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WO2016197015A1 - Produits de soins personnels : kit et procédés d'utilisation et de fabrication - Google Patents

Produits de soins personnels : kit et procédés d'utilisation et de fabrication Download PDF

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Publication number
WO2016197015A1
WO2016197015A1 PCT/US2016/035855 US2016035855W WO2016197015A1 WO 2016197015 A1 WO2016197015 A1 WO 2016197015A1 US 2016035855 W US2016035855 W US 2016035855W WO 2016197015 A1 WO2016197015 A1 WO 2016197015A1
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WIPO (PCT)
Prior art keywords
composition
oil
volume
salt
total volume
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2016/035855
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English (en)
Inventor
Tara NADER
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Longeva LLC
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Longeva LLC
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Filing date
Publication date
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Publication of WO2016197015A1 publication Critical patent/WO2016197015A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • Tooth whitening is a common procedure in general dentistry. Whitening restores natural tooth color. It has become desirable for a person's teeth to appear white. Teeth can become stained by food and drink products, including tobacco, vegetables, coffee, tea, and wine. Teeth can also become stained by certain medications. Whitening agents can help remove stains on teeth. Flavorings may be used to add scent, flavor, and color to whitening agents to make the whitening compositions more desirable.
  • a composition of the current disclosure may be applied to a skin cell, or a portion of an area of skin.
  • the composition may decrease the appearance of wrinkles, fine lines, scars, and make a portion of skin appear to be more radiant.
  • a composition of the current disclosure may be used on a skin condition, wherein the skin condition can be cause by a bacterium, a virus, an allergic reaction, or a weakened immune system.
  • the present disclosure provides a composition and method for whitening and restoring natural tooth color.
  • An aspect of the present disclosure provides a composition for whitening a tooth surface comprising a whitening agent, a sugar, a salt, coconut oil, cinnamon oil, clove oil and peppermint oil.
  • the composition further comprises castor oil.
  • the composition further comprises squalane oil.
  • the composition further comprises hemp oil.
  • the composition further comprises black seed oil.
  • the composition further comprises black currant oil.
  • the composition further comprises rose hip oil.
  • the composition further comprises jojoba oil.
  • the composition further comprises sesame oil.
  • the composition further comprises apricot oil.
  • the composition further comprises avocado oil.
  • the composition further comprises argan oil. In some embodiments, the composition further comprises almond oil. In some embodiments, the composition further comprises grape seed oil. In some embodiments, the composition further comprises castor oil, squalane oil, hemp oil, black seed oil, black currant oil, rose hip oil, jojoba oil, sesame oil, apricot oil, avocado oil, argan oil, almond oil and grape seed oil.
  • the whitening agent is selected from the group consisting of peroxides, carbonates, bicarbonates, percarbonates, perborates, peroxyacids, and any
  • the whitening agent is a carbonate. In some embodiments, the whitening agent is sodium bicarbonate. In some embodiments, the sugar is selected from the group consisting of glucose, fructose, sucrose, erythritol, maltitol, xylitol and any combination thereof. In some embodiments, the sugar is xylitol. In some embodiments, the salt is a sea salt. In some embodiments, the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 1 : 1 : 1. In some embodiments, the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 1 :2:3. In some embodiments, the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 2: 1 :3. In some embodiments, the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 3:1:2.
  • the composition further comprises castor oil, squalane oil, hemp oil, black seed oil, black currant oil, rose hip oil, jojoba oil, sesame oil, apricot oil, avocado oil, argan oil, almond oil and grape seed oil, and wherein the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 2: 1 :3.
  • the tooth surface is the tooth surface of a human subject. In some embodiments, the tooth surface is the tooth surface of a denture. In some embodiments, the tooth surface is the tooth surface of a pet. In some
  • the composition is suitable for application by a professional dentist. In some embodiments, the composition is suitable for application by a user. In some embodiments, the composition is applied to at least one tooth in a layer. In some embodiments, the composition is combined with a toothpaste. In some embodiments, the composition is suitable for application on a dental floss. In some embodiments, the composition is suitable for application on a dental tray. In some embodiments, the composition is suitable for application on a disposable plastic strip. In some embodiments, a tooth whitening kit comprises the composition. In some embodiments, a tooth whitening kit comprises the composition and an application tool.
  • compositions comprising a whitening agent, a sugar, a salt, coconut oil, cinnamon oil, clove oil and peppermint oil.
  • the composition further comprises castor oil.
  • the composition further comprises squalane oil.
  • the composition further comprises hemp oil.
  • the composition further comprises black seed oil.
  • the composition further comprises black currant oil.
  • the composition further comprises rose hip oil.
  • the composition further comprises jojoba oil.
  • the composition further comprises sesame oil.
  • the composition further comprises apricot oil.
  • the composition further comprises avocado oil. In some embodiments, the composition further comprises argan oil. In some embodiments, the composition further comprises almond oil. In some embodiments, the composition further comprises grape seed oil. In some embodiments, the composition further comprises castor oil, squalane oil, hemp oil, black seed oil, black currant oil, rose hip oil, jojoba oil, sesame oil, apricot oil, avocado oil, argan oil, almond oil and grape seed oil.
  • the whitening agent is selected from the group consisting of peroxides, carbonates, bicarbonates, percarbonates, perborates, peroxyacids, and any
  • the whitening agent is a carbonate. In some embodiments, the whitening agent is sodium bicarbonate. In some embodiments, the sugar is selected from the group consisting of glucose, fructose, sucrose, erythritol, maltitol, xylitol and any combination thereof. In some embodiments, the sugar is xylitol. In some embodiments, the salt is a sea salt. In some embodiments, the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 1 : 1 : 1. In some embodiments, the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 1 :2:3.
  • the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 2: 1 :3. In some embodiments, the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 3 : 1 :2. In some embodiments, the composition further comprises castor oil, squalane oil, hemp oil, black seed oil, black currant oil, rose hip oil, jojoba oil, sesame oil, apricot oil, avocado oil, argan oil, almond oil and grape seed oil, and wherein the cinnamon oil, the clove oil, and the peppermint oil are in a ratio of about 2: 1 :3. In some embodiments, the tooth surface is the tooth surface of a human subject.
  • the tooth surface is the tooth surface of a denture. In some embodiments, the tooth surface is the tooth surface of a pet. In some embodiments, application of the composition is by a professional dentist. In some embodiments, application of the
  • composition is by a user. In some embodiments, purchasing is from a professional dentist. In some embodiments, purchasing is over the counter. In some embodiments, application of the composition is to at least one tooth in a layer. In some embodiments, applying the composition to a tooth surface is with a toothbrush.
  • the current disclosure provides a composition comprising: at least one plant, extract thereof, oil thereof, or a part thereof; i) at least one molecule comprising one alcohol functional group and at least 8 carbon atoms, or a salt thereof; or ii) at least one molecule comprising at least two alcohol functional groups and 2 to 8 carbons, or a salt thereof; or any combination thereof; at least one vitamin, or a salt thereof; and at least one molecule comprising an oxo group, an acidic group, and at least 4 carbons, ester thereof, salt thereof, or any
  • the composition is topical composition.
  • the at least one plant, extract thereof, oil thereof is a plant.
  • the plant is selected from the group consisting of aloe vera, green tea, green tea extract, flaxseed, chamomile, lavender, white tea, and saberry.
  • the composition comprises at least two of the at least one plant, extract thereof, oil thereof, or part thereof. In some embodiments, the composition comprises at least three of the at least one plant, extract thereof, oil thereof, or part thereof.
  • the composition comprises at least 2 volume % of the at least one molecule comprising one alcohol functional group and at least 8 carbons, or a salt thereof; or at least one molecule comprising at least two alcohol functional groups and 2 to 8 carbons, or a salt thereof, wherein the volume % is based on a total volume % of the composition.
  • the composition comprises at least 0.5 volume % of the at least one molecule comprising an oxo group, an acidic group, and at least 4 carbons, ester thereof, salt thereof, or any combination thereof, wherein the volume % is based on a total volume % of the composition.
  • the composition comprises fragrance citrus punch, fragrance clean linen, fragrance coconut, fragrance coconut lime verbena, fragrance coral reef, fragrance lemon verbena, fragrance mandarin-berry, fragrance mangosteen, fragrance neroli, fragrance peppermint oil, fragrance pineapple lily, fragrance sweet orange essential oil, fragrance tea tree essential oil, fragrance vanilla grapefruit, fragrance white peach & ginger, or fragrance white tea.
  • the current disclosure provides a method for treatment of a skin condition comprising contacting of a composition of the current disclosure to a subject in need thereof.
  • the skin cell an area of skin around the skin cell, or both, is first washed and dried before the contact.
  • the skin cell is a skin cell of the face, neck, or hands.
  • the skin cell is a skin cell of the face, abdomen, thighs, buttocks, or arms.
  • the method further comprises application of an adhesive bandage to the area of skin after the contact.
  • the composition is contacted for a period of time of at least 1 second.
  • the composition is packaged into a container selected from the group consisting of a tube, ajar, and a vial.
  • the tube contains information describing directions for use.
  • Figure 1 diagrams a schematic of an example of a tooth whitening system.
  • a tooth surface 100 can undergo a contact step 105 with a whitening composition, thereby yielding a whitened tooth surface 110.
  • the present application relates to compositions to whiten a tooth surface and compositions for application to a skin cell.
  • salt refers to salts derived from a variety of organic and inorganic counter ions known in the art.
  • Pharmaceutically acceptable acid addition salts can be formed with inorganic acids and organic acids.
  • Inorganic acids from which salts can be derived include, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid, and the like.
  • Organic acids from which salts can be derived include, for example, acetic acid, propionic acid, glycolic acid, pyruvic acid, oxalic acid, maleic acid, malonic acid, succinic acid, fumaric acid, tartaric acid, citric acid, benzoic acid, cinnamic acid, mandelic acid, methanesulfonic acid, ethanesulfonic acid, p toluenesulfonic acid, salicylic acid, and the like.
  • Pharmaceutically acceptable base addition salts can be formed with inorganic and organic bases.
  • Inorganic bases from which salts can be derived include, for example, sodium, potassium, lithium, ammonium, calcium, magnesium, iron, zinc, copper, manganese, aluminum, and the like.
  • Organic bases from which salts can be derived include, for example, primary, secondary, and tertiary amines, substituted amines including naturally occurring substituted amines, cyclic amines, basic ion exchange resins, and the like, specifically such as
  • the pharmaceutically acceptable base addition salt is chosen from ammonium, potassium, sodium, calcium, and magnesium salts.
  • the oral care compositions of the various embodiments can be in the form of a paste, gel, or liquid formulation.
  • the composition may be in any desired form, such as a homogeneous mix, deep striped, surface striped, multi-layered, having a gel surround the paste, or any combinations thereof.
  • the composition comprises an oil.
  • the oil may be a plant oil, an animal oil, or a synthetic oil.
  • the plant oil may be extracted or pressed from a plant, the seed of a plant, or a fruit.
  • plant oils are agar oil, almond oil, ajwain oil, angelica root oil, anise oil, apricot oil, argan oil, avocado oil, balsam of Peru, basil oil, bay oil, beech nut oil, bergamot oil, black currant oil, black seed oil, black pepper oil, buchu oil, birch oil, cannabis flower essential oil, caraway oil, cardamom seed oil, carrot seed oil, cashew oil, castor oil, cedarwood oil, chamomile oil, coconut oil, corn oil, cotton seed oil, davana oil, dill oil, eucalyptus oil, evening primrose oil, fennel seed oil, flaxseed oil, frankincense oil, geranium oil, ginger
  • animal oil examples include cow oil, pig oil, horse oil, sheep oil, deer oil, goat oil, or any combinations thereof.
  • Non-limiting examples of plant derivatives include cocoa butter, cocoa seed butter, aloe vera, aloe vera gel, green tea, green tea extract, flaxseed, chamomile, chamomile extract, chamomile flower oil, calendula officinalis flower, calendula officinalis flower extract, tamanu oil, lavender, matricaria flower, white tea, arnica montana flower, aloe barbadensis leaf, borage oil, soy, soy protein, hydrolyzed soy protein, aloe barbadensis leaf juice, carrot seed, saberry, saberry extract, lemon peel extract, cucumber, and cucumber extract; and extracts, oils, juice, stems, leaves, flowers, and roots of the aforementioned plants.
  • Vitamins may be added to a composition of the current disclosure.
  • vitamins include vitamin A, vitamin B, vitamin B3, vitamin B5, vitamin BIO, vitamin C, ascorbic acid, ascorbyl palmitate, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, tetrahexyldecyl ascorbate, vitamin E, tocopherol, tocopheryl acetate,
  • the oils may be combined to form a mixture of oils.
  • the oils may be combined to form a blend of 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, or 100 or more oils.
  • the composition may comprise cinnamon oil. In another non-limiting example, the composition may comprise clove oil. In another non-limiting example, the composition may comprise peppermint oil. In yet another non-limiting example, the composition may comprise cinnamon oil and clove oil. In another non-limiting example, the composition may comprise cinnamon oil and peppermint oil. In another non-limiting example, the composition may comprise clove oil and peppermint oil. In one non-limiting example, the composition can comprise cinnamon oil, clove oil, and peppermint oil. In another non-limiting example, the composition can comprise coconut oil, cinnamon oil, clove oil, and peppermint oil.
  • Some non-limiting examples of synthetic oils include petroleum jelly, isopropyl esters, ethylhexyl esters, propoxylated alcohols, oleic acid esters, polymer oils, or any combinations thereof.
  • the composition comprises an alcohol.
  • Non-limiting examples of an alcohol include simple alcohols, emulsifying wax, wax, glycerin, ethanol, propanol, 1,2-propanediol, stearyl alcohol, glyceryl stearate, phenoxyethanol, glyceryl monolaurate, resveratrol, phenol, resorcinol, benzyl alcohol, methylhexylglycerin, ethylhexylglycerin, panthenol, cetyl alcohol, haloxyl (fluoxymesterone), butanol, pentanol, hexanol, heptanol, octyl alcohol, triglycerides, and capric triglyceride.
  • simple alcohols emulsifying wax, wax, glycerin, ethanol, propanol, 1,2-propanediol, stearyl alcohol, glyceryl stearate, phenoxyethanol
  • the composition comprises a sugar.
  • a sugar include fructose, glucose, galactose, sucrose, lactose, maltose, xylitol, erythritol, arabitol, ribitol, mannitol, glycerol, aspartame, cyclamate, saccharin, sucralose, or any combinations thereof.
  • Some non-limiting examples of unrefined sugars include cane juice, molasses, raw sugar, brown sugar, sweet sorghum syrup, maize sugar, agave nectar, maple syrup, palm sugar, sweet beet syrup, sweet cicely root, licorice root, barley malt syrup, brown rice malt syrup, watermelon sugar, pumpkin sugar, date syrup, stevia, honey, or any combinations thereof.
  • the sugar can be aspartame.
  • the sugar can be xylitol.
  • the sugar can be honey.
  • the sugar can be brown sugar.
  • the composition comprises a salt.
  • a salt include refined sodium chloride salt, potassium chloride, lithium chloride, calcium chloride, magnesium chloride, sea salt, canning salt, pickling salt, table salt, kosher salt, or any
  • the salt can be sea salt.
  • the salt can be potassium chloride.
  • the salt can be table salt.
  • the composition comprises a whitening agent.
  • whitening agents are peroxides, carbonates, bicarbonates, percarbonates, perborates, peroxyacids.
  • a whitening agent are hydrogen peroxide, carbamide peroxide, sodium carbonate, sodium bicarbonate, sodium perborate, perphthalic acid, diperoxycarboxylic acids, 1,12-dodecanedioic peroxy acid, peroxy acetic acid, or any
  • the whitening agent can be hydrogen peroxide. In another non-limiting example, the whitening agent can be sodium carbonate. In one non-limiting example, the whitening agent can be sodium bicarbonate.
  • the oral care compositions of the present invention may furthermore comprise optional, conventional ingredients such as pharmaceutically acceptable carriers like starch, sucrose, water, or any combinations thereof.
  • optional, conventional ingredients such as pharmaceutically acceptable carriers like starch, sucrose, water, or any combinations thereof.
  • Small amounts of surfactants or abraisive materials may also be included.
  • Some non-limiting examples include anionic, nonionic amphoteric surfactants, silicas, aluminas, calcium carbonates, dicalciumphosphates, calcium pyrophosphates hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates, or any combinations thereof.
  • additives include apple powder, citrus pectins, arabic gum, ascorbic acid, beeswax, betaine hydrochloride, biotin, cetyl alcohol, choline chloride, citric acid, cobalt carbonate, copper sulfate, corn starch, dextrose, folic acid, glycine, lanolin, lemon powder, maltodextrin, manganese sulfate, magnesium chloride, magnesium oxide, malic acid, niacin, pantothenic acid, potassium chloride, potassium sulfate, polysorbate, propylene glycol, purple pigment, riboflavin, sodium citrate, steryl alcohol, vaseline, vitamin A, vitamin B 12, vitamin D, vitamin E, vitamin K, and zinc sulfate.
  • additives include, for example, thickening agents, humectants, ionic active ingredients, buffering agents, aniicalculus agents, abrasive polishing materials, peroxide sources, alkali metal bicarbonate salts, surfactants, titanium dioxide, coloring agents, flavor systems, sweetening agents, antimicrobial agents, herbal agents, desensitizing agents, stain reducing agents, stabilizing agents, or any combinations thereof,
  • an ingredient in a composition of the current disclosure is selected from acrylate copolymer, acticaps argireline, acticaps retinol, aha fruit acids, algae extract, algae extract, organic, algae extract & hyaluronate, allantoin, almond oil, aloe vera, aloe vera powder, alpha-arbutin, alpha olefin sulfonate, aluminum chlorohydrate, amodimethicone, argan oil, argireline, arnica extract, avobenzone, avocado butter, avocado oil, bacillus ferment, bamboo extract, baobab oil, baobab protein, hydrolyzed, bees wax, behentrimonium, benzylalcohol, bht, beta glucan, bilberry fruit extract, bismuth oxychloride, C12- 15 alkyl benzoate, camelina oil, candelilla wax, caprylic acid combo, caprylyl glycol
  • pigment red no. 7 pigment red no. 40, pigment yellow no. 5, polyamide 3, polyethylene, polyglucose, polyglyceryl oleate, polyisobutene 250, polyisobutene 1200, polylactic acid beads, polyquaternium 10, polysorbate 20, polysorbate 60, polysorbate 80, potassium sorbate, propylene glycol,
  • provitamin b5 (d-panthenol), PVP (polyvinylpyrrolidone), red raspberry seed oil, resveratrol powder, rhodiola hairactive, rhubarb root extract, rice bran beads, rice quat, rose hip oil, rosemary leaf extract, rosemary leaf extract, organic, sage extract, salicylic acid, sea fennel extract, seaferment sa, sea kelp extract, sebum, shea nut, silicone gel, silk protein, cocoyl taurate, soapwort extract, sodium gluconate, sodium lauryl sulfate, sorbitan oleate, sorbitan stearate, sorbitol, soy-rice peptides, squalane, stearic acid, stearyl palmitate, sucrose cocoate, sulfosuccinate, sulphur mud, sunflower oil, talc, tapioca starch, tea tree essential oil, tepre
  • a dye may be added to a composition of the current disclosure.
  • dyes include D&C Red Nos. 2, 5, 6, 7, 10, 11, 12, 13, 30, 34, D&C Yellow No. 5, D&C Blue No. 1, a metal oxide, and a metal hydroxide, silicic acid, silicic acid anhydride, magnesium silicate, talc, sericite, mica, kaolin, iron oxide red, clay, bentonite, titanium-coated mica, bismuth oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, aluminium oxide, calcium sulfate, barium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, iron oxide, ultramarine blue, chromium oxide, chromium hydroxide, carmine, carbon black, polyamide, polyester, polypropylene, polystyrene,
  • an ingredient can be individually present in an amount from 0.0001% to 99.9999%, wherein the amount can be based on weight %, volume %, or mole %, based on the total weight %, volume %, or mole % of the composition.
  • an ingredient can be present in an amount from 0.001% to 99.99%, 0.1% to 99.9%, 1% to 99%, 5% to 95%, 10% to 90%, 20% to 80%, 30% to 70%, or 50% to 60%, wherein the amount can be based on weight %, volume %, or mole %, based on the total % of the composition.
  • each ingredient of the composition can have a volume by volume percent equal to or less than about 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 100%.
  • each ingredient of the composition has a volume by volume percent equal to or greater than about 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1%, 0.15%, 0.20%, 0.25%, 0.30%, 0.35%, 0.40%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 100%.
  • sodium bicarbonate can have a w/w % of about 20-80%, about 40-60%, about 55%, or about 52%.
  • xylitol can have a w/w % of about 10-50%, about 20-30%, or about 25%.
  • sea salt can have a w/w % of about 0.1-5%, or about 1%.
  • coconut oil can have a w/w % of about 5-25%, about 10-15%, or about 13%.
  • cinnamon oil can have a w/w % of about 1-5%, or 3%.
  • clove oil can have a w/w % of about 0.1-5%, or about 1%.
  • peppermint oil can have a w/w % of about 1-5%, or about 3%.
  • squalane oil can have a w/w % of about 0.01-5%, or about 0.1%.
  • hemp oil can have a w/w % of about 0.01-5%, or about 0.1%.
  • black seed oil can have a w/w % of about 0.01-5%, or about 0.1%.
  • black currant oil can have a w/w % of about 0.01-5%,or about 0.1%.
  • rose hip oil can have a w/w % of about 0.01-5%, or about 0.1%.
  • jojoba oil can have a w/w % of about 0.01-5%, or about 0.1%.
  • sesame oil can have a w/w % of about 0.01-5%, or about 0.1%.
  • apricot can have a w/w % of about 0.01-5%, or about 0.1%.
  • avocado oil can have a w/w % of about 0.01-5%,or about 0.1%.
  • argan oil can have a w/w % of about 0.01-5%, orabout 0.1%.
  • almond oil can have a w/w % of about 0.01-5%, orabout 0.1%.
  • grape seed oil can have a w/w % of about 0.01-5%, or about 0.1%.
  • the amount of a compound in a composition is expressed by weight %, wherein the weight % of the compound is based on a total weight % of the
  • an ingredient can be present in a composition in about 0.1 weight %, 0.2 weight %, 0.3 weight %, 0.4 weight %, 0.5 weight %, 0.6 weight %, 0.7 weight %, 0.8 weight %, 0.9 weight %, 1 weight %, 2 weight %, 3 weight %, 4 weight %, 5 weight %, 6 weight %, 7 weight %, 8 weight %, 9 weight %, 10 weight %, 11 weight %, 12 weight %, 13 weight %, 14 weight %, 15 weight %, 16 weight %, 17 weight %, 18 weight %, 19 weight %, 20 weight %, 21 weight %, 22 weight %, 23 weight %, 24 weight %, 25 weight %, 26 weight %, 27 weight %, 28 weight %, 29 weight %, 30 weight %, 35 weight %, 40 weight %, 50 weight %, 60 weight %, 70 weight %, 80 weight %, 90
  • a compound is present in a composition in greater than about 0.1 weight %, 0.2 weight %, 0.3 weight %, 0.4 weight %, 0.5 weight %, 0.6 weight %, 0.7 weight %, 0.8 weight %, 0.9 weight %, 1 weight %, 2 weight %, 3 weight %, 4 weight %, 5 weight %, 6 weight %, 7 weight %, 8 weight %, 9 weight %, 10 weight %, 11 weight %, 12 weight %, 13 weight %, 14 weight %, 15 weight %, 16 weight %, 17 weight %, 18 weight %, 19 weight %, 20 weight %, 21 weight %, 22 weight %, 23 weight %, 24 weight %, 25 weight %, 26 weight %, 27 weight %, 28 weight %, 29 weight %, 30 weight %, 35 weight %, 40 weight %, 50 weight %, 60 weight %, 70 weight %, 80 weight %, 90 weight %, 0.5
  • an ingredient is present in a composition in a positive amount and less than about 0.1 weight %, 0.2 weight %, 0.3 weight %, 0.4 weight %, 0.5 weight %, 0.6 weight %, 0.7 weight %, 0.8 weight %, 0.9 weight %, 1 weight %, 2 weight %, 3 weight %, 4 weight %, 5 weight %, 6 weight %, 7 weight %, 8 weight %, 9 weight %, 10 weight %, 11 weight %, 12 weight %, 13 weight %, 14 weight %, 15 weight %, 16 weight %, 17 weight %, 18 weight %, 19 weight %, 20 weight %, 21 weight %, 22 weight %, 23 weight %, 24 weight %, 25 weight %, 26 weight %, 27 weight %, 28 weight %, 29 weight %, 30 weight %, 35 weight %, 40 weight %, 50 weight %, 60 weight %, 70 weight %,
  • the amount of a compound in a composition is expressed by a volume %, wherein the volume % of the compound is based on a total volume % of the composition.
  • an ingredient can be present in a composition in about 0.1 volume %, 0.2 volume %, 0.3 volume %, 0.4 volume %, 0.5 volume %, 0.6 volume %, 0.7 volume %, 0.8 volume %, 0.9 volume %, 1 volume %, 2 volume %, 3 volume %, 4 volume %, 5 volume %, 6 volume %, 7 volume %, 8 volume %, 9 volume %, 10 volume %, 11 volume %, 12 volume %, 13 volume %, 14 volume %, 15 volume %, 16 volume %, 17 volume %, 18 volume %, 19 volume %, 20 volume %, 21 volume %, 22 volume %, 23 volume %, 24 volume %, 25 volume %, 26 volume %, 27 volume %, 28 volume %, 29 volume %, 30 volume %, 35 volume %, 40 volume %, 50 volume %, 60 volume %, 70 volume %, 80 volume %, 90
  • two ingredients in a composition can be expressed by ratio, wherein the ratio is based on weight %. In some embodiments, two ingredients in a composition can be expressed by ratio, wherein the ratio is based on volume %.
  • any of two ingredients can be in a ratio of about 1:1, 1:2, 1:3, 1 :4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 1:55, 1:60, 1:65, 1:70, 1:75, 1:80, 1:85, 1:90, 1:95, 1:100, 1:150, 1:200, 1:250, 1:300, 1:400, 1:500, 1:600, 1:700, 1:800, 1:900, 1:1000, 1:1500, 1:2000, 1:3000, 1:4000, 1 :5000, 1 :6000, 1 :7000, 1 :8000, 1 :9000, or 1 : 10000, wherein the ratio is based on weight.
  • any of two ingredients can be in a ratio of about 1:1, 1:2, 1:3, 1 :4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 1:55, 1:60, 1:65, 1:70, 1:75, 1:80, 1:85, 1:90, 1:95, 1:100, 1:150, 1:200, 1:250, 1:300, 1:400, 1:500, 1:600, 1:700, 1:800, 1:900, 1:1000, 1:1500, 1:2000, 1:3000, 1:4000, 1 :5000, 1 :6000, 1 :7000, 1 :8000, 1 :9000, or 1 : 10000, wherein the ratio is based on volume.
  • any of two ingredients can be in a ratio of about 1:1, 1 :2, 1:3, 1 :4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 1:55, 1:60, 1:65, 1:70, 1:75, 1:80, 1:85, 1:90, 1:95, 1:100, 1:150, 1:200, 1:250, 1:300, 1:400, 1:500, 1:600, 1:700, 1:800, 1:900, 1:1000, 1:1500, 1:2000, 1:3000, 1:4000, 1 :5000, 1 :6000, 1 :7000, 1 :8000, 1 :9000, or 1 : 10000, wherein the ratio is based on moles.
  • the composition can comprise sodium bicarbonate and xylitol in a relative ratio of about 2:1. In one non-limiting example, the composition can comprise sodium bicarbonate and xylitol in a relative ratio of about 2.36:1.
  • the composition can comprise coconut oil and cinnamon oil in a relative ratio of about 6.4:1. In another non-limiting example, the composition can comprise coconut oil and clove oil in a relative ratio of about 12.8:1. In another non-limiting example, the composition can comprise coconut oil and peppermint oil in a relative ratio of about 3.9:1.
  • the composition can comprise cinnamon oil, clove oil, and peppermint oil in a relative ratio of about 1 : 1 : 1.
  • the composition can comprise cinnamon oil, clove oil, and peppermint oil in a relative ratio of about 1:2:3.
  • the composition can comprise cinnamon oil, clove oil, and peppermint oil in a relative ratio of about 2: 1 :3.
  • the composition can comprise cinnamon oil, clove oil, and peppermint oil in a relative ratio of about 3:1:2.
  • the viscosity of the individual ingredients or the final paste composition is about 10, 100, 1000, 2000, 3000, 4000, 5000, 6000, 7000, 8000, 9000, 10,000, 20,000, 30,000, 40,000, 50,000, 60,000, 70,000, 80,000, 90,000, 100,000, 150,000, 200,000, 250,000, 500,000, 750,000, or 1,000,000 cP.
  • a user can pay for the composition.
  • the composition can be paid for by cash, credit card, debit card or promotional code.
  • the composition may be available for purchase from a variety of sources. Some non-limiting examples of sources for purchasing the composition are over-the-counter, online, and in specially stores.
  • the composition may be made available by a professional.
  • the composition may be prescribed by a professional.
  • compositions of the current disclosure may be contacted with a skin cell.
  • the skin cell may be a human skin cell.
  • the skin cell, area of skin around a skin cell, or both, may be first washed and dried before contact.
  • a skin cell may be a skin cell of the face, neck, hands, abdomen, thighs, buttocks, toes, feet, scalp, knees, or arms.
  • compositions of the current disclosure may be used on an infected skin cell.
  • the infection of the skin cell may be caused by a bacterium, a virus, or a fungus.
  • Bacterial skin infections include, but are not limited to, leprosy, carbuncles, staphylococcus aureus infection, cellulitis, impetigo, boils, pilonidal cyst, abscess, or combinations thereof.
  • Fungal skin infections include, but are not limited to, ringworm, athlete's foot, yeast infection, sporotrichosis, fungal nail infection, or combinations thereof.
  • a composition of the current disclosure is used on a skin condition, wherein the skin condition is rosacea, a wart, a mole, chickenpox, acne, rashes, hives, eczema (atopic, allergic, or nummular dermatitis), skin cancer, rosacea, seborrheic dermatitis (causing cradle cap or dandruff), psoriasis, vitiligo, impetigo, warts, eczema (atopic dermatitis), diaper dermatitis, seborrheic dermatitis (cradle cap), chickenpox, measles, warts, acne, roseola, hives, ringworm, or a rash.
  • the skin condition is rosacea, a wart, a mole, chickenpox, acne, rashes, hives, eczema (atopic, allergic, or nummular dermatitis), skin cancer
  • the cause of a skin condition may be a bacteria, a virus, an allergic reaction, fungus, a parasite, or a microorganism living in the skin, a weakened immune system (with or without coexisting infection), contact with allergens, irritants, or another person's infected skin, diaper rash, dehydration, cold, poor nutrition, side effect of medical procedures, conditions, or medication, such as radiation therapy, pregnancy, diabetes, hypothyroidism, kidney failure, sun, exposure to extreme temperatures, exercise, heat from sunlight, sunburns, anxiety, stress, or a burn.
  • a composition of the current disclosure may be used on a subject with a skin condition as a result of a weakened immune system, side effect of medical procedures, or from a burn. In some embodiments, a composition of the current disclosure may be used on a subject with a skin condition as a result of radiation therapy.
  • composition of the current disclosure may be used on skin that exhibits a symptom.
  • a composition may contain components that act synergistically, or more than the additive effects of each individual component.
  • a composition may have a combination index of less than 1, signifying a synergistic effect of the components.
  • the components acting synergistically may be 2 components, 3 components, 4 components, 5 components, 6 components, 7 components, 8 components, 9 components, 10 components, 15 components, 20 components, or more. Synergy within a composition, or between 2 or more components, may be determined by a skin comparison of different parts of skin on one person, 2 people, 3 people, or more.
  • components of a composition disclosed herein can be individually applied onto a distinct surface of an area of skin, e.g. arm, leg, torso. The number of components applied may be 2, 3, 4, 5, 6, 7, 8, 9, 10, or more. The distinct surfaces may be compared, and the comparative result may determine the level or amount of synergy between two or more components.
  • the ratio of two individual components of a composition disclosed herein that have a synergistic effect may be in a ratio about 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1 :7, 1:8, 1:9, 1:10, 1:11, 1:12, 1:13, 1:14, 1:15, 1:16, 1:17, 1:18, 1:19, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 1:55, 1:60, 1:65, 1:70, 1:75, 1:80, 1:85, 1:90, 1:95, 1:100, 1:150, 1:200, 1:250, 1:300, 1:400, 1:500, 1:600, 1:700, 1:800, 1:900, 1:1000, 1:1500, 1:2000, 1:3000, 1:4000, 1:5000, 1:6000, 1:7000, 1:8000, 1:9000, or 1 : 10000, wherein the ratio is based on weight %, volume %, or mole %.
  • a symptom of a skin condition may be a dry patch of skin, a wart, a bump, a dark spot, a colored speck, coloration of a patch of skin, peeling of skin, soreness of skin, an abnormal skin growth, a rash, an itch, scaly or rough skin, dry, cracked skin, chafing and peeling skin, open sores or lesions, changes in mole color or size, loss of skin pigment, excessive flushing with or without stimulus discolored patches of skin, or any combination thereof.
  • a composition can comprise one or more of the following ingredients: anise seed, amaranth, argan, pomegranate extract, perilla seed extract, black seed, borage, grapeseed extract, sea buckthorne, and gossypium herbaceum.
  • a composition can comprise one or more of the following ingredients: helianthus annuus (sunflower) oil, olea europaea (olive) oil, carrubba efa blend, lebermuth oil blend,tocopheryl acetate (vitamin e), Oenothera biennis (evening primrose) oil, cocos nucifera (coconut) oil, and theobroma cacao (cocoa) seed butter.
  • a composition can comprise one or more of the following ingredients: purified water, emulsifying wax, glycerin, safflower oil, octyl palmitate, glyceryl stearate, stearyl alcohol, glyceryl stearate, phenoxyethanol, glyceryl mono laurate, tocopheryl acetate (vitamin e), magnesium ascorbyl phosphate, squalane, carrubba efa blend lebermuth omni blend, syncoll, saberry, argeiline, coqlO, resveratrol, benzyl alcohol, lecithin, ethylhexylglycerin, stearic acid, panthenol, aloe vera gel, vitamin e, xanthane gum, allantoin, camellia, sinensis (green tea) extract, allantoin, camellia sinensis, green
  • a composition can comprise one or more of the following ingredients: purified water, carthamus tinctorius (safflower) oil, octyl palmitate, glycerin, glyceryl stearate, stearic acid, benzyl alcohol, helianthus annuus (sunflower) oil, caprilic/capric triglyceride, phenoxyethanol, fragrance, glycereth-7 cocoate, carrubba efa blend, lebermuth omni blend, cetyl alcohol, soy lecithin, carbomer, ethylhexylglycerin, panthenol, papain (and) bromelain (and) maltodextrin, mixed tocopherols (vitamin e), allantoin, lavandula angustifolia (lavender) flower/leaf/stem extract (+) chamomile recutita (matricaria) flower extract (+
  • a composition can comprise one or more of the following ingredients: purified water, sodium cl4-16 olefin sulfonate, cocamidopropyl betaine, glycerin, lebermuth oil blend, hydrolyzed soy protein, panthenol, sodium benzoate, potassium sorbate, ethylhexylglycerin, aloe barbadensis leaf juice (aloe vera gel), and allantoin. in some
  • a composition can comprise one or more of the following ingredients: purified water, sodium cl4-16 olefin sulfonate, cocamidopropyl betaine, glycerin, ethylhexylglycerin, citric acid, carrubba efa blend, lebermuth oil blend, potassium sorbate, panthenol, sodium benzoate, allantoin, magnesium ascorbyl phosphate, sodium pea, disodium cocyl glutamate, and aloe barbadensis leaf juice.
  • a composition can comprise one or more of the following ingredients: purified water, emulsifying wax, glycerin, squalane, magnesium ascorbyl phosphate, tocopheryl acetate (vitamin e), benzyl alcohol, panthenol, glyceryl mono laurate, phenoxyethanol, cetyl alcohol, glyceryl stearate, helianthus annuus (sunflower) oil, mixed tocopherols (vitamin e), amodimethicone, lecithin, algin (sodium alginate), ethylhexylglycerin, carrto seed oil, carrubba efa blend, lebermuth oil blend, emblica extract (saberry), argeriline, syncoll, theobroma cacao (cocoa) seed butter, aloe barbadensis leaf juice, allantoin, borago officinalis (borage
  • a composition can comprise one or more of the following ingredients: purified water, zinc oxide, caprilic/capric triglyceride, polyglyceryl-4 isostearate (and) cetyl dimethicone (and) hexyl laurate, glycerin, hydrogenated castor oil, dimethicone, magnesium sulfate, sorbitan sesquioleate, carrubba efa blend, lebermuth oil blend, syncoll, emblica extract (saberry), argeriline, coqlO, resveratrol, phenoxyethanol, and ethylhexylglycerin.
  • a composition can comprise one or more of the following ingredients: helianthus annuus (sunflower) oil, olea europaea (olive) oil, carrubba efa blend, lebermuth oil blend, tocopheryl acetate (vitamin e), Oenothera biennis (evening primrose) oil, cocos nucifera (coconut) oil, shea butter, and theobroma cacao (cocoa) seed butter, in some embodiments, a composition can comprise one or more of the following ingredients: purified water, emulsifying wax, phenoxyethanol, squalane, dipalmitoyl hydroxyproline, carbomer, soy lecithin, saffron extract, gold extract, carruba efa blend, resveratrol, lebermuth oil blend, hyaluronic acid, ethylhexylglycerin, magnesium ascorbyl phosphate, and
  • a composition can comprise one or more of the following ingredients: purified water, emulsifying wax, glycerin, carthamus tinctorius (safflower) oil, octyl palmitate, glyceryl stearate, stearyl alcohol, glyceryl stearate, haloxyl, eyeliss, magnesium ascorbyl phosphate, glyceryl mono laurate, tocopheryl acetate (vitamin e), phenoxyethanol, squalane, benzyl alcohol, lecithin, ethylhexylglycerin, stearic acid, mixed tocopherols (vitamin e), xanthane gum, allantoin, camellia sinensis (green tea) extract, borago officinalis (borage) oil, aloe barbadensis leaf juice, rosa canina (rosehip) fruit oil, linum usitatiss
  • a composition can comprise one or more of the following ingredients: purified water, emulsifying wax, glycerin, carthamus tinctorius (safflower) oil, octyl palmitate, glyceryl stearate, stearyl alcohol, glyceryl stearate, haloxyl, eyeliss, magnesium ascorbyl phosphate, glyceryl mono laurate, tocopheryl acetate (vitamin e), phenoxyethanol, squalane, benzyl alcohol, lecithin, ethylhexylglycerin, stearic acid, mixed tocopherols (vitamin e), xanthane gum, allantoin, camellia sinensis (green tea) extract, borago officinalis (borage) oil, aloe barbadensis leaf juice, rosa canina (rosehip) fruit oil, linum usitatiss
  • a composition can comprise one or more of the following ingredients: purified water, glycerin, benzyl alcohol, sorbitan oleate decylglucoside crosspolymer, phenoxyethanol, sodium pea, panthenol, ethylhexylglycerin, aloe barbadensis leaf juice, allantoin, cucumis sativus (cucumber) extract, camellia sinensis (green tea) extract, anthemis nobilis (chamomile) extract, carrubba efa blend, lebermuth oil blend, echinacea purpurea extract, and magnesium ascorbyl phosphate, in some embodiments, a composition can comprise one or more of the following ingredients: purified water, glycerin, benzyl alcohol, sorbitan oleate
  • decylglucoside crosspolymer phenoxyethanol, sodium pea, panthenol, ethylhexylglycerin, aloe barbadensis leaf juice, allantoin, cucumis sativus (cucumber) extract, camellia sinensis (green tea) extract, anthemis nobilis (chamomile) extract, carrubba efa blend, lebermuth oil blend, echinacea purpurea extract, and magnesium ascorbyl phosphate.
  • a composition can comprise one or more of the following ingredients: sodium bicarbonate, xylitol, sea salt, coconut oil, cinnamon oil, clove oil, peppermint oil, squalane oil, hemp oil, black seed oil, black current oil, rose hip oil, jojoba oil, sesame oil, apricot oil, avocado oil, argan oil, almond oil, and grape seed oil.
  • a composition of the current disclosure may be used as a facial washing cream, facial washing foam, cleansing cream, cleansing milk, cleansing lotion, massage cream, lotion, face lotion, body lotion, skin nourishing lotion, cold cream, moisturizing cream, emulsion, lotion, pack, after-shaving cream, sun-screening cream, sunian oil, night cream, night lotion, morning lotion, eye cream, eye essence, cleaning cream, makeup, makeup base, foundation, body shampoo, hair shampoo, hair rinse, hair conditioner, hair-nourishing agent, hair-growing agent, stick pomade, hair cream, hair liquid, hair-setting lotion, hair spray, hair dye, hair bleach, coloring rinse, coloring spray, permanent wave liquid, pressed powder, loose powder, eye shadow, hand cream, lipstick, or any combination thereof.
  • a composition of the current disclosure may be used to promote lipolysis, reduce fat, reduce the appearance of fat, reduce celMite, or reduce the appearance of cellulite.
  • the skin infection is benign or non-cancerous. Skin infections of the current disclosure may be contagious. In some embodiments, the skin infection is cancerous. Skin infections of the current disclosure may be noncontagious. In some embodiments, the skin infection is cancer.
  • the composition of the current disclosure retains greater than 50% of the main ingredients after placement in a sealed container for 6 months at a temperature of about 25 °C and a relative humidity level of about 50%. In some embodiments, the
  • composition of the current disclosure retains at least 80% of the main ingredients after placement in a sealed container for 6 months at a temperature of about 25 °C and a relative humidity level of about 50%.
  • a composition of the current disclosure may be packaged into a container selected from the group consisting of a tube, ajar, a vial, a bag, a tray, a drum, a bottle, a syringe, and a can.
  • a composition of the current disclosure may be packaged into a tube.
  • a composition of the current disclosure may be packaged into a tube, wherein the tube contains information describing directions for use.
  • a composition of the current disclosure may be packaged into a tube, wherein the tube contains information describing directions for use.
  • compositions described herein may contain one or more compounds as active ingredients, and include additives such as excipients, carriers, diluents, permeation enhancers, solubilizers and adjuvants.
  • Excipients include lactose, dextrose, sucrose, sorbitol, mannitol, starches, gum acacia, calcium phosphate, alginates, tragacanth, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, cellulose, water, sterile saline, syrup, and methyl cellulose.
  • compositions can additionally include: lubricating agents such as talc, magnesium stearate, mineral oil; wetting agents; emulsifying and suspending agents; preserving agents such as methyl- and propylhydroxy-benzoates; sweetening agents; fragrances; and flavoring agents.
  • lubricating agents such as talc, magnesium stearate, mineral oil
  • wetting agents such as talc, magnesium stearate, mineral oil
  • emulsifying and suspending agents such as methyl- and propylhydroxy-benzoates
  • sweetening agents such as methyl- and propylhydroxy-benzoates
  • fragrances such as methyl- and propylhydroxy-benzoates
  • a composition of the current disclosure may optionally comprise other ingredients, including, but not limited to, excipients, fillers, emulsifying agents, antioxidants, surfactants, film formers, chelating agents, gelling agents, thickeners, emollients, humectants, moisturizers, vitamins, minerals, viscosity and/or rheology modifiers, sunscreens, keratolytics, depigmenting agents, retinoids, hormonal compounds, alpha-hydroxy acids, alpha-keto acids, anti- mycobacterial agents, antifungal agents, antimicrobials, antivirals, analgesics, peptides, high molecular peptides, moisturizers, emollients, surfactants, ultraviolet absorbents, pH regulators, lipidic compounds, anti-allergenic agents, anti-inflammatory agents, anti-irritants, antineoplastics, immune system boosting agents, immune system suppressing agents, anti-acne agents, anesthetics,
  • compositions of the current disclosure may be administered by topical, intradermal, oral, transdermal/transmucosal routes, or any combination thereof.
  • a composition may include, for example, one or more of the following: a sterile diluent such as water, saline solution, preferably physiological saline, Ringer's solution, isotonic sodium chloride, fixed oils that may serve as the solvent or suspending medium, polyethylene glycols, glycerin, propylene glycol or other solvents; antibacterial agents; antioxidants; chelating agents; buffers and agents for the adjustment of tonicity such as sodium chloride or dextrose.
  • a sterile diluent such as water, saline solution, preferably physiological saline, Ringer's solution, isotonic sodium chloride, fixed oils that may serve as the solvent or suspending medium, polyethylene glycols, glycerin, propylene glycol or other solvents
  • antibacterial agents such as sodium chloride or dextrose
  • antioxidants preferably chelating agents
  • buffers and agents for the adjustment of tonicity such as sodium chloride or dextrose.
  • a composition may comprise an oil that has been isolated and purified.
  • the oil can be purified by distillation, by silica gel chromatography, by fluorination, by carbon filtration, by ultrafiltration, by electrodeionization, by mechanical filtration, or any combination thereof.
  • a composition may comprise water that has been isolated and purified.
  • the water can be purified by distillation, by fluorination, by deionization, by carbon filtration, by ultrafiltration, by electrodeionization, by mechanical filtration, by reserve osmosis, or any combination thereof.
  • At least one of the compounds described herein can be used alone or in combination with appropriate additives to make tablets, powders, granules or capsules, and if desired, with diluents, buffering agents, moistening agents, preservatives, coloring agents, and flavoring agents.
  • the compounds may be formulated with a buffering agent to provide for protection of the compound from low pH of the gastric environment and/or an enteric coating.
  • a compound included in a pharmaceutical composition may be formulated for oral delivery with a flavoring agent, e.g., in a liquid, solid or semi-solid formulation and/or with an enteric coating
  • a composition comprising any one of the compounds described herein may be formulated for sustained or slow release (also called timed release or controlled release). Such compositions be prepared and administered by, for example, oral, intradermal, or topical routes. Sustained-release formulations may contain the compound dispersed in a carrier matrix and/or contained within a reservoir surrounded by a rate controlling membrane. Excipients for use within such formulations are biocompatible, and may also be biodegradable; preferably the formulation provides a relatively constant level of active component release. Non-limiting examples of excipients include water, alcohol, glycerol, chitosan, alginate, chondroitin, Vitamin E, mineral oil, and dimethyl sulfoxide (DMSO).
  • DMSO dimethyl sulfoxide
  • compositions may be formulated as oral sprays.
  • Compositions for inhalation or insufflation include solutions and suspensions in pharmaceutically acceptable, aqueous or organic solvents, or mixtures thereof, and powders.
  • the liquid or solid compositions may contain suitable pharmaceutically acceptable excipients as described supra.
  • Compositions in preferably pharmaceutically acceptable solvents may be nebulized by use of inert gases. Nebulized solutions may be inhaled directly from the nebulizing device or the nebulizing device may be attached to a face mask tent, or intermittent positive pressure breathing machine. Solution, suspension, or powder compositions may be administered, preferably orally or nasally, from devices which deliver the formulation in an appropriate manner.
  • compositions can be in the form of emulsions, creams, jelly, solutions, gels, or ointments.
  • Compatible carriers which may be used in this disclosure, comprise e.g. an aqueous solution, such as saline solutions, oil solutions or ointments.
  • a pharmaceutical composition of the disclosure can be made isotonic with blood by the incorporation of a suitable tonicity modifier.
  • a pharmaceutical composition of the disclosure may have a pH of about 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14, as measured by, for example, a pH probe or pH paper.
  • a composition may have a pH from about 4 to about 10.
  • composition may be formulated to be at physiologically neutral pH.
  • kits may be made available to the end user.
  • the kit can comprise the composition.
  • the kit can comprise the composition and an application tool.
  • a kit can come in a box.
  • a kit can be any shape.
  • the contents of the kit can be individually packaged.
  • the contents of the kit can be individually wrapped.
  • Such kits may include a container containing a unit dose, an
  • the kit may further comprise any device suitable for administration of the
  • composition for example, a kit comprising a topical formulation of pharmaceutical
  • compositions may comprise gel suitable for topical administration and an alcohol wipe for sterilization of the application site.
  • kits may be provided with instructions.
  • the instructions may be provided in the kit or they may be accessed electronically (e.g., on the World Wide Web).
  • the instructions may provide information on how to use the compositions of the present disclosure.
  • the kit comprises instructions for use in treating a wart.
  • the instructions may provide information on how to perform the methods of the disclosure.
  • the kit comprises instructions for methods of treating a wart.
  • the instructions may provide dosing information.
  • the instructions may provide drug information such as the mechanism of action, the formulation of the drug, adverse risks, contraindications, and the like.
  • the kit may be purchased by a physician or health care provider for administration at a clinic or hospital.
  • a user can pay for the kit.
  • the kit can be paid for by cash, credit card, debit card or promotional code.
  • the kit may be available for purchase from a variety of sources. Some non- limiting examples of sources for purchasing the kit are over-the-counter, online, and in specially stores.
  • the kit may be made available by a professional.
  • the kit may be prescribed by a professional.
  • a method of use can be application of the composition to at least one tooth in a layer.
  • the method of use can be application of the composition to at least a row of teeth.
  • the method of use can be application of the composition to all the teeth of a subject.
  • compositions can be formulated in any suitable application form, such as gels, mouthwashes, toothpowders, toothpastes, dental trays, and disposable plastic strips. They may be formulated into a single formulation or they may be formulated for multi-compartment containers into different formulations.
  • the composition may be applied using a brush, a sponge, a bare finger, a roller, an applicator, a cloth, gauze, cotton wool, via a spray bottle, or any combination thereof.
  • An application tool may be used to apply the composition onto a tooth surface.
  • Non-limiting examples of an application tool include a mouthwash, toothpowder, toothpaste, dental tray, disposable plastic strip, spatula, brush, cotton ball, and cotton swab.
  • the method comprises application of the composition onto a toothbrush and brushing a tooth surface with the toothbrush.
  • the method comprises application of the composition and toothpaste onto a toothbrush and brushing a tooth surface with the toothbrush.
  • the method comprises application of the composition onto a toothbrush and brushing a denture tooth surface with the toothbrush.
  • the method comprises application of the composition and toothpaste onto a toothbrush and brushing a denture tooth surface with the toothbrush.
  • the method comprises application of the composition onto a toothbrush and brushing a pet tooth surface with the toothbrush.
  • the method of use may include application of the composition onto dental floss.
  • the method of use may include application of the composition onto a dental tray that may be held in contact with a tooth surface.
  • the method of use may include application of the composition onto a disposable plastic strip that may be placed directly on a tooth surface.
  • the period of application of the method can be at least 5, 10, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 150, 200, 250, 300, 400, or 500 seconds.
  • a unit dose can be administered simultaneously or sequentially.
  • the composition can be administered for an extended period of time.
  • the period of time of administration can be about 1 minute, 1 hour, 12 hours, 1 day, 2 days, 3 days, 7 days, 14 days, 28 days, 1 month, 2 months, 3 months, 6 months, 1 year, or more.
  • the administration period may be until symptoms recede.
  • the composition is applied for at least 10 seconds, 30 seconds, 1 minute, 2 minutes, 5 minutes, 10 minutes, 1 hour, 2 hours, or more. In some embodiments, the composition is applied for at least 1 hour.
  • a composition of the current disclosure is administered at least once a day, twice a day, three times a day, once a week, twice a week, three times a week, or more.
  • a composition of the current disclosure is administered at least once a day for a period of at least one week. In some embodiments, a composition of the current disclosure is administered at least twice a day for a period of at least one week. In some embodiments, a composition of the current disclosure is administered at least once a day for a period of at least one month.
  • a composition of the current disclosure can be contacted with a skin cell at least once a day for a period of at least one week. In some embodiments, a composition of the current disclosure can be contacted with a skin cell at least twice a day for a period of at least one week. In some embodiments, a composition of the current disclosure can be contacted with a skin cell at least once a day for a period of at least one month.
  • the composition is applied and left on the skin cell. In some embodiments, the composition is applied onto the skin cell, and washed off after a contact period of 10 seconds, 30 seconds, 1 minute, 2 minutes, 5 minutes, 10 minutes, 1 hour, 2 hours, or more.
  • the ingredients of a composition are combined via mixing, blending, adding, stirring, or any combination thereof.
  • the period of time of combining may be at least 1 minute, 5 minutes, 10 minutes, 30 minutes, 1 hour, 2 hours, 5 hours, or more.
  • composition can be applied on a human subject.
  • the composition can be applied on a denture.
  • the composition can be used on a pet.
  • a pet include alpaca, cat, cattle, chicken, dog, domestic camel, canary, camel, duck, goose, guinea pig, guineafowl, hedgehog, horse, llama, pigeon, mouse, rabbit, rat, sheep, silver fox, water buffalo, yak and zebu.
  • the composition may be applied by a professional.
  • the composition may be applied by the end-user.
  • the composition may be applied at a dental office.
  • the composition may be applied at a home.
  • the composition may be applied at non-dental options.
  • Non-limiting examples of non-dental options include a mall kiosk, a salon, and a spa.
  • a composition was prepared by combining the ingredients listed in Table 1.
  • a composition was prepared by combining the ingredients listed in Table 2. TABLE 2.
  • a composition was prepared by combining the ingredients listed in Table 3.
  • a composition was prepared by combining the ingredients listed in Table 5.
  • a composition was prepared by combining the ingredients listed in Table 6.
  • a composition was prepared by combining the ingredients listed in Table 7.
  • a composition was prepared by combining the ingredients listed in Table 8.
  • a composition was prepared by combining the ingredients listed in Table 10.
  • a composition was prepared by combining the ingredients listed in Table 11.
  • a composition was prepared by combining the ingredients listed in Table 12.
  • An oral care composition of the present disclosure in the form of a paste was prepared.
  • the composition of this oral care composition is listed in Table 14 below.
  • a composition of any of examples 1-13 may be applied to a skin cell.
  • the skin cell may be a human skin cell.
  • a skin cell may be a skin cell of the face, neck, hands, abdomen, thighs, buttocks, toes, feet, scalp, knees, or arms. Appearance of undesired symptoms may decrease, such as appearance of lines or wrinkles is decreased, skin cell looks more radiant, makeup and impurities are removed, or combinations thereof.
  • the composition may be applied using a brush, a sponge, a bare finger, a roller, an applicator, a cloth, gauze, cotton wool, or via a spray bottle.
  • the composition may be applied at least once a day for a period of at least one week.
  • the composition of example 14 may be applied to a tooth surface.
  • the composition may decrease the appearance of wine stains, tobacco stains, coffee stains, or tea stains on the surface of the tooth.
  • the composition may be applied using a brush or a toothbrush.
  • the composition may be applied at least twice a day for a period of at least one week.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne une composition et un procédé pour le blanchiment et la restauration de la couleur naturelle des dents, et une composition conçue pour une application sur une cellule de la peau ou une partie d'une zone de la peau. Le blanchiment des dents est une procédure commune en dentisterie générale. Il est devenu souhaitable que les dents d'une personne soient blanches. Les dents peuvent être tachées par les produits alimentaires et les boissons, y compris le tabac, les légumes, le café, le thé, et le vin. Les dents peuvent également être tachées par certains médicaments. Les agents de blanchiment peuvent aider à éliminer les taches sur les dents. Des agents aromatisants peuvent être utilisés pour ajouter un parfum, un arôme et une couleur aux agents de blanchiment afin de fabriquer des compositions de blanchiment plus attractives. Une composition selon la présente invention peut être appliquée sur une cellule de la peau ou une partie d'une zone de la peau. La composition peut diminuer l'apparition de rides, de ridules et de cicatrices, et rendre une partie de la peau plus rayonnante. Une composition selon la présente invention peut être utilisée sur un état pathologique de la peau, qui peut être provoqué par une bactérie, un virus, une réaction allergique ou un système immunitaire affaibli.
PCT/US2016/035855 2015-06-05 2016-06-03 Produits de soins personnels : kit et procédés d'utilisation et de fabrication Ceased WO2016197015A1 (fr)

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CN107854395A (zh) * 2017-11-27 2018-03-30 大连丹特生物技术有限公司 一种睡前用牙膏及其制备方法
CN108714119A (zh) * 2018-06-29 2018-10-30 陈磊 一种抑菌、美白的陨石洁牙液
WO2018212771A1 (fr) 2017-05-17 2018-11-22 Colgate-Palmolive Company Compositions de soins bucco-dentaires et leurs méthodes d'utilisation
US20180360735A1 (en) * 2016-12-21 2018-12-20 Mge Holdings Llc Oral Care Products and Methods
CN109167892A (zh) * 2018-08-22 2019-01-08 银河互联网电视有限公司 一种视频图像细节增强方法与系统
WO2021127672A1 (fr) * 2019-12-16 2021-06-24 Colgate-Palmolive Company Compositions de soins personnels à multiples bénéfices et leurs procédés
EP3737351A4 (fr) * 2017-08-31 2021-11-24 MGE Holdings LLC Compositions et méthodes d'hygiène buccale
EP4000594A1 (fr) * 2020-11-12 2022-05-25 Ariel Lenharo Compositions orales pour implants post-dentaires
US20230255870A1 (en) * 2022-02-12 2023-08-17 Lilliana Rehder Temporary anti-brassy and restorative blue oil for black or dark hair with highlights or balayage
US11957778B2 (en) 2017-05-17 2024-04-16 Colgate-Palmolive Company Oral care compositions and methods of use
US12097280B2 (en) 2019-12-16 2024-09-24 Colgate-Palmolive Company Personal care compositions and methods for the same
CN119345085A (zh) * 2024-10-28 2025-01-24 浙江睛姿化妆品有限公司 一种含有睫毛生长成分的天然植物眼线液及其制备方法

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US20180360735A1 (en) * 2016-12-21 2018-12-20 Mge Holdings Llc Oral Care Products and Methods
US11957778B2 (en) 2017-05-17 2024-04-16 Colgate-Palmolive Company Oral care compositions and methods of use
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CN107811890A (zh) * 2017-10-31 2018-03-20 丹东欣时代生物医药科技有限公司 一种口腔养护牙膏组合物
CN107854395A (zh) * 2017-11-27 2018-03-30 大连丹特生物技术有限公司 一种睡前用牙膏及其制备方法
CN108714119A (zh) * 2018-06-29 2018-10-30 陈磊 一种抑菌、美白的陨石洁牙液
CN109167892A (zh) * 2018-08-22 2019-01-08 银河互联网电视有限公司 一种视频图像细节增强方法与系统
WO2021127672A1 (fr) * 2019-12-16 2021-06-24 Colgate-Palmolive Company Compositions de soins personnels à multiples bénéfices et leurs procédés
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AU2020405262B2 (en) * 2019-12-16 2024-02-29 Colgate-Palmolive Company Multi-benefit personal care compositions and methods for the same
US12097280B2 (en) 2019-12-16 2024-09-24 Colgate-Palmolive Company Personal care compositions and methods for the same
EP4000594A1 (fr) * 2020-11-12 2022-05-25 Ariel Lenharo Compositions orales pour implants post-dentaires
US20230255870A1 (en) * 2022-02-12 2023-08-17 Lilliana Rehder Temporary anti-brassy and restorative blue oil for black or dark hair with highlights or balayage
CN119345085A (zh) * 2024-10-28 2025-01-24 浙江睛姿化妆品有限公司 一种含有睫毛生长成分的天然植物眼线液及其制备方法

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