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WO2017081335A1 - Dispositif, procédé et programme d'ordinateur pour générer un ou plusieurs signaux de stimulation électrique sacculo-utriculaire chez un patient - Google Patents

Dispositif, procédé et programme d'ordinateur pour générer un ou plusieurs signaux de stimulation électrique sacculo-utriculaire chez un patient Download PDF

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Publication number
WO2017081335A1
WO2017081335A1 PCT/ES2016/000021 ES2016000021W WO2017081335A1 WO 2017081335 A1 WO2017081335 A1 WO 2017081335A1 ES 2016000021 W ES2016000021 W ES 2016000021W WO 2017081335 A1 WO2017081335 A1 WO 2017081335A1
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WO
WIPO (PCT)
Prior art keywords
unit
patient
measurement signals
signals
stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/ES2016/000021
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English (en)
Spanish (es)
Inventor
Ángel RAMOS DE MIGUEL
Ángel RAMOS MACÍAS
María Teresa PÉREZ ZABALLOS
Juan Carlos FALCÓN GONZÁLEZ
Silvia BORKOSKI BARREIRO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de las Palmas de Gran Canaria
Original Assignee
Universidad de las Palmas de Gran Canaria
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de las Palmas de Gran Canaria filed Critical Universidad de las Palmas de Gran Canaria
Publication of WO2017081335A1 publication Critical patent/WO2017081335A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/02—Radiation therapy using microwaves
    • A61N5/04—Radiators for near-field treatment

Definitions

  • the present description refers to the electrical stimulation of the vestibular apparatus of a patient. More specifically, the present description refers to procedures for generating one or more electrical stimulation signals of! vestibular apparatus of a patient. In addition, it also refers to devices and software to bait these procedures. STATE OF THE PREVIOUS TECHNIQUE
  • the vestibular apparatus also known as the vestibular system, is the part of the inner ear and brain responsible for managing the balance and spatial control of an individual.
  • the vestibular apparatus is formed by a system of semicircular canals, which indicate the movements of rotation, and by two widening called the saccule and the utricle, which indicate the linear accelerations. Basically, the latter report the position of the head with respect to the ground.
  • a malfunction of this vestibular apparatus (for example, when the inner ear and / or the brain has been affected by a disease or accident) can give the individual a feeling of dizziness, nausea, vertigo and even insecurity and lack of security. I balance walking or making any movement.
  • REPLACEMENT SHEET (RULE 26) Therefore, there is a need for a device that at least partially solves the problems described above.
  • a device for generating one or more signals of electrical stimulation of the vestibular apparatus (more specifically, the saccule and the etricle) of a patient is described.
  • the device may comprise:
  • a measurement signal processing unit provided by a measurement unit comprising at least the following sensor elements:
  • the generation unit is configured to generate at least one electrical stimulation signal to be applied to The patient's vestibular apparatus (more specifically, the stimulation signals will be applied over the region of the saccule and / or the region of the utricle, of its vestibular apparatus).
  • the device may also comprise a unit for acomfeloncenting of the measurement signals provided by the measurement unit, this conditioning unit being configured to reduce the noise of these measurement signals before being processed by the processing uméaá .
  • this conditioning unit may comprise one or more elements of filtering of the acceleration measurement signals provided by the accelerometers comprised in the unit of measurement and one or more elements of filtering of the angelar velocity measurement signals provided by the Gyros included in the unit of measure.
  • These filtering elements can be, for example, median filters, media filters, atiaptat ⁇ vos filters and / or maximum or minimum filters or a combination of both.
  • the unit of generation of the electrical stimulation signal of the patient's vestibular apparatus can be configured to generate the one or more electrical stimulation signals from the measurement signals processed by the processing unit and determined characteristics of the patient, such as the maximum stimulation current that the patient is able to withstand, the minimum stimulation current with which the patient is able to perceive the stimulus, the maximum range of stimulation frequencies and the minimum frequency range of stimulation It will be described below how this generation unit is capable of generating the one or more effective stimulation signals from all these cited data,
  • the processing unit may comprise an element configured to apply a Kaiman filter on the measurement signals, so that the processed measurement signals may comprise the pitch, bead and yaw measurement signals, more specifically , the application of a aiman filter is suitable to achieve more precise measurement signals from the combination of the measured signals provided by the sensor elements. It is important to emphasize that these sensor elements provide measurement signals with sometimes significant errors. With the application of the Kaiman filter, three measurements are obtained (pitch, warp and yaw), which can be assumed as correct.
  • the measurement unit may comprise as sensor elements three agnetrometers to provide signals measuring the intensity of the magnetic fields on each axis.
  • the measurement signals provided by the metering unit are nine in total.
  • the presence of the magnetrometers is mainly due to the fact that they are essential sensor elements and have no drift.
  • accelerometers are very noisy sensors, that gyros give a good reading but suffer from drift and that magnetrometers are stable and have no drift
  • the accelerometers are corrected by gyroscopes, while gyroscopes are corrected. by the magnetrometers. Therefore, the presence of gynecopes magnetrometers is basically due to the measurement error of these sensor elements.
  • the subsequent application of the alman filter on the measurement signals provided by these sensor elements since it is a filter that combines the measurement signals of all the sensor elements, allows a more precise measurement to be obtained.
  • the conditioning unit of the measuring signal may further comprise one or more fritting elements of the measurement signals of the intensity of the magnetic fields on each axis provided by the magnetrámatros included in the unit of measure.
  • These filtering elements can be, for example, median filters, media filters, ad pta ive filters and / or maximum or minimum filters or a combination of both.
  • an electrical stimulation signal from the patient's vestibular apparatus generated by the generation unit may comprise a muitiygasic electrical pulse, which may comprise two or more pulses of alternating polarity, with varying amplitude and pulse width , during a period of duration of the electrical pulse and a time spacing between electrical impulses.
  • this mufllhasic electric pulse can be a biphasic pulse, one of the Impulses being positive and the other negative or the other way around (that is, it is alternating polarity), in which the pulse width and amplitude are ios same both in e! positive impulse as in the negative impulse, for each electrical stimulus.
  • the amplitude of stimulation of each electrical impulse may depend at least on the characteristics of the patient relative to the maximum stimulation current that the patient is able to withstand and the minimum stimulation current with which the patient is capable of perceiving e! stimulus. More specifically, the amplitude of each Impulse 5 can be obtained from the formula:
  • F m3 ⁇ 4s represents the maximum range of stimulation frequencies
  • F f represents the minimum range of stimulation frequencies
  • ⁇ is a standard acceleration factor that depends on the processed measurement signals, that is, in some examples, of the warp, pitch and yaw measurement signals provided by the processing unit (for example, at the output of the filter of aman, if this is the one used in the unit of
  • ⁇ can take values from -1 to 1, which correspond to the values of each of the warp, pitch and yaw measurement signals, with a maximum and a minimum (for example, -1 can correspond with a maximum warping to the right and 1 maximum warping to the left).
  • a device for generating one or more electrical stimulation signals of a patient's vestibular apparatus is described.
  • the device may be configured to:
  • measurement signals m provided by a unit of measurement comprising at least the following sensor elements:
  • the device may also be configured to condition, for part of a conditioning unit, the measurement signals provided by the measurement unit, this conditioning unit being configured to reduce the noise of these measurement signals before being processed by the unlóaü processing.
  • a procedure for generating one or more electrical stimulation signals of! vestibular apparatus of a patient may include:
  • measurement serials provided by a unit of measurement which comprises at least the following sensor elements:
  • a computer system that can comprise a memory or processor is described, instructions executable by the processor being stored in the memory and these instructions comprising functionalities for executing a procedure to generate one or more electrical stimulation signals of! a patient's vestibular apparatus, as described above.
  • REPLACEMENT SHEET (RULE 26) According to another aspect, a system for stimulating a patient's vestibular apparatus by one or more electrical stimulation signals is described.
  • This system can be an impiable device that can include:
  • a unit of measure that can comprise at least the following sensor elements:
  • the unit of measurement may further comprise three magnetromereres as sensor elements to provide signals measuring the intensity of the magnetic fields on each axis.
  • the application unit may comprise an electrode plate.
  • This electrode pad may comprise a plurality of electrodes, for example, between 7 and 12 electrodes.
  • the electrode plate may be configured to dispose at least one electrode in the region of the saccule and at least one electrode in the utricule region of the patient's vestibular apparatus.
  • the plurality of electrode may comprise at least one electrode configured to record the voltage produced by the vestibular nerve once the electrical stimulation is applied. Therefore, the system may use an electrode (or more) to perform the stimulation. , while with another electrode (or more) you can record the voltage produced by the vestibular nerve after stimulation. In this way, it is possible to know if the vestibular nerve has actually been stimulated ⁇ this functionality can be referred to as Telemetry of the Vestibular Response, in English Vestibular Respmse Teiemeiry - VRT).
  • the application unit may comprise a reference electrode, which may be configured to be disposed in the patient's mass.
  • the implant device may comprise an element s for the transmission and / or reception of energy, such as a first coil.
  • system may comprise a device external to the patient that may comprise
  • An element for the transmission and / or reception of energy connect to the power supply, such as a third coil.
  • the first coil of the impiantable device and the third 0 coil of the external device may be configured to establish an Inductive coupling.
  • the external device may comprise an element for the transmission and / or reception of data, such as a fourth coil.
  • the second coil of the impiantable device and the fourth coil of the external device may be configured to establish an inductive coupling.
  • Figure 6 shows a schematic diagram of the system shown in Figure 2, arranged in a patient according to some examples.
  • the receiving unit is configured to receive the measurement signals provided by the different sensor elements that are part of the measuring unit 1 1.
  • this receiving unit can be an element disposed between the measuring unit and the conditioning unit 16 (for example, in the form of connectors or similar to those on which, on the one hand, the measuring unit is connected and, on the other hand, the conditioning unit is connected) or it may be integrated in the same conditioning unit (for example, if the conditioning unit is part of a processor or an electronic device, the receiving unit may be pins of the own processor or electronic device intended for the reception of measurement signals). In the latter case, the measurement unit may be connected directly to the conditioning unit 16,
  • the provision unit of the one or more electrical stimulation signals may be configured to provide the one or more electrical stimulation signals generated by the generation unit 18 to the application unit 13.
  • this provisioning unit may be an element disposed between the generating unit 18 and the application unit 13 of the one or more electrical stimulation signals (for example, in the form of collectors or similar to those which, by a on the other hand, the generation unit is connected and v on the other side, the application unit is connected) or it can be integrated in the same generation unit (for example, if the generation unit is part of a processor or of a device electronic, the provisioning unit may be pins of the own processor or electronic device intended for the provision of the one or more electrical stimulation signals. ⁇ In the latter case * the generation unit may be directly connected to the application unit * by For example, by welding or any other fixing means, it could even be understood that this provisioning unit does not exist in the device.
  • the application unit 13 of the one or more electrical stimulation signals may comprise an electrode plate 40, this electrode plate 40 being formed by a support 41 and a plurality of electrode 42 ⁇ for example, between seven and twelve electrodes ⁇ tai as shown in Figure 4.
  • the plate holder 41 may have a flat configuration.
  • REPLACEMENT SHEET (RULE 26) say, on the macula), it would possibly be sufficient to use two electrodes for each X, Y and Z axis.
  • the plurality of electrodes 42 may comprise a! less an electrode configured to record the voltage produced by the vestibular nerve once the electrical stimulation has been applied. Therefore, the system can use one or more electrodes to perform the stimulation, while with another electrode (or more) it can record the voltage produced by the vestibular nerve after stimulation ⁇ WO * ⁇ . In this way, it is possible to know if it has really been possible to stimulate e! vestibular nerve
  • the application unit 13 can also comprise a reference electrode, which can be arranged in the patient's eimastoids.
  • the generating unit 18 has generated the one or more electrical stimulation signals, it is necessary to send to each electrode selected according to its position in the macula, the electrical stimulus.
  • the positions of the electrodes in the macula are defined du ⁇ 3 ⁇ 4r> e the activation of the system 10 and can be generated, for example, a table, a repository or the like ⁇ it can be stored in for example a memory comprised in the system 10, more specifically in the implantable device) in which data concerning, patiently, which electrode stimulates which regions (saccule, utricle) of the vestibular apparatus are stored.
  • the system 10 for stimulating the patient's vestibular apparatus, apart from the implantable device described up to this point, can also comprise an external device.
  • This external device may comprise a de..alimentaissus electronics system (both the external device and the implantable device) source, such as as' ba and IA: ⁇ ft ⁇ o ion, a nickel -cadmio, etc., as well as, an element for the transmission and / or reception of energy, such as a third coil, connected to the power supply.
  • a EMAs "This external device may also comprise an element for the transmission and / or reception of data, such as a fourth coil.
  • the third coil of the element for the transmission and / or reception of energy and the 0 fourth coil of the element for the transmission and / or reception of data may be the same coil.
  • the implantable device comprises the first and second coils and the external device comprises the third and fourth coils
  • two inductive couplings would be produced, one between the coils intended for the transmission and / or reception of energy (first and third coils) and another between the coils intended for the transmission and / or reception of data between the devices (second and fourth coils).
  • the calibration process of the sensor elements is carried out at the first activation, before deciding which electrodes are to be stimulated, given that the sensors are implanted in the patient and are fixed. Thus, this should be done only during the activation of the implant, unless a strong blow, accident, etc. may cause the implantable device to move from its position.
  • the calibration process basically consists of putting the patient's head in such a way that it is completely upright (that is, the patient has to be in a sitting or standing position, with a stiff head looking straight ahead). Thus, it is defined that this position is state 0, the system registering the values of its sensor elements (accelerometers, gyroscopes, magnetrometers). From these values, by means of a numerical calculation (a rotation matrix), the output of the measurement signals of the sensor elements to the position of the patient's head is calibrated.
  • REPLACEMENT SHEET (RULE 26) In the external device all the data generated and / or obtained in the implanted device are collected, such as the electrical impedance of the tissue for each “no of the electrodes, the response of the vestibular nerve to an electrical stimulus (VRT) or the state general of the im ⁇ ntantabie device.
  • the conditioning unit 16 configured to reduce the noise of these measurement signals before being processed by the unit 1? of processing and the unit of measurement comprising at least the following sensor elements:
  • the conditioning stage of the described procedure would only be possible in those examples in which the device 12 comprises the conditioning unit.
  • this device 2 (that is, the different units that comprise it) to generate the one or more electrical stimulation signals described above can be used according to different configurations.
  • the device can be a computer system, understood as any set of interrelated parts (basically hardware and software) that allows
  • REPLACEMENT SHEET (RULE 26) storing and processing information, part of the hardware may include computers or any other type of intelligent electronic device, consisting of processors, memory, ate, suitable to be implanted in the patient.
  • the software may include operating systems, firmware and applications.
  • the device 12 for generating the one or more electrical stimulation signals may be a computer system comprising a memory and a processor, executable instructions for the processor being stored in the memory and these instructions comprising functionalities for executing the procedure for generating «Na or more electrical stimulation signals of the vestibular apparatus of a patient described above.
  • These instructions executable by the processor can form a computer program to cause e! computer system can execute the procedure described.
  • This computer program may be stored in physical storage media, such as recording media, computer memory, or read-only memory, or it may be carried by a carrier wave, such as electrical or optical.
  • the computer program may be in the form of source code, object code or in an Intermediate code between source code and object code, such as in partially compiled form, or in any other form suitable for use in the implementation of the described procedure.
  • the carrier medium can be any ntaritód or device capable of carrying the program.
  • the carrier medium may comprise a storage medium, such as a ROM, for example a CD ROM or a semiconductor O, or a magnetic recording medium, for example an uro disk.
  • the carrier means can be a transmissible carrier medium such as an electrical or optical signal that can be transmitted via electrical or optical cable or by radio or other means.
  • the carrier medium may be constituted by said cable or other device or medium, alternate, the carrier medium may be an integrated circuit. that the computer program is capped (embedded), said integrated circuit being adapted to perform or for use in carrying out the described procedures.
  • each unit (the conditioning unit 18, the processing unit 17 and the generation unit 18) that makes up the device 12 can be a Computer system by itself, such as the design, or the same computer system can comprise several or all of the units.
  • each of these units 16,17,10 of the device 12 can be connected by electronic means, computer means or a combination of both.
  • Examples of a device 12 comprising only electronic means ⁇ ie, a purely electronic configuration can be a programmable electronic device such as a CPLD ⁇ Logic Devices Prog maÉi & s Complex ⁇ Comp ⁇ ex Progra mahiB Logic Dome), an FPGA (Programmable Door Matrix of C & mpo - Fi & ⁇ Programmable (£ & t® ⁇ ? y ⁇ or ASIC (Ckc itQ integrated by Apiicac ms Esp & ifiom - Appiiáafiof ⁇ -Spec ⁇ fi int & grat & Ci wiX suitable for implanting itself patient.
  • Examples of a device 12 that only includes computer means they can be the computer system described above.
  • Examples of a device 12 comprising a combination of computer media and electronic media may be a computer system such as ios described above in
  • FIG. 8 shows a possible anatomical arrangement in the patient of! system 10 to stimulate the patient's vestibular apparatus by means of one or more electrical stimulation signals, the system of which can correspond to the system examples described in particular, this point is sufficient, in the figure the arrangement of the external device 50 can be seen, which comprises a source of supply and a coil, and of the implanfabte device 51.
  • a coil 52 can be seen, which inductively engages with the coil (not shown) of the external device 50 for feeding the electronics of the implantadle device 51, as well as for the exchange of data between both devices; a housing 53 in which the different sensor elements (accelerometers, gyroscopes - and / or magnetrometers) and the device 12 are housed to generate one or more electrical stimulation signals of the patient's vestibular apparatus from the measurement signals obtained by the sensor elements; a cable 54 connecting the device 12 to generate one or more electrical stimulation signals with the electrode plate 40 (application unit 3) in which the plurality of metal electrodes 42 configured to effect the electrical stimulations of the macula are housed (utricle and saccule) of the vestibular nerve; and a reference electrode 55.
  • the electrode plate 40 application unit 3

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Otolaryngology (AREA)
  • Electrotherapy Devices (AREA)
  • Gyroscopes (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La description se rapporte à un dispositif (12) destiné à générer un ou plusieurs signaux de stimulation électrique de l'appareil vestibulaire (saccule, utricule) d'un patient. Le dispositif est caractérisé en ce qu'il est composé d'une unité (17) de traitement de signaux de mesure fournis par une unité (11) de mesure qui comprend au moins trois accéléromètres (14a) destinés à fournir des signaux de mesure d'accélération, et trois gyroscopes (14b) destinés à fournir des signaux de mesure de vitesse angulaire, l'unité de traitement étant configurée pour supprimer les erreurs des signaux de mesure; et une unité (18) de génération desdits un ou plusieurs signaux de stimulation électrique de l'appareil vestibulaire du patient, au moins à partir des signaux de mesure traités par l'unité de traitement (17).
PCT/ES2016/000021 2015-11-12 2016-02-05 Dispositif, procédé et programme d'ordinateur pour générer un ou plusieurs signaux de stimulation électrique sacculo-utriculaire chez un patient Ceased WO2017081335A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP201500835 2015-11-12
ES201500835A ES2616246A1 (es) 2015-11-12 2015-11-12 Dispositivo, procedimiento y programa informático para generar o una o más señales de estimulación eléctrica sáculo utricular de un paciente

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3769809A1 (fr) 2019-07-24 2021-01-27 Cochlear Limited Prothèse de stimulation vestibulaire
EP3769810A1 (fr) * 2019-07-24 2021-01-27 University of Las Palmas de Gran Canaria Stimulation du nerf vestibulaire
US11806530B2 (en) 2020-04-21 2023-11-07 Cochlear Limited Balance compensation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060282A2 (fr) * 2000-02-16 2001-08-23 Massachusetts Eye & Ear Infirmary Prothese d'equilibrage
US20130066424A1 (en) * 2011-09-09 2013-03-14 Med-El Elektromedizinische Geraete Gmbh Vestibular Implant Parameter Fitting
WO2013134873A1 (fr) * 2012-03-12 2013-09-19 The Hospital For Sick Children Systèmes et procédés de stabilisation d'équilibre
WO2014165462A1 (fr) * 2013-04-01 2014-10-09 Motion Therapeutics Inc. Méthode et appareil de médiation par capteurs de peau et de corps proprioceptifs, de la sensation visuelle, vestibulaire et de somatique agissant en association avec la fonction cérébrale ou la fonction du système moteur neurosensoriel
US20150039057A1 (en) * 2010-01-12 2015-02-05 The Johns Hopkins University Implantable vestibular prosthesis
WO2015077773A1 (fr) * 2013-11-25 2015-05-28 Massachusetts Eye & Ear Infirmary Implants cochléaires basse puissance

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001060282A2 (fr) * 2000-02-16 2001-08-23 Massachusetts Eye & Ear Infirmary Prothese d'equilibrage
US20150039057A1 (en) * 2010-01-12 2015-02-05 The Johns Hopkins University Implantable vestibular prosthesis
US20130066424A1 (en) * 2011-09-09 2013-03-14 Med-El Elektromedizinische Geraete Gmbh Vestibular Implant Parameter Fitting
WO2013134873A1 (fr) * 2012-03-12 2013-09-19 The Hospital For Sick Children Systèmes et procédés de stabilisation d'équilibre
WO2014165462A1 (fr) * 2013-04-01 2014-10-09 Motion Therapeutics Inc. Méthode et appareil de médiation par capteurs de peau et de corps proprioceptifs, de la sensation visuelle, vestibulaire et de somatique agissant en association avec la fonction cérébrale ou la fonction du système moteur neurosensoriel
WO2015077773A1 (fr) * 2013-11-25 2015-05-28 Massachusetts Eye & Ear Infirmary Implants cochléaires basse puissance

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3769809A1 (fr) 2019-07-24 2021-01-27 Cochlear Limited Prothèse de stimulation vestibulaire
EP3769810A1 (fr) * 2019-07-24 2021-01-27 University of Las Palmas de Gran Canaria Stimulation du nerf vestibulaire
US11351372B2 (en) 2019-07-24 2022-06-07 Universidad De Las Palmas De Gran Canaria Vestibular nerve stimulation
EP4353300A1 (fr) * 2019-07-24 2024-04-17 University of Las Palmas de Gran Canaria Stimulation du nerf vestibulaire
US12121723B2 (en) 2019-07-24 2024-10-22 Universidad De Las Palmas De Gran Canaria Vestibular nerve stimulation
US12186560B2 (en) 2019-07-24 2025-01-07 Cochlear Limited Vestibular stimulation prosthesis
US11806530B2 (en) 2020-04-21 2023-11-07 Cochlear Limited Balance compensation

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