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WO2016121650A1 - Composition de dentifrice - Google Patents

Composition de dentifrice Download PDF

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Publication number
WO2016121650A1
WO2016121650A1 PCT/JP2016/051874 JP2016051874W WO2016121650A1 WO 2016121650 A1 WO2016121650 A1 WO 2016121650A1 JP 2016051874 W JP2016051874 W JP 2016051874W WO 2016121650 A1 WO2016121650 A1 WO 2016121650A1
Authority
WO
WIPO (PCT)
Prior art keywords
dentifrice composition
mass
oil
sodium
composition according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2016/051874
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English (en)
Japanese (ja)
Inventor
深澤　哲
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to CN201680007255.8A priority Critical patent/CN107205900A/zh
Priority to KR1020177016627A priority patent/KR20170104996A/ko
Publication of WO2016121650A1 publication Critical patent/WO2016121650A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention has a high dentinal tubule sealing effect and an excellent pH lowering suppression effect, suppresses the pH drop over time, has a good metallic feel and a good feeling of use, and contains aluminum lactate suitable for suppressing hypersensitivity It relates to a dentifrice composition.
  • Aluminum lactate has dentinal tubule stenosis occlusion and is effective in preventing or treating dentin hypersensitivity, but when aluminum lactate is added to the oral composition, the pH decreases over time, and it tends to become acidic. There have been problems of decalcification of the teeth and exfoliation of the oral mucosa and poor stability, and the appearance of a metallic taste peculiar to aluminum has also been a problem.
  • Patent Document 1 Japanese Patent Laid-Open No. 10-231237
  • Patent Document 2 Japanese Patent Laid-Open No. 2013-119520 discloses an anionic surfactant, a specific water-soluble polymer substance, a dentifrice composition containing potassium nitrate and / or aluminum lactate
  • Patent Document 3 Japanese Patent Laid-Open No. 7-165550 discloses that it is effective in preventing and treating dentinal hypersensitivity.
  • an oral composition an oral band (Example 7) containing aluminum lactate and sodium pyrophosphate is described.
  • Patent Document 4 Japanese Patent Application Laid-Open No. 2002-302429 proposes a non-aqueous oral composition in which aluminum lactate is blended as an acidic component together with a non-aqueous oral composition base material and baking soda to improve bitterness and itchiness.
  • Patent Document 5 Japanese Patent Application Laid-Open No. 2004-268166 discloses that aluminum lactate, sodium pyrophosphate, sodium polyphosphate, and the like can be blended in a solid dosage form oral composition.
  • the present invention has been made in view of the above circumstances.
  • Aluminum lactate exhibits a high dentinal tubule sealing effect and is excellent in pH lowering suppression effect, suppressed pH decrease over time, and suppressed metallic taste and good usability. It aims at providing the dentifrice composition containing.
  • the present inventor has found (A) a dentifrice composition containing 0.01 to 5% by mass of aluminum lactate and (B) 0.01 to 5% of condensed phosphate.
  • A a dentifrice composition containing 0.01 to 5% by mass of aluminum lactate and (B) 0.01 to 5% of condensed phosphate.
  • B 0.01 to 5% of condensed phosphate.
  • C ⁇ -olefin sulfonate
  • the metal taste was suppressed, the usability was improved, and it was found that it can be suitably used to suppress hypersensitivity, and the present invention has been made.
  • a dentifrice composition containing aluminum lactate does not contain pyrophosphate and ⁇ -olefin sulfonate, and does not contain anionic surfactant sodium lauryl sulfate.
  • the pH decreases over time, the pH fluctuates, the metal taste appears and the taste is poor (Comparative Example 7), and either pyrophosphate and ⁇ -olefin sulfonate are blended. If the amount is inadequate, the pH will drop, or a metallic taste or oily feeling will appear and the feeling of use will worsen (Comparative Examples 3 to 6).
  • the present invention provides the following dentifrice composition and a method for suppressing the decrease in pH and expression of metallic taste in the dentifrice composition.
  • [1] (A) 0.01-5% by mass of aluminum lactate, (B) 0.01-5% by mass of condensed phosphate, and (C) 0.1-3% by mass of ⁇ -olefin sulfonate.
  • a dentifrice composition characterized by comprising [2] The dentifrice composition according to [1], wherein the condensed phosphate of component (B) is pyrophosphate or tripolyphosphate.
  • (B) / (A) has a mass ratio of 0.005 to 50, and (C) / (A) has a mass ratio of 0.05 to 100, and the pH reduction in the dentifrice composition according to [8] A method for suppressing the expression of metallic taste.
  • (D) A method for suppressing a decrease in pH and expression of metallic taste in the dentifrice composition according to [8] or [9], wherein 0.1 to 7% by mass of potassium nitrate is blended.
  • a dentifrice composition containing aluminum lactate suitable for suppression can be provided.
  • the dentifrice composition of the present invention contains (A) aluminum lactate, (B) condensed phosphate, and (C) ⁇ -olefin sulfonate.
  • (A) Aluminum lactate is a reaction product of lactic acid and metallic aluminum, is represented by the chemical formula C 9 H 15 AlO 9 , and is a white, odorless powder. As an effect on the teeth, a dentinal tubule sealing effect that narrows or occludes the dentinal tubule is known, and has an effect of reducing dentinal hypersensitivity caused by exposure of the dentinal tubule.
  • Commercially available aluminum lactate can be used.
  • the blending amount of the component (A) aluminum lactate is 0.01 to 5% (mass%, hereinafter the same) of the whole composition, preferably 0.1 to 3%, more preferably 1 to 2%. It is.
  • the combination of (B) condensed phosphate and (C) ⁇ -olefin sulfonate gives a high dentinal tubule sealing effect and an excellent pH reduction inhibiting effect, and also provides a feeling of use. Improve. If the component (B) is absent, the pH drop cannot be suppressed, and if the component (C) is absent, the metallic taste is not suppressed and the usability is poor.
  • a linear or cyclic condensed phosphate represented by the following general formula (1) or (2) may be used.
  • M represents Na or K
  • n is an integer of 2 or more
  • m is an integer of 3 or more.
  • These condensed phosphates can be used singly or in combination of two or more, and among them, linear water-soluble condensed phosphates are preferable, and pyrophosphates, tripolyphosphates, especially pyrophosphoric acid are particularly preferable. A salt is more preferable, and a sodium salt is still more preferable.
  • commercially available products can be used, for example, sodium pyrophosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Tohoku Chemical Co., Ltd.), potassium pyrophosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Toagosei Co., Ltd.) ), Sodium tripolyphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Central Glass Co., Ltd., Nippon Builder Co., Ltd.) and the like can be used.
  • sodium pyrophosphate manufactured by Taihei Chemical Sangyo Co., Ltd., Tohoku Chemical Co., Ltd.
  • potassium pyrophosphate manufactured by Taihei Chemical Sangyo Co., Ltd., Toagosei Co., Ltd.
  • Sodium tripolyphosphate manufactured by Taihei Chemical Sangyo Co., Ltd., Central Glass Co., Ltd., Nippon Builder Co., Ltd.
  • the blending amount of the (B) component condensed phosphate is 0.01 to 5%, preferably 0.1 to 1%, more preferably 0.3 to 0.5% of the entire composition. If the blending amount is 0.01% or more, a satisfactory pH reduction suppressing effect can be imparted. If too much is added, it is suitable for improving the feeling of use, and if it exceeds 5%, the metallic taste is strongly developed and the feeling of use is lowered.
  • an alkali metal salt such as a sodium salt or potassium salt of an ⁇ -olefin sulfonic acid having 14 to 16 carbon atoms can be used, and an ⁇ -olefin sulfonic acid having 14 carbon atoms can be used. Salts, particularly sodium salts (generic name; sodium tetradecenesulfonate) are preferred.
  • these ⁇ -olefin sulfonates commercially available products can be used.
  • sodium tetradecene sulfonate ( ⁇ -olefin (C14) sodium sulfonate, manufactured by Lion Specialty Chemicals Co., Ltd., “K Lipolane PJ-400CJ”) and the like can be used.
  • the ⁇ -olefin sulfonate may contain a hydroxyalkyl sulfonate as a by-product, and the ratio is not particularly limited, but is usually 20% or less. Acid salts can be used in the present invention.
  • the blending amount of the component (C) ⁇ -olefin sulfonate is 0.1 to 3% of the total composition, preferably 0.5 to 2%, more preferably 0.7 to 1.5%. is there. A feeling in use can be improved as it exists in the range of the said compounding quantity. If the blending amount is less than 0.1%, the metal taste cannot be suppressed, and if it exceeds 3%, an oily feeling is strongly expressed, the taste is poor and the feeling of use is inferior.
  • (B) / (A) indicating the blending amount of the component (B) with respect to the blending amount of the component (A) can be 0.005 to 50 as the mass ratio, preferably 0.005 to 5 More preferably, it is 0.1-3.
  • (C) / (A) indicating the blending amount of the component (C) with respect to the blending amount of the component (A) can be 0.05 to 100 as a mass ratio, preferably 0.05 to 3, More preferably, it is 0.3 to 1.
  • the effect of this invention is more excellent in (B) / (A) and / or (C) / (A) being in the range of the said ratio.
  • (D) potassium nitrate can be mix
  • the blending amount of component (D) potassium nitrate is preferably 0.1 to 7%, more preferably 0.5 to 5% of the total composition. Addition within this range is suitable for enhancing the effect of suppressing hypersensitivity. Moreover, it is suitable also in the suppression effect of pH fall of this invention, and suppression of expression of a metallic taste.
  • the dentifrice composition of the present invention preferably has a pH at 25 ° C. of 5 or more, particularly 5 to 10, more preferably 6 to 8, and is preferably adjusted to such a pH.
  • a pH adjuster for example, hydroxide of alkali metals, such as sodium hydroxide, hydrogencarbonate, carbonate, etc. can also be added.
  • the dentifrice composition of the present invention is suitably prepared as a toothpaste, such as a toothpaste, a liquid toothpaste, and a toothpaste.
  • a toothpaste such as a toothpaste, a liquid toothpaste, and a toothpaste.
  • another well-known component can be mix
  • an abrasive, a binder, a thickener, a surfactant, and a sweetener, a colorant, a preservative, a fragrance, an active ingredient, and the like can be blended as necessary.
  • water can be mix
  • abrasive examples include silica-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, calcium phosphate-based compounds, calcium carbonate, aluminum hydroxide, and synthetic resin-based abrasives.
  • the blending amount of the abrasive is usually 10 to 50% for toothpaste and 0 to 30% for liquid toothpaste.
  • binder examples include gums such as carrageenan and xanthan gum, organic binders such as cellulose derivatives such as carboxymethylcellulose sodium, and inorganic binders such as gelling silica and gelling aluminum silica.
  • the amount of the binder is usually 0.1 to 10%, preferably 0.1 to 5% for toothpaste and 0 to 5% for liquid toothpaste.
  • the thickener examples include sugar alcohols such as sorbit, xylit, and propylene glycol, and polyhydric alcohols.
  • the blending amount of the thickener is usually 5 to 50%, particularly preferably 20 to 45%.
  • an anionic surfactant As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant can be blended.
  • the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate.
  • Nonionic surfactants include polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 5 to 60, sugar fatty acid esters, sugar alcohol fatty acid esters, polyglycerin fatty acid esters, polyoxy Examples include ethylene higher alcohol ethers.
  • Examples of cationic surfactants include alkylammonium types, and examples of amphoteric surfactants include betaine types and imidazoline types. The blending amount of the surfactant can be adjusted according to the form, purpose of use, and the like, for example, 0 to 10% for toothpaste and 0 to 5% for liquid toothpaste.
  • sweeteners include sodium saccharin and the like, and examples of colorants include blue No. 1, yellow No. 4, and titanium dioxide.
  • colorants include blue No. 1, yellow No. 4, and titanium dioxide.
  • preservative include paraoxybenzoic acid esters such as methyl paraben and ethyl paraben, benzoic acid or a salt thereof.
  • Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, bran oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfumed, menthol, moss Bonn, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxyprop
  • the blending amount is not particularly limited, but the above fragrance material is preferably used at 0.000001 to 1% in the preparation composition.
  • the flavoring fragrance using the fragrance material is preferably used in an amount of 0.1 to 2% in the preparation composition.
  • the active ingredient known ingredients that are usually blended in dentifrice compositions, such as bactericides, anti-inflammatory agents, enzymes, fluorides, plant extracts, tartar inhibitors, dental plaque inhibitors, and the like can be blended.
  • bactericides such as isopropylmethylphenol
  • cationic fungicides such as isopropylmethylphenol
  • cationic fungicides tranexamic acid
  • anti-inflammatory agents such as allantoin
  • enzymes such as dextranase, sodium fluoride, sodium monofluorophosphate, etc. Fluoride etc.
  • the said active ingredient can be mix
  • Dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by a conventional method and evaluated by the following methods. The results are shown in Tables 1 to 3. In addition, the dentifrice composition was adjusted so that pH in 25 degreeC might be set to 7.0.
  • ⁇ Evaluation method> Evaluation method of dentinal tubule sealing effect According to the method of Pashley et al. (J. Dent. Res. 57, 187-193, 1987), the permeability of dentinal tubule fluid was measured, and dentinal tubules by each dentifrice composition The degree of blockade of was evaluated. A dentin block was cut out from a human tooth root and polished with water-resistant abrasive paper # 2000 to prepare a sample, which was used as a sample.
  • Passability suppression rate (%) ((Amount of fluid before treatment -Amount of fluid after treatment) / (Amount of fluid before treatment)) ⁇ 100 Passage volume: Saline volume ( ⁇ L) passing in 10 minutes
  • the degree of dentinal tubule sealing was judged from the average value of the obtained permeability inhibition rate according to the following evaluation criteria, and the dentinal tubule sealing effect was evaluated. Evaluation criteria for ivory tubule sealing effect; A: The permeability inhibition rate is 90% or more. O: The permeability inhibition rate is 80% or more and less than 90%. ⁇ : The permeability inhibition rate is 60% or more and less than 80%. X: The permeability inhibition rate is 60. Less than%
  • pH change amount is less than 0.5 ⁇ : pH change amount is 0.5 or more and less than 1.0 ⁇ : pH change amount is 1.0 or more and less than 1.5 ⁇ : pH change amount is 1.5 or more
  • the raw materials used are the same as described above, and the pH of the preparation at 25 ° C. is in the range of 5-10.
  • Dentifrice (A) Aluminum lactate 1.5 (B) Sodium pyrophosphate 1 (C) Sodium ⁇ -olefin sulfonate 1 (D) Potassium nitrate 5 Sodium monofluorophosphate 1.1 Silicic anhydride 20 Sodium lauryl sulfate 1.5 70% sorbite solution 30 Propylene glycol 3 Xanthan gum 0.8 Saccharin sodium 0.3 Fragrance 1.4 Water balance Total 100.0%

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition de dentifrice qui présente un excellent effet de scellement des tubules dentinaires fins, supprime efficacement une diminution du pH, présente une diminution contrôlée du pH au cours du temps, produit une suppression du goût métallique et une sensation agréable lors de l'utilisation et est utilisable de manière appropriée pour inhiber l'hyperesthésie dentinaire, ladite composition de dentifrice comprenant : (A) 0,01 à 5 % en masse de lactate d'aluminium ; (B) de 0,01 à 5 % en masse d'un phosphate condensé ; et (C) 0,1 à 3 % en masse d'un acide α-oléfinesulfonique. L'invention concerne également un procédé pour supprimer une diminution du pH et l'expression d'un goût métallique dans ladite composition de dentifrice mentionnée ci-dessus, ledit procédé comprenant le mélange d'une composition de dentifrice contenant 0,01 à 5 % en masse de composant (A) avec 0,01 à 5 % en masse de composant (B) et 0,1 à 3 % en masse de composant (C).
PCT/JP2016/051874 2015-01-26 2016-01-22 Composition de dentifrice Ceased WO2016121650A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201680007255.8A CN107205900A (zh) 2015-01-26 2016-01-22 洁齿剂组合物
KR1020177016627A KR20170104996A (ko) 2015-01-26 2016-01-22 치마 조성물

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-012486 2015-01-26
JP2015012486A JP2016138047A (ja) 2015-01-26 2015-01-26 歯磨組成物

Publications (1)

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WO2016121650A1 true WO2016121650A1 (fr) 2016-08-04

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JP (1) JP2016138047A (fr)
KR (1) KR20170104996A (fr)
CN (1) CN107205900A (fr)
WO (1) WO2016121650A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021172213A1 (fr) * 2020-02-25 2021-09-02 富士フイルム株式会社 Matériau biocompatible

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7031253B2 (ja) * 2017-11-29 2022-03-08 ライオン株式会社 歯磨剤組成物
US11071704B2 (en) * 2017-12-27 2021-07-27 Kao Corporation Oral composition
JP7388126B2 (ja) * 2018-11-01 2023-11-29 ライオン株式会社 口腔用組成物

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07165550A (ja) * 1994-03-22 1995-06-27 Lion Corp 口腔用組成物
JP2000302655A (ja) * 1999-04-16 2000-10-31 Kao Corp 口腔用組成物
JP2001172146A (ja) * 1999-12-21 2001-06-26 Kobayashi Pharmaceut Co Ltd 口腔用組成物
JP2002302429A (ja) * 2001-04-03 2002-10-18 Nippon Zettoc Co Ltd 口腔用組成物
JP2009155216A (ja) * 2007-12-25 2009-07-16 Lion Corp 口腔用組成物
JP2010037290A (ja) * 2008-08-06 2010-02-18 Cmic Ss Cmo Co Ltd 歯磨剤
JP2011105690A (ja) * 2009-11-20 2011-06-02 Lion Corp 液体口腔用組成物
WO2015008823A1 (fr) * 2013-07-18 2015-01-22 ライオン株式会社 Agent d'élimination de biofilm de la cavité buccale et composition pour cavité buccale

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07165550A (ja) * 1994-03-22 1995-06-27 Lion Corp 口腔用組成物
JP2000302655A (ja) * 1999-04-16 2000-10-31 Kao Corp 口腔用組成物
JP2001172146A (ja) * 1999-12-21 2001-06-26 Kobayashi Pharmaceut Co Ltd 口腔用組成物
JP2002302429A (ja) * 2001-04-03 2002-10-18 Nippon Zettoc Co Ltd 口腔用組成物
JP2009155216A (ja) * 2007-12-25 2009-07-16 Lion Corp 口腔用組成物
JP2010037290A (ja) * 2008-08-06 2010-02-18 Cmic Ss Cmo Co Ltd 歯磨剤
JP2011105690A (ja) * 2009-11-20 2011-06-02 Lion Corp 液体口腔用組成物
WO2015008823A1 (fr) * 2013-07-18 2015-01-22 ライオン株式会社 Agent d'élimination de biofilm de la cavité buccale et composition pour cavité buccale

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021172213A1 (fr) * 2020-02-25 2021-09-02 富士フイルム株式会社 Matériau biocompatible
JPWO2021172213A1 (fr) * 2020-02-25 2021-09-02
JP7377945B2 (ja) 2020-02-25 2023-11-10 富士フイルム株式会社 生体適合性材料

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KR20170104996A (ko) 2017-09-18
JP2016138047A (ja) 2016-08-04
CN107205900A (zh) 2017-09-26

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