[go: up one dir, main page]

WO2016107110A1 - Endoprothèse neuronale artificielle d'hydroxyapatite et son procédé de préparation - Google Patents

Endoprothèse neuronale artificielle d'hydroxyapatite et son procédé de préparation Download PDF

Info

Publication number
WO2016107110A1
WO2016107110A1 PCT/CN2015/082175 CN2015082175W WO2016107110A1 WO 2016107110 A1 WO2016107110 A1 WO 2016107110A1 CN 2015082175 W CN2015082175 W CN 2015082175W WO 2016107110 A1 WO2016107110 A1 WO 2016107110A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxyapatite
nerve
stent
film
scaffold
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2015/082175
Other languages
English (en)
Chinese (zh)
Inventor
李扬德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DONGGUAN DIANFU PRODUCT DESIGN Co Ltd
Original Assignee
DONGGUAN DIANFU PRODUCT DESIGN Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DONGGUAN DIANFU PRODUCT DESIGN Co Ltd filed Critical DONGGUAN DIANFU PRODUCT DESIGN Co Ltd
Publication of WO2016107110A1 publication Critical patent/WO2016107110A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Definitions

  • the invention relates to the technical field of nerve stents, in particular to a hydroxyapatite nerve stent and a preparation method thereof.
  • Peripheral nerve damage or breakage due to various trauma causes a decrease or loss of sensory and motor function. Severe peripheral nerve injury often leads to paralysis or permanent loss of labor. Peripheral nerve injury has a high incidence in China. According to statistics, in trauma patients, nerve injury of the extremities accounts for about 10% of the total number of trauma, and about 60% of the fractures of firearm injuries have neurological injuries. To this end, we need to find the ideal treatment for peripheral nerve injury. For peripheral nerve fractures, if the fracture gap is large, the fractured peripheral nerve must be regenerated and repaired by bridging the graft.
  • Hydroxyapatite is the main inorganic component of human and animal bones and teeth. Its physical and chemical composition is very similar to the inorganic composition of human bone. It has good biocompatibility, bioactivity and osteoconductivity, and human bone tissue. Excellent chemical and biological affinity. Bioactive ceramics prepared from hydroxyapatite are not only safe, non-toxic, but also capable of conducting bone growth. However, the use of hydroxyapatite for the preparation of nerve scaffolds for nerve repair has not been reported so far.
  • the present invention provides a hydroxyapatite nerve scaffold and a preparation method thereof.
  • the neural scaffold prepared by the method has good mechanical properties, is biodegradable, and has a three-dimensional structure required for nerve regeneration. Repair has far-reaching significance.
  • a hydroxyapatite nerve stent comprising a stent film and a degradable metal wire wrapped by a stent film, and the main component of the stent film is hydroxyapatite.
  • the stent is in the form of a sheet, a strip or a cylinder.
  • the degradable wires are distributed along the lateral and longitudinal directions of the stent.
  • the main component of the degradable metal wire is magnesium, zinc, calcium, iron or an alloy thereof.
  • the preparation method of the hydroxyapatite nerve stent comprises the following steps:
  • hydroxyapatite powder was taken, calcined at 900 ° C for 3 hours, cooled and dissolved in distilled water, and ultrasonically shaken for 30 min to make it uniformly dispersed to obtain a hydroxyapatite slurry.
  • the mass concentration is 10-50%;
  • the nerve scaffold has a porosity of 40-65%.
  • the hydroxyapatite nerve scaffold of the invention has good mechanical properties, biodegradability, and has the three-dimensional structure required for nerve regeneration, and has profound significance for nerve repair.
  • FIG. 1 is a schematic view showing the structure of a hydroxyapatite nerve stent according to the present invention.
  • Figures 2a, 2b and 2c are photographs of the upper surface, lower surface and longitudinal surface of the resulting hydroxyapatite nerve stent observed under a microscope.
  • a hydroxyapatite nerve stent comprises a stent film 1 and a degradable metal wire 2 wrapped by a stent film 1.
  • the degradable wires are distributed along the lateral and longitudinal directions of the stent.
  • the stent can be prepared into various shapes according to the needs of use, and is generally cylindrical or sheet-shaped.
  • the nerve scaffold has a porosity of 40-65%.
  • the stent film 1 is hydroxyapatite.
  • the main component of the degradable metal wire 2 is magnesium, zinc, calcium, iron or an alloy thereof.
  • Embodiment 1 a method for preparing a hydroxyapatite nerve stent, comprising the following steps:
  • hydroxyapatite powder was taken, calcined at 900 ° C for 3 hours, cooled and dissolved in distilled water, and ultrasonically shaken for 30 min to make it uniformly dispersed to obtain a hydroxyapatite slurry.
  • the mass concentration is 40%;
  • Figures 2a, 2b and 2c are photographs of the upper surface, lower surface and longitudinal surface of the artificial nerve stent obtained under a microscope.
  • Embodiment 2 a method for preparing a hydroxyapatite nerve stent, comprising the following steps:
  • hydroxyapatite powder is taken, calcined at 800-° C. for 3 hours, cooled, dissolved in distilled water, and shaken by ultrasonic for 40 min to uniformly disperse to obtain a hydroxyapatite slurry. Its mass concentration is 50%;

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une endoprothèse neuronale artificielle d'hydroxyapatite, laquelle endoprothèse comprend un film (1) et des fils métalliques dégradables (2) enrobant le film (1) formé essentiellement d'hydroxyapatite. Avantages de l'endoprothèse neuronale artificielle selon le procédé de préparation de cette invention : propriétés mécaniques satisfaisantes, biodégradabilité, structure 3D de croissance neuronale et réparation efficace.
PCT/CN2015/082175 2014-12-29 2015-06-24 Endoprothèse neuronale artificielle d'hydroxyapatite et son procédé de préparation Ceased WO2016107110A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410834302.9A CN104524628B (zh) 2014-12-29 2014-12-29 一种羟基磷灰石神经支架及其制备方法
CN201410834302.9 2014-12-29

Publications (1)

Publication Number Publication Date
WO2016107110A1 true WO2016107110A1 (fr) 2016-07-07

Family

ID=52840374

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2015/082175 Ceased WO2016107110A1 (fr) 2014-12-29 2015-06-24 Endoprothèse neuronale artificielle d'hydroxyapatite et son procédé de préparation

Country Status (2)

Country Link
CN (1) CN104524628B (fr)
WO (1) WO2016107110A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN204394742U (zh) * 2014-12-29 2015-06-17 东莞颠覆产品设计有限公司 一种内置可降解金属丝的实芯神经支架
CN104524628B (zh) * 2014-12-29 2016-11-02 东莞颠覆产品设计有限公司 一种羟基磷灰石神经支架及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1562383A (zh) * 2004-03-16 2005-01-12 武汉理工大学 复合型聚乳酸缓释人工神经导管材料及制备方法
US20100047310A1 (en) * 2008-08-21 2010-02-25 Taipei Medical University Bio-acceptable conduits and method providing the same
CN102000362A (zh) * 2010-12-02 2011-04-06 上海纳米技术及应用国家工程研究中心有限公司 丝素蛋白/纳米羟基磷灰石多孔支架材料及其制备方法
CN102149859A (zh) * 2009-06-25 2011-08-10 三维生物科技有限公司 用于制备三维多孔管状支架的方法及设备
CN104107096A (zh) * 2014-07-18 2014-10-22 上海交通大学 可弯曲全降解镁合金神经导管及其制备方法
CN104524628A (zh) * 2014-12-29 2015-04-22 东莞颠覆产品设计有限公司 一种羟基磷灰石神经支架及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1562383A (zh) * 2004-03-16 2005-01-12 武汉理工大学 复合型聚乳酸缓释人工神经导管材料及制备方法
US20100047310A1 (en) * 2008-08-21 2010-02-25 Taipei Medical University Bio-acceptable conduits and method providing the same
CN102149859A (zh) * 2009-06-25 2011-08-10 三维生物科技有限公司 用于制备三维多孔管状支架的方法及设备
CN102000362A (zh) * 2010-12-02 2011-04-06 上海纳米技术及应用国家工程研究中心有限公司 丝素蛋白/纳米羟基磷灰石多孔支架材料及其制备方法
CN104107096A (zh) * 2014-07-18 2014-10-22 上海交通大学 可弯曲全降解镁合金神经导管及其制备方法
CN104524628A (zh) * 2014-12-29 2015-04-22 东莞颠覆产品设计有限公司 一种羟基磷灰石神经支架及其制备方法

Also Published As

Publication number Publication date
CN104524628A (zh) 2015-04-22
CN104524628B (zh) 2016-11-02

Similar Documents

Publication Publication Date Title
CN101474430B (zh) 一种生物活性组织再生膜及其制备方法
WO2016107109A1 (fr) Endoprothèse neuronale artificielle de collagène et d'hydroxyapatite et son procédé de préparation
CN104353110B (zh) 用于颌骨修复的具有形状记忆功能的骨支架材料及其制备方法
JP2022088628A (ja) 骨移植片代用品
CN101987208A (zh) 墨鱼骨转化多相大孔径骨再生支架材料及制备方法
WO2017118293A1 (fr) Implant osseux dégradable et son procédé de fabrication
Vyas et al. Sustainable sources of raw materials as substituting biomaterials for additive manufacturing of dental implants: a review
CN104761253A (zh) 一种功能仿生复合生物压电陶瓷材料及其制备方法
EP3241524A1 (fr) Endoprothèse neuronale à noyau solide renfermant des fils métalliques dégradables
KR20150006507A (ko) 모니터링이 가능한 다공성 뼈이식재 제조방법 및 뼈이식재 주입기구
CN111773432A (zh) 镁基非晶-磷酸钙/硅酸钙复合填充物及其制备与应用
CN116392638B (zh) 载万古霉素多级孔人工骨支架模型的3d打印构建及制备方法
WO2016107110A1 (fr) Endoprothèse neuronale artificielle d'hydroxyapatite et son procédé de préparation
WO2011130812A2 (fr) Suspensions pour la préparation de greffons osseux (échafaudages) à base de biosilicate, greffons osseux obtenus et procédés d'obtention de ceux-ci
WO2016107112A1 (fr) Endoprothèse neuronale artificielle riche en collagène et son procédé de préparation
WO2016107107A1 (fr) Endoprothèse neuronale artificielle de source animale et son procédé de préparation
RU2554804C1 (ru) Способ получения композиционного материала на основе фосфата кальция
CN102764454A (zh) 可降解吸收性PLGA-Mg系复合材料医用植入体及其制备方法
CN107899088B (zh) 一种用于预防去除内固定物后再骨折的多孔生物支架及其制备
WO2016107108A1 (fr) Endoprothèse neuronale artificielle d'acide polylactique et son procédé de préparation
CN105031727A (zh) 一种载药复合骨修复材料及其制备方法
CN109316627A (zh) 一种新型人工骨材料及其制备方法和应用
CN111773434A (zh) 镁锶-磷酸钙/硅酸钙复合骨水泥填充物及其制备与应用
Bag Biodegradable composite scaffold for bone tissue regeneration
CN104623742A (zh) 具有生物活性的可吸收医用捆扎带及成型方法

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 15874800

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205N DATED 16/11/2017)

122 Ep: pct application non-entry in european phase

Ref document number: 15874800

Country of ref document: EP

Kind code of ref document: A1