. Accordingly, the wiring layer formed on the substrate located outside the biological tissue can effectively detect the ions and biological factors constituting the biological tissue in the body without undergoing an incision procedure, and reduce the physical and economic burden on the subject. The advantage is that early screening of the disease can be made more popular.

In addition, the present invention, the pillar portion is provided with a plurality of first and second pillars are arranged on the substrate, the wiring layer has a first and second wiring formed on the first and second pillars, respectively. According to this configuration, by detecting the same or different types of electrical signals from the same or different biological tissues through the first and second wirings, the cross-check of the electrical signals detected through the first and second wirings ( It is possible to cross-check and to detect several kinds of electrical signals at the same time, which can reduce the time required for inspection.

1 is a perspective view showing a wearable biological device according to an embodiment of the present invention.

FIG. 2 is a diagram conceptually illustrating a cross section of the wearable biodevice illustrated in FIG. 1.

3 is a flowchart illustrating a method of manufacturing a wearable biodevice according to another exemplary embodiment of the present invention.

4 is a diagram illustrating a manufacturing process according to the method of manufacturing the wearable biodevice shown in FIG. 3 step by step.

Hereinafter, a wearable biological device and a manufacturing method thereof according to the present invention will be described in detail with reference to the accompanying drawings.

Singular expressions include plural expressions unless the context clearly indicates otherwise.

Even if different embodiments, the same or similar reference numerals are given to the same or similar components as the foregoing embodiments, and redundant description thereof will be omitted.

In the following description of the embodiments disclosed herein, if it is determined that the detailed description of the related known technology may obscure the gist of the embodiments disclosed herein, the detailed description thereof will be omitted.

The accompanying drawings are only for easily understanding the embodiments disclosed in the present specification, and the technical idea disclosed in the present specification is not limited by the accompanying drawings, and all changes and equivalents included in the spirit and technical scope of the present invention are included. It should be understood to include water or substitutes.

1 is a perspective view illustrating a wearable biodevice 100 according to an exemplary embodiment of the present invention, and FIG. 2 is a view conceptually illustrating a cross section of the wearable biodevice 100 illustrated in FIG. 1.

1 and 2, the wearable bio device 100 includes a substrate 110, a pillar 120, and a wiring layer 130.

The substrate 110 may be formed in a flat plate shape and may provide a space for arranging at least one pillar 120 to be described later. The substrate 110 is located outside the living tissue, and the living tissue mainly refers to skin tissue of the human body, but may refer to a specific organ located in the body. In addition, the substrate 110 may be formed to be elastically deformable so that the surface facing the living tissue is in close contact.

The pillar portion 120 extends in one direction on the substrate 110 and has a needle-shaped end portion 121, and may be formed to be inserted into the biological tissue, and on the substrate 110. At least one may be formed. In addition, the pillar portion 120 may be formed to have a cylindrical or square column shape to have a circular or rectangular cross section, and the diameter or the length of one side of the pillar portion 120 is 20 micrometers or more and 400 micrometers or less. Can be, The height of the pillar portion 120 may be formed to 50 micrometers or more and 1000 micrometers or less. For reference, the skin tissue of the human body is composed of the stratum corneum of 10 μm to 20 μm, the epidermal layer of 70 μm to 120 μm, the dermal layer in which the blood vessel is located has a thickness of 500 μm to 3,000 μm.

Accordingly, the pillar portion 120 of the present invention can invade to the depth where the dermis layer is located. In addition, the height of the pillar portion 120 is formed to be at least 50 micrometers or more, the depth of the outer wall of the organ 50μm thickness of the organ that does not perform a normal function when the internal organs are exposed to the air by incision to diagnose the inevitable disease Invasion is possible.

In addition, the angle formed by the end portion 121 of the pillar part 120 may be formed to 10 degrees or more and 20 degrees or less. Note that, In the micro unit, the force acting on the volume (gravity and inertia) that dominated the phenomenon in the macro unit is relatively small, and the force acting on the surface area (friction and surface tension) which was negligible in the macro unit dominates the phenomenon. Accordingly, the pillar portion 120 of the present invention has an advantage that it can effectively invade the skin tissue or internal organs having a large surface tension.

The wiring layer 130 is made of a conductive material, and is formed on the end 121 and the substrate 110 provided in the pillar part 110 to be electrically connected between the end 121 and the substrate 110. Can be. The conductive material may be made of any one material of Au, Ag, Cu, Pt.

According to the present invention described above, the electrical signal inside the biological tissue from the outside of the biological tissue through the wiring layer 130 formed on the substrate 110 positioned outside the biological tissue without undergoing an incision, for example For example, it is possible to effectively detect specific ions or specific biological factors present in the body or internal organs, and through this detection method, various diseases such as cholera and diabetes can be screened. In addition, there is an advantage that can reduce the physical and economic burden of the test subject to more popularized early screening of the disease.

The wearable biological device 100 may further include a first insulating layer 140.

The first insulating layer 140 is made of an insulator so as to block an electrical signal of the body tissue in contact with the remaining area except the end 121 provided in the pillar part 120, as shown in FIGS. 1 and 2. As described above, the substrate may be formed to surround the remaining area of the wiring layer 130 except for the end portion 121 and the portion of the substrate 110. According to this structure, the pillar portion 120 except for the end 121 in the inside or outside of the biological tissue and the other portion of the substrate 110 except for the portion of the substrate 110 is the first insulating layer 140 The electrical signal transmission of the body tissue through the wiring layer 130 is blocked. Accordingly, unnecessary electrical signals to other areas of the body tissue that are not subject to the examination are blocked, and only electrical signals through the end 121 provided in the pillar part 120 are obtained to increase reliability of the examination result. It can increase. In addition, the first insulating layer 140 may be formed of any one selected from the group consisting of silica (SiO 2), aluminum oxide (Al 2 O 3), and parylene.

The wearable biological device 100 may further include a second insulating layer 150.

The second insulating layer 150 may be made of an insulating material, and may be formed to surround the substrate 110 and the pillar part 120. Here, the wiring layer 130 may be disposed between the first insulating layer 140 and the second insulating layer 150. Accordingly, the wiring layer 130 is configured in such a manner that the outer surface of the wiring layer 130 is entirely covered by the insulator by the first insulating layer 140 and the second insulating layer 150, thereby forming the end 121 of the pillar part 120. It has the advantage that it can effectively detect only the electrical signal of the biological tissue through. In addition, the second insulating layer 150 may be formed of any one selected from the group consisting of silica (SiO 2), aluminum oxide (Al 2 O 3), and parylene, like the first insulating layer 140.

Meanwhile, as illustrated in FIG. 1, the pillar part 120 may include the first pillar 120a and the second pillar 120b and may be arranged on the substrate 110. In addition, the wiring layer 130 may include a first wiring 130a and a second wiring 130b formed to correspond to the first pillar 120a and the second pillar 120b, respectively. The first and second wires 130a and 130b may be configured to detect different types of electrical signals from inside the biological tissue, respectively. For example, the first wire 130a may be configured to acquire an electrical signal related to cholera from inside the living tissue or the internal organs, and the second wire 130b may be configured to acquire an electrical signal related to diabetes.

In addition, the first and second wirings 130a and 130b may be configured to cross-check the electrical signal detected through the first and second wirings 130a and 130b. It can be configured to sense the same kind of electrical signals from inside. For example, the electronic device may be configured to acquire an electrical signal related to diabetes through the first wiring 130a and the second wiring 130b.

In addition, although not shown in the drawing, the first wire 130a and the second wire 130b exposed on the substrate 110 may be configured to meet each other at one point and be exposed to the outside. That is, an electrical signal may be acquired through each end of the first pillar 120a and the second pillar 120b through one point of the wiring layer 130 exposed on the substrate 110.

According to this structure, the same In performing the examination of the internal organs or internal organs, the electrical signal to the internal organs or internal organs can be detected by dividing the signal into a plurality of areas. Reduces the physical pain of the, there is an advantage that can ensure a sufficient cross-sectional area of the contact portion with the end 121 for the detection of the electrical signal.

According to the present invention described above, the pillar portion 120 is provided with a plurality of first and second pillars (120a, 120b) arranged on the substrate 110, the wiring layer 130 is the first and second pillars First and second wirings 130a and 130b are formed on the 120a and 120b, respectively. Accordingly, the same or different types of electrical signals may be detected from the same or different biological tissues through the first and second wirings 130a and 130b and the first and second wirings 130a and 130b may be used. Cross-check of the detected electrical signals is possible, and several types of electrical signals can be detected at the same time, further reducing the time required for inspection.

On the other hand, the pillar portion is composed of the first and second pillars (120a, 120b) having a first and a second end (not shown), respectively, is arranged on the substrate 110, the wiring layer 130 is the first First and second wires 130a and 130b formed on the first and second pillars 120a and 120b, respectively, wherein the first and second ends are located at different portions within the biological tissue. The first and second pillars 120a and 120b may be formed to have different heights.

Hereinafter, a wearable biodevice manufacturing method according to another embodiment of the present invention will be described in detail.

3 is a flowchart illustrating a method of manufacturing a wearable biodevice according to another embodiment of the present invention, and FIG. 4 is a step-by-step view illustrating a manufacturing process according to the method of manufacturing the wearable biodevice shown in FIG. 3.

3 and 4, in the method of manufacturing a wearable biodevice, first, at least one pillar portion 120 extending in one direction as shown in FIG. 3A is formed on a substrate 110. Needle end (121) of the pillar portion 120, so that the pillar portion 120 can be inserted into the biological tissue as shown in (b) of FIG. In the second step (S120) of processing to a shape, and to enable the detection of electrical signals inside the biological tissue from the outside of the biological tissue, as shown in (d) of Figure 3 to the pillar portion 120 The third step (S130) to form a wiring layer 130 between the end 121 and the substrate 110 to electrically connect between the end 121 is provided and the substrate 110 located outside the biological tissue (S130) ) And a first insulating layer 140 made of an insulator on the wiring layer 130 as shown in FIG. The end 121 as shown in (f) of FIG. 3 to block the electrical signal of the biological tissue in contact with the remaining area except the end 121, and finally, the fourth step (S140) to attach. And a fifth step S150 of exposing the wiring layer 130 to the outside by removing the first insulating layer 140 formed on a portion of the substrate 110.

In addition, in the first step S110, the pillar 120 may be processed by a deep reactive ion etching (DRIE) process. In addition, in the second step S120, the processing of the end 121 may be performed by polishing using an ion beam.

In addition, the fourth step (S140) may be performed to deposit the first insulating layer 140 by an insulator such as silica (SiO 2) or parylene by chemical vapor deposition (CVD). . In addition, the fifth step S150 may be performed by etching a portion of the first insulating layer 140 by laser or plasma.

Meanwhile, in the method of manufacturing the wearable biological device, as shown in FIG. 3C, after the second step S120, the pillar part 120 and the second insulating layer 150 made of an insulator are formed. The method further includes a step (S160) of depositing on the substrate 110, wherein the third step (S130) is the end portion 121 and the second insulating layer 150 is deposited on the wiring layer 130 and the It may be made to form between the substrate (110). In addition, the second insulating layer 150 may be formed of an insulating material such as silica (SiO 2) or parylene.

Embodiments of the present invention by providing a wearable bio-device and a method of manufacturing the same having a substrate having a columnar structure having a needle-shaped end portion on one surface to effectively perform the examination of the biological tissue in the body without the incision procedure It can be applied to various industries.

Claims (12)

A substrate located outside the biological tissue; At least one pillar portion extending in one direction on the substrate and having a needle-shaped end portion to be inserted into the biological tissue; And A wiring layer made of a conductive material and formed on the end portion and the substrate to electrically detect an electrical signal inside the biological tissue outside the biological tissue and electrically connecting the end portion and the substrate. Wearable biological device comprising a. The method of claim 1, And a first insulating layer formed of an insulator so as to block an electrical signal of the biological tissue in contact with the remaining areas except for the end, and covering the remaining area of the wiring layer except for the end and a portion of the substrate. Wearable bio device, characterized in that. The method of claim 2, It is made of an insulator, and further comprises a second insulating layer formed to surround the substrate and the pillar portion, The wiring layer may be disposed between the first insulating layer and the second insulating layer. The method of claim 3, The first insulating layer and the second insulating layer is wearable biological device, characterized in that composed of any one selected from the group consisting of silica (SiO2), aluminum oxide (Al2O3), parylene (parylene). The method of claim 1, The cross section of the pillar portion is formed in a circular or rectangular shape, the diameter of the pillar portion or the length of one side, wearable bio-element, characterized in that formed in 20 micrometers or more and 400 micrometers or less. The method of claim 1, Wearable bio-device, the height of the pillar portion is formed to 50 micrometers or more and 1000 micrometers or less. The method of claim 1, Wearable bio-device, characterized in that the angle formed by the end is formed at 10 degrees or more and 20 degrees or less. The method of claim 1, The pillar portion is composed of first and second pillars arranged on the substrate, The wiring layer has first and second wirings formed on the first and second pillars, respectively. The first and second wires may be configured to sense different types of electrical signals from inside the biological tissue, respectively. The method of claim 1, The pillar portion is composed of first and second pillars arranged on the substrate, The wiring layer has first and second wirings formed on the first and second pillars, respectively. In order to cross-check the electrical signals sensed through the first and second wires, the first and second wires are configured to sense electrical signals of the same kind from inside the biological tissue. Wearable bio device, characterized in that. The method of claim 1, The pillar portion is composed of first and second pillars having first and second ends respectively arranged on the substrate, The wiring layer has first and second wirings formed on the first and second pillars, respectively. The first and second pillars are formed to have different heights so that the first and second ends are located at different portions in the biological tissue. A first step of forming at least one pillar portion extending in one direction on a substrate; A second step of processing an end portion of the pillar portion into a needle shape so that the pillar portion can be inserted into the biological tissue; A wiring layer formed between the end portion and the substrate to electrically connect the end portion and the substrate positioned outside the biological tissue to enable sensing of an electrical signal inside the biological tissue outside of the biological tissue. Three steps; Depositing a first insulating layer made of an insulator on the wiring layer; And And a fifth step of exposing the wiring layer to the outside by removing the first insulating layer formed on the end portion and the portion of the substrate so as to block an electrical signal of the biological tissue in contact with the remaining region except the end portion. Wearable biodevice manufacturing method. The method of claim 11, After the second step, further comprising depositing a second insulating layer made of an insulator on the pillar and the substrate, In the third step, the wiring layer is formed between the substrate on which the second insulating layer is deposited and the substrate.

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