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WO2016195126A1 - Appareil d'extraction et de séparation du sang pour extraire des plaquettes riches en facteur de croissance - Google Patents

Appareil d'extraction et de séparation du sang pour extraire des plaquettes riches en facteur de croissance Download PDF

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Publication number
WO2016195126A1
WO2016195126A1 PCT/KR2015/005481 KR2015005481W WO2016195126A1 WO 2016195126 A1 WO2016195126 A1 WO 2016195126A1 KR 2015005481 W KR2015005481 W KR 2015005481W WO 2016195126 A1 WO2016195126 A1 WO 2016195126A1
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WO
WIPO (PCT)
Prior art keywords
separation
blood
platelet
coupled
space
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2015/005481
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English (en)
Korean (ko)
Inventor
이은혜
송동판
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Individual
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Individual
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Priority to PCT/KR2015/005481 priority Critical patent/WO2016195126A1/fr
Priority to CN201680000764.8A priority patent/CN108290086B/zh
Priority to PCT/CN2016/080994 priority patent/WO2016192502A1/fr
Publication of WO2016195126A1 publication Critical patent/WO2016195126A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/38—Removing constituents from donor blood and storing or returning remainder to body, e.g. for transfusion

Definitions

  • the present invention relates to a blood separation and extraction device for platelet-rich growth factor extraction, in particular to allow the separation and concentration operation to proceed in one container at the same time, and to perform the separation and extraction by only the first centrifugation
  • the present invention relates to a blood separation and extraction apparatus for platelet-rich growth factor extraction with improved structure.
  • the present invention also relates to a blood separation and extraction apparatus for platelet-rich growth factor extraction whose structure has been improved so that most of the leukocytes extracted in the container can be recovered using a syringe.
  • Blood circulating in blood vessels in a human or animal body carries oxygen taken from the lungs to tissue cells, transports carbon dioxide from the tissues to the lungs for release, and transports nutrients absorbed from the digestive tract to organs or tissue cells, As a decomposition product of, it transports substances that are unnecessary to the living body to the kidneys and discharges them out of the body, carries hormones secreted from the endocrine glands to the working organs and tissues, distributes body heat evenly, maintains constant body temperature, and invades the living body It performs various functions such as destroying and detoxifying bacteria and foreign substances.
  • Blood is composed of red blood cells, white blood cells, platelets, etc. Among them, platelets are mainly present in plasma, and plasma is divided into a platelet rich plasma (PRP) layer and a plate poor plasma (PPP) layer.
  • PRP platelet rich plasma
  • PPP plate poor plasma
  • Platelet-rich plasma called Platelet Rich Plasma (PRP)
  • PRP Platelet Rich Plasma
  • Platelet-free plasma also called PPP (Platelet Poor Plasma) is used as an autologous filler or a cosmetic product derived from autologous plasma.
  • PRP layer is only about 1% of the collected blood and the viscosity is high, it is difficult to collect because it is attached to red blood cells.
  • PRP is implanted in the pain area, especially the knee restraint, ligaments and muscles, and it is used for therapeutic purposes because it stimulates the stem cells around and helps to generate the cells. Sampling was difficult, and red blood cells entered the human body, causing considerable pain, which could cause inflammation, and the emphasis was on the technique of collecting concentrated platelets (PRP), except red blood cells.
  • PRP concentrated platelets
  • the first and second centrifugation processes have a process of concentrating, and this process is performed after injecting the blood into the lower liquid chamber of the primary separation vessel having the upper and lower liquid chambers.
  • the injected primary separation vessel is first centrifuged, and the leukocytes and buffy coat layer separated in the first centrifugation process are pushed to the upper liquid chamber.
  • the leukocytes and buffy coat layer of the upper liquid chamber are transferred to the secondary separation vessel side, and further centrifuged and concentrated to extract concentrated platelets.
  • the present invention was created in view of the above-mentioned problems, and the object thereof is to allow a process for extracting and extracting concentrated platelets into a single container and simplifying the centrifugal separation process.
  • the present invention provides a blood separation and extraction device for platelet-rich growth factor extraction, the structure of which is improved to enable the separation and extraction of concentrated platelets only by centrifugation.
  • Another object of the present invention is to provide a blood separation and extraction apparatus for platelet-rich growth factor extraction, the structure of which is improved so that the separation and extraction of platelets in the separation layer of the separated blood easily.
  • the present invention for achieving the above object is formed in the lower accommodating space for accommodating blood, the inclined portion has a narrower inner diameter than the lower portion formed in the upper portion of the accommodating space is formed in the upper passage is formed, the centrifugation of the blood
  • a slider which is slidably coupled to the accommodation space and pushes the separation layer of blood separated by the centrifugation to the separation space through the passage;
  • the coupling portion is formed to be coupled to the upper end of the passage portion when coupled with the body tube in the lower center, is formed to extend to the lower side of the coupling portion of the blood when the slider is raised
  • an upper cap having a storage unit in which concentrated platelets are introduced and accommodated in a separation layer of the separation layer.
  • the upper cap is an injection port through which the first syringe for injecting the blood through the passage portion on the upper surface thereof, a first outlet through which the second syringe extracts the concentrated platelets contained in the reservoir to the outside; A second outlet for allowing entry of the third syringe for extracting the white blood cells contained in the separation space to the outside is formed,
  • the inlet, the first outlet, the second outlet is characterized in that the first, second, third rubber stopper of elastic to which the needle (needle) of each of the first, second, third syringe can enter It is done.
  • the guide tube is composed of a large diameter portion coupled to the third rubber stopper, a small diameter portion eccentrically extending with the large diameter portion, and an inclined portion connecting the large diameter portion and the small diameter portion,
  • An incision portion through which an end of the needle of the third syringe passes is formed at a lower end of the small diameter portion.
  • the center further comprises a lower cap formed with a through hole to enable the entrance and exit of the lifting mechanism for pushing up the slider upwards It is done.
  • the upper cap is characterized in that it further comprises a separator plate protruding perpendicular to the bottom surface of the reservoir.
  • the present invention has the following effects.
  • the separating space portion and the receiving space portion is formed inside the body tube via the intermediate passage portion is formed, and when the upper cap is coupled to the storage portion communicating with the passage portion is disposed under the upper cap, in one container As a result, the separation layers of blood can be separated and extracted, thereby preventing loss during transport and significantly reducing work time.
  • the present invention has the advantage that since the separation and extraction of blood in the first centrifugation process is made in one container, the convenience of the operation is increased and the efficiency of the operation is improved.
  • the needle 31 of the third syringe 30 is guided to the guide tube 400, it is possible to stable recovery.
  • the receiving space 102 and the separation space 104 is partitioned by the inclined portion 105a so that the lower portion of the separation space 104 toward the inner wall surface side of the body tube 100 becomes narrower.
  • the end of the needle 31 guided to the guide tube 400 is located at a position corresponding to the middle portion of the inclined portion 105a, so that the extraction of the white blood cells remaining in the lowermost portion of the separating space 104 gradually narrows.
  • the end portion of the needle 31 is guided by the small diameter portion 402 and the incision portion 402a which are eccentrically positioned on the lower side of the guide tube 400 and remain at the bottom of the separation space 104. Enable the extraction of leukocytes.
  • FIG. 1 is an exploded perspective view showing a blood separation and extraction device for platelet-rich growth factor extraction according to the present invention.
  • FIG. 2 is an exploded perspective view showing FIG. 1 from the bottom;
  • FIG. 3 is a coupled state of FIG.
  • FIG. 4 is a perspective view showing a coupling portion and a storage portion of the present invention.
  • Figures 5a, 5b, 5c, 5d, 5e, 5f, 5g is a use state diagram sequentially showing the use state of the present invention.
  • Figure 6 is a partially cut perspective view showing another embodiment of the present invention storage unit.
  • FIG. 8 is a cross-sectional view showing another embodiment of the device of the present invention.
  • FIG. 9 is a perspective view of the guide tube of FIG. 8.
  • the present invention is centrifuged in a state in which the blood is accommodated in the receiving space portion formed in the lower portion of the body tube, and after separating the white blood cells, which are separation layers of the centrifuged blood, into the separation space portion of the body tube, the upper cap passage portion of the body tube.
  • the receiving space 102 is formed in the lower portion receiving the blood, the receiving space portion
  • a passage portion 105 having an inclined portion 105a and an upper end thereof is formed at an upper portion of the upper portion 102 so as to have an inner diameter narrower than a lower portion thereof, and a portion of the separation layer of blood separated by centrifugation of the blood is formed in the passage portion.
  • a body tube (100) formed with a separation space (104) to be received via (105);
  • the slider 200 is slidably coupled to the receiving space 102 and pushes the separation layer of blood separated by the centrifugal separation to the separation space 104 through the passage 105.
  • the coupling portion 310 is formed to be coupled to the upper end of the passage portion 105 when the body tube 100 is coupled to the lower center, the coupling It is formed to extend to one side of the lower portion 310, the upper cap 300 having a storage unit 320 is introduced into the concentration platelet (P) of the separation layer of blood when the slider 200 is raised; do.
  • P concentration platelet
  • the upper surface of the upper cap 300, the injection port (300c) that can be entered into the first syringe 10 for injecting the blood through the passage portion 105, and the concentrated platelets (received in the storage 320) ( The first outlet (300a) that can enter the second syringe 20 to extract the P and the outside of the third syringe 30 to extract the leukocytes (W) accommodated in the separation space 104 to the outside
  • the second outlet 300b which is accessible is formed.
  • a guide tube 400 extending to the lower portion of the separation space 104 and guided by the needle 31 of the third syringe 30 is coupled to the second outlet 300b.
  • the separation space 104 is a structure partitioned through the passage portion 105 from the accommodation space 102 on the upper side of the body tube 100, the blood separated by the centrifugation of the blood A portion of the separation layer is formed to be received and received through the passage portion 105 when the slider 200 is raised.
  • the lower portion of the body tube 100 to prevent the departure of the slider 200 the lower portion formed with a through hole 255 to allow the entrance and exit of the lifting tool (not shown) for pushing up the slider 200 upwards.
  • the cap 250 is detachably coupled.
  • the passage part 105 is formed perpendicular to the upper side of the accommodation space 102, and has an inclined portion 105a to have an inner diameter that is narrower than the internal diameter of the accommodation space 102.
  • the receiving space 102 and the separating space 104 is partitioned by the inclined portion 105a so that the lower portion of the separating space 104 is received toward the inner wall surface of the body tube 100 toward the white blood cell (W)
  • the space becomes narrower.
  • Coupling portion 310 of the upper cap 300 is formed with a coupling hole 312 having a lower opening to be fitted to the outer peripheral surface of the upper end of the passage portion 105.
  • the storage unit 320 has a structure formed such that the lower bottom surface is positioned at a lower position than the lower end of the coupling unit 310.
  • the storage unit 320 has a structure in which the concentrated platelets P introduced through the passage unit 105 are accommodated.
  • the slider 200 is composed of first and second closure members 210 and 220.
  • the first closure member 210 maintains hermeticity around the outer circumferential surface, and a plurality of ring-shaped sealing members are coupled to reduce the volume of the accommodation space 102 at a uniform pressure during the ascending operation.
  • the second plug member 220 may be bonded to the lower portion of the first plug member 210 as a silicon material to protect the first plug member 210 during the lifting operation of the first plug member 210 by the elevating tool. Make sure
  • the first stopper member 210 is moved up by a lifting force transmitted from a separate lifting tool (actuator or human finger, such as a cylinder) to be raised along the inner circumferential surface of the receiving space 102 of the body tube 100.
  • a separate lifting tool actuator or human finger, such as a cylinder
  • the elevating tool may enter the interior of the receiving space 102 through the through hole 255 of the lower cap 250 may impart a rising pressure to the slider 200.
  • the extraction amount (eg, 1.0 to 2.5 cc) of the concentrated platelets P may change.
  • the concentrated platelets P extracted in the storage unit 320 may be extracted to the outside through the second syringe 20 after the predetermined volume of the platelets P is collected.
  • the storage unit 320 and the coupling portion 310 may be integrally formed on the lower surface of the upper cap 300 in one body, or may be detachably coupled to the lower portion of the upper cap 300.
  • the first injection syringe 10 containing the blood is passed through the entrance port 304 and then the passage portion 105 is opened. Blood is injected into the receiving space 102 of the body tube 100, and the blood injected into the receiving space 102 using a centrifuge is centrifuged as shown in FIG. 5B.
  • the injection amount of blood can be injected about 30 ⁇ 50cc.
  • the upper cap 300 is maintained in a state coupled to the upper portion of the body tube 100 so that the separation space 104 is sealed during the centrifugal separation process.
  • red blood cells (R), leukocytes (W), and platelets (P) are divided into cells, and white blood cells (W), platelets (P), and red blood cells (R) from the upper side according to the specific gravity difference. Are separated in order.
  • the lifting tool enters the inside of the through hole 255 of the lower cap 250 and pushes the slider 200 upward, the slider 200 is lifted up inside the receiving space 102 while the blood separation layer is formed.
  • the volume in the accommodation space 102 accommodated is reduced.
  • the slider 200 causes the leukocyte (W) layer of the separation layers of blood stored in the accommodation space 102 to be injected into the separation space 104 of the body tube 100 through the passage 105 when the slider 200 rises. .
  • the upward movement of the slider 200 is raised until the injection of the white blood cells (W) into the separation space 104 is completed.
  • the concentrated platelet (P) is located in the passage portion 105, the red blood cells (R) is maintained in the state accommodated in the lower portion of the receiving space (102).
  • the secondary ascending operation of the slider 200 is performed until the concentrated platelets P are introduced into the storage unit 320.
  • the capacity of the concentrated platelets (P) stored in the storage unit 320 varies depending on the amount of blood injected and the traits of the blood, and approximately 1.5 to 3.0 cc are concentrated and stored.
  • the operator passes the second syringe 20 through the second rubber stopper 302 of the upper cap 300 and stores it. Extracting the concentrated platelets (PRP) stored in the unit 320 to the outside.
  • PRP concentrated platelets
  • the third syringe 30 passes through the third rubber stopper 303 of the upper cap 300 to extract the leukocytes W stored in the separation space 104 to the outside. Do this. At this time, the needle 31 of the third syringe 30 is guided to the guide tube 400 to be stably guided to the deep receiving space 104.
  • FIG. 6 and 7 are views illustrating another embodiment of the storage unit of the present invention.
  • Another embodiment of the present invention storage unit is the same as the components of the above-described line embodiment, but is formed to protrude upwardly perpendicularly to the bottom surface of the storage unit 320 so that the inside of the storage unit 320 on the left and right in the drawing It is further provided with a separator plate 330 for partitioning.
  • Separation plate 330 is separated even if the concentrated platelet (P) and the red blood cells (R) is not separated into the storage unit 320 without being separated due to the misoperation caused by excessive operation of the slider 200, separation of the mixed blood
  • the layers are separated from each other by using a specific gravity difference in the partitioned storage 320.
  • the concentrated platelets P and the red blood cells R contained in the receiving space 102 may pass through the passage 105 and enter the storage 320.
  • the enriched platelets P are separated in the storage unit 320 on the left side based on the separator plate 330 and the red blood cells R are maintained in the right storage unit 320.
  • the receiving space 102 and the separation space 104 is partitioned by the inclined portion 105a so that the lower portion of the separation space 104 toward the inner wall surface side of the body tube 100 The space becomes narrow.
  • the end portion of the needle 31 guided to the guide tube 400 is located at a position corresponding to the middle portion of the inclined portion 105a as shown in FIG. 5G and remains at the bottom of the separating space 104 that gradually narrows. It is difficult to take out white blood cells.
  • the device of this embodiment is a needle 31 by a small diameter portion 402 and an incision 402a which are eccentrically positioned on the lower side of the guide tube 400.
  • the end of the) is guided to the inner wall surface side of the body tube 100 to enable extraction of the white blood cells remaining at the bottom of the separation space 104.
  • the blood separation and extraction device for platelet-rich growth factor extraction of the present invention occurs in the existing transfer process because the separation and concentration operation through centrifugation of blood is performed through one container and one centrifugation process. In addition to preventing the loss, and has the effect of increasing the convenience of work.
  • the present invention relates to a blood separation and extraction device for platelet-rich growth factor extraction, in particular to allow the separation and concentration operation can be carried out in one container at the same time, and to perform the separation and extraction by only the first centrifugation
  • the structure is improved.

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
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Abstract

La présente invention effectue une centrifugation alors que le sang est reçu dans une partie d'espace de réception formée au niveau de la partie inférieure d'un tube principal, injecte des globules blancs, qui constituent une phase de séparation du sang centrifugé, dans une partie d'espace de séparation du tube principal, et couple ensuite un capuchon supérieur de sorte que le capuchon supérieur communique avec une partie de passage du tube principal, ce qui permet de ne collecter et de n'extraire que les plaquettes concentrées, et, de ce fait, la séparation de sang et l'opération d'extraction des plaquettes concentrées peuvent être effectuées simultanément en réalisant une seule centrifugation et avec un seul récipient.
PCT/KR2015/005481 2015-06-01 2015-06-01 Appareil d'extraction et de séparation du sang pour extraire des plaquettes riches en facteur de croissance Ceased WO2016195126A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/KR2015/005481 WO2016195126A1 (fr) 2015-06-01 2015-06-01 Appareil d'extraction et de séparation du sang pour extraire des plaquettes riches en facteur de croissance
CN201680000764.8A CN108290086B (zh) 2015-06-01 2016-06-17 用于提取富含血小板的生长因子的血液分离机提取装置
PCT/CN2016/080994 WO2016192502A1 (fr) 2015-06-01 2016-06-17 Dispositif d'extraction de séparateur de sang pour l'extraction d'un facteur de croissance d'un plasma riche en plaquettes

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2015/005481 WO2016195126A1 (fr) 2015-06-01 2015-06-01 Appareil d'extraction et de séparation du sang pour extraire des plaquettes riches en facteur de croissance

Publications (1)

Publication Number Publication Date
WO2016195126A1 true WO2016195126A1 (fr) 2016-12-08

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PCT/KR2015/005481 Ceased WO2016195126A1 (fr) 2015-06-01 2015-06-01 Appareil d'extraction et de séparation du sang pour extraire des plaquettes riches en facteur de croissance
PCT/CN2016/080994 Ceased WO2016192502A1 (fr) 2015-06-01 2016-06-17 Dispositif d'extraction de séparateur de sang pour l'extraction d'un facteur de croissance d'un plasma riche en plaquettes

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PCT/CN2016/080994 Ceased WO2016192502A1 (fr) 2015-06-01 2016-06-17 Dispositif d'extraction de séparateur de sang pour l'extraction d'un facteur de croissance d'un plasma riche en plaquettes

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CN (1) CN108290086B (fr)
WO (2) WO2016195126A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110856775B (zh) * 2018-08-23 2024-09-24 康膝生物医疗(深圳)有限公司 医用分离提取装置和借此分离和提取富血小板血浆的方法
RU2698723C1 (ru) * 2018-10-08 2019-08-29 Александр Александрович Шаршуков Система стерильная для сепарирования крови и способ получения обогащенной тромбоцитами плазмы из цельной крови
RU2758123C1 (ru) * 2020-12-21 2021-10-26 Руслан Илдусович Муллин Пробирка для получения плазмы, обогащённой тромбоцитами
CN115770414B (zh) * 2023-01-30 2023-07-11 冠昊生物科技股份有限公司 一种制备富血小板血浆的离心管及其离心方法
CN119677550A (zh) * 2023-06-13 2025-03-21 瑞金尼克斯有限责任公司 血液和骨髓分馏装置和方法

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CN104704106B (zh) * 2013-04-11 2016-08-24 早安生物株式会社 提取自血小板的血液分离容器
CN203609925U (zh) * 2013-10-25 2014-05-28 永康医材科技股份有限公司 密闭式血小板浓缩器
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KR101110576B1 (ko) * 2009-03-16 2012-02-15 주식회사 메디사랑 피알피 및 필러 추출과 피브린 생성을 위한 혈액분리 및 농축용기
KR101026599B1 (ko) * 2010-12-30 2011-04-04 문상호 자가 혈소판 농축물질 분리용 용기
KR101128163B1 (ko) * 2011-09-22 2012-03-23 황의재 일회용 자가 혈소판 농축물질 분리장치
KR101170146B1 (ko) * 2011-11-30 2012-07-31 (주)알엠바이오 혈소판이 풍부한 성장인자 추출을 위한 혈액분리 및 농축장치
KR101433293B1 (ko) * 2012-05-03 2014-08-22 이은혜 혈소판이 풍부한 성장인자 추출을 위한 혈액분리 및 추출장치

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CN108290086B (zh) 2021-06-08
CN108290086A (zh) 2018-07-17
WO2016192502A1 (fr) 2016-12-08

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