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WO2017037743A3 - Dabigatran etexilate 1,4-butanedisulfonate salt and its crystal form - Google Patents

Dabigatran etexilate 1,4-butanedisulfonate salt and its crystal form Download PDF

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Publication number
WO2017037743A3
WO2017037743A3 PCT/IN2016/050290 IN2016050290W WO2017037743A3 WO 2017037743 A3 WO2017037743 A3 WO 2017037743A3 IN 2016050290 W IN2016050290 W IN 2016050290W WO 2017037743 A3 WO2017037743 A3 WO 2017037743A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystal form
dabigatran etexilate
salt
butanedisulfonate
butanedisulfonate salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2016/050290
Other languages
French (fr)
Other versions
WO2017037743A2 (en
Inventor
Rajamannar Thennati
Shriprakash Dhar DWIVEDI
Kanaksinh Jesingbhai Jadav
Vijaykumar Muljibhai Patel
Rutvij Manharlal Bhatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Pharmaceutical Industries Ltd
Original Assignee
Sun Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Ltd filed Critical Sun Pharmaceutical Industries Ltd
Publication of WO2017037743A2 publication Critical patent/WO2017037743A2/en
Anticipated expiration legal-status Critical
Publication of WO2017037743A3 publication Critical patent/WO2017037743A3/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

The present invention provides a 1:1 salt of dabigatran etexilate with 1,4-butanedisulfonic acid, its crystal form and process for its preparation.
PCT/IN2016/050290 2015-09-03 2016-09-02 Dabigatran etexilate 1,4-butanedisulfonate salt and its crystal form Ceased WO2017037743A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3391MU2015 2015-09-03
IN3391/MUM/2015 2015-09-03

Publications (2)

Publication Number Publication Date
WO2017037743A2 WO2017037743A2 (en) 2017-03-09
WO2017037743A3 true WO2017037743A3 (en) 2018-09-27

Family

ID=58186977

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2016/050290 Ceased WO2017037743A2 (en) 2015-09-03 2016-09-02 Dabigatran etexilate 1,4-butanedisulfonate salt and its crystal form

Country Status (1)

Country Link
WO (1) WO2017037743A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2305665A1 (en) * 2005-06-04 2011-04-06 Boehringer Ingelheim International GmbH Polymorphs of 3-[(2-{[4-(hexyloxy carbonyl amino-imino-methyl)-phenyl amino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propion acid-ethyl ester
CN103864756A (en) * 2012-12-11 2014-06-18 四川海思科制药有限公司 Butanedisulfonic acid dabigatran etexilate and preparation method and application thereof
WO2015124764A1 (en) * 2014-02-24 2015-08-27 Erregierre S.P.A. Synthesis process of dabigatran etexilate mesylate, intermediates of the process and novel polymorph of dabigatran etexilate

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2305665A1 (en) * 2005-06-04 2011-04-06 Boehringer Ingelheim International GmbH Polymorphs of 3-[(2-{[4-(hexyloxy carbonyl amino-imino-methyl)-phenyl amino]methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propion acid-ethyl ester
CN103864756A (en) * 2012-12-11 2014-06-18 四川海思科制药有限公司 Butanedisulfonic acid dabigatran etexilate and preparation method and application thereof
WO2015124764A1 (en) * 2014-02-24 2015-08-27 Erregierre S.P.A. Synthesis process of dabigatran etexilate mesylate, intermediates of the process and novel polymorph of dabigatran etexilate

Also Published As

Publication number Publication date
WO2017037743A2 (en) 2017-03-09

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