[go: up one dir, main page]

WO2016167254A1 - Substance nutritive tonique contenant des larves d'abeilles - Google Patents

Substance nutritive tonique contenant des larves d'abeilles Download PDF

Info

Publication number
WO2016167254A1
WO2016167254A1 PCT/JP2016/061822 JP2016061822W WO2016167254A1 WO 2016167254 A1 WO2016167254 A1 WO 2016167254A1 JP 2016061822 W JP2016061822 W JP 2016061822W WO 2016167254 A1 WO2016167254 A1 WO 2016167254A1
Authority
WO
WIPO (PCT)
Prior art keywords
bee
tonic
bees
fatigue
male
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2016/061822
Other languages
English (en)
Japanese (ja)
Inventor
倫世 結石
忍 福島
智樹 生田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamada Bee Co Inc
Original Assignee
Yamada Bee Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamada Bee Co Inc filed Critical Yamada Bee Co Inc
Priority to SG11201708300YA priority Critical patent/SG11201708300YA/en
Priority to JP2017512543A priority patent/JP6483244B2/ja
Priority to CN201680021368.3A priority patent/CN107427538A/zh
Publication of WO2016167254A1 publication Critical patent/WO2016167254A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods

Definitions

  • the present invention relates to tonic tonics, sexual function improving agents, male menopausal symptoms improving agents and anti-fatigue agents.
  • menopause One of the problems related to aging faced by men is the onset of menopause. It is estimated that about 40% of men in their 40s and 60s experience some menopause.
  • Male climacteric disorder with the background of age-related androgen decline, shows autonomic ataxia and neuropsychiatric symptoms similar to those of female climacteric disorder, and in most cases is associated with a decline in male function (Okuyama Akihiko, book Male Menopause Disorder, LOH Syndrome I Menopause Disorder, D. From the perspective of psychosomatic medicine, page 24 (Nanzandou Co., Ltd.) 2007.).
  • the secretion of sex hormones including testosterone is regulated through negative feedback of hormone secretion including testosterone via the hypothalamus-pituitary-testis system (Akihiko Okuyama, Book Male Menopause Disorder LOH Syndrome) II. Diagnosis of male climacteric disorder C. Hormone measurement and its evaluation, page 65 (Nanzandou Co., Ltd.) 2007.). For this reason, it is difficult to judge male climacteric disorder based on testosterone measurements alone.
  • Patent Documents 1 to 3 report various components that increase testosterone.
  • Patent Document 1 it is reported that Tangshenosides, Lancemaside-A and Syringin contained in a plant of the genus Turrundin have an action of suppressing a decrease in blood testosterone.
  • Patent Document 2 reports that geranylgeraniol has a testosterone enhancing action.
  • Patent Document 3 reports that a black vinegar-related material and a combination of the material and a specific material significantly promote testosterone secretion.
  • PSA prostate-specific antigen
  • sildenafil a PDE5 inhibitor
  • nitrates such as nitroglycerin
  • bees have been eaten as a nutrient source for proteins in various countries and regions since ancient times.
  • health foods made from powders obtained by drying and pulverizing bees have been known. This health food contains abundant proteins, amino acids, vitamins and minerals of bees.
  • bee pups are known to have an antioxidative effect, but other actions are often unknown.
  • JP 2006-306889 A Japanese Patent No. 5382512 JP 2013-181031 A Japanese Patent No. 5405067
  • An object of the present invention is to provide a tonic tonic, a sexual function improving agent, a male menopausal symptom improving agent, and an anti-fatigue agent that do not increase androgen and are highly safe.
  • the present inventors have a tonicity effect, sexual function improvement effect, male menopausal symptom improvement effect and anti-fatigue effect. It was found that the child did not raise androgen and was highly safe.
  • the present invention has been completed based on these findings and has been completed.
  • the present invention provides the following tonic tonic, sexual function improving agent, male menopausal symptom improving agent, anti-fatigue agent and the like.
  • Item 1 Tonic tonic containing bee pups. Item 2. Sexual function improving agent containing bee pups. Item 3. Men's menopausal symptoms-improving agent including bee pups. Item 4. Anti-fatigue agent including bee cubs. Item 5. A vitality improver containing a bee. Item 6. Item 5. The tonic tonic preparation according to Item 1, the sexual function improving agent according to Item 2, the male climacteric symptom improving agent according to Item 3, and the male climacteric symptom improving agent according to Item 4. 6. An anti-fatigue agent or a vitality improver according to Item 5. Item 7.
  • a composition for tonic use including bee pups, for improving sexual function, for improving menopausal symptoms, for anti-fatigue and / or for improving vitality.
  • Item 8. A food composition for tonic use, including bee pups, for improving sexual function, for improving menopausal symptoms, for anti-fatigue and / or for improving vitality.
  • Item 9. The composition according to Item 7 or 8, wherein the bee is treated with a protein hydrolase.
  • Item 10. A tonicity method, a sexual function improvement method, a male climacteric symptom improvement method, a fatigue improvement method, or a vitality improvement method, comprising a step of administering an effective amount of a bee pup to a mammal.
  • Item 11. Item 11.
  • Item 10 The method according to Item 10, wherein the bee is treated with a protein hydrolase.
  • Item 12. Use of bees in the manufacture of tonic tonics, sexual function improvers, male menopausal symptoms improvers, anti-fatigue agents, or vitality enhancers.
  • Item 13. Item 13. The use according to Item 12, wherein the bee is treated with a protein hydrolase.
  • bee Since the bee has a tonic tonic effect improving action, sexual function improving action, male climacteric symptoms and anti-fatigue action, it is an active ingredient of tonic tonic, sexual function improving agent, male climacteric symptom improving agent and anti-fatigue agent Useful as. In addition, bees are safe because they do not raise androgens.
  • the tonic tonic, sexual function improving agent, male menopausal symptom improving agent and anti-fatigue agent of the present invention are characterized by containing a bee.
  • the tonic tonic, sexual function improving agent, male menopausal symptom improving agent and anti-fatigue agent of the present invention are highly safe because they do not increase androgen.
  • Androgen is a general term for steroid hormones, also called male hormones, and includes, in addition to typical testosterone, dihydrotestosterone, dehydroepiandrosterone, androsterone, androstenedione, and epiandrosterone.
  • bee pupa means bee larvae and pupae.
  • the kind of bee is not particularly limited, and known bees such as honey bees such as Japanese honey bees and western honey bees, African bee honey bees, wasps (including cross wasps), wasps and bumble bees can be widely used.
  • honey bees such as Japanese honey bees and western honey bees, African bee honey bees, wasps (including cross wasps), wasps and bumble bees
  • a bee is preferable, and a western bee is more preferable because of availability.
  • males and females are not necessarily distinguished and are preferably males.
  • Larvae and pupae are not particularly limited as long as they hatch from eggs. Among them, bee larvae and pupae that have passed 16 to 23 days after hatching are preferred, and bee larvae and pupae that have passed 18 to 21 days after hatching are more preferred.
  • the bee cub accumulates nutrients in the body.
  • bee males have long been used as traditional Chinese herbal medicines and contain a variety of amino acids including essential amino acids in a well-balanced manner, as well as vitamins such as proteins, lipids, sugars, vitamin Bs, folic acid, nicotinic acid, and pantothenic acid. And rich in minerals such as zinc and selenium.
  • amino acids including essential amino acids in a well-balanced manner, as well as vitamins such as proteins, lipids, sugars, vitamin Bs, folic acid, nicotinic acid, and pantothenic acid.
  • minerals such as zinc and selenium.
  • As the physiological activity and pharmacological action of bee pupae antibacterial action, anti-inflammatory action, antiviral action, antiprotozoal action, tinnitus elimination action and the like are known.
  • a bee is used in a state in which a raw bee and a raw bee are processed.
  • processed bees were pulverized bees (raw or dried), dried bees (raw or crushed), bees (raw, dried) Or pulverized product), and those obtained by extracting honeybees with water, hydrous ethanol, or the like.
  • Preferable examples include dried powder of bees prepared by drying and then pulverizing the bees (raw).
  • ⁇ bee '' in addition to a raw bee, a processed product obtained by subjecting the bee to drying, pulverization, or heating, a bee ( (Including raw, dried and pulverized products) extracted with water, hydrous ethanol, and the like, and bees and processed products thereof treated with proteolytic enzymes (peptidases).
  • a bee (Including raw, dried and pulverized products) extracted with water, hydrous ethanol, and the like, and bees and processed products thereof treated with proteolytic enzymes (peptidases).
  • drying method known methods employed in general food processing, such as natural drying such as ventilation drying and sun drying, forced drying by heating with electricity and the like, freeze drying and the like can be used.
  • it is freeze-dried.
  • the drying time is not particularly limited.
  • natural drying such as ventilation and sun drying
  • forced drying by heating with electricity, etc. it is about 1 to 3 days at about 50 ° C.
  • the degree can be mentioned.
  • drying is preferably performed so that the water content is 10% by mass or less, preferably 5% by mass or less.
  • a treatment for further reducing the water content can be performed with a freeze dryer.
  • the pulverization treatment can be performed using a known method such as a pulverization method using a pulverizer (mill) or a grinding method using a stone mortar.
  • the method for heating the bees is not particularly limited, and a method of heat treatment at 70 to 120 ° C. is preferable. In order to avoid elution of active ingredients such as various vitamins and amino acids as much as possible, it is possible to simply heat bees (including raw, dried and pulverized products) in boiling water. As the heat treatment, a method of steaming a bee with steam is preferably used.
  • the extraction method is to add water, hydrous ethanol, etc. to bees (including raw, dried and crushed), stir and then obtain the supernatant by centrifugation, filter with filter paper, The method of obtaining is used.
  • the bees and their processed products are treated with proteolytic enzymes to reduce the molecular weight of the protein contained in the bees and their processed products, so that allergic reactions caused by the proteins are suppressed ( It is expected that a product with reduced allergenase will be obtained.
  • Peptidase can be preferably mentioned as a proteolytic enzyme used for enzymatic treatment of bees and processed products thereof.
  • the peptidase used may have at least one of an endopeptidase action and an exopeptidase action.
  • Proteolytic enzymes having at least endopeptidase activity are derived from animals (eg, trypsin, chymotrypsin, etc.), plants (eg, papain, etc.), microorganisms (eg, lactic acid bacteria, yeast, mold, Bacillus subtilis, actinomycetes, etc.) And endopeptidase.
  • animals eg, trypsin, chymotrypsin, etc.
  • plants eg, papain, etc.
  • microorganisms eg, lactic acid bacteria, yeast, mold, Bacillus subtilis, actinomycetes, etc.
  • endopeptidase derived from animals (eg, trypsin, chymotrypsin, etc.), plants (eg, papain, etc.), microorganisms (eg, lactic acid bacteria, yeast, mold, Bacillus subtilis, actinomycetes, etc.) And endopeptidase.
  • proteolytic enzyme having at least exopeptidase activity, carboxypeptidase, aminopeptidase, exopeptidase derived from microorganisms (e.g., lactic acid bacteria, Aspergillus sp., Rhizopus sp., Etc.), pancreatin, pepsin, etc. that also have endopeptidase activity Is mentioned.
  • enzymes having both exopeptidase activity and endopeptidase activity include Streptomyces griseus-produced peptidase (trade name: Actinase AS), Aspergillus oryzae (Aspergillus oryzae) orizae) -produced peptidase (trade name: protease A, flavorzyme), Aspergillus melleus-produced peptidase (trade name: protease P), and the like.
  • Preferred examples of the enzyme having an exoprotease action include Aspergillus oryzae-produced peptidase (trade name: equinezyme G, Promod 192P, Promod 194P, Sumiteam FLAP), Aspergillus sojae-produced peptidase ( Product name: Sternzyme B15024), Aspergillus genus peptidase (product name: Cochlase P), Rhizopus oryzae production peptidase (product name: peptidase R), and the like.
  • Aspergillus oryzae-produced peptidase trade name: equinezyme G, Promod 192P, Promod 194P, Sumiteam FLAP
  • Aspergillus sojae-produced peptidase Product name: Sternzyme B15024
  • Aspergillus genus peptidase product name: Cochlase P
  • Rhizopus oryzae production peptidase product name: peptidase
  • preferred examples of the enzyme having endoprotease action include Bacillus subtilis producing peptidase (trade name: orientase 22BF, nucleicin), Bacillus licheniformis producing peptidase (trade name: Alkalase), Bacillus stearothermophilus production peptidase (trade name: Protease S), Bacillus amyloliquefaciens production peptidase (trade name: Neutase), Bacillus genus production peptidase (Product) Name: Protamex).
  • the enzyme treatment for reducing the allergenicity of bees and their processed products can be performed, for example, according to the description in JP-A-2009-159997.
  • the tonic tonic, sexual function improving agent, male climacteric symptom improving agent and anti-fatigue agent of the present invention may contain additional components as long as the effects of the present invention are not hindered.
  • the proportion of bees in tonic tonics, sexual function improving agents, male menopausal symptoms improving agents and anti-fatigue agents is 0.01 to 99% by mass, preferably 1 to 80% by mass, more Preferably, 10 to 70 mass%, more preferably 20 to 50 mass% can be exemplified.
  • the tonic tonic, sexual function improving agent, male menopausal symptom improving agent and anti-fatigue agent of the present invention are not particularly limited in form, for example, powder, granule, tablet, capsule, liquid, suspension, It may have a pharmaceutical form such as an emulsion.
  • the tonic tonic, sexual function improving agent, male menopausal symptom improving agent and anti-fatigue agent of the present invention can be suitably used as ingredients of food compositions, quasi drugs and pharmaceuticals (particularly oral drugs).
  • the tonic tonic, sexual function improving agent, male menopausal symptom improving agent and anti-fatigue agent of the present invention are foods and beverages (e.g., health food, functional food, nutritional composition (nutritional) composition), nutritional supplements, supplements, foods for health use, foods for specified health use, nutritional functional foods, or functional labeling foods), quasi-drugs and pharmaceuticals (especially oral medicines).
  • the tonic tonic, sexual function improving agent, male menopausal symptom improving agent and anti-fatigue agent of the present invention impart tonic tonicity action, sexual function improving action, male menopausal symptom improving action, anti-fatigue action and vitality improving action.
  • the meaning of the additive is also included.
  • excipients in the above food and drink, as necessary, excipients, brighteners, minerals, vitamins, flavonoids, quinones, polyphenols, amino acids, nucleic acids, essential fatty acids, cooling agents, binders, sweeteners, Disintegrating agents, lubricants, colorants, fragrances, stabilizers, preservatives, sustained release regulators, surfactants, solubilizers, wetting agents and the like can be blended.
  • the types of the above-mentioned food and drink are not particularly limited.
  • beverages soft drinks such as coffee, juice, tea drinks, milk drinks, lactic acid bacteria drinks, yogurt drinks, carbonated drinks, sake, Western liquor, fruit seeds, etc.
  • Spreads such as custard cream
  • pastes such as fruit paste
  • pastries Chocolate, donuts, pies, cream puffs, gum, jelly, candy, cookies, cakes, puddings, etc.
  • Japanese confectionery Daifuku
  • ice confectionery ice cream, popsicle, sherbet, etc.
  • foods curry, beef bowl, miso soup, soup, meat sauce, pasta, pickles, jam etc.
  • Seasonings dressing, sprinkles, umami seasonings, soup ingredients, etc.
  • the dosage unit form for use as a supplement is not particularly limited and can be appropriately selected. Examples thereof include tablets, capsules, granules, liquids, powders and the like.
  • the ratio of the bees contained in the food and drink is, for example, 0.01 to 99% by mass, preferably 1 to 80% by mass, more preferably 10 to 70% by mass, and still more preferably 20 to 50% by mass. Can be mentioned.
  • the intake of the above food and drink can be set as appropriate according to various conditions such as the weight, age, sex, and symptoms of the user.
  • tonic tonic, sexual function improving agent, male climacteric symptom improving agent and anti-fatigue agent of the present invention are prepared as quasi-drugs or pharmaceuticals, they can be referred to as bee candy preparations.
  • the above-mentioned bees can be used alone or in combination with other pharmaceutical ingredients such as vitamins and herbal medicines described in the Japanese Pharmacopoeia.
  • the bee When preparing the tonic agent, sexual function improving agent, male menopausal symptom improving agent and anti-fatigue agent of the present invention as a quasi-drug or pharmaceutical product, the bee is a non-toxic carrier or diluent acceptable in the pharmaceutical product. Or with excipients, tablets (including plain tablets, sugar-coated tablets, effervescent tablets, film-coated tablets, chewable tablets, troches, etc.), capsules, pills, powders (powder), fine granules, granules, liquids It can be prepared in the form of suspensions, emulsions, syrups, pastes, and the like to make oral preparations.
  • the dose of the quasi-drug or drug can be determined as appropriate according to various conditions such as the patient's weight, age, sex, and symptoms, and more than 0.5 g of bees per day, preferably 0.7 g. As mentioned above, it is desirable to set it as 1 g or more.
  • the ratio of the bees contained in the quasi-drug or pharmaceutical is not particularly limited as long as the effect of the present invention is exhibited, and is, for example, 0.01 to 99% by mass, preferably 1 to 80% by mass, and more preferably 10%.
  • a concentration of ⁇ 70 mass%, more preferably 20-50 mass% can be mentioned.
  • the tonicity enhancing agent, sexual function improving agent, male climacteric symptom improving agent and anti-fatigue agent of the present invention described above are applied to mammals including humans (preferably humans, particularly males).
  • the food / beverage products, quasi drugs and pharmaceuticals of the present invention have a tonic effect, sexual function improvement effect, male climacteric symptom improvement effect, anti-fatigue effect and vitality improvement effect. Moreover, since the food / beverage products, quasi-drugs, and pharmaceuticals of the present invention do not increase androgen, they are highly safe.
  • ⁇ Test method> Eleven subjects ingested 6 capsules of soft capsule-shaped food containing 180 mg of bees per capsule every day for 12 weeks.
  • the following table shows the nutritional components per capsule of the test food.
  • the subject recorded subjective symptoms including the presence or absence of an early morning erection, daily life information, etc. in a diary from one week before the test start date to the end of intake.
  • AMS Self-rating (depression) scale
  • IIEF5 international erectile function score simplified version
  • AMS score is a self-filled questionnaire widely used for symptom inquiry of LOH syndrome.
  • Psychological factors are 5 items (25 points)
  • physical factors are 7 items (35 points)
  • sexual function factors are 5 items. It consists of a total of 17 items (25 points) (85 points).
  • Each item is rated on a five-point scale: “None”, “Light”, “Medium”, “Heavy”, “Very heavy”, with a score of 1 to 5 points. The higher the score, the more severe the symptoms.
  • the SDS is an index indicating the degree of depression and consists of 20 question items that ask about depressive symptoms. The higher the score, the more severe the symptoms.
  • IIEF5 is an international index used for screening ED and judging the effect of treatment, which is a simplification of IIEF International Index of Erectile Function (International Erectile Function Score). The lower the score, the more severe the symptoms.
  • the left end of the straight line of 10 cm is “the best sensation that you have never experienced, never felt fatigue”, and the right end is anything that you have never experienced.
  • the location on the straight line is recorded with a cross, and the distance from the left end to the recorded location is quantified.
  • TT TT
  • FT physical examination
  • hematological examination hematological examination
  • blood biochemical examination performed the corresponding t-test.
  • IIEF5 In comparison between before and after taking the test food, IIEF5 showed a significant increase at the end of ingestion (FIG. 2).
  • Soft capsule 180 mg of bee edible, edible oil, ⁇ -aminobutyric acid, glycerin, soybean-derived plant lecithin, beeswax, vitamin B2, and vitamin B12 are mixed and filled into a soft capsule containing gelatin and caramel pigment.
  • a soft capsule formulation was obtained.
  • Soft capsules of 100 mg bees, edible oils and fats, maca extract powder, tonkat ant extract powder, cordyceps mycelium powder, zinc-containing yeast, baboon extract powder, beeswax, and soybean-derived plant lecithin are mixed, gelatin and A soft capsule containing cacao pigment was filled to obtain a soft capsule preparation.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Insects & Arthropods (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

L'invention concerne une substance tonique pour restauration comprenant des larves d'abeilles, un agent améliorant la fonction sexuelle comprenant des larves d'abeilles, un agent améliorant les symptômes de la ménopause chez les mâles comprenant des larves d'abeilles, et un agent anti-fatigue comprenant des larves d'abeilles.
PCT/JP2016/061822 2015-04-17 2016-04-12 Substance nutritive tonique contenant des larves d'abeilles Ceased WO2016167254A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SG11201708300YA SG11201708300YA (en) 2015-04-17 2016-04-12 Nutrient tonic containing bee larvae
JP2017512543A JP6483244B2 (ja) 2015-04-17 2016-04-12 蜂の子を含有する滋養強壮剤
CN201680021368.3A CN107427538A (zh) 2015-04-17 2016-04-12 含有蜂子的滋养强壮剂

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2015-085118 2015-04-17
JP2015085118 2015-04-17

Publications (1)

Publication Number Publication Date
WO2016167254A1 true WO2016167254A1 (fr) 2016-10-20

Family

ID=57126769

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2016/061822 Ceased WO2016167254A1 (fr) 2015-04-17 2016-04-12 Substance nutritive tonique contenant des larves d'abeilles

Country Status (5)

Country Link
JP (1) JP6483244B2 (fr)
CN (1) CN107427538A (fr)
SG (1) SG11201708300YA (fr)
TW (1) TW201642882A (fr)
WO (1) WO2016167254A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102334546B1 (ko) * 2019-12-10 2021-12-03 대한민국 수벌번데기 추출물을 포함하는 항염증 조성물

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11504902A (ja) * 1995-04-28 1999-05-11 ゾナゲン，インコーポレイテッド ヒトの性的応答を調節するための方法及び製剤
JP2005179307A (ja) * 2003-12-22 2005-07-07 Lion Corp 更年期障害治療剤および該更年期障害治療剤を含有する製剤組成物
JP2006511531A (ja) * 2002-12-13 2006-04-06 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 男性更年期が原因の異常の予防および／または治療のためのカルニチンの使用
JP2007024822A (ja) * 2005-07-21 2007-02-01 Aska Pharmaceutical Co Ltd 男性の更年期又はうつ病の鑑別方法
JP2007116939A (ja) * 2005-10-26 2007-05-17 Asahi Breweries Ltd 滋養強壮飲料
WO2009048148A1 (fr) * 2007-10-10 2009-04-16 Kyowa Hakko Bio Co., Ltd. Préparation orale à action rapide pouvant augmenter le taux d'arginine dans le sang contenant de la citrulline et de l'arginine
JP2009159997A (ja) * 2009-04-27 2009-07-23 Yamada Bee Farm Corp 低分子化ハチノコ含有食品組成物及びその製造方法
RU2376978C2 (ru) * 2007-12-29 2009-12-27 Валентин Васильевич Хижа Комплексный апипрепарат в виде суппозиториев для лечения андрологических заболеваний и способ его получения
JP2010030975A (ja) * 2008-06-23 2010-02-12 Api Co Ltd 可溶化蜂の子処理物、その製造方法、並びに可溶化蜂の子処理物を含有する医薬品、化粧品又は飲食品

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101036722A (zh) * 2006-03-15 2007-09-19 张丽英 一种缓解疲劳、改善男性更年期综合征的保健食品及制备
CN102134545B (zh) * 2010-12-10 2012-06-27 黄淑辉 一种蜂蛹配制酒及其制备方法
CN103750094B (zh) * 2013-06-29 2015-09-30 明光市昊昊蜂业有限公司 雄蜂蛹保健膏及其制备方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11504902A (ja) * 1995-04-28 1999-05-11 ゾナゲン，インコーポレイテッド ヒトの性的応答を調節するための方法及び製剤
JP2006511531A (ja) * 2002-12-13 2006-04-06 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 男性更年期が原因の異常の予防および／または治療のためのカルニチンの使用
JP2005179307A (ja) * 2003-12-22 2005-07-07 Lion Corp 更年期障害治療剤および該更年期障害治療剤を含有する製剤組成物
JP2007024822A (ja) * 2005-07-21 2007-02-01 Aska Pharmaceutical Co Ltd 男性の更年期又はうつ病の鑑別方法
JP2007116939A (ja) * 2005-10-26 2007-05-17 Asahi Breweries Ltd 滋養強壮飲料
WO2009048148A1 (fr) * 2007-10-10 2009-04-16 Kyowa Hakko Bio Co., Ltd. Préparation orale à action rapide pouvant augmenter le taux d'arginine dans le sang contenant de la citrulline et de l'arginine
RU2376978C2 (ru) * 2007-12-29 2009-12-27 Валентин Васильевич Хижа Комплексный апипрепарат в виде суппозиториев для лечения андрологических заболеваний и способ его получения
JP2010030975A (ja) * 2008-06-23 2010-02-12 Api Co Ltd 可溶化蜂の子処理物、その製造方法、並びに可溶化蜂の子処理物を含有する医薬品、化粧品又は飲食品
JP2009159997A (ja) * 2009-04-27 2009-07-23 Yamada Bee Farm Corp 低分子化ハチノコ含有食品組成物及びその製造方法

Also Published As

Publication number Publication date
TW201642882A (zh) 2016-12-16
JPWO2016167254A1 (ja) 2018-01-11
CN107427538A (zh) 2017-12-01
SG11201708300YA (en) 2017-11-29
JP6483244B2 (ja) 2019-03-13

Similar Documents

Publication Publication Date Title
JP6596024B2 (ja) 組成物
JP2024026804A (ja) 疲労感、意欲低下または眠気の改善剤
JP2016199491A (ja) 気分状態改善剤
JP6782381B1 (ja) 脳機能改善用食品組成物、脳機能改善剤、脳由来神経栄養因子増加用食品組成物、ストレスホルモン分泌抑制用食品組成物、脳由来神経栄養因子増加剤及びストレスホルモン分泌抑制剤
JP6483244B2 (ja) 蜂の子を含有する滋養強壮剤
CN109310661B (zh) 血流改善剂、蜂王浆组合物及蜂王浆组合物的制造方法
JP2015050991A (ja) 健康補助食品
JP7624193B2 (ja) サルコペニア改善剤
JP2004131407A (ja) ローヤルゼリー又はその水溶性画分を有効成分とする抗うつ性組成物
JP2017184718A (ja) リンゴポリフェノール及びオレアノール酸を含有する食品組成物
HK1241284A1 (en) Nutrient tonic containing bee larvae
JP7687715B2 (ja) Ｂ細胞数増加剤
JP7359440B2 (ja) 毛穴ケアのための食品組成物
JP6514502B2 (ja) 焦燥感改善剤
JP6717509B2 (ja) めまい改善剤
JP2024114358A (ja) 腸内細菌叢改善剤
JP2016113412A (ja) 関節痛及び腰痛改善剤
JP2025039266A (ja) 空腹感緩和剤
JP2017197491A (ja) 筋肉増強用組成物
JP2017137247A (ja) 経口免疫機能調整剤及び免疫機能調整用食品
JP6514501B2 (ja) 皮膚掻痒感改善剤
JP6514499B2 (ja) 胸痛改善剤
JP6537887B2 (ja) めまい改善剤
JP2022099458A (ja) グルカゴン様ペプチド－１分泌促進用組成物
JP2021187792A (ja) 造血幹細胞数増加剤

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 16780045

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2017512543

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 11201708300Y

Country of ref document: SG

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 16780045

Country of ref document: EP

Kind code of ref document: A1