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WO2016110276A1 - Composition topique renfermant de l'obacunone et procédé pour le blanchiment de la peau - Google Patents

Composition topique renfermant de l'obacunone et procédé pour le blanchiment de la peau Download PDF

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Publication number
WO2016110276A1
WO2016110276A1 PCT/CN2016/070544 CN2016070544W WO2016110276A1 WO 2016110276 A1 WO2016110276 A1 WO 2016110276A1 CN 2016070544 W CN2016070544 W CN 2016070544W WO 2016110276 A1 WO2016110276 A1 WO 2016110276A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
cedarone
tyrosinase
group
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2016/070544
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English (en)
Chinese (zh)
Inventor
韩强
张翌
李廷钊
杜军
李波
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Access Business Group International LLC
Original Assignee
Access Business Group International LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Access Business Group International LLC filed Critical Access Business Group International LLC
Publication of WO2016110276A1 publication Critical patent/WO2016110276A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • compositions comprising cedarone are described, and their use in methods of inhibiting tyrosinase activity and melanin synthesis in the skin and methods of skin whitening.
  • Skin color depends mainly on the amount of melanin in the skin.
  • Melanin is a brownish black pigment present in the skin. Since the pigment is dark, the lower the amount of melanin, the lighter the skin tone, and the higher the amount, the deeper the skin tone.
  • Melanin is formed by oxidizing amino acid tyrosine to dihydroxyphenylalanine in melanocytes. This reaction is catalyzed by tyrosinase.
  • a further embodiment is directed to a topical composition
  • a topical composition comprising a cosmetically acceptable carrier and about 75-100% pure phbodone, wherein the cedarone comprises from about 1 to 99% by weight of the composition.
  • Another embodiment is directed to a method of whitening skin comprising topically applying a composition described herein to the skin, wherein the composition is applied in an amount and for a duration sufficient to significantly whiten the skin.
  • compositions comprising purified corkone (in an amount sufficient to achieve a reduction in melanin production and/or a decrease in tyrosinase activity), and their use in skin whitening or whitening methods are described.
  • the aqueous hydro-ethanolic extraction technique can also be used to obtain extracts and/or active compounds that are useful in the unique compositions of the present invention. Usually this is called total extraction.
  • the extract produced in this process will contain a variety of plantings present in the extracted material. Learn substances, including fats and water solubles. After collecting the extract solution, the solvent was evaporated to obtain an extract.
  • the corkone active material can be purified by high speed countercurrent chromatography.
  • Example 1 Passing in B16F10 cells Cytotoxicity of obacunone (CTG) Luminescent Cell Viability test (Luminescent Cell Viability Assay) carried out / safety evaluation
  • the phbodone was dissolved in DMSO and added to B16F10 cells, which were seeded at a density of 18,000 cells/mL for 24 hours in a 24-well plate prior to treatment. The final concentration of the test compound was 1 x.
  • the cytoplasmic pH of B16F10 cells in this experiment was approximately 5-7. Each dose of corkone was added to the cells in triplicate. The plates were then incubated at 37 ° C, 5% CO 2 , under humid conditions for 72 hours.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne une composition topique à action inhibitrice de la synthèse de la mélanine et de l'activité de la tyrosinase renfermant de l'obacunone dont la pureté est comprise entre 75 et 100 %, un vecteur cosmétiquement acceptable et un ou plusieurs composants cosmétiques et/ou agents d'éclaircissement de la peau. La composition contient de l'obacunone en quantité suffisante pour réduire efficacement la synthèse de la mélanine et/ou inhiber l'activité de la tyrosinase. Application : blanchiment de la peau.
PCT/CN2016/070544 2015-01-09 2016-01-11 Composition topique renfermant de l'obacunone et procédé pour le blanchiment de la peau Ceased WO2016110276A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510013057.X 2015-01-09
CN201510013057.XA CN105816342A (zh) 2015-01-09 2015-01-09 包括黄柏酮的组合物和其在皮肤美白应用中的使用方法

Publications (1)

Publication Number Publication Date
WO2016110276A1 true WO2016110276A1 (fr) 2016-07-14

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PCT/CN2016/070544 Ceased WO2016110276A1 (fr) 2015-01-09 2016-01-11 Composition topique renfermant de l'obacunone et procédé pour le blanchiment de la peau

Country Status (3)

Country Link
CN (1) CN105816342A (fr)
TW (1) TW201630589A (fr)
WO (1) WO2016110276A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016183203A1 (fr) * 2015-05-14 2016-11-17 Access Business Group International Llc Compositions comprenant de l'obacunone et procédés d'utilisation de celles-ci dans des applications pour lutter contre le vieillissement de la peau
CN115252630A (zh) * 2022-09-02 2022-11-01 深圳技术大学 黄柏酮在制备预防、改善或治疗非酒精性脂肪肝的药物中的应用

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109998950A (zh) * 2019-03-04 2019-07-12 湖南商务职业技术学院 一种防晒美白化妆品组合物
CN113208959A (zh) * 2021-04-30 2021-08-06 广州市科能化妆品科研有限公司 一种抑制黑色素生成的组合物、美白精华及其制备方法和应用
CN113318031A (zh) * 2021-06-21 2021-08-31 杭州友丽医疗科技(集团)有限公司 淡化黄褐斑的靓肤水光组合物、靓肤水光液及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101695470A (zh) * 2009-10-27 2010-04-21 天津郁美净集团有限公司 化妆品用组合物、含有该组合物的化妆品及其制备方法
CN102357066A (zh) * 2011-10-26 2012-02-22 天津郁美净集团有限公司 一种黄柏提取液及其制备方法
CN102573787A (zh) * 2009-08-14 2012-07-11 株式会社爱茉莉太平洋 含有天然提取物的组合物
CN102614101A (zh) * 2012-04-25 2012-08-01 天津郁美净集团有限公司 含有黄柏提取物的化妆品用组合物及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101257706B1 (ko) * 2011-01-13 2013-04-24 강원대학교산학협력단 오베큐논을 함유하는 혈관질환의 치료 또는 예방용 조성물

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102573787A (zh) * 2009-08-14 2012-07-11 株式会社爱茉莉太平洋 含有天然提取物的组合物
CN101695470A (zh) * 2009-10-27 2010-04-21 天津郁美净集团有限公司 化妆品用组合物、含有该组合物的化妆品及其制备方法
CN102357066A (zh) * 2011-10-26 2012-02-22 天津郁美净集团有限公司 一种黄柏提取液及其制备方法
CN102614101A (zh) * 2012-04-25 2012-08-01 天津郁美净集团有限公司 含有黄柏提取物的化妆品用组合物及其制备方法与应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016183203A1 (fr) * 2015-05-14 2016-11-17 Access Business Group International Llc Compositions comprenant de l'obacunone et procédés d'utilisation de celles-ci dans des applications pour lutter contre le vieillissement de la peau
CN115252630A (zh) * 2022-09-02 2022-11-01 深圳技术大学 黄柏酮在制备预防、改善或治疗非酒精性脂肪肝的药物中的应用
CN115252630B (zh) * 2022-09-02 2024-02-09 深圳技术大学 黄柏酮在制备预防、改善或治疗非酒精性脂肪肝的药物中的应用

Also Published As

Publication number Publication date
TW201630589A (zh) 2016-09-01
CN105816342A (zh) 2016-08-03

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