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WO2016016766A3 - A process for the preparation of isavuconazonium or its salt thereof - Google Patents

A process for the preparation of isavuconazonium or its salt thereof Download PDF

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Publication number
WO2016016766A3
WO2016016766A3 PCT/IB2015/055511 IB2015055511W WO2016016766A3 WO 2016016766 A3 WO2016016766 A3 WO 2016016766A3 IB 2015055511 W IB2015055511 W IB 2015055511W WO 2016016766 A3 WO2016016766 A3 WO 2016016766A3
Authority
WO
WIPO (PCT)
Prior art keywords
isavuconazonium
salt
preparation
iodide
sulfate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IB2015/055511
Other languages
French (fr)
Other versions
WO2016016766A2 (en
Inventor
Rupesh Chhaganbhai KHUNT
Mohammad Rafeeq
Arvind Yekanathsa Merwade
Keshav Deo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wockhardt Ltd
Original Assignee
Wockhardt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wockhardt Ltd filed Critical Wockhardt Ltd
Priority claimed from IN2588MU2014 external-priority patent/IN2014MU02588A/en
Publication of WO2016016766A2 publication Critical patent/WO2016016766A2/en
Publication of WO2016016766A3 publication Critical patent/WO2016016766A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a process for the preparation of stable Isavuconazonium or its salt thereof. In particular of the present invention relates to process for the preparing of isavuconazonium sulfate, Isavuconazonium iodide hydrochloride and Boc-protected isavuconazonium iodide has purity more than 90%. The process is directed to preparation of solid amorphous form of isavuconazonium sulfate, isavuconazonium iodide hydrochloride and Boc-protected isavuconazonium iodide. The present invention process of Isavuconazonium or its salt thereof is industrially feasible, simple and cost effective to manufacture of isavuconazonium sulfate with the higher purity and better yield.
PCT/IB2015/055511 2014-07-26 2015-07-21 A process for the preparation of isavuconazonium or its salt thereof Ceased WO2016016766A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN2424/MUM/2014 2014-07-26
IN2424MU2014 2014-07-26
IN2588/MUM/2014 2014-08-11
IN2588MU2014 IN2014MU02588A (en) 2014-08-11 2015-07-21

Publications (2)

Publication Number Publication Date
WO2016016766A2 WO2016016766A2 (en) 2016-02-04
WO2016016766A3 true WO2016016766A3 (en) 2016-03-24

Family

ID=54150472

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2015/055511 Ceased WO2016016766A2 (en) 2014-07-26 2015-07-21 A process for the preparation of isavuconazonium or its salt thereof

Country Status (1)

Country Link
WO (1) WO2016016766A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106883226A (en) * 2017-03-30 2017-06-23 成都绿林科技有限公司 The preparation method of Ai Shakang azoles sulfuric esters

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106916152B (en) * 2017-04-27 2019-09-17 扬子江药业集团有限公司 The method of redox reaction preparation Chinese mugwort Saperconazole monosulfate
CN110551064B (en) * 2018-06-01 2021-01-01 重庆世森医药科技有限公司 Preparation method of isavuconazole sulfate and intermediate thereof
EP3830084B1 (en) * 2018-08-01 2025-08-06 Basilea Pharmaceutica International AG, Allschwil Methods for purifying isavuconazonium sulfate
CN110128420A (en) * 2019-05-08 2019-08-16 阴启明 Bisulfate ion/sulfate radical type anionexchangetechnique preparation Chinese mugwort Saperconazole monosulfate method
CN112279846B (en) * 2019-07-25 2022-05-06 上海医药工业研究院 A kind of method for preparing antifungal drug isavuconazolium sulfate
WO2021037597A1 (en) * 2019-08-26 2021-03-04 Synthon B.V. Isavuconazonium salts and process for preparing thereof
CN113024539B (en) * 2019-12-25 2023-11-28 上海迪赛诺医药集团股份有限公司 A kind of preparation method of isavuconazole sulfate
CN115215857B (en) * 2022-08-17 2025-02-14 扬子江药业集团上海海尼药业有限公司 Preparation method of isavuconazole sulfate
WO2024189550A1 (en) * 2023-03-13 2024-09-19 Apitoria Pharma Private Limited Process for the preparation of isavuconazonium sulfate and its crystalline forms
CN116768879A (en) * 2023-06-15 2023-09-19 上海方予健康医药科技有限公司 Synthesis method of antifungal drug
WO2025008993A1 (en) * 2023-07-04 2025-01-09 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of Glycine, N-methyl-, [2-[[[1-[1-((2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester, sulfate (1:1)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812238B1 (en) * 1999-11-02 2004-11-02 Basilea Pharmaceutica Ag N-substituted carbamoyloxyalkyl-azolium derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812238B1 (en) * 1999-11-02 2004-11-02 Basilea Pharmaceutica Ag N-substituted carbamoyloxyalkyl-azolium derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106883226A (en) * 2017-03-30 2017-06-23 成都绿林科技有限公司 The preparation method of Ai Shakang azoles sulfuric esters

Also Published As

Publication number Publication date
WO2016016766A2 (en) 2016-02-04

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