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WO2016028019A1 - Appareil de diagnostic photodynamique - Google Patents

Appareil de diagnostic photodynamique Download PDF

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Publication number
WO2016028019A1
WO2016028019A1 PCT/KR2015/008301 KR2015008301W WO2016028019A1 WO 2016028019 A1 WO2016028019 A1 WO 2016028019A1 KR 2015008301 W KR2015008301 W KR 2015008301W WO 2016028019 A1 WO2016028019 A1 WO 2016028019A1
Authority
WO
WIPO (PCT)
Prior art keywords
image
wavelength
light
beam splitter
target object
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2015/008301
Other languages
English (en)
Korean (ko)
Inventor
송원국
신민선
권기철
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MGB Endoscopy Co Ltd
Original Assignee
MGB Endoscopy Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MGB Endoscopy Co Ltd filed Critical MGB Endoscopy Co Ltd
Publication of WO2016028019A1 publication Critical patent/WO2016028019A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/13—Ophthalmic microscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/13—Ophthalmic microscopes
    • A61B3/135—Slit-lamp microscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand

Definitions

  • Embodiments of the present invention relate to an optical system structure of a surgical microscope, and more particularly to a multi-fluorescence photodynamic diagnostic device combined with a surgical microscope.
  • the eye is an organ that detects the intensity and wavelength of light, and detects the intensity of the light, finds the direction of the light, and recognizes the image of the object.
  • the sclera is usually called black sclera.
  • the above-described eye is undergoing surgery for diseases such as cataract, dry eye, and glaucoma due to changes in modern environment, LASIK surgery, LASEK surgery, excimer laser surgery, ICL surgery, etc. Surgical microscopes are used a lot.
  • the surgical microscope generally includes a light source for irradiating light by a power source, an optical cable for connecting the light of the light source to the affected part of the patient, an objective lens for enlarging the eyeball of the patient, and the enlarged It consists of an eyepiece for visual confirmation of the eye.
  • the surgical microscope is a light irradiated from the light source shines brightly on the affected part of the patient along the optical cable, and the eye is greatly enlarged by the objective lens to observe and operate through the eyepiece.
  • Korean Patent Publication No. 10-0499243 name of the invention: a surgical microscope using infrared rays, registered date: June 24, 2005.
  • the image for each wavelength separated by the beam splitter is converted into image data through each camera and displayed on each display device, thereby displaying color and monochrome images of the affected part of the patient through different screens. It provides a photodynamic diagnostic device that can be checked at the same time.
  • An optical dynamics diagnostic device includes a plurality of light sources for irradiating a plurality of light having different wavelengths; An objective lens disposed to face the target object; A zoom lens in which light reflected by the target object and passed through the objective lens is incident; A video member which photographs the light emitted from the zoom lens to generate an image of the target object differently for each wavelength, and separates and outputs the generated image for each wavelength into a plurality of channels; An eyepiece configured to visually observe an image of the object; And a plurality of display devices configured to display an image for each wavelength output for each channel.
  • the video member may include a beam splitter for simultaneously displaying the image of the target object formed through the objective lens on the eyepiece and the display device.
  • the beam splitter may be detachably formed.
  • the beam splitter is preferably designed in the shape of a Y-shaped easily removable on the back of the surgical microscope.
  • the Y-shaped beam splitter may be configured of an optical system using two cube-shaped beam splitters provided in optical paths corresponding to the left eye and the right eye, and four prism mirrors that change a movement path of the light passing through each beam splitter. have.
  • the beam splitter may include a filter for filtering light of a specific wavelength.
  • the video member may further include a camera unit photographing an image of the target object separated by the beam splitter and outputting the image for each wavelength to the plurality of display apparatuses through the respective channels.
  • the video member is an image of the target object, and generates an Indocyanine Green (ICG) image, an ICG color image, a 5-Aminolevulinic acid (5-ALA) image, and a 5-ALA color image for each of the wavelengths. Can be printed separately.
  • ICG Indocyanine Green
  • 5-ALA 5-Aminolevulinic acid
  • the color and black and white image for the affected part of the patient different screen You can check at the same time through this, it is possible to solve the existing problem that the information on the affected part is not visible because the color is mixed.
  • FIG. 1 is a view illustrating a photodynamic diagnostic apparatus according to an embodiment of the present invention.
  • FIG. 2 is a diagram illustrating a configuration of a beam splitter provided in the video member of FIG. 1.
  • FIG. 3 is an exemplary diagram illustrating a Y-shaped beam splitter applied to an embodiment of the present invention.
  • FIG. 4 is a diagram illustrating a configuration in which an image for each wavelength separated through a beam splitter is output and displayed for each channel according to an embodiment of the present invention.
  • FIG. 1 is a view illustrating a photodynamic diagnostic apparatus according to an embodiment of the present invention.
  • the photodynamic diagnosis apparatus 100 may include a plurality of light sources a, b, and c, an objective lens 110, a zoom lens 120, a video member 130,
  • the eyepiece 140 may include a plurality of display devices 150.
  • the plurality of light sources a, b, and c irradiate a plurality of lights having different wavelengths.
  • the irradiated plurality of lights may be guided to the object lens 110 and irradiated onto the object object 101 which is in close proximity to the object lens 110.
  • the light sources a, b, and c may irradiate light in a wavelength band that reacts with fluorescent materials such as IGC (Indocyanine green) and 5-ALA (5-Aminolevulinic acid).
  • fluorescent materials such as IGC (Indocyanine green) and 5-ALA (5-Aminolevulinic acid).
  • the plurality of light sources a, b, and c may radiate white light, which is a wavelength band of visible light.
  • the light source (a) can be irradiated with visible light visible through the halogen, etc.
  • the light source (b) responds to 5-ALA that can see the affected area, for example tumor (tumor) tissue
  • the light source (c) may be irradiated with light in a wavelength band (for example, 410 nm), and the light source (c) may irradiate light in a wavelength band (for example, 760 nm) in response to an ICG for viewing an affected part, for example, vascular tissue. Confirmation of where the tumor is roughly can be made through the light source (b), and the actual surgery reports the visible light of the light source (a).
  • the light source a is not limited to visible light and may irradiate near infrared rays.
  • the near-infrared ray means the light having the shortest wavelength among infrared rays whose wavelength range is 750 nm or more. Since near-infrared rays are beyond the visible range of the human eye, there are almost no side effects such as glare or delayed recovery after surgery compared to visible rays of the same amount of energy, for example in ophthalmic surgery.
  • the objective lens 110 is disposed to face the target object 101.
  • the target object 101 may be the affected part of the patient.
  • the target object 101 may be the eye of the patient.
  • the objective lens 110 receives a plurality of lights irradiated from the plurality of light sources a, b, and c so that the objective lens 110 may be irradiated to the affected part of the patient.
  • the light sources a, b, and c have different wavelengths, light of various wavelength bands may be irradiated to the affected part of the patient through the objective lens 110.
  • the zoom lens 120 may enlarge or reduce the incident light through a zoom in or zoom out function.
  • the video member 130 photographs the light emitted from the zoom lens 120 to generate an image of the object 101 differently for each wavelength, and separates the generated image for each wavelength into a plurality of channels.
  • the video member 130 may include beam splitters 210, 220, 230, and 240, as shown in FIG. 2.
  • the beam splitters 210, 220, 230, and 240 separate the image of the target object 101 formed through the objective lens 110 for each of the wavelengths, and output the plurality of channels to the eyepiece 140. And simultaneously display image data of the target object 101 on the display device 150.
  • L1 and L2 are incident light through a light path corresponding to the left eye of a surgical microscope observer, and are separated into respective channels, and may represent an indocyanine green (ICG) image and an ICG color image, respectively.
  • R1 and R2 are light incident through a light path corresponding to the right eye of a surgical microscope observer and separated into respective channels, and represent 5-ALA (5-Aminolevulinic acid) images and 5-ALA color images, respectively. Can be.
  • the beam splitters 210, 220, 230, and 240 may be detachably formed on the surgical microscope. At this time, the beam splitters 210, 220, 230, 240 is preferably designed in a Y-shape so that the detachable to the back of the surgical microscope.
  • 3 is an exemplary view illustrating the Y-shaped beam splitter.
  • the Y-shaped beam splitter 300 includes two cube-shaped beam splitters 310 and 320 provided in an optical path corresponding to the left and right eyes, and the beam splitters 310 and 320.
  • An optical system may be configured by four prism mirrors 330 and 340 that change a moving path of light passing through the light.
  • the Y-shaped beam splitter 300 may include a filter for filtering light having a specific wavelength.
  • the Y-shaped beam splitter 300 may output light having a different wavelength to each channel through the filter.
  • the video member 130 captures an image of the target object 101 separated by the beam splitters 210, 220, 230, and 240 to display the image for each wavelength through the plurality of channels.
  • the apparatus may further include a camera unit 135 output to the display device 150.
  • the video member 130 may separate an image of the target object 101 output through the camera unit 135 into the respective channels and output the divided images to the plurality of display apparatuses 150.
  • the video member 130 generates an ICG image, an ICG color image, a 5-ALA image, and a 5-ALA color image for each wavelength as an image of the target object 101, and separates the image into the respective channels. You can print
  • the eyepiece 140 is formed to visually observe an image of the target object 101. To this end, the eyepiece 140 may be disposed at a position facing the video member 130.
  • the plurality of display devices 150 displays images for each wavelength output by the video member 130 for each channel.
  • a configuration of displaying an image for each wavelength for each channel will be described in detail with reference to FIG. 4.
  • the image for each wavelength branched through the beam splitter 410 is input to the camera unit 420 through channels 1, 2, 3, and 4. That is, the image passing through the channel 1 is input to the camera 1 421, and the image passing through the channel 2 is input to the camera 2 422. In addition, the image passing through the channel 3 is input to the camera 3 (423), the image passing through the channel 4 is input to the camera 4 (424).
  • the image input to the camera 1 421 may be an ICG image
  • the image input to the camera 2 422 may be an ICG color image
  • an image input to the camera 3 423 may be a 5-ALA image
  • an image input to the camera 4 424 may be a 5-ALA color image.
  • Images for each wavelength input to the camera unit 420 are output to the display device 430 and displayed. That is, the image input to the camera 1 421 is displayed through the monitor 1 431, and the image input to the camera 2 422 is displayed through the monitor 2 432. Also, the image input to the camera 3 423 is displayed through the monitor 343 3, and the image input to the camera 4 424 is displayed through the monitor 4 434.
  • the image for each wavelength separated by the beam splitter (for example, L1, L2, R1, and R2 of FIG. 2) is converted into image data through each camera to each display apparatus.
  • the color and black and white image of the affected part of the patient can be checked at the same time through a different screen, through which the existing problem that the information on the affected part is not easily seen due to the mixed color.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Vascular Medicine (AREA)
  • Microscoopes, Condenser (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pathology (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

Un appareil de diagnostic photodynamique selon un mode de réalisation de la présente invention comprend : une pluralité de sources lumineuses qui irradient une pluralité de lumières présentant des longueurs d'onde différentes les unes des autres ; une lentille d'objectif qui est disposée pour faire face à un objet ; une lentille de zoom dans laquelle la lumière réfléchie par l'objet et passant à travers la lentille d'objectif entre ; un élément vidéo qui crée une image différente de l'objet pour chaque longueur d'onde en photographiant la lumière sortie de la lentille de zoom et émet l'image créée pour chaque longueur d'onde par séparation de l'image créée pour chaque longueur d'onde dans une pluralité de canaux ; une lentille oculaire qui est conçue pour permettre l'observation de l'image de l'objet à l'œil nu ; et une pluralité de dispositifs d'affichage qui affichent l'image pour chaque longueur d'onde émise pour chaque canal.
PCT/KR2015/008301 2014-08-19 2015-08-07 Appareil de diagnostic photodynamique Ceased WO2016028019A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2014-0107776 2014-08-19
KR1020140107776A KR101651271B1 (ko) 2014-08-19 2014-08-19 광역학 진단 기기

Publications (1)

Publication Number Publication Date
WO2016028019A1 true WO2016028019A1 (fr) 2016-02-25

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PCT/KR2015/008301 Ceased WO2016028019A1 (fr) 2014-08-19 2015-08-07 Appareil de diagnostic photodynamique

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KR (1) KR101651271B1 (fr)
WO (1) WO2016028019A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2737309C1 (ru) * 2017-08-31 2020-11-26 ЭлДжи ЭЛЕКТРОНИКС ИНК. Промывочный насос и посудомоечная машина, включающая в себя его

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107582023B (zh) * 2017-09-01 2023-07-14 杭州爱视界医疗器械有限公司 一种可3d检查眼睑板腺的裂隙灯显微镜

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004255177A (ja) * 2003-02-03 2004-09-16 Carl-Zeiss-Stiftung Trading As Carl Zeiss 眼科外科手術用顕微鏡システムおよび照射方法
JP2006006653A (ja) * 2004-06-25 2006-01-12 Topcon Corp 眼底撮影システム
JP2008237432A (ja) * 2007-03-27 2008-10-09 Kyushu Univ 眼底血流画像化装置
KR20090012771A (ko) * 2007-07-31 2009-02-04 전자부품연구원 프로브 핀에 대한 정렬장치

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090127719A (ko) * 2008-06-09 2009-12-14 (주)프리즘테크 미세 물체의 관찰을 위한 입체영상 디스플레이 시스템

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004255177A (ja) * 2003-02-03 2004-09-16 Carl-Zeiss-Stiftung Trading As Carl Zeiss 眼科外科手術用顕微鏡システムおよび照射方法
JP2006006653A (ja) * 2004-06-25 2006-01-12 Topcon Corp 眼底撮影システム
JP2008237432A (ja) * 2007-03-27 2008-10-09 Kyushu Univ 眼底血流画像化装置
KR20090012771A (ko) * 2007-07-31 2009-02-04 전자부품연구원 프로브 핀에 대한 정렬장치

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2737309C1 (ru) * 2017-08-31 2020-11-26 ЭлДжи ЭЛЕКТРОНИКС ИНК. Промывочный насос и посудомоечная машина, включающая в себя его

Also Published As

Publication number Publication date
KR101651271B1 (ko) 2016-08-26
KR20160022109A (ko) 2016-02-29

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