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WO2017176045A3 - 효율적인 피부 천공을 위한 마이크로니들 구조 - Google Patents

효율적인 피부 천공을 위한 마이크로니들 구조 Download PDF

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Publication number
WO2017176045A3
WO2017176045A3 PCT/KR2017/003724 KR2017003724W WO2017176045A3 WO 2017176045 A3 WO2017176045 A3 WO 2017176045A3 KR 2017003724 W KR2017003724 W KR 2017003724W WO 2017176045 A3 WO2017176045 A3 WO 2017176045A3
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WO
WIPO (PCT)
Prior art keywords
microneedle
skin
target material
present
dissolved
Prior art date
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Ceased
Application number
PCT/KR2017/003724
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English (en)
French (fr)
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WO2017176045A2 (ko
Inventor
심우선
황영민
강내규
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LG H&H Co Ltd
Original Assignee
LG Household and Health Care Ltd
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Filing date
Publication date
Application filed by LG Household and Health Care Ltd filed Critical LG Household and Health Care Ltd
Priority to US16/090,937 priority Critical patent/US20190117850A1/en
Priority to EP17779345.2A priority patent/EP3441106B1/en
Priority to CN201780022301.6A priority patent/CN109069815B/zh
Priority to CN202210808947.XA priority patent/CN115068405A/zh
Priority to JP2018552670A priority patent/JP7106186B2/ja
Publication of WO2017176045A2 publication Critical patent/WO2017176045A2/ko
Publication of WO2017176045A3 publication Critical patent/WO2017176045A3/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/042—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0259—Adhesive bandages or dressings characterised by the release liner covering the skin adhering layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
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    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
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    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 용해성 마이크로니들에 관한 것으로, 마이크로니들을 이용해 피부 천공 후, 천공된 피부를 통해 마이크로니들이 삽입되었을 때 마이크로니들이 용해됨으로써 마이크로니들 내 목적물질이 피부 내에 투여되는 마이크로니들 및 이러한 마이크로니들을 포함하는 마이크로니들 패치에 관한 것이다. 본 발명에 따른 마이크로니들을 사용하면, 적절한 기계적 강도, 점성 및 경도를 가져서 휘거나 부러지는 등의 형태 변화없이 피부 내 용이하게 삽입할 수 있고, 효과적인 피부 천공이 가능하다. 또한, 천공된 피부를 통해, 본 발명에 따른 마이크로니들이 용해되면서 목적물질의 우수한 피부 투과율을 보이므로, 강한 힘으로 가압하지 않아도 무방하고 마이크로니들의 어느 부분에 목적물질을 함유하여도 피부 내에 효과적으로 전달할 수 있다.
PCT/KR2017/003724 2016-04-05 2017-04-05 효율적인 피부 천공을 위한 마이크로니들 구조 Ceased WO2017176045A2 (ko)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US16/090,937 US20190117850A1 (en) 2016-04-05 2017-04-05 Microneedle Structure For Efficient Skin Perforation
EP17779345.2A EP3441106B1 (en) 2016-04-05 2017-04-05 Microneedle structure for efficient skin perforation
CN201780022301.6A CN109069815B (zh) 2016-04-05 2017-04-05 用于有效的皮肤穿孔的微针结构
CN202210808947.XA CN115068405A (zh) 2016-04-05 2017-04-05 用于有效的皮肤穿孔的微针结构
JP2018552670A JP7106186B2 (ja) 2016-04-05 2017-04-05 効率的な皮膚穿孔のためのマイクロニードルの構造

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020160041577A KR101719319B1 (ko) 2016-04-05 2016-04-05 효율적인 피부 천공을 위한 마이크로니들 구조
KR10-2016-0041577 2016-04-05

Publications (2)

Publication Number Publication Date
WO2017176045A2 WO2017176045A2 (ko) 2017-10-12
WO2017176045A3 true WO2017176045A3 (ko) 2018-08-02

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ID=58496132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2017/003724 Ceased WO2017176045A2 (ko) 2016-04-05 2017-04-05 효율적인 피부 천공을 위한 마이크로니들 구조

Country Status (6)

Country Link
US (1) US20190117850A1 (ko)
EP (1) EP3441106B1 (ko)
JP (1) JP7106186B2 (ko)
KR (1) KR101719319B1 (ko)
CN (2) CN115068405A (ko)
WO (1) WO2017176045A2 (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102033686B1 (ko) 2017-05-19 2019-10-18 보령제약 주식회사 도네페질을 함유하는 마이크로니들 경피 패치
US11596592B2 (en) * 2017-09-19 2023-03-07 Lg Household & Health Care Ltd. Hyaluronic acid filler using microneedle patch
CN111433001B (zh) * 2017-12-05 2022-03-18 古河电气工业株式会社 功能性构件及其制造方法
JP7324210B2 (ja) * 2018-01-31 2023-08-09 ティダブリューアイ・バイオテクノロジー・インコーポレイテッド トファシチニブを含む局所製剤
KR102703839B1 (ko) * 2018-04-24 2024-09-05 주식회사 엠씨넷 피부투과성이 우수한 다층 마이크로니들 패치의 제조 방법
KR102740968B1 (ko) * 2020-09-18 2024-12-11 강원대학교산학협력단 비타민c 유도체를 포함하는 피부미백 및 주름개선 이중기능성 마이크로니들, 이의 제조방법 및 이를 포함하는 경피전달용 패치
JP7670306B2 (ja) 2020-10-02 2025-04-30 株式会社東洋新薬 溶解型マイクロニードル製剤
KR102522220B1 (ko) 2020-11-18 2023-04-14 성창규 스피룰리나 미셀의 제조방법 및 이를 통해 제조된 스피룰리나 미셀이 탑재된 마이크로니들
KR102244030B1 (ko) * 2021-02-16 2021-04-23 주식회사 피테크 무바늘 무통주사기용 약액주입 보조 키트
WO2023080200A1 (ja) * 2021-11-05 2023-05-11 コスメディ製薬株式会社 眼科用マイクロニードルアレイ
CN114796842B (zh) * 2022-05-30 2024-03-29 深圳高性能医疗器械国家研究院有限公司 经皮药物导入结构及其制备方法、经皮药物导入系统
CN115501168A (zh) * 2022-09-20 2022-12-23 河南大学 一种双层可溶性膳食营养素透皮递送系统的构建方法
KR20250000925A (ko) 2023-06-26 2025-01-06 주식회사 톡시온 뱀독 유래 펩타이드 및 생체적합성 고분자를 포함하는 마이크로니들 형성용 조성물을 유효성분으로 포함하는 마이크로니들 패치

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JP2008029710A (ja) * 2006-07-31 2008-02-14 Hamamatsu Kagaku Gijutsu Kenkyu Shinkokai マイクロニードル型パッチ及びその製造方法
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