WO2016034779A1 - System for holding an adapter on an end cone of a syringe, and assembly comprising such a holding system - Google Patents
System for holding an adapter on an end cone of a syringe, and assembly comprising such a holding system Download PDFInfo
- Publication number
- WO2016034779A1 WO2016034779A1 PCT/FR2014/052202 FR2014052202W WO2016034779A1 WO 2016034779 A1 WO2016034779 A1 WO 2016034779A1 FR 2014052202 W FR2014052202 W FR 2014052202W WO 2016034779 A1 WO2016034779 A1 WO 2016034779A1
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- WO
- WIPO (PCT)
- Prior art keywords
- adapter
- shells
- syringe
- holding system
- holding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3134—Syringe barrels characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/347—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub rotatable, e.g. bayonet or screw
Definitions
- the invention relates to a system for holding an adapter, such as a luer lock, on an end cone of a glass syringe, an assembly comprising such a holding system.
- Injection syringes for medical products are often provided with an adapter, commonly called a luer lock, provided around an end cone, or cone luer, of the syringe.
- an adapter commonly called a luer lock, provided around an end cone, or cone luer, of the syringe.
- Such an adapter includes an internal thread for screwing a plug or locking the connection of the luer cone of the syringe with a needle or tubing.
- the standard defining the cone is ISO 594-1 (Part 1: General Specifications).
- the standard defining the locking net is ISO 594-2 (Part 2: Locking Assemblies).
- the adapter is involuntarily disengaged from the syringe, for example when the cap is unscrewed from the adapter, or when a tubing is mounted on the adapter. During such an operation, a large torque can be applied to the adapter and cause it to separate from the syringe, leakage of the contents of the syringe and possible contaminations.
- Another known solution is to combine a reinforcing ring which surrounds the adapter with an abrasive surface treatment on the glass syringe at the connection with the adapter.
- This abrasive surface treatment which can in particular be obtained by sandblasting, makes it possible to have a better attachment of the adapter and thus prevent the sliding thereof and its disengagement from the syringe inadvertently.
- This solution involves a complex process for the surface treatment of glass and does not completely solve the problem because cases of uncoupling are still possible.
- the invention intends to remedy by proposing a new system for holding an adapter on a tip cone of a syringe, which can be put in place after filling the syringe in a pharmaceutical zone. not controlled.
- the invention relates to a system for holding an adapter on an end cone of a glass syringe, this system comprising two half-shells, each having a first portion adapted to fitly surround the adapter and a second portion distinct from the first portion and adapted to tightly surround a portion of the syringe, and a locking ring adapted to be screwed on a thread formed on the half-shells so as to secure the half-shells l to each other, to the adapter and to the glass syringe.
- the adapter can be locked on the syringe, after filling and sterilization. This solution has little impact on the pharmaceutical production process and therefore has a flexibility and simplicity of implementation.
- such a holding system may incorporate one or more of the following features, taken in any technically permissible combination:
- the locking ring comprises an internal thread, and the internal thread and the thread have threads whose apex angle is between 0.1 0 and 10 °.
- One of the half-shells comprises protruding reliefs adapted to be inserted in recessed reliefs of corresponding shape of the other half-shell.
- the half-shells each comprise a skirt forming the second part, and which surround the syringe fittingly to a cylindrical portion of the glass syringe.
- the skirts of the half-shells comprise an outer portion bearing against the cylindrical portion of the glass syringe.
- the outer portion of the skirts comprises bosses distributed on the circumference of the skirts.
- the system comprises, on the outer portion of the skirts, at least one viewing slot of the syringe formed by notches in the outer portions.
- the notches forming the viewing slot or slots are formed on the longitudinal edges of the half-shells.
- the first part of the half-shells is formed by a cylindrical portion of the half-shells.
- the half-shells comprise, on an inner cylindrical surface of the cylindrical portions, protruding reliefs adapted to cooperate with reliefs projecting from the adapter so as to lock in rotation the adapter about a central axis of the syringe .
- the projecting reliefs of the half-shells and the adapter are formed by longitudinal ribs.
- the locking ring comprises external bosses distributed over its circumference.
- the invention also relates to an assembly comprising a glass syringe and an adapter attached to an end cone of the syringe, characterized in that it comprises a holding system as mentioned above.
- FIG. 1 is a perspective view of an assembly according to the invention
- Figure 2 is a longitudinal sectional view of the assembly of Figure 1;
- Figure 3 is an exploded perspective view of all of Figures 1 and 2;
- FIG. 4 is a perspective view of all of Figures 1 to 3, a cap screwed into an adapter of the assembly being omitted;
- FIG. 5 is an exploded view of two half-shells belonging to a holding system according to the invention
- - Figure 6 is a perspective view of a locking ring belonging to the holding system according to the invention.
- FIG. 1 An assembly 1, comprising a glass syringe 3, an adapter 5, and a system 7 for holding the adapter 5 on the syringe 3 is shown in FIG.
- the syringe 3 comprises an end cone 30, sometimes called "luer cone", crossed by a conduit 32 connected to a reservoir 34.
- the reservoir 34 is bounded by a cylindrical portion 36 of the syringe 3, which is connected to the cone 30 by an intermediate wall 38.
- the syringe 3 defines a longitudinal central axis X-X ', which also forms a longitudinal axis of the assembly 1.
- the adapter 5 also commonly called “luer lock”, is a member having a U-shaped cross-section, a radial portion of which comprises an orifice 56 enabling it to be mounted on the cone 30.
- the adapter 5 comprises an internal thread 54 allowing the screwing of a plug 9 or, not shown, fixing a needle or tubing.
- the adapter 5 is made of thermoplastic polymer, preferably PP (polypropylene).
- the holding system 7 allows the locking of the adapter 5 on the cone 30, so as to avoid the accidental disconnection of the adapter 5 of the syringe 3 and the possible leakage and contamination problems of the liquid contained in the syringe 3 that could ensue.
- the holding system 7 comprises two half-shells 70 and 72 adapted to surround the adapter 5 and a portion of the syringe 3.
- Each of the half-shells 70 and 72 comprises a respective cylindrical portion 701 and 703 which extends over the Half of the circumference of the adapter 5.
- the cylindrical portions 701 and 703 surround the adapter 5 in an adjusted manner, i.e. so as to allow minimal freedom of movement to the adapter 5 in the half shells 70 and 72.
- the half-shell 70 comprises two transverse edges 700 and 702 which join transverse edges 720 and 722 of the half-shell 72. In the vicinity of the edges 700 and 702, the half-shell 70 comprises projecting reliefs 704 and 706 adapted to inserted in recessed reliefs 724 and 726 of corresponding shape of the half-shell 72.
- the half-shells 70 and 72 fit around the adapter 5 so as to encompass most of its circumference.
- the locking ring 76 comprises an internal thread 760.
- the tapping 760 and the thread 74 preferably have threads of low conicity, that is to say the angle at the top is between 0.1 ° and 10 ° This low conicity allows a progressive tightening ensuring a sufficient holding force.
- the reliefs 704, 706 and 724, 726 allow the preliminary assembly of the half-shells 60 and 70 by means of a machine before the locking ring 76 is screwed on by the machine for mounting the system 7. These reliefs also make it possible to facilitate the placement of the half-shells 70 and 72 relative to each other through the indexing provided by the reliefs, which ensures the accuracy and repeatability of the assembly of the half-shells 70 and 72.
- the projecting reliefs 704, 706, 724 and 726 have a slightly beveled parallelepiped shape.
- these protruding reliefs may have a cylindrical shape or any other form allowing interlocking.
- the half-shells 70 and 72 each comprise a distinct portion of the cylindrical portions 701 and 703, formed by respective skirts 708 and 728 which surround the syringe 3 in a manner adjusted by its intermediate portion 38 to the cylindrical portion 36.
- the skirts 708 and 728 are separated from the cylindrical portions 701 and 703 by the reliefs 704, 706, 724 and 726.
- a respective outer portion 708a and 728a skirts 708 and 728 extends parallel to the axis XX 'and bears against the cylindrical portion 36 of the glass syringe 3. This support allows the system 7 to prevent the swiveling of the adapter 5 with respect to the cone 30, for example under the effect of a torsional stress, keeping the adapter 5 locked in a position coaxial with the axis X-X '.
- the outer portions 708a and 728a provide increased torsional rigidity to the half-shells 70 and 72, in the case of multidirectional stresses.
- the outer surface of the outer portion 708a and outer portion 728a has bosses 710 and 730 that extend radially outwardly. These bosses 710 and 730 make it possible to block in rotation the half-shells 70 and 72 around the central axis XX 'of the syringe 3 during the screwing of the locking ring 76. Thus, the half-shells 70 and 72 are not in danger. not turn on themselves and drive the adapter 5 in this rotation when screwing the locking ring 76.
- the system 7 comprises two viewing slots 78 of the syringe 3 through the skirts 708 and 728. These slots 78 provide a direct view of the liquid contained in the syringe 3. This direct vision can be very useful for the mirage of product before injection or in case of manual bleeding of an air bubble present in the syringe 3.
- the slots 78 are formed diametrically opposite by notches 708b and 728b formed respectively in the outer portions 708a and 728a, in the extension transverse edges 700, 702, 720 and 722. Alternatively not shown, the notches 708b and 728b may not be arranged in the extension of the transverse edges 700, 702, 720 and 722.
- the system 7 may also include only one single viewing slot 78.
- respective inner cylindrical surfaces 712 and 732 of the half-shells 70 and 72 which are in contact with the adapter 5, have protruding reliefs 712a and 732a adapted to cooperate in complementary form with protruding reliefs 50 of the adapter 5, formed on an outer surface 52 of the adapter 5.
- the protruding reliefs 712a and 732a are formed by longitudinal ribs formed on the inner circumference of the cylindrical portions 701 and 703 such that they are placed between similar ribs forming the protruding reliefs 50 of the adapter 5.
- the user can hold the holding system 7 and screw the tubing ensuring that the adapter 5 will not rotate inside the system 7 gr that the rotational locking provided by projecting reliefs 712a, 732a and 50.
- the locking ring 76 comprises external bosses 762 distributed around its circumference, making it easier to screw the locking ring 76 onto the half-shells 70 and 72.
- the half-shells 70 and 72 are made of a thermoplastic polymer with good transparency and flexibility properties such as certain PP (polypropylene) or PA (polyamide).
- PP polypropylene
- PA polyamide
- the locking ring 76 is preferably made of a thermoplastic polymer having good sliding properties such as HDPE (high density polyethylene) or POM (polyformaldehyde).
- HDPE high density polyethylene
- POM polyformaldehyde
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Abstract
Description
SYSTEME DE MAINTIEN D'UN ADAPTATEUR SUR UN CONE D'EXTREMITE D'UNE SERINGUE, ET ENSEMBLE COMPRENANT UN TEL SYSTEME DE MAINTIEN SYSTEM FOR MAINTAINING AN ADAPTER ON A CONE END OF A SYRINGE, AND ASSEMBLY COMPRISING SUCH A HOLDING SYSTEM
L'invention concerne un système de maintien d'un adaptateur, tel qu'un luer lock, sur un cône d'extrémité d'une seringue en verre, un ensemble comprenant un tel système de maintien. The invention relates to a system for holding an adapter, such as a luer lock, on an end cone of a glass syringe, an assembly comprising such a holding system.
Les seringues d'injection de produits médicaux sont souvent munies d'un adaptateur, communément appelé luer lock, prévu autour d'un cône d'extrémité, ou cône luer, de la seringue. Un tel adaptateur comprend un filet interne permettant de visser un bouchon ou de verrouiller la connexion du cône Luer de la seringue avec une aiguille ou une tubulure. La norme définissant le cône est la norme ISO 594-1 (Partie 1 : Spécifications générales). La norme définissant le filet de verrouillage est la norme ISO 594-2 (Partie 2: Assemblages à verrouillage). Injection syringes for medical products are often provided with an adapter, commonly called a luer lock, provided around an end cone, or cone luer, of the syringe. Such an adapter includes an internal thread for screwing a plug or locking the connection of the luer cone of the syringe with a needle or tubing. The standard defining the cone is ISO 594-1 (Part 1: General Specifications). The standard defining the locking net is ISO 594-2 (Part 2: Locking Assemblies).
Sur les seringues en plastique, la technologie de fabrication permet d'intégrer ce filet de verrouillage dans le corps de la seringue. La technologie de formage du verre ne permet pas autant de liberté sur les formes finales. Il est donc nécessaire d'ajouter sur les seringues en verre un adaptateur à même de réaliser cette fonction. On plastic syringes, the manufacturing technology makes it possible to integrate this locking net into the body of the syringe. Glass forming technology does not allow as much freedom on the final shapes. It is therefore necessary to add on the glass syringes an adapter capable of performing this function.
La fixation de l'adaptateur sur le cône d'extrémité d'une seringue en verre est généralement permise par un léger bossage sur une surface externe du cône d'extrémité comme décrit dans les documents EP 0 707 859 et WO 2010/052517. La technologie de formage du verre ne permet pas d'avoir des surfaces d'arrêt franches qui auraient permis une bonne tenue de l'adaptateur. Toutes les arêtes finales sont en effet arrondies. Si l'on ajoute à ce fait les excellentes propriétés de glissement du verre, la solidité de la fixation de l'adaptateur sur la seringue est ainsi réduite. Fixing the adapter on the end cone of a glass syringe is generally permitted by a slight projection on an outer surface of the end cone as described in EP 0 707 859 and WO 2010/052517. The glass forming technology does not allow for stopping surfaces that would have allowed a good hold of the adapter. All the final edges are indeed rounded. If one adds to this fact the excellent sliding properties of the glass, the strength of the attachment of the adapter on the syringe is thus reduced.
Au cours de l'utilisation de la seringue munie de son adaptateur, il est courant que l'adaptateur soit involontairement désolidarisé de la seringue, par exemple lorsque le bouchon est dévissé de l'adaptateur, ou lorsqu'une tubulure est montée sur l'adaptateur. Au cours d'une telle opération, un couple important peut être appliqué sur l'adaptateur et provoquer sa désolidarisation de la seringue, des fuites du contenu de la seringue et d'éventuelles contaminations. During the use of the syringe with its adapter, it is common that the adapter is involuntarily disengaged from the syringe, for example when the cap is unscrewed from the adapter, or when a tubing is mounted on the adapter. During such an operation, a large torque can be applied to the adapter and cause it to separate from the syringe, leakage of the contents of the syringe and possible contaminations.
Le montage de la seringue sur un pousse-seringue peut également fragiliser la tenue de l'adaptateur sur la seringue notamment lorsque que l'injecteur est positionné tête en haut pour l'opération de purge de la seringue. En effet la rigidité des tubulures vient au moment de cette rotation induire un couple sur l'adaptateur et ainsi réduire sa tenue. Cette fragilisation entraine des risques d'expulsion de celui-ci en cours d'utilisation de la seringue. Pour résoudre ce problème, diverses solutions ont été développées. L'une d'elles consiste à monter en force une pièce de maintien sur l'adaptateur avant le remplissage de la seringue. Un tel dispositif implique le dévissage du bouchon, ce qui ne peut être réalisé qu'en zone pharmaceutique contrôlée. Pour réaliser une telle étape en zone pharmaceutique non contrôlée, une étape supplémentaire de stérilisation de l'ensemble après mise en place de la pièce de maintien et revissage du bouchon est nécessaire. Mounting the syringe on a syringe pump can also weaken the holding of the adapter on the syringe especially when the injector is positioned head up for the bleeding operation of the syringe. In fact the rigidity of the pipes comes at the moment of this rotation induce a couple on the adapter and thus reduce its behavior. This embrittlement entails the risk of expulsion of it during use of the syringe. To solve this problem, various solutions have been developed. One of them is to force a holding piece on the adapter before filling the syringe. Such a device involves unscrewing the cap, which can only be achieved in a controlled pharmaceutical zone. To perform such a step in the uncontrolled pharmaceutical zone, an additional sterilization step of the assembly after placing the retaining piece and screwing the cap is necessary.
Une autre solution connue consiste à combiner un anneau de renfort qui entoure l'adaptateur à un traitement de surface abrasif sur la seringue en verre au niveau de la liaison avec l'adaptateur. Ce traitement de surface abrasif, qui peut notamment être obtenu par sablage, permet d'avoir une meilleure d'accroché de l'adaptateur et ainsi d'éviter le glissement de celui-ci et sa désolidarisation de la seringue par inadvertance. Cette solution implique un procédé complexe pour le traitement de surface du verre et ne résout pas totalement le problème car des cas de désolidarisation sont encore possibles. Another known solution is to combine a reinforcing ring which surrounds the adapter with an abrasive surface treatment on the glass syringe at the connection with the adapter. This abrasive surface treatment, which can in particular be obtained by sandblasting, makes it possible to have a better attachment of the adapter and thus prevent the sliding thereof and its disengagement from the syringe inadvertently. This solution involves a complex process for the surface treatment of glass and does not completely solve the problem because cases of uncoupling are still possible.
C'est à ces inconvénients qu'entend remédier l'invention en proposant un nouveau système de maintien d'un adaptateur sur un cône d'extrémité d'une seringue, pouvant être mis en place après le remplissage de la seringue dans une zone pharmaceutique non contrôlée. It is these drawbacks that the invention intends to remedy by proposing a new system for holding an adapter on a tip cone of a syringe, which can be put in place after filling the syringe in a pharmaceutical zone. not controlled.
A cet effet, l'invention concerne un système de maintien d'un adaptateur sur un cône d'extrémité d'une seringue en verre, ce système comprenant deux demi-coquilles, présentant chacune une première partie adaptée pour entourer de manière ajustée l'adaptateur et une seconde partie distincte de la première partie et adaptée pour entourer de manière ajustée une partie de la seringue, et une bague de verrouillage adaptée pour être vissée sur un filetage formé sur les demi-coquilles de manière à solidariser les demi- coquilles l'une à l'autre, à l'adaptateur et à la seringue en verre. To this end, the invention relates to a system for holding an adapter on an end cone of a glass syringe, this system comprising two half-shells, each having a first portion adapted to fitly surround the adapter and a second portion distinct from the first portion and adapted to tightly surround a portion of the syringe, and a locking ring adapted to be screwed on a thread formed on the half-shells so as to secure the half-shells l to each other, to the adapter and to the glass syringe.
Grâce à l'invention, l'adaptateur peut être verrouillé sur la seringue, postérieurement à son remplissage et sa stérilisation. Cette solution a donc peu d'impact sur le processus de production pharmaceutique et présente donc une souplesse et une simplicité de mise en œuvre significative. Thanks to the invention, the adapter can be locked on the syringe, after filling and sterilization. This solution has little impact on the pharmaceutical production process and therefore has a flexibility and simplicity of implementation.
Selon des aspects avantageux mais non obligatoires de l'invention, un tel système de maintien peut incorporer une ou plusieurs des caractéristiques suivantes, prises dans toute combinaison techniquement admissible : According to advantageous but non-mandatory aspects of the invention, such a holding system may incorporate one or more of the following features, taken in any technically permissible combination:
- la bague de verrouillage comprend un taraudage interne, et le taraudage interne et le filetage présentent des filets dont l'angle au sommet est compris entre 0.1 0 et 10° . - The locking ring comprises an internal thread, and the internal thread and the thread have threads whose apex angle is between 0.1 0 and 10 °.
- L'une des demi-coquilles comprend des reliefs en saillie adaptés pour s'insérer dans des reliefs en creux de forme correspondante de l'autre demi-coquille. - Les demi-coquilles comportent chacune une jupe formant la seconde partie, et qui entourent la seringue de manière ajustée jusqu'à une partie cylindrique de la seringue en verre. - One of the half-shells comprises protruding reliefs adapted to be inserted in recessed reliefs of corresponding shape of the other half-shell. - The half-shells each comprise a skirt forming the second part, and which surround the syringe fittingly to a cylindrical portion of the glass syringe.
- Les jupes des demi-coquilles comprennent une portion extérieure en appui contre la partie cylindrique de la seringue en verre. - The skirts of the half-shells comprise an outer portion bearing against the cylindrical portion of the glass syringe.
- La portion extérieure des jupes comprend des bossages répartis sur la circonférence des jupes. - The outer portion of the skirts comprises bosses distributed on the circumference of the skirts.
- Le système comprend, sur la portion extérieure des jupes, au moins une fente de visualisation de la seringue formée par des encoches ménagées dans les portions extérieures. - The system comprises, on the outer portion of the skirts, at least one viewing slot of the syringe formed by notches in the outer portions.
- Les encoches formant la ou les fentes de visualisation sont formées sur des bords longitudinaux des demi-coquilles. - The notches forming the viewing slot or slots are formed on the longitudinal edges of the half-shells.
- La première partie des demi-coquilles est formée par une partie cylindrique des demi-coquilles. - The first part of the half-shells is formed by a cylindrical portion of the half-shells.
- Les demi-coquilles comprennent, sur une surface cylindrique interne des parties cylindriques, des reliefs en saillie adaptés pour coopérer avec des reliefs en saillie de l'adaptateur de manière à bloquer en rotation l'adaptateur autour d'un axe central de la seringue. - The half-shells comprise, on an inner cylindrical surface of the cylindrical portions, protruding reliefs adapted to cooperate with reliefs projecting from the adapter so as to lock in rotation the adapter about a central axis of the syringe .
- Les reliefs en saillie des demi-coquilles et de l'adaptateur sont formés par des nervures longitudinales. - The projecting reliefs of the half-shells and the adapter are formed by longitudinal ribs.
- La bague de verrouillage comprend des bossages externes répartis sur sa circonférence. - The locking ring comprises external bosses distributed over its circumference.
L'invention concerne également un ensemble comprenant une seringue en verre et un adaptateur fixé sur un cône d'extrémité de la seringue, caractérisé en ce qu'il comprend un système de maintien tel que mentionné ci-dessus. The invention also relates to an assembly comprising a glass syringe and an adapter attached to an end cone of the syringe, characterized in that it comprises a holding system as mentioned above.
L'invention sera mieux comprise et d'autres avantages de celle-ci apparaîtront plus clairement à la lumière de la description qui va suivre d'un système de maintien et d'un ensemble conformes à son principe, faite à titre d'exemple non limitatif en référence aux dessins annexés dans lesquels : The invention will be better understood and other advantages thereof will appear more clearly in the light of the following description of a holding system and a set in accordance with its principle, made by way of non-standard example. limiting with reference to the accompanying drawings in which:
- la figure 1 est une vue en perspective d'un ensemble conforme à l'invention ; - Figure 1 is a perspective view of an assembly according to the invention;
- la figure 2 est une vue en coupe longitudinale de l'ensemble de la figure 1 ; - Figure 2 is a longitudinal sectional view of the assembly of Figure 1;
- la figure 3 est une vue en perspective éclatée de l'ensemble des figures 1 et 2 ; - Figure 3 is an exploded perspective view of all of Figures 1 and 2;
- la figure 4 est une vue en perspective de l'ensemble des figures 1 à 3, un bouchon vissé dans un adaptateur de l'ensemble étant omis ; - Figure 4 is a perspective view of all of Figures 1 to 3, a cap screwed into an adapter of the assembly being omitted;
- la figure 5 est une vue éclatée de deux demi-coquilles appartenant à un système de maintien conforme à l'invention ; - la figure 6 est une vue en perspective d'une bague de verrouillage appartenant au système de maintien selon l'invention. - Figure 5 is an exploded view of two half-shells belonging to a holding system according to the invention; - Figure 6 is a perspective view of a locking ring belonging to the holding system according to the invention.
Un ensemble 1 , comprenant une seringue en verre 3, un adaptateur 5, et un système 7 de maintien de l'adaptateur 5 sur la seringue 3 est représenté sur la figure 1 . La seringue 3 comprend un cône d'extrémité 30, parfois appelé « cône luer », traversé par un conduit 32 relié à un réservoir 34. Le réservoir 34 est limité par une partie cylindrique 36 de la seringue 3, qui est reliée au cône 30 par une paroi intermédiaire 38. La seringue 3 définit un axe central longitudinal X-X', qui forme également un axe longitudinal de l'ensemble 1 . An assembly 1, comprising a glass syringe 3, an adapter 5, and a system 7 for holding the adapter 5 on the syringe 3 is shown in FIG. The syringe 3 comprises an end cone 30, sometimes called "luer cone", crossed by a conduit 32 connected to a reservoir 34. The reservoir 34 is bounded by a cylindrical portion 36 of the syringe 3, which is connected to the cone 30 by an intermediate wall 38. The syringe 3 defines a longitudinal central axis X-X ', which also forms a longitudinal axis of the assembly 1.
L'adaptateur 5, également communément appelé « luer lock», est un élément présentant une section transversale en U dont une partie radiale comprend un orifice 56 lui permettant d'être monté sur le cône 30. L'adaptateur 5 comprend un filetage interne 54 permettant le vissage d'un bouchon 9 ou, de façon non représentée, la fixation d'une aiguille ou d'une tubulure. Préférentiellement, l'adaptateur 5 est en polymère thermoplastique, préférentiellement en PP (polypropylène). The adapter 5, also commonly called "luer lock", is a member having a U-shaped cross-section, a radial portion of which comprises an orifice 56 enabling it to be mounted on the cone 30. The adapter 5 comprises an internal thread 54 allowing the screwing of a plug 9 or, not shown, fixing a needle or tubing. Preferably, the adapter 5 is made of thermoplastic polymer, preferably PP (polypropylene).
Le système de maintien 7 permet le verrouillage de l'adaptateur 5 sur le cône 30, de manière à éviter la désolidarisation accidentelle de l'adaptateur 5 de la seringue 3 et les éventuels problèmes de fuite et de contamination du liquide contenu dans la seringue 3 qui pourraient s'ensuivre. The holding system 7 allows the locking of the adapter 5 on the cone 30, so as to avoid the accidental disconnection of the adapter 5 of the syringe 3 and the possible leakage and contamination problems of the liquid contained in the syringe 3 that could ensue.
Le système de maintien 7 comprend deux demi-coquilles 70 et 72 adaptées pour entourer l'adaptateur 5 et une partie de la seringue 3. Chacune des demi-coquilles 70 et 72 comprend une partie cylindrique respective 701 et 703 qui s'étend sur la moitié de la circonférence de l'adaptateur 5. Les parties cylindriques 701 et 703 entourent l'adaptateur 5 de manière ajustée, c'est-à-dire de façon à autoriser une liberté de mouvement minimale à l'adaptateur 5 dans les demi-coquilles 70 et 72. The holding system 7 comprises two half-shells 70 and 72 adapted to surround the adapter 5 and a portion of the syringe 3. Each of the half-shells 70 and 72 comprises a respective cylindrical portion 701 and 703 which extends over the Half of the circumference of the adapter 5. The cylindrical portions 701 and 703 surround the adapter 5 in an adjusted manner, i.e. so as to allow minimal freedom of movement to the adapter 5 in the half shells 70 and 72.
La demi-coquille 70 comprend deux bords transversaux 700 et 702 qui joignent des bords transversaux 720 et 722 de la demi-coquille 72. Au voisinage des bords 700 et 702, la demi-coquille 70 comprend des reliefs en saillie 704 et 706 adaptés pour s'insérer dans des reliefs en creux 724 et 726 de forme correspondante de la demi-coquille 72. Ainsi, les demi-coquilles 70 et 72 s'emboîtent autour de l'adaptateur 5 de manière à l'englober sur la majeure partie de sa circonférence. The half-shell 70 comprises two transverse edges 700 and 702 which join transverse edges 720 and 722 of the half-shell 72. In the vicinity of the edges 700 and 702, the half-shell 70 comprises projecting reliefs 704 and 706 adapted to inserted in recessed reliefs 724 and 726 of corresponding shape of the half-shell 72. Thus, the half-shells 70 and 72 fit around the adapter 5 so as to encompass most of its circumference.
Les surfaces externes des parties cylindriques 701 et 703 forment ensemble un filetage 74, sur lequel une bague de verrouillage 76 du système 7 est vissée de manière à solidariser les demi-coquilles 70 et 72 l'une à l'autre d'une part, à l'adaptateur 5 et à la seringue 3 d'autre part. La bague de verrouillage 76 comprend à cet effet un taraudage interne 760. Le taraudage 760 et le filetage 74 présentent préférentiellement des filets de faible conicité, c'est-à-dire dont l'angle au sommet est compris entre 0.1 ° et 10° Cette faible conicité permet un serrage progressif garantissant un effort de maintien suffisant. The external surfaces of the cylindrical portions 701 and 703 together form a thread 74, on which a locking ring 76 of the system 7 is screwed so as to secure the half-shells 70 and 72 to one another on the one hand, to the adapter 5 and the syringe 3 on the other hand. For this purpose, the locking ring 76 comprises an internal thread 760. The tapping 760 and the thread 74 preferably have threads of low conicity, that is to say the angle at the top is between 0.1 ° and 10 ° This low conicity allows a progressive tightening ensuring a sufficient holding force.
Les reliefs 704, 706 et 724, 726 permettent l'assemblage préalable des demi- coquilles 60 et 70 grâce à une machine avant le vissage de la bague de verrouillage 76 par la machine de montage du système 7. Ces reliefs permettent également de faciliter le placement des demi-coquilles 70 et 72 l'une par rapport à l'autre grâce à l'indexation fournie par les reliefs, ce qui permet d'assurer la précision et la répétabilité de l'assemblage des demi-coquilles 70 et 72. The reliefs 704, 706 and 724, 726 allow the preliminary assembly of the half-shells 60 and 70 by means of a machine before the locking ring 76 is screwed on by the machine for mounting the system 7. These reliefs also make it possible to facilitate the placement of the half-shells 70 and 72 relative to each other through the indexing provided by the reliefs, which ensures the accuracy and repeatability of the assembly of the half-shells 70 and 72.
Dans l'exemple, les reliefs en saillies 704, 706, 724 et 726 présentent une forme parallélépipédique légèrement biseautée. En variante non représentée, ces reliefs en saillie peuvent présenter une forme cylindrique ou toute autre forme permettant un emboîtement. In the example, the projecting reliefs 704, 706, 724 and 726 have a slightly beveled parallelepiped shape. In variant not shown, these protruding reliefs may have a cylindrical shape or any other form allowing interlocking.
Les demi-coquilles 70 et 72 comprennent chacune une partie distincte des parties cylindriques 701 et 703, formées par des jupes respectives 708 et 728 qui entourent la seringue 3 de façon ajustée par sa partie intermédiaire 38 jusqu'à la partie cylindrique 36. Les jupes 708 et 728 sont séparées des parties cylindriques 701 et 703 par les reliefs 704, 706, 724 et 726. La présence de deux parties distinctes sur les demi-coquilles pour s'appuyer directement sur l'adaptateur 5 et sur la seringue 3 permet de stabiliser les demi-coquilles 70 et 72. The half-shells 70 and 72 each comprise a distinct portion of the cylindrical portions 701 and 703, formed by respective skirts 708 and 728 which surround the syringe 3 in a manner adjusted by its intermediate portion 38 to the cylindrical portion 36. The skirts 708 and 728 are separated from the cylindrical portions 701 and 703 by the reliefs 704, 706, 724 and 726. The presence of two distinct parts on the half-shells for pressing directly on the adapter 5 and on the syringe 3 makes it possible to stabilize the half-shells 70 and 72.
Une portion extérieure respective 708a et 728a des jupes 708 et 728 s'étend parallèlement à l'axe X-X' et est en appui contre la partie cylindrique 36 de la seringue en verre 3. Cet appui permet au système 7 d'empêcher le rotulage de l'adaptateur 5 par rapport au cône 30, par exemple sous l'effet d'une sollicitation en torsion, en maintenant l'adaptateur 5 bloqué dans une position coaxiale à l'axe X-X'. En outre, les portions extérieures 708a et 728a procurent une rigidité en torsion accrue aux demi-coquilles 70 et 72, en cas de contraintes multidirectionnelles. A respective outer portion 708a and 728a skirts 708 and 728 extends parallel to the axis XX 'and bears against the cylindrical portion 36 of the glass syringe 3. This support allows the system 7 to prevent the swiveling of the adapter 5 with respect to the cone 30, for example under the effect of a torsional stress, keeping the adapter 5 locked in a position coaxial with the axis X-X '. In addition, the outer portions 708a and 728a provide increased torsional rigidity to the half-shells 70 and 72, in the case of multidirectional stresses.
La surface externe de la portion extérieure 708a et de la portion extérieure 728a comporte des bossages 710 et 730 qui s'étendent radialement vers l'extérieur. Ces bossages 710 et 730 permettent de bloquer en rotation les demi-coquilles 70 et 72 autour de l'axe central X-X' de la seringue 3 lors du vissage de la bague de verrouillage 76. Ainsi, les demi-coquilles 70 et 72 ne risquent pas de tourner sur elles-mêmes et d'entraîner l'adaptateur 5 dans cette rotation lors du vissage de la bague de verrouillage 76. The outer surface of the outer portion 708a and outer portion 728a has bosses 710 and 730 that extend radially outwardly. These bosses 710 and 730 make it possible to block in rotation the half-shells 70 and 72 around the central axis XX 'of the syringe 3 during the screwing of the locking ring 76. Thus, the half-shells 70 and 72 are not in danger. not turn on themselves and drive the adapter 5 in this rotation when screwing the locking ring 76.
Le système 7 comprend deux fentes de visualisation 78 de la seringue 3 à travers les jupes 708 et 728. Ces fentes 78 permettent d'avoir une vision directe sur le liquide contenu dans la seringue 3 .Cette vision directe peut s'avérer très utile pour le mirage du produit avant injection ou en cas de purge manuelle d'une bulle d'air présente dans la seringue 3. Les fentes 78 sont formées de façon diamétralement opposée par des encoches 708b et 728b ménagées respectivement dans les portions extérieures 708a et 728a, dans le prolongement des bords transversaux 700, 702, 720 et 722. En variante non représentée, les encoches 708b et 728b peuvent ne pas être ménagées dans le prolongement des bords transversaux 700, 702, 720 et 722. Le système 7 peut également ne comprendre qu'une seule fente de visualisation 78. The system 7 comprises two viewing slots 78 of the syringe 3 through the skirts 708 and 728. These slots 78 provide a direct view of the liquid contained in the syringe 3. This direct vision can be very useful for the mirage of product before injection or in case of manual bleeding of an air bubble present in the syringe 3. The slots 78 are formed diametrically opposite by notches 708b and 728b formed respectively in the outer portions 708a and 728a, in the extension transverse edges 700, 702, 720 and 722. Alternatively not shown, the notches 708b and 728b may not be arranged in the extension of the transverse edges 700, 702, 720 and 722. The system 7 may also include only one single viewing slot 78.
Afin d'éviter la rotation de l'adaptateur 5 autour de l'axe X-X' par rapport aux demi- coquilles 70 et 72, des surfaces cylindriques internes respectives 712 et 732 des demi- coquilles 70 et 72, qui sont en contact avec l'adaptateur 5, comportent des reliefs en saillie 712a et 732a adaptés pour coopérer par complémentarité de forme avec des reliefs en saillie 50 de l'adaptateur 5, formés sur une surface externe 52 de l'adaptateur 5. Comme cela est représenté sur la figure 4, les reliefs en saillie 712a et 732a sont formés par des nervures longitudinales ménagées sur la circonférence interne des parties cylindriques 701 et 703 de telle manière qu'ils se placent entre des nervures similaires formant les reliefs en saillie 50 de l'adaptateur 5. Ainsi, lorsqu'un utilisateur connecte une tubulure dans l'adaptateur 5, l'utilisateur peut maintenir le système de maintien 7 et visser la tubulure en étant assuré que l'adaptateur 5 ne tournera pas à l'intérieur du système 7 grâce au blocage en rotation assurés par les reliefs en saillie 712a, 732a et 50. In order to avoid the rotation of the adapter 5 about the axis XX 'with respect to the half-shells 70 and 72, respective inner cylindrical surfaces 712 and 732 of the half-shells 70 and 72, which are in contact with the adapter 5, have protruding reliefs 712a and 732a adapted to cooperate in complementary form with protruding reliefs 50 of the adapter 5, formed on an outer surface 52 of the adapter 5. As shown in FIG. 4, the protruding reliefs 712a and 732a are formed by longitudinal ribs formed on the inner circumference of the cylindrical portions 701 and 703 such that they are placed between similar ribs forming the protruding reliefs 50 of the adapter 5. Thus, when a user connects a tubing in the adapter 5, the user can hold the holding system 7 and screw the tubing ensuring that the adapter 5 will not rotate inside the system 7 gr that the rotational locking provided by projecting reliefs 712a, 732a and 50.
Selon un aspect optionnel de l'invention représenté sur les figures, la bague de verrouillage 76 comprend des bossages externes 762 répartis sur sa circonférence, permettant de faciliter le vissage de la bague de verrouillage 76 sur les demi-coquilles 70 et 72. According to an optional aspect of the invention shown in the figures, the locking ring 76 comprises external bosses 762 distributed around its circumference, making it easier to screw the locking ring 76 onto the half-shells 70 and 72.
Préférentiellement, les demi-coquilles 70 et 72 sont réalisées dans un polymère thermoplastique offrant de bonnes propriétés de transparence et de souplesse comme certains PP (polypropylène) ou PA (polyamide). Preferably, the half-shells 70 and 72 are made of a thermoplastic polymer with good transparency and flexibility properties such as certain PP (polypropylene) or PA (polyamide).
La bague de verrouillage 76 est réalisée préférentiellement dans un polymère thermoplastique offrant de bonnes propriétés de glissement comme le PEHD (polyéthylène haute densité) ou le POM (polyformaldéhyde). The locking ring 76 is preferably made of a thermoplastic polymer having good sliding properties such as HDPE (high density polyethylene) or POM (polyformaldehyde).
Claims
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/FR2014/052202 WO2016034779A1 (en) | 2014-09-05 | 2014-09-05 | System for holding an adapter on an end cone of a syringe, and assembly comprising such a holding system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/FR2014/052202 WO2016034779A1 (en) | 2014-09-05 | 2014-09-05 | System for holding an adapter on an end cone of a syringe, and assembly comprising such a holding system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2016034779A1 true WO2016034779A1 (en) | 2016-03-10 |
Family
ID=51655774
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/FR2014/052202 Ceased WO2016034779A1 (en) | 2014-09-05 | 2014-09-05 | System for holding an adapter on an end cone of a syringe, and assembly comprising such a holding system |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2016034779A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110898292A (en) * | 2019-12-31 | 2020-03-24 | 山东威高普瑞医药包装有限公司 | Syringe and adapter thereof |
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| WO1992004927A1 (en) * | 1990-09-21 | 1992-04-02 | Novo Nordisk A/S | An injection unit |
| FR2697555A1 (en) * | 1992-10-29 | 1994-05-06 | Techniport | Mechanical coupling system for round-section concrete reinforcing rods - comprises half-shells with threaded inner and outer surfaces, with threaded locking rings to hold them in place |
| EP0707859A1 (en) | 1994-09-28 | 1996-04-24 | Schott Glaswerke | Containers for storage and administration of preparations suited for injection infusion or diagnostic purpose |
| JP2005296135A (en) * | 2004-04-07 | 2005-10-27 | Jms Co Ltd | Syringe with connector, connector used for syringe, and syringe |
| JP2005296140A (en) * | 2004-04-07 | 2005-10-27 | Jms Co Ltd | Syringe with connector and connector |
| WO2010052517A1 (en) | 2008-11-06 | 2010-05-14 | Becton Dickinson France | Improved drug container |
| DE102008061541A1 (en) * | 2008-12-03 | 2010-06-10 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | An injection system |
| WO2011159136A2 (en) * | 2010-06-17 | 2011-12-22 | Medikan Co., Ltd. | Adapter for syringe, adapter assembly for syringe, syringe and the fabrication method thereof |
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2014
- 2014-09-05 WO PCT/FR2014/052202 patent/WO2016034779A1/en not_active Ceased
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992004927A1 (en) * | 1990-09-21 | 1992-04-02 | Novo Nordisk A/S | An injection unit |
| FR2697555A1 (en) * | 1992-10-29 | 1994-05-06 | Techniport | Mechanical coupling system for round-section concrete reinforcing rods - comprises half-shells with threaded inner and outer surfaces, with threaded locking rings to hold them in place |
| EP0707859A1 (en) | 1994-09-28 | 1996-04-24 | Schott Glaswerke | Containers for storage and administration of preparations suited for injection infusion or diagnostic purpose |
| JP2005296135A (en) * | 2004-04-07 | 2005-10-27 | Jms Co Ltd | Syringe with connector, connector used for syringe, and syringe |
| JP2005296140A (en) * | 2004-04-07 | 2005-10-27 | Jms Co Ltd | Syringe with connector and connector |
| WO2010052517A1 (en) | 2008-11-06 | 2010-05-14 | Becton Dickinson France | Improved drug container |
| DE102008061541A1 (en) * | 2008-12-03 | 2010-06-10 | Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg | An injection system |
| WO2011159136A2 (en) * | 2010-06-17 | 2011-12-22 | Medikan Co., Ltd. | Adapter for syringe, adapter assembly for syringe, syringe and the fabrication method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110898292A (en) * | 2019-12-31 | 2020-03-24 | 山东威高普瑞医药包装有限公司 | Syringe and adapter thereof |
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