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WO2016107107A1 - Endoprothèse neuronale artificielle de source animale et son procédé de préparation - Google Patents

Endoprothèse neuronale artificielle de source animale et son procédé de préparation Download PDF

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Publication number
WO2016107107A1
WO2016107107A1 PCT/CN2015/082158 CN2015082158W WO2016107107A1 WO 2016107107 A1 WO2016107107 A1 WO 2016107107A1 CN 2015082158 W CN2015082158 W CN 2015082158W WO 2016107107 A1 WO2016107107 A1 WO 2016107107A1
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WO
WIPO (PCT)
Prior art keywords
stent
animal
nerve
film
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2015/082158
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English (en)
Chinese (zh)
Inventor
李扬德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DONGGUAN DIANFU PRODUCT DESIGN Co Ltd
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DONGGUAN DIANFU PRODUCT DESIGN Co Ltd
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Filing date
Publication date
Application filed by DONGGUAN DIANFU PRODUCT DESIGN Co Ltd filed Critical DONGGUAN DIANFU PRODUCT DESIGN Co Ltd
Publication of WO2016107107A1 publication Critical patent/WO2016107107A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials

Definitions

  • the invention relates to the technical field of nerve repair, and in particular to an animal-derived nerve stent and a preparation method thereof.
  • Peripheral nerve damage or breakage due to various trauma causes a decrease or loss of sensory and motor function. Severe peripheral nerve injury often leads to paralysis or permanent loss of labor. Peripheral nerve injury has a high incidence in China. According to statistics, in trauma patients, nerve injury of the extremities accounts for about 10% of the total number of trauma, and about 60% of the fractures of firearm injuries have neurological injuries. To this end, we need to find the ideal treatment for peripheral nerve injury. For peripheral nerve fractures, if the fracture gap is large, the fractured peripheral nerve must be regenerated and repaired by bridging the graft.
  • Autologous transplantation is undoubtedly the most ideal method for repairing nerve defects.
  • a large number of experimental and clinical results have confirmed that autologous nerve transplantation is superior to artificial stents.
  • autologous nerve transplantation inevitably causes new nerve damage, resulting in impaired function of the donor site, and even local formation of scars, neuroma, resulting in motor or sensory disturbances.
  • autologous nerve sources are limited, especially for long segments of important large nerves, and it is often difficult to find a suitable donor. Therefore, the development of autologous nerve transplantation is very limited and difficult to promote. Therefore, it is especially necessary to find nerve defect repair materials and methods to replace autologous nerve transplantation.
  • the present invention provides an animal-derived nerve stent and a preparation thereof
  • the nerve scaffold is of animal origin, solves the problem of insufficient supply of autologous nerves, and also solves the problem that autologous nerve transplantation inevitably causes new nerve damage, leading to impaired function of the donor area, and has far-reaching significance for nerve repair.
  • an animal-derived nerve stent comprising a stent film and a degradable metal wire wrapped by a stent film, the main component of which is an animal-derived blood vessel, a lymphatic vessel, a neural tube or an intestinal tract. .
  • the stent is in the form of a sheet, a strip or a cylinder.
  • the main component of the degradable metal wire is magnesium, zinc, calcium, iron or an alloy thereof.
  • the degradable wires are distributed along the longitudinal and transverse directions of the nerve stent.
  • the method for preparing the animal-derived nerve stent comprises the following steps:
  • Animal source film powder animal source blood vessels, lymphatic vessels, neural tubes or intestines are freeze-dried, sterilized and pulverized into powder, and animal source film powder is obtained;
  • the animal source film powder is completely dissolved in methylene chloride, and the ultrasonic dispersion is uniform, and the slurry is obtained, which is transferred into the mold cavity of the film forming mold, and the horizontal and vertical directions are placed in the mold cavity along the stent forming direction.
  • the metal wire is degraded, the degradable metal wire is immersed in the slurry, the solvent is naturally volatilized and dried, vacuumed for 48 hours, dried at a low temperature, and the dried stent film is wrapped with the magnesium wire to obtain the animal-derived nerve stent.
  • Raw materials such as blood vessels, lymphatic vessels, neural tubes or intestines have good biocompatibility with human body and can provide morphological support for nerve growth.
  • Scanning electron fiber mirrors show that the internal structure of the obtained animal-derived nerve scaffold is Honeycomb provides space for the nerve cells to crawl and grow; the degradable metals and their alloys can guide the growth of nerve cells, thereby facilitating the repair of nerve cells.
  • the invention has the beneficial effects that the nerve scaffold of the invention is of animal origin, solves the problem of insufficient supply of autologous nerve, and solves the problem that the autologous nerve transplantation inevitably causes new nerve damage, resulting in impaired function of the donor area, Nerve repair has far-reaching significance.
  • FIG. 1 is a schematic view showing the structure of a collagen-rich artificial nerve stent of the present invention.
  • an animal-derived nerve stent comprises a stent film 1 and a degradable metal wire 2 wrapped by a stent film 1.
  • the degradable metal wire 2 is distributed along the longitudinal and transverse directions of the nerve stent.
  • the stent can be prepared into various shapes according to the needs of use, and is generally cylindrical or sheet-shaped.
  • the main component of the scaffold film 1 is an animal-derived blood vessel, a lymphatic vessel, a neural tube or an intestinal tract.
  • the main component of the degradable metal wire 2 is magnesium, zinc, calcium, iron or an alloy thereof.
  • Example 1 A method for preparing the animal-derived nerve stent, comprising the following steps:
  • Animal source film powder animal source blood vessels are freeze-dried, sterilized and pulverized into powder, and animal source film powder is obtained;
  • the animal source film powder is completely dissolved in methylene chloride, the ultrasonic dispersion is uniform, the slurry is obtained, and transferred into the mold cavity of the film forming mold, and the transverse and longitudinal magnesium are placed in the mold cavity along the stent forming direction.
  • Zinc alloy wire, the magnesium-zinc alloy wire is immersed in the slurry, the solvent is naturally volatilized and dried, vacuumed for 48 hours, dried at a low temperature, and the dried stent film is wrapped with the magnesium wire to obtain the animal-derived nerve stent.
  • Example 2 A method for preparing the animal-derived nerve stent, comprising the following steps:
  • Animal source film powder the animal source neural tube is freeze-dried, sterilized and pulverized into powder, and the animal source film powder is obtained;
  • the animal source film powder is completely dissolved in methylene chloride, and the ultrasonic dispersion is uniform, and the slurry is obtained, which is transferred into the mold cavity of the film forming mold, and the horizontal and vertical directions are placed in the mold cavity along the stent forming direction.
  • the metal wire is degraded, the degradable metal wire is immersed in the slurry, the solvent is naturally volatilized and dried, vacuumed for 48 hours, dried at a low temperature, and the dried stent film is wrapped with the magnesium wire to obtain the animal-derived nerve stent.
  • Example 3 A method for preparing the animal-derived nerve stent, comprising the following steps:
  • Animal source film powder the animal source is lyophilized and dried, sterilized and pulverized into powder, and the animal source film powder is obtained;
  • the animal source film powder is completely dissolved in methylene chloride, and the ultrasonic dispersion is uniform, and the slurry is obtained, which is transferred into the mold cavity of the film forming mold, and the horizontal and vertical directions are placed in the mold cavity along the stent forming direction.
  • the metal wire is degraded, the degradable metal wire is immersed in the slurry, the solvent is naturally volatilized and dried, vacuumed for 48 hours, dried at a low temperature, and the dried stent film is wrapped with the magnesium wire to obtain the animal-derived nerve stent.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une endoprothèse neuronale artificielle de source animale et son procédé de préparation, laquelle endoprothèse comprend un film (1) et des fils métalliques dégradables (2) enrobant le film (1) formé essentiellement de vaisseaux sanguins, de vaisseaux lymphatiques, d'un tube neural ou du tractus intestinal de source animale. Le procédé de préparation de la présente invention comprend une étape de préparation de poudre de source animale et une étape d'enrobage dudit film (1) par les fils métalliques dégradables (2).
PCT/CN2015/082158 2014-12-29 2015-06-24 Endoprothèse neuronale artificielle de source animale et son procédé de préparation Ceased WO2016107107A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410835135.X 2014-12-29
CN201410835135.XA CN104548205B (zh) 2014-12-29 2014-12-29 一种动物源神经支架及其制备方法

Publications (1)

Publication Number Publication Date
WO2016107107A1 true WO2016107107A1 (fr) 2016-07-07

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PCT/CN2015/082158 Ceased WO2016107107A1 (fr) 2014-12-29 2015-06-24 Endoprothèse neuronale artificielle de source animale et son procédé de préparation

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CN (1) CN104548205B (fr)
WO (1) WO2016107107A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN204394742U (zh) * 2014-12-29 2015-06-17 东莞颠覆产品设计有限公司 一种内置可降解金属丝的实芯神经支架
CN104548205B (zh) * 2014-12-29 2017-07-21 东莞颠覆产品设计有限公司 一种动物源神经支架及其制备方法
CN109513041B (zh) * 2018-12-29 2023-10-03 南通纺织丝绸产业技术研究院 一种镁丝蚕丝复合编织结构神经导管及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN200951213Y (zh) * 2005-12-20 2007-09-26 广州知光生物科技有限公司 生物型神经导管
CN101366975A (zh) * 2008-09-03 2009-02-18 陕西瑞盛生物科技有限公司 脱细胞小肠粘膜下层生物材料的制备方法
US7942918B2 (en) * 2005-12-29 2011-05-17 Ethicon, Inc. Device for treating carpal tunnel syndrome
WO2014058586A1 (fr) * 2012-10-08 2014-04-17 Cormatrix Cardiovascular, Inc. Compositions, structures et procédés pour la régénération neurale
CN104107096A (zh) * 2014-07-18 2014-10-22 上海交通大学 可弯曲全降解镁合金神经导管及其制备方法
CN104548205A (zh) * 2014-12-29 2015-04-29 东莞颠覆产品设计有限公司 一种动物源神经支架及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN200951213Y (zh) * 2005-12-20 2007-09-26 广州知光生物科技有限公司 生物型神经导管
US7942918B2 (en) * 2005-12-29 2011-05-17 Ethicon, Inc. Device for treating carpal tunnel syndrome
CN101366975A (zh) * 2008-09-03 2009-02-18 陕西瑞盛生物科技有限公司 脱细胞小肠粘膜下层生物材料的制备方法
WO2014058586A1 (fr) * 2012-10-08 2014-04-17 Cormatrix Cardiovascular, Inc. Compositions, structures et procédés pour la régénération neurale
CN104107096A (zh) * 2014-07-18 2014-10-22 上海交通大学 可弯曲全降解镁合金神经导管及其制备方法
CN104548205A (zh) * 2014-12-29 2015-04-29 东莞颠覆产品设计有限公司 一种动物源神经支架及其制备方法

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CN104548205B (zh) 2017-07-21
CN104548205A (zh) 2015-04-29

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