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WO2013077127A1 - Composition de dentifrice et agent pour favoriser la recalcification des dents - Google Patents

Composition de dentifrice et agent pour favoriser la recalcification des dents Download PDF

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Publication number
WO2013077127A1
WO2013077127A1 PCT/JP2012/077286 JP2012077286W WO2013077127A1 WO 2013077127 A1 WO2013077127 A1 WO 2013077127A1 JP 2012077286 W JP2012077286 W JP 2012077286W WO 2013077127 A1 WO2013077127 A1 WO 2013077127A1
Authority
WO
WIPO (PCT)
Prior art keywords
dentifrice composition
remineralization
polyethylene glycol
calcium carbonate
component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2012/077286
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English (en)
Japanese (ja)
Inventor
誠 吉江
佐野　浩史
剛太郎 飯泉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to CN201280057760.5A priority Critical patent/CN103974689B/zh
Priority to PH1/2014/501027A priority patent/PH12014501027B1/en
Priority to KR1020147010267A priority patent/KR101909321B1/ko
Publication of WO2013077127A1 publication Critical patent/WO2013077127A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a dentifrice composition and a tooth remineralization accelerator that are excellent in the effect of promoting tooth remineralization and effective in preventing dental caries.
  • the calcium concentration in human saliva is said to be about 1.0 to 3.0 mM, and if more calcium ions are present, the saturation with respect to hydroxyapatite increases and remineralization has been promoted for a long time.
  • the saturation with respect to hydroxyapatite increases and remineralization has been promoted for a long time.
  • colloidal calcium carbonate is used as a neutralizing agent for acid produced in plaque, and as a result of neutralization, it is released into the oral cavity as Ca 2+ ions (patented) (Reference 1: Japanese Patent Laid-Open No. 9-295924), calcium phosphate compounds, eggshell, cereal powder, etc. are mixed and fermented, and the liquefied substance is used in the oral cavity to promote remineralization and whiten the teeth.
  • Patent Document 2 JP-A-8-319224
  • polyethylene glycol is generally used as a humectant or thickener.
  • highly polymerized polyethylene glycol having a molecular weight of 100,000 or more in the preparation, and there are some examples (Patent Document 3; JP-A-2006-506359) used for improving the foaming performance of liquid dentifrices.
  • Patent Document 3 JP-A-2006-506359
  • highly polymerized polyethylene glycol has any effect on remineralization. No mention is made of remineralization with highly polymerized polyethylene glycol.
  • xylitol erythritol and the like have been attracting attention as substitute sweeteners, and are blended in strawberries, gums, soft drinks and the like.
  • the functions of polyhydric alcohols typified by xylitol have been reported to be non-fermentative, suppressive growth of Streptococcus mutans (S. mutans) bacteria, which are said to be cariogenic, and promote remineralization.
  • Patent Document 4 JP 55-34098 A, Patent Document 5; JP-A-10-33138
  • Patent Document 5 shows that the anti-cariogenic property of erythritol is quite similar to that of xylitol.
  • erythritol there is no literature that mentions decalcification.
  • This invention is made
  • the applicant as calcium carbonate capable of exhibiting the acid neutralizing ability of dental plaque or the effect of preventing dental caries, has a particle size of 50% by mass or more as a primary particle size within a particle diameter of 0.04 to 0.5 ⁇ m.
  • Patent Document 1 it was proposed in Patent Document 1 that a certain fine calcium carbonate is effective, the effect of promoting remineralization by the fine calcium carbonate is not sufficient and there is room for improvement. Therefore, the present inventors have further studied the promotion of remineralization by fine calcium carbonate.
  • the highly polymerized polyethylene glycol (B) is used in combination with the fine calcium carbonate (A), both of them are surprisingly both.
  • dental remineralization means that the pH in the plaque tends to be acidic and the elution of minerals (Ca 2+ and HPO 4 2 ⁇ ) occurs, and then the pH tends to neutral due to the action of saliva, This is the action that minerals once melted return to the tooth surface and restore the melted tooth surface.
  • fine calcium carbonate spreads to the details in the oral cavity and the acid caused by dental plaque. It is presumed that mineral re-deposition is promoted by neutralization and calcium ion supplementation, and remineralization is promoted.
  • the highly polymerized polyethylene glycol enhances the remineralization accelerating effect and exhibits a special effect. From the blend of polyethylene glycol as a moisturizing agent and a thickener of the dentifrice composition, ( The exceptional effects of the combined use of components A) and (B) cannot be expected.
  • the present invention provides the following dentifrice composition and tooth remineralization accelerator.
  • A Fine calcium carbonate having an average primary particle size of 1 ⁇ m or less
  • B A dentifrice composition comprising a highly polymerized polyethylene glycol.
  • the dentifrice composition according to [1] wherein the highly polymerized polyethylene glycol (B) has an average molecular weight of 100,000 or more.
  • a tooth remineralization accelerator comprising fine calcium carbonate having an average primary particle diameter of 1 ⁇ m or less and (B) highly polymerized polyethylene glycol.
  • B highly polymerized polyethylene glycol.
  • C The tooth remineralization promoter according to [9] or [10], comprising erythritol.
  • a dentifrice composition that improves the effect of promoting remineralization of teeth and exhibits a high caries prevention effect. Moreover, a demineralization inhibitory effect improves with a remineralization promotion effect, and the caries prevention effect can be improved more. Furthermore, a refreshing feeling can be improved and a preparation with a good feeling of use can be provided.
  • the dentifrice composition of the present invention is characterized by blending (A) fine calcium carbonate having an average primary particle diameter of 1 ⁇ m or less and (B) highly polymerized polyethylene glycol. Furthermore, (C) erythritol can be mix
  • Fine calcium carbonate having an average primary particle size of 1 ⁇ m or less is blended as a remineralization accelerator.
  • the fine calcium carbonate as component (A) has an average primary particle size of 1 ⁇ m or less, preferably 0.04 to 0.5 ⁇ m.
  • the primary particle diameter of the fine calcium carbonate is a value obtained by measuring the size of the particles with an electron microscope, and the measurement method is as follows.
  • For the measurement of the particle diameter only particles that could be recognized as primary particles from four different visual fields were selected (25 particles per visual field) and measured. When the particles were indefinite, the square root of the product of the longest diameter and the shortest diameter was taken as the primary particle diameter. A total of 100 primary particle sizes were averaged as the average particle size of the primary particles.
  • the fine calcium carbonate as the component (A) those having 50% by mass or more, especially 90% by mass or more of particles having a primary particle size of 0.04 to 0.5 ⁇ m as the primary particle size are remineralized. This is more preferable from the viewpoint of effectiveness of the promoting effect.
  • the fine calcium carbonate releases free calcium ions and suppresses dissolution of minerals (calcium apatite), and at the same time promotes remineralization (mineral re-deposition).
  • the particle diameter exceeds the primary particle size the effect is inferior.
  • the average primary particle diameter of calcium carbonate used as an abrasive exceeds 1 ⁇ m, and most is 5 to 8 ⁇ m. In this case, particles having a primary particle diameter of 0.5 ⁇ m or less are contained in an amount of about 1 to 3% by mass, but such calcium carbonate does not have an effect of promoting remineralization.
  • fine calcium carbonate As the fine calcium carbonate, light calcium carbonate can be suitably used from the viewpoint of the production method such as easy control of the particle size distribution.
  • fine calcium carbonate of component (A) for example, commercially available products such as trade names Calessen-A, Corocarso-EX, Corocarso-MG manufactured by Shiraishi Calcium Co., Ltd. can be used.
  • the blending amount of the component (A) is preferably 0.1 to 10% (mass%, the same applies hereinafter), particularly 0.5 to 10%, particularly 0.5 to 2% of the total composition. If the blending amount is 0.1% or more, a sufficient blending effect can be obtained, but even if blending exceeds 10%, the effect may not be expected.
  • the remineralization effect of the component (A) is improved, and a high remineralization promoting effect is achieved. If the component is absent, the effect of promoting remineralization is not exhibited, and if the component (B) is absent, the effect of promoting remineralization is inferior, and the object of the present invention is not achieved.
  • a highly polymerized polyethylene glycol having an average molecular weight of 100,000 or more, particularly 100,000 to 5,000,000 is suitable, more preferably an average molecular weight of 100,000 to 4,000,000, still more preferably 200,000 to Those in the range of 1 million, especially 200,000 to 250,000 are preferred.
  • Those having an average molecular weight of 100,000 or more are preferable because a high remineralization promoting effect can be expected. If it exceeds 5 million, the remineralization promoting effect may not be observed, and the stability of the dentifrice may be lowered.
  • the above average molecular weight is a viscosity average molecular weight
  • this viscosity average molecular weight is a value converted from viscosity measurement. Specifically, a chain height that satisfies the relationship expressed by the Staudinger equation between the molecular weight and the molecular weight. It is a value obtained by measuring the intrinsic viscosity of a molecule (hereinafter the same). Further, as a substitute characteristic in place of the viscosity average molecular weight, the viscosity of a 4 mass% aqueous solution at 25 ° C. (B8H viscometer, rotor No. 4, 20 rpm, 2 minutes, 25 ° C.) measured with a B type viscometer is used. You can also.
  • the viscosity of the highly polymerized polyethylene glycol when measured by this method is preferably 50 to 50,000 mPa ⁇ s, more preferably 70 to 10,000 mPa ⁇ s, and 100 to 5,000 mPa ⁇ s. Is particularly preferred.
  • the blending amount of the highly polymerized polyethylene glycol is preferably 0.01 to 0.5% of the total composition, more preferably 0.03 to 0.2%, and particularly preferably 0.05 to 0.1%. If the blending amount is less than 0.01%, the improvement effect of remineralization may not be recognized, and if it exceeds 0.5%, no further effect may be expected, and the stability of the dentifrice May decrease.
  • the blending ratio of (A) fine calcium carbonate and (B) highly polymerized polyethylene glycol is not particularly limited, but (A) / (B) is preferably 0.2 to 1,000, more preferably 5 as a mass ratio. It is desirable to be in the range of ⁇ 100, more preferably in the range of 5 to 40, and in this range, the effect of promoting remineralization is excellent. The improvement of the remineralization promotion effect can be expected as it is 0.2 or more.
  • (C) erythritol is further blended in the composition of the present invention.
  • the remineralization promoting effect is further improved, and the decalcification inhibiting action is improved in addition to the remineralization promoting effect, and the caries prevention effect is further enhanced.
  • a refreshing feeling can be improved and a good feeling of use can be given.
  • Erythritol is a sugar alcohol, and a commercially available product can be used.
  • the blending amount is preferably 5 to 30%, particularly 10 to 30%, particularly 10 to 25% of the total composition. If it is less than 5%, the blending effect may not be expected, and if it exceeds 30%, no further effect can be expected and the stability of the dentifrice may be lowered.
  • the composition of the present invention preferably further contains (D) a fluorine compound.
  • a fluorine compound By adding a fluorine compound, the effect of suppressing the decalcification of teeth can be further improved, and the effect of preventing dental caries can be further enhanced.
  • Fluorine compounds include soluble fluorides such as alkali fluorides such as sodium fluoride, ammonium fluoride and potassium fluoride, monofluorophosphates such as sodium monofluorophosphate, ammonium monofluorophosphate and potassium monofluorophosphate. Compounds.
  • the blending amount is preferably 400 to 1,500 ppm, particularly 500 to 1,000 ppm as fluorine ions with respect to the entire composition. If it is less than 400 ppm, the blending effect may not be obtained, and if it exceeds 1,500 ppm, the stability of the dentifrice composition may be lowered.
  • the dentifrice composition of the present invention is suitably prepared as a toothpaste, a liquid dentifrice or the like, particularly as a toothpaste.
  • the well-known component normally used besides the said component can be mix
  • abrasives, thickeners, binders, surfactants, and if necessary, fragrances, sweeteners, preservatives, colorants, active ingredients other than those described above, and the like, within a range that does not interfere with the effects of the present invention Can be used.
  • Fine calcium carbonate has almost no function as an abrasive, so an abrasive is added separately.
  • abrasive conventionally used calcium carbonate for abrasives having an average primary particle size of about 5 to 8 ⁇ m, silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, dicalcium phosphate, water, etc. Examples thereof include aluminum oxide, alumina, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, and synthetic resin-based abrasive.
  • silica-based abrasives are more preferably blended from the viewpoint of the effect since the stability of the dentifrice composition is improved.
  • the blending amount of the abrasive is usually 5 to 50% of the entire composition.
  • thickening agent examples include sugar alcohols other than erythritol such as sorbit, xylit, malt, and lactit, glycerin, propylene glycol, and polyhydric alcohols such as polyethylene glycol having an average molecular weight of 190 to 1,540.
  • sugar alcohols other than erythritol such as sorbit, xylit, malt, and lactit
  • glycerin glycerin
  • propylene glycol examples of the thickening agent
  • polyhydric alcohols such as polyethylene glycol having an average molecular weight of 190 to 1,540.
  • the amount of these thickeners is usually 5 to 50%.
  • binder examples include sodium carboxymethyl cellulose, hydroxyethyl cellulose, xanthan gum, carrageenan, sodium polyacrylate, and the like.
  • the amount of the binder is usually 0 to 5%, particularly 0.1 to 5%.
  • anionic surfactant an anionic surfactant, a cationic surfactant, a nonionic surfactant, and an amphoteric surfactant can be blended.
  • anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, N-acyl sarcosine sodium such as sodium N-lauroyl sarcosine and sodium N-myristoyl sarcosine, and sodium ⁇ -olefin sulfonate.
  • Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Ether type or ester type activator such as polyhydric alcohol fatty acid ester such as fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, And fatty acid alkanolamides such as lauric acid diethanolamide.
  • sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid este
  • Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts.
  • Examples of amphoteric surfactants include betaine acetate, imidazolinium betaine, and lecithin.
  • the blending amount of the surfactant is preferably 0.5 to 5% of the entire composition.
  • sweetener examples include saccharin sodium
  • preservative examples include paraoxybenzoic acid ester and sodium benzoate.
  • colorant examples include blue No. 1, yellow No. 4, and the like.
  • Perfumes include peppermint oil, spearmint oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, coconut oil, Iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid-liquid extraction, essence, powder Perfume and menthol) Carvone, Anethole, Cineol, Methyl salicylate, Synamic aldehyde, Eugenol, 3-l-Mentoxypropane-1
  • Active ingredients include water-soluble phosphate compounds, enzymes such as dextranase, mutanase, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, tranexamic acid, epsilon aminocaproic acid, acetic acid dl-tocophenol, ⁇ -bisabolol, isopropylmethylphenol, chlorohexidine salts, cetylpyridinium chloride, azulene, glycyrrhetinic acid, copper chlorophyllin sodium, copper gluconate and other copper compounds, aluminum lactate, strontium chloride, potassium nitrate, berberine, etc. .
  • an effective amount can be mix
  • the amount of water in the composition of the present invention is not particularly limited, but is preferably 50% or less, more preferably 25% or less, and particularly preferably 15% or less, from the viewpoint of deashing suppression effect and imparting a refreshing feeling.
  • erythritol is added, especially when erythritol is blended at a high concentration of 10% or more, it is desirable that the water content is 25% or less, thereby improving the refreshing feeling due to the interaction with erythritol. It can give a very good refreshing feeling that the user can satisfy.
  • the tooth remineralization accelerator of the present invention comprises (A) fine calcium carbonate having an average primary particle diameter of 1 ⁇ m or less and (B) highly polymerized polyethylene glycol, and more preferably (C) erythritol. .
  • the components (A), (B), and (C) are the same as described above, and the ratio of the component (A) / (B) is the same as described above.
  • the details of the raw materials used are as follows.
  • the average primary particle diameter of the fine calcium carbonate is a value measured with an electron microscope in the same manner as described above.
  • the viscosity average molecular weight of the highly polymerized polyethylene glycol was measured in the same manner as described above.
  • A Fine calcium carbonate Corocalso-EX (Shiraishi Calcium Co., Ltd., average primary particle size 0.25 ⁇ m) Cal Essen-A (Shiraishi Calcium Co., Ltd., average primary particle size 0.07 ⁇ m)
  • B Highly polymerized polyethylene glycol POLYOX WSR N-80 (manufactured by Union Carbide, viscosity average molecular weight 200,000) POLYOX WSR N-10 (Union Carbide, viscosity average molecular weight 100,000) POLYOX WSR N-750 (manufactured by Union Carbide, viscosity average molecular weight 300,000) POLYOX WSR N-12K (manufactured by Union Carbide, viscosity average molecular weight 1 million) (C) Erythritol (Cargill, 60 mesh product)
  • Deashing suppression rate is 70% or more
  • Deashing suppression rate is 50% or more and less than 70%
  • Deashing suppression rate is 30% or more and less than 50%
  • Deashing suppression rate Less than 30%

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Abstract

L'invention concerne une composition de dentifrice et un agent pour favoriser la recalcification des dents qui sont excellents en termes de promotion de la recalcification des dents et efficaces dans la prévention des caries. La composition de dentifrice est caractérisée en ce qu'elle contient (A) des microparticules de carbonate de calcium ayant un diamètre de particule primaire moyen de 1 µm ou plus petit et (B) un polyéthylèneglycol ayant un degré élevé de polymérisation. La composition de dentifrice contient en plus (C) de l'érythritol et (D) un composé de fluor. L'agent pour favoriser la recalcification des dents comprend (A) des microparticules de carbonate de calcium ayant un diamètre de particule primaire moyen de 1 µm ou plus petit et (B) un polyéthylèneglycol ayant un degré élevé de polymérisation.
PCT/JP2012/077286 2011-11-25 2012-10-23 Composition de dentifrice et agent pour favoriser la recalcification des dents Ceased WO2013077127A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201280057760.5A CN103974689B (zh) 2011-11-25 2012-10-23 洁齿剂组合物和牙齿的再钙化促进剂
PH1/2014/501027A PH12014501027B1 (en) 2011-11-25 2012-10-23 Dentifrice composition and agent for promoting tooth remineralization
KR1020147010267A KR101909321B1 (ko) 2011-11-25 2012-10-23 치마제 조성물 및 치아의 재석회화 촉진제

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-257057 2011-11-25
JP2011257057A JP5720546B2 (ja) 2011-11-25 2011-11-25 歯磨剤組成物及び歯牙の再石灰化促進剤

Publications (1)

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WO2013077127A1 true WO2013077127A1 (fr) 2013-05-30

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PCT/JP2012/077286 Ceased WO2013077127A1 (fr) 2011-11-25 2012-10-23 Composition de dentifrice et agent pour favoriser la recalcification des dents

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JP (1) JP5720546B2 (fr)
KR (1) KR101909321B1 (fr)
CN (1) CN103974689B (fr)
MY (1) MY164108A (fr)
PH (1) PH12014501027B1 (fr)
WO (1) WO2013077127A1 (fr)

Cited By (3)

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Publication number Priority date Publication date Assignee Title
WO2015133358A1 (fr) * 2014-03-03 2015-09-11 ライオン株式会社 Composition de pâte dentifrice
WO2015158637A1 (fr) * 2014-04-17 2015-10-22 Unilever Plc Compositions solides d'hygiène buccale
WO2018166673A1 (fr) * 2017-03-13 2018-09-20 Unilever Plc Compositions de soins buccodentaires

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6409618B2 (ja) * 2015-02-26 2018-10-24 ライオン株式会社 歯磨組成物
JP6693504B2 (ja) * 2015-02-26 2020-05-13 ライオン株式会社 歯磨剤組成物
WO2020115974A1 (fr) * 2018-12-04 2020-06-11 花王株式会社 Composition destinée à la cavité buccale

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JP2004083825A (ja) * 2002-08-29 2004-03-18 Kao Corp ペースト状組成物
JP2006506359A (ja) * 2002-10-04 2006-02-23 ザ プロクター アンド ギャンブル カンパニー 液体歯磨剤組成物
WO2010073975A1 (fr) * 2008-12-22 2010-07-01 ライオン株式会社 Composition de dentifrice

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Publication number Priority date Publication date Assignee Title
JPH09295924A (ja) * 1996-04-30 1997-11-18 Lion Corp 歯垢の酸中和剤及び口腔用組成物
JPH11310522A (ja) * 1997-04-24 1999-11-09 Sunstar Inc 口腔用組成物
JP2000191483A (ja) * 1998-12-28 2000-07-11 Kao Corp 歯磨剤組成物
JP2002114658A (ja) * 2000-09-29 2002-04-16 Lion Corp 口腔用組成物
JP2004083825A (ja) * 2002-08-29 2004-03-18 Kao Corp ペースト状組成物
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015133358A1 (fr) * 2014-03-03 2015-09-11 ライオン株式会社 Composition de pâte dentifrice
JPWO2015133358A1 (ja) * 2014-03-03 2017-04-06 ライオン株式会社 練歯磨組成物
WO2015158637A1 (fr) * 2014-04-17 2015-10-22 Unilever Plc Compositions solides d'hygiène buccale
CN106456505A (zh) * 2014-04-17 2017-02-22 荷兰联合利华有限公司 固体口腔护理组合物
WO2018166673A1 (fr) * 2017-03-13 2018-09-20 Unilever Plc Compositions de soins buccodentaires

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KR20140098059A (ko) 2014-08-07
JP2013112613A (ja) 2013-06-10
PH12014501027B1 (en) 2019-04-26
KR101909321B1 (ko) 2018-10-17
MY164108A (en) 2017-11-30
CN103974689A (zh) 2014-08-06
CN103974689B (zh) 2016-09-14
JP5720546B2 (ja) 2015-05-20
PH12014501027A1 (en) 2014-06-23

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