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WO2015133358A1 - Composition de pâte dentifrice - Google Patents

Composition de pâte dentifrice Download PDF

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Publication number
WO2015133358A1
WO2015133358A1 PCT/JP2015/055591 JP2015055591W WO2015133358A1 WO 2015133358 A1 WO2015133358 A1 WO 2015133358A1 JP 2015055591 W JP2015055591 W JP 2015055591W WO 2015133358 A1 WO2015133358 A1 WO 2015133358A1
Authority
WO
WIPO (PCT)
Prior art keywords
component
toothpaste composition
mass
composition according
viscosity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2015/055591
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English (en)
Japanese (ja)
Inventor
剛太郎 飯泉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to JP2016506445A priority Critical patent/JP6528762B2/ja
Priority to CN201580010367.4A priority patent/CN106029053B/zh
Priority to KR1020167017861A priority patent/KR102306478B1/ko
Publication of WO2015133358A1 publication Critical patent/WO2015133358A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a toothpaste composition that suppresses foam dripping from the mouth when brushing teeth, has an excellent creamy feel, and has a high flavor.
  • the feeling of foam in the oral cavity is one of the textures that can give a feeling of cleaning.
  • saliva is constantly secreted in the oral cavity, and especially if you brush your teeth for a long time, the dentifrice composition is diluted with saliva. As a result, there was a problem that bubbles dropped from the mouth, the creamy feeling of the bubbles was not felt, and the satisfaction of brushing the teeth was lowered.
  • the surfactant generally used as a foaming agent has a problem that it develops the bitterness peculiar to it or reduces the expression of a fragrance to be blended for masking unpleasant taste. For this reason, in a dentifrice composition, it was difficult to improve foam performance, maintaining favorable flavor standing.
  • Patent Document 1 Japanese Translation of PCT International Publication No. 2011-105647.
  • Patent Document 1 does not mention bubble dripping from the mouth.
  • polyethylene glycol is generally used as a humectant or thickener in the oral field, but there are few examples of blending highly polymerized polyethylene glycol having an average molecular weight of 50,000, particularly 100,000 or more, into the preparation.
  • Patent Document 2 JP 2006-506359 A
  • Patent Document 3 JP-A-2013-112613
  • Patent Document 4 International Publication No. 10/073975
  • the present invention has been made in view of the above circumstances, and an object of the present invention is to provide a toothpaste composition that suppresses foam dripping from the mouth when brushing teeth, is excellent in foam creaminess, and has a high flavor.
  • the present inventor has obtained (A) highly polymerized polyethylene glycol, (B) alkyl sulfate, (C) amphoteric surfactant, and (D) nonionic surfactant. Containing (C) component / (D) component in a mass ratio of 0.05 to 5, foam dripping from the mouth during tooth brushing is suppressed, foam creamy feeling is excellent, and flavor is high It has been found that a toothpaste composition can be obtained.
  • the toothpaste composition of the present invention is less likely to drip from the mouth when brushing teeth, gives a foam that can be held appropriately in the mouth, improves the creamy feeling of the foam, has a high flavor of the blended fragrance, and feels good to use Is excellent, and can provide sufficient toothpaste and satisfaction with use.
  • the present invention provides the following toothpaste composition and a method for improving bubble sag in the toothpaste composition.
  • A Highly polymerized polyethylene glycol, (B) alkyl sulfate, (C) amphoteric surfactant and (D) nonionic surfactant are contained, and (C) component / (D) component has a mass ratio of 0.
  • the highly polymerized polyethylene glycol as component (A) has a viscosity of 10 mPa ⁇ s or more at 25 ° C. measured at 25 ° C. measured with a Brookfield viscometer and 2 W / V at 25 ° C. measured with the viscometer.
  • the (C) component betaine amphoteric surfactant is fatty acid amidopropyl betaine and / or 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine in [1], [2] or [3] The toothpaste composition as described.
  • the highly polymerized polyethylene glycol as component (A) has a viscosity of 10 mPa ⁇ s or more at 25 ° C. measured at 25 ° C. measured with a Brookfield viscometer and 2 W / V at 25 ° C. measured with the viscometer.
  • Component (A) is 0.05 to 0.5% by mass
  • Component (B) is 1 to 3.5% by mass
  • Component (C) is 0.05 to 1% by mass
  • Component (D) is 0.1 to A method for improving dripping by combining the components (A) and (B) in the toothpaste composition according to [8] or [9] containing 3% by mass.
  • the present invention it is possible to provide a toothpaste composition in which foam dripping from the mouth during brushing is suppressed, the creamy feeling of the foam is excellent, and the flavor is high.
  • This toothpaste composition can provide sufficient toothpaste feeling and satisfaction with use.
  • the toothpaste composition of the present invention comprises (A) highly polymerized polyethylene glycol, (B) alkyl sulfate, (C) amphoteric surfactant, (D) nonionic surfactant, and (C) component / ( D) The ratio of the component is within a specific range.
  • the highly polymerized polyethylene glycol of component (A) is a polymer compound having a structure in which ethylene glycol is polymerized, and is a 5 W / V (mass / volume (volume))% aqueous solution at 25 ° C. measured with a Brookfield viscometer. It is preferable that the viscosity is 10 mPa ⁇ s or more and the viscosity of the 2 W / V% aqueous solution at 25 ° C. measured by the viscometer is 800 mPa ⁇ s or less.
  • the highly polymerized polyethylene glycol preferably has the following viscosity physical properties (1) or (2).
  • Viscosity of 5 W / V% aqueous solution at 25 ° C. is 10 to 20,000 mPa ⁇ s
  • the viscosity of the 2 W / V% aqueous solution at 25 ° C. is 800 mPa ⁇ s or less.
  • more preferable highly polymerized polyethylene glycol is 5 W at 25 ° C.
  • the viscosity of the / V% aqueous solution is 10 to 18,000 mPa ⁇ s, particularly 30 to 10,000 mPa ⁇ s, especially 55 to 2,000 mPa ⁇ s.
  • the present invention by using highly polymerized polyethylene glycol having a viscosity within the above specific range as the component (A), it is possible to sufficiently contribute to the improvement of foam dripping from the mouth and to further improve the creamy feeling of the foam. If the viscosity of the 5 W / V% aqueous solution is less than 10 mPa ⁇ s, it may not sufficiently contribute to the improvement of foam dripping from the mouth, and the effect of improving the creamy feeling of the foam may be inferior. When it exceeds 800 mPa ⁇ s, not only the flavor is deteriorated, but also the stability of the toothpaste composition may be lowered.
  • component (A) As the highly polymerized polyethylene glycol of component (A), the following commercially available products can be used.
  • ⁇ POLYOX WSR N-10 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 12 to 50 mPa ⁇ s, measuring device: Brookfield RVT, rotor No. 1, rotation speed 50 rpm, measuring temperature 25 ° C., measuring time 0.5 minutes
  • ⁇ POLYOX WSR N-80 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 55 to 115 mPa ⁇ s, measuring equipment: Brookfield RVT, rotor No.
  • the blending amount of the highly polymerized polyethylene glycol is preferably 0.05 to 0.5% (mass%, the same applies hereinafter) of the whole composition, more preferably 0.1 to 0.3%.
  • the blending amount is 0.05% or more, the dripping from the mouth can be sufficiently improved, and the creamy feeling of the foam can be sufficiently improved.
  • a content of 0.5% or less is suitable for suppressing deterioration in flavor.
  • alkyl sulfate is mix
  • sodium alkyl sulfate such as sodium lauryl sulfate and sodium myristyl sulfate can be used, and sodium lauryl sulfate is particularly preferred from the standpoint of flavor.
  • sodium lauryl sulfate manufactured by Toho Chemical Industry Co., Ltd .
  • sodium lauryl sulfate sodium myristyl sulfate
  • Nikko Chemicals Co., Ltd .; NIKKOL SMS and the like can be used.
  • the amount of alkyl sulfate is preferably 1 to 3.5%, more preferably 1.5 to 2.5% of the total composition. If the blending amount is 1% or more, the creamy feeling of the foam can be improved. 3.5% or less is suitable for suppressing deterioration in flavor. Furthermore, in order to prevent the foaming property of the toothpaste composition from increasing too much and dripping the foam from the mouth, and to prevent the feeling of use such as irritation in the oral cavity from becoming worse, It is preferably not too much, and is preferably 3.5% or less.
  • a betaine amphoteric surfactant can be suitably blended.
  • the betaine amphoteric surfactant include fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolium betaine, and the number of carbon atoms of the hydrocarbon group of the betaine amphoteric surfactant is 8-18 are preferred.
  • Particularly preferred is fatty acid amidopropyl betaine having 8 to 18 carbon atoms in the fatty acid, and among these, coconut oil fatty acid amidopropyl betaine is more preferred from the standpoint of flavor.
  • Amphoteric surfactant can use a commercial item, and specifically, the following are mentioned.
  • ⁇ Palm oil fatty acid amidopropyl betaine EVONIC, TEGO BETAIN CK OK
  • 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolium betaine manufactured by Lion Corporation; Enacol C-40H
  • the blending amount of the amphoteric surfactant is preferably 0.05 to 1% of the total composition in terms of pure content in terms of foamy creamy feeling, dripping from the mouth, and good taste. Preferably it is 0.1 to 1%, more preferably 0.1 to 0.5%.
  • the blending amount is 0.05% or more, the creamy feeling of the foam is improved, and the dripping from the mouth can be further suppressed. It is suitable for suppressing that the foaming property of a toothpaste composition increases too much and foam dripping from a mouth worsens that it is 1% or less. Furthermore, it is also preferable for preventing the bitterness peculiar to amphoteric surfactants from occurring.
  • the nonionic surfactant is particularly preferably polyoxyethylene hydrogenated castor oil, more preferably polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 20 to 40, particularly 20.
  • polyoxyethylene hydrogenated castor oil polyoxyethylene (40) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-40, average number of moles of ethylene oxide added 40), polyoxyethylene (20) hydrogenated castor oil (Nippon Emulsion Co., Ltd .: EMALEX HC-20, average added mole number of ethylene oxide 20).
  • the amount of the nonionic surfactant is preferably 0.1 to 3%, more preferably 0, based on the creamy feeling of the foam, the dripping from the mouth, and the flavor. .2 to 1.5%.
  • the blending amount is 0.1% or more, the creamy feeling of the foam is improved, and the dripping from the mouth can be further suppressed. 3% or less is suitable for suppressing deterioration in flavor.
  • the blending ratio of (C) amphoteric surfactant and (D) nonionic surfactant is such that (C) / (D) is 0.05 to 5, preferably 0.1 to 5, more preferably 0.1 to 3, and still more preferably 0.5 to 1.5.
  • (C) / (D) is 0.05 to 5, preferably 0.1 to 5, more preferably 0.1 to 3, and still more preferably 0.5 to 1.5.
  • the total content of the surfactant including the components (B), (C) and (D) is 1.15 to 7.5%, particularly 1.5 to 5.2% of the whole composition.
  • the range of 2 to 4% is preferable. If it is within this range, the dripping of the foam can be further suppressed, and the creamy feeling of the foam is also more excellent. Moreover, flavor standing improves more.
  • the total content is not too much to suppress the foaming property of the toothpaste composition from being excessively increased and to prevent the dripping of the foam from becoming worse and to prevent the flavor from becoming worse. Furthermore, it is also preferable for suppressing the bitterness derived from the surfactant.
  • surfactants other than the components (B), (C), and (D) may be blended as necessary within a range not impeding the effects of the present invention.
  • anionic surfactants other than alkyl sulfates for example, N-acyl sarcosine salts such as N-lauroyl sarcosine sodium and N-myristoyl sarcosine sodium, N-acyl glutamate, N-methyl-N-acyl Examples include sodium taurine, sodium N-methyl-N-acylalanine, sodium ⁇ -olefin sulfonate, and the like.
  • the toothpaste composition of the present invention preferably further contains (E) a fragrance.
  • a fragrance a natural fragrance added as a general fragrance for a dentifrice, a fragrance obtained by processing a natural fragrance, a single fragrance, a blended fragrance, and the like are known fragrance materials used in dentifrice compositions.
  • One species can be used alone, or two or more species can be used in combination.
  • the flavor of the blended fragrance can be sufficiently exhibited.
  • Preferable fragrances include mint-based fragrances, spice-based fragrances, and fruit-based fragrances. When these are used, particularly good flavor standing is obtained.
  • the blending amount of the fragrance of the component (E) is preferably 0.5 to 2.5%, more preferably 0.8 to 1.8% of the whole composition from the viewpoint of good flavor. As the amount is increased, the flavor is improved, and when 0.5% or more is blended, a good flavor can be imparted. A content of 2.5% or less is suitable for suppressing deterioration in flavor. When there are too many compounding quantities, it may become impossible to maintain favorable flavor standing.
  • abrasive, a thickener, a binder, and a sweetener, a colorant, a preservative, a medicinal component, etc. can be blended if necessary.
  • a compounding quantity may be a normal quantity in the range which does not prevent the effect of this invention.
  • silica-based abrasives such as silica gel, precipitated silica, aluminosilicate, zirconosilicate, dicalcium phosphate dihydrate and anhydrous, tertiary calcium phosphate, tetracalcium phosphate, calcium pyrophosphate, etc.
  • Agents calcium carbonate, aluminum hydroxide, alumina, zeolite, hydroxyapatite, synthetic resin abrasives, and the like.
  • the blending amount of these abrasives is usually 2 to 50%, particularly 10 to 30% of the whole composition.
  • the thickener examples include sugar alcohols such as sorbit and xylit, and polyhydric alcohols such as glycerin and propylene glycol.
  • polyethylene glycol having an average molecular weight of 190 to 2,000 is compatible with the component (A) which is a polymer, so that it can swell and disperse in the aqueous phase. It can be preferably used.
  • the blending amount of these thickeners is usually preferably 5 to 50%, particularly preferably 20 to 45% of the whole composition.
  • an organic or inorganic binder can be blended.
  • sodium carboxymethylcellulose, methylcellulose, hydroxymethylcellulose, cellulose derivatives such as cationized cellulose, alginic acid derivatives such as sodium alginate, propylene glycol alginate, gums such as xanthan gum, karaya gum, gum arabic, sodium polyacrylate examples thereof include organic binders such as polyvinyl alcohol, carboxyvinyl polymer, polyvinyl pyrrolidone, and carrageenan, and inorganic binders such as gelling silica, gelling aluminum silica, bee gum, and laponite.
  • the amount of the binder is usually 0.1 to 10%, particularly preferably 0.5 to 5%.
  • sweetening agent examples include saccharin sodium, stevioside, stevia extract and the like.
  • colorant examples include Red No. 2, No. 3, 225, No. 226, Yellow No. 4, No. 5, Blue No. 1, No. 2, Mica titanium, titanium oxide and the like.
  • preservative examples include paraoxybenzoic acid esters such as methylparaben and ethylparaben, benzoic acid such as sodium benzoate, and salts thereof.
  • known ingredients that are usually blended such as bactericides, anti-inflammatory agents, enzymes, fluorides, copper compounds, vitamins, plant extracts, anticalculus agents, antiplaque agents, etc. of the present invention are used.
  • An effective amount can be blended within a range that does not interfere with the effect.
  • nonionic fungicides such as isopropylmethylphenol
  • cationic fungicides such as cetylpyridinium chloride, chlorhexidine hydrochloride, benzalkonium chloride, benzethonium chloride, tranexamic acid, epsilon aminocaproic acid, allantoin, glycyrrhetic acid, glycyrrhizin
  • Anti-inflammatory agents such as dipotassium acid, enzymes such as dextranase, mutanase, amylase and protease, fluorides such as sodium fluoride and sodium monofluorophosphate, water-soluble phosphate compounds, copper compounds such as copper gluconate, potassium nitrate Inorganic salts such as aluminum lactate, zinc chloride, zinc citrate and strontium chloride, vitamins such as ascorbic acid and tocopherol acetate, plant extracts and the like.
  • Dentifrice compositions having the compositions shown in Tables 1 to 3 were prepared by conventional methods and evaluated by the following methods. The results are shown in the table.
  • Evaluation criteria A Average point 3.5 points or more and 4.0 points or less ⁇ : Average point 3.0 points or more and less than 3.5 points ⁇ : Average point 2.0 points or more and less than 3.0 points ⁇ : Average point 1. 0 points or more and less than 2.0 points
  • Evaluation criteria A Average point 3.5 points or more and 4.0 points or less ⁇ : Average point 3.0 points or more and less than 3.5 points ⁇ : Average point 2.0 points or more and less than 3.0 points ⁇ : Average point 1. 0 points or more and less than 2.0 points
  • Evaluation criteria A Average point 3.5 points or more and 4.0 points or less ⁇ : Average point 3.0 points or more and less than 3.5 points ⁇ : Average point 2.0 points or more and less than 3.0 points ⁇ : Average point 1. 0 points or more and less than 2.0 points
  • the viscosity of the highly polymerized polyethylene glycol is the viscosity at 25 ° C. measured with a Brookfield viscometer (Brookfield RVT or RVF), as described above. Moreover, the viscosity of 5 W / V% of polyethylene glycol 4000 measured by the same method was less than 10 mPa ⁇ s. ⁇ Highly polymerized polyethylene glycol; POLYOX WSR N-80 (Viscosity of 5 W / V% aqueous solution manufactured by Dow Chemical Company: 85 mPa ⁇ s (rotor No.
  • POLYOX WSR N-10 Manufactured by Dow Chemical Co., Ltd., viscosity of 5 W / V% aqueous solution: 35 mPa ⁇ s (rotor No. 1, rotation speed 50 rpm, measurement time 0.5 minutes)
  • POLYOX WSR N-750 (Dow Chemical Co., Viscosity of 5 W / V% aqueous solution: 1,100 mPa ⁇ s (Rotor No.
  • Table 4 below shows formulation examples. All of these toothpaste compositions were difficult to drip, excellent in creamy feeling, and good in flavor.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition de pâte dentifrice qui empêche que des bulles tombent de la bouche pendant le brossage des dents, qui présente une onctuosité de bulles supérieure, qui a une bonne saveur et qui comprend : (A) un polyéthylèneglycol hautement polymérisé ; (B) un sulfate d'alkyle ; (C) un agent tensioactif ampholytique ; et (D) un agent tensioactif non ionique. La composition de pâte dentifrice est caractérisée en ce que le rapport massique de constituant (C)/constituant (D) est de 0,05-5. L'invention concerne également un procédé d'amélioration de chute de bulles dans lequel les constituants (C) et (D) sont mélangés au rapport massique de constituant (C)/constituant (D) en une composition pour brossage de dents, dans laquelle les constituants (A) et (B) sont mélangés, et utilisés conjointement avec les constituants (A) et (B) dans la composition de pâte dentifrice.
PCT/JP2015/055591 2014-03-03 2015-02-26 Composition de pâte dentifrice Ceased WO2015133358A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2016506445A JP6528762B2 (ja) 2014-03-03 2015-02-26 練歯磨組成物
CN201580010367.4A CN106029053B (zh) 2014-03-03 2015-02-26 牙膏组合物
KR1020167017861A KR102306478B1 (ko) 2014-03-03 2015-02-26 치약 조성물

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014040122 2014-03-03
JP2014-040122 2014-03-03

Publications (1)

Publication Number Publication Date
WO2015133358A1 true WO2015133358A1 (fr) 2015-09-11

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ID=54055167

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PCT/JP2015/055591 Ceased WO2015133358A1 (fr) 2014-03-03 2015-02-26 Composition de pâte dentifrice

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JP (1) JP6528762B2 (fr)
KR (1) KR102306478B1 (fr)
CN (1) CN106029053B (fr)
MY (1) MY180536A (fr)
WO (1) WO2015133358A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022066391A (ja) * 2017-10-12 2022-04-28 サンスター株式会社 シリカ含有口腔用組成物

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110801404A (zh) * 2019-11-19 2020-02-18 庐山百草堂生物制药有限公司 一种含二氢杨梅素牙齿美白修护牙膏及其制备方法
KR20250100081A (ko) 2023-12-26 2025-07-03 조선대학교산학협력단 구취 제거 및 충치 예방 효과가 있는 구강용 조성물

Citations (5)

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Publication number Priority date Publication date Assignee Title
US5820854A (en) * 1997-03-27 1998-10-13 The Procter & Gamble Company Oral compositions containing polyoxyethylene
US5833956A (en) * 1997-04-02 1998-11-10 Colgate-Palmolive Company Oral composition containing an anionic, a nonionic and an amphoteric surfactant system
JP2009084277A (ja) * 2007-09-14 2009-04-23 Sunstar Inc 歯磨組成物
WO2012106016A2 (fr) * 2011-02-04 2012-08-09 Colgate-Palmolive Company Compositions de soins bucco-dentaires
WO2013077127A1 (fr) * 2011-11-25 2013-05-30 ライオン株式会社 Composition de dentifrice et agent pour favoriser la recalcification des dents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040126331A1 (en) 2002-10-04 2004-07-01 The Procter & Gamble Company Use of an oral composition
JP2007145740A (ja) * 2005-11-25 2007-06-14 Lion Corp 歯磨剤組成物
CN102264343B (zh) * 2008-12-22 2014-03-05 狮王株式会社 牙膏组合物
JP2011105647A (ja) 2009-11-18 2011-06-02 Lion Corp 歯磨組成物

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5820854A (en) * 1997-03-27 1998-10-13 The Procter & Gamble Company Oral compositions containing polyoxyethylene
US5833956A (en) * 1997-04-02 1998-11-10 Colgate-Palmolive Company Oral composition containing an anionic, a nonionic and an amphoteric surfactant system
JP2009084277A (ja) * 2007-09-14 2009-04-23 Sunstar Inc 歯磨組成物
WO2012106016A2 (fr) * 2011-02-04 2012-08-09 Colgate-Palmolive Company Compositions de soins bucco-dentaires
WO2013077127A1 (fr) * 2011-11-25 2013-05-30 ライオン株式会社 Composition de dentifrice et agent pour favoriser la recalcification des dents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022066391A (ja) * 2017-10-12 2022-04-28 サンスター株式会社 シリカ含有口腔用組成物
JP7331182B2 (ja) 2017-10-12 2023-08-22 サンスター株式会社 シリカ含有口腔用組成物

Also Published As

Publication number Publication date
CN106029053A (zh) 2016-10-12
KR20160120275A (ko) 2016-10-17
MY180536A (en) 2020-12-01
CN106029053B (zh) 2019-10-22
JP6528762B2 (ja) 2019-06-12
KR102306478B1 (ko) 2021-09-29
JPWO2015133358A1 (ja) 2017-04-06

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