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WO2015087343A3 - An improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof - Google Patents

An improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof Download PDF

Info

Publication number
WO2015087343A3
WO2015087343A3 PCT/IN2014/000754 IN2014000754W WO2015087343A3 WO 2015087343 A3 WO2015087343 A3 WO 2015087343A3 IN 2014000754 W IN2014000754 W IN 2014000754W WO 2015087343 A3 WO2015087343 A3 WO 2015087343A3
Authority
WO
WIPO (PCT)
Prior art keywords
nilotinib
preparation
pharmaceutically acceptable
acceptable salts
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2014/000754
Other languages
French (fr)
Other versions
WO2015087343A2 (en
Inventor
Satyanarayana Chava
Seeta Rama Anjaneyulu GORANTLA
Venkata Sunil Kumar Indukuri
Venkata Rama Krishna Murthy MOTURU
Srivardhana Rao JAMJANAM
Venkata Purushottama Siva Prasad SELA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laurus Labs Pvt Ltd
Original Assignee
Laurus Labs Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Pvt Ltd filed Critical Laurus Labs Pvt Ltd
Publication of WO2015087343A2 publication Critical patent/WO2015087343A2/en
Publication of WO2015087343A3 publication Critical patent/WO2015087343A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof, with high purity and yields.
PCT/IN2014/000754 2013-12-09 2014-12-08 An improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof Ceased WO2015087343A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN5653/CHE/2013 2013-12-09
IN5653CH2013 IN2013CH05653A (en) 2013-12-09 2014-12-08

Publications (2)

Publication Number Publication Date
WO2015087343A2 WO2015087343A2 (en) 2015-06-18
WO2015087343A3 true WO2015087343A3 (en) 2015-08-27

Family

ID=53371924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000754 Ceased WO2015087343A2 (en) 2013-12-09 2014-12-08 An improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof

Country Status (2)

Country Link
IN (1) IN2013CH05653A (en)
WO (1) WO2015087343A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3404025B1 (en) * 2017-05-16 2019-12-04 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure nilotinib and its salt
SG10201909596RA (en) * 2019-10-14 2021-05-28 Esco Aster Pte Ltd Synthesis of Tyrosine Kinase Inhibitors
CN112745300A (en) * 2021-01-21 2021-05-04 杭州浙中医药科技有限公司 Method for preparing N- (5-carboxyl-2-methylphenyl) -4- (3-pyridine) -2-pyrimidinamine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010009402A2 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
CN103288804A (en) * 2013-05-24 2013-09-11 苏州明锐医药科技有限公司 Preparation method of nilotinib

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010009402A2 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
CN103288804A (en) * 2013-05-24 2013-09-11 苏州明锐医药科技有限公司 Preparation method of nilotinib

Also Published As

Publication number Publication date
WO2015087343A2 (en) 2015-06-18
IN2013CH05653A (en) 2016-06-24

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