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WO2016000075A1 - Système et procédé d'augmentation de la longueur des télomères - Google Patents

Système et procédé d'augmentation de la longueur des télomères Download PDF

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Publication number
WO2016000075A1
WO2016000075A1 PCT/CA2015/050612 CA2015050612W WO2016000075A1 WO 2016000075 A1 WO2016000075 A1 WO 2016000075A1 CA 2015050612 W CA2015050612 W CA 2015050612W WO 2016000075 A1 WO2016000075 A1 WO 2016000075A1
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Prior art keywords
pins
electromagnetic
frequencies
telomeres
spectrum
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Dan Grebenisan
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/06—Electrodes for high-frequency therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/326—Applying electric currents by contact electrodes alternating or intermittent currents for promoting growth of cells, e.g. bone cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0636—Irradiating the whole body
    • A61N2005/0637—Irradiating the whole body in a horizontal position
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0635—Radiation therapy using light characterised by the body area to be irradiated
    • A61N2005/0643—Applicators, probes irradiating specific body areas in close proximity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
    • A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
    • A61N2005/066—Radiation therapy using light characterised by the wavelength of light used infrared far infrared

Definitions

  • This invention relates generally to the field of medical therapeutic, health, wellness and longevity technologies, bio-physics, bio-electromagnetics, bio-resonance, microwave resonance therapy, anti-aging and life extension and more particularly, to a method, device and system effective in the rejuvenation of the chromosomes, telomeres and the DNA, extending the length of the telomeres and stimulation of the catalytic activity of telomerase, and in slowing, stopping and reversing the aging process of living things in general and humans in particular.
  • Telomeres are repeat protein-DNA complexes forming a protective cap at the ends of linear and X chromosomes. The normal cell division results in a progressive shortening of the telomere length. After a certain degree of shortening, the cells lose the ability to divide and replicate, leading to cell senescence and death.
  • telomere length is the source and the basis of the "biological clock", as they shorten with age.
  • the length of the telomeres is determined in part and cumulates the influence of genetic and epigenetic factors, sex hormones, the reactive oxidative stress, the inflammatory reactions, the environmental stressors, and also internal and external stress factors, including intrinsic and extrinsic factors acting both at the level of the whole organism and the level of a singular cell. The influence of all these factors is independent of the chronological age.
  • the length of the telomeres shortens with each cell division and correlates inversely with age.
  • telomere length of the somatic cells One of the key biomarker of the biological age is the telomere length of the somatic cells. A minimum length of telomeres reaching a critical level, triggers a cell cycle arrest or senescence of the cell and death.
  • telomere The telomeric DNA and the accompanied proteins maintain a "capped” structure called also a "functional telomere” and protect the end of the chromosome from illegitimate recombination and fusion with another telomere or DNA end.
  • telomere shortening of the telomeres that happen on each cell division was shown to occur both in vitro and in vivo, where the age reflects the total and cumulative effect of cell divisions - the biological clock. This phenomenon was demonstrated in human fibroblasts, hematopoietic stem cells, leukocytes, keratinocytes, epithelial and endothelial cells.
  • telomere length reflects two aspects:
  • telomere a ribonucleic protein enzyme that can synthesize new telomere G- rich strands using its own telomere sequence-specific RNA template.
  • Telomerase catalytic activity requires the association of two subunits: RNA (TER) and telomerase reverse transcriptase (TERT).
  • telomere length results from a dynamic balance between elongation and shortening of the chromosome ends.
  • the mean telomere length within cells is a d irect function of the level of telomerase activity.
  • telomere length and telomerase activity do not always tightly corre late in somatic cells, like activated lymphocytes or the senescence of hematopoietic stem cells.
  • telomere length extend in a limited range of 10-20 Kb, dependent on tissue type.
  • In vitro stud ies revealed that with every cell d ivision, 40-200 bp are lost until they reach a critical length of 4-5 Kb - the Hayflick's limit, although this level varies between cell types and individ uals.
  • telomere shortening has been shown in several large studies to pred ict cardiovascular morbidity and mortality, includ ing myocard ial infarction, congestive heart failure, and death, and a lso associations with risk factors for coronary artery d isease.
  • the immune system also, is highly sensitive to shortening of telomeres. Its ability depends tightly on cell renewal and clonal expansion of T- and B-cell populations. Cells of the immune system a re uniq ue a mong normal somatic cells as they can up-regulate telomerase, the telomere extending enzyme, and limit telomere attrition in the process of cell
  • Dr. Peter P. Gariaev The work and research of Russian scientist Dr. Peter P. Gariaev, is mostly presented in the Russian patents 2355009 and 2383133. Dr. Gariaev has demonstrated the wave structure of DNA and the resonant interactions of chromosomes, telomeres, the genes, and the environment. His "Wave Genetics" method and therapy uses electromagnetic waves, also laser light and acoustic waves too.
  • Dr. Gariaev work is the paper titled “Crisis in Life Sciences. The Wave Genetics Response.” by P.P. Gariaev, M.J. Friedman, and E.A. Leonova- Ga riaeva, with other good references can be found at this link:
  • Dr. Gariaev applied method has successful regenerative and anti-aging applications. His method was successfully and independently tested and demonstrated in 2001, at the University of Toronto, Canada.
  • MRT Microwave Resonance Therapy
  • M icrowave Resonance Therapy involves the application of
  • electromagnetic freq uencies of low spectral density with frequency range of 30-300 GHz, mostly in the DNA resonance range of 52-78 GHz, for therapeutic effects.
  • the application is done mostly to acupuncture points, but not only.
  • the M icrowave Resonance Therapy is considered as an efficient non-invasive biophysical medical treatment.
  • the M RT therapy is well described and a pplied in the patents of Sergei P. Sit'ko: Ukraine patent N 2615, Russian patent N 2053757, and USA patent 5507791 A.
  • the Microwave Resonance Therapy is officially approved by Ministry of Healthcare of the Russian Federation and in Ukraine.
  • the VIDHUK R&D Center of Quantum Medicine a leading organization of the Ministry of Public Health of Ukraine, founded by Prof. Sit'ko, have been cured more than 600,000 patients, using the Microwave Resonance DNA Therapy.
  • AMRT-01 "AMRT-02”, “Electronics”, “AMT-Covert-04” and “ARIA-SC”
  • AMRT-01 "AMRT-02", “Electronics”, “AMT-Covert-04” and “ARIA-SC”
  • Devices like “Porig-1”, “Porig-3”, “Artsakh”, “Shlem” and “MU-2001” use the creation of broadband noise signals.
  • Devices like AMRT-01 or Artsakh are combined devices generating noise as harmonic signals.
  • the output voltage of the device is 20,000 to 50,000 volts, which is very high voltage that can be very dangerous for the patient in different situations, like if the users spill accidentally a drink over the device-mattress.
  • One objective of the present invention is to overcome the above limitations, and to provide novel and better methods and designs for generating and applying the
  • telomeres chromosomes, telomeres and DNA resonant frequencies.
  • telomeres use the enhancing hTERT expression in the cell and by increasing the processivity of telomerase in the cells.
  • Patent WO 2006066247 A2 describes a method of telomere elongation by transiently enhancing the hTERT expression, by using endogenous or exogenous methods like creating hypoxic conditions.
  • Other options presented are regulating, activating or modulating one or more genes that are responsible and are associated with telomerase processivity.
  • Patent WO 2004099385 A2 describes how to affect the telomere elongation by fusing a polypeptide having telomerase catalytic activity, with a telomere binding
  • polypeptide comprising the catalytic protein subunit of telomerase reverse transcriptase (hTERT).
  • Patents US 20110236483 Al and US 20110237653 Al describe microscopic medical payload delivery devices that act as a transport vector to deliver a variety of cellular ribonucleic acid molecules to the cells in the body. When reaching the destination, the medical payload delivery devices insert their payload of cellular ribonucleic acid molecules into the target cells. By delivering cellular ribonucleic acid molecules into specific cells, the gene expression is capable of being modulated, and telomere synthesis is enhanced.
  • telomere elongation is using a variety of compounds, formulations, and dietary supplements.
  • Some dietary supplements support an increased life span by enhancing metabolic function, activating anti-aging genes, and encouraging the production of new cells with longer telomeres (patent US 20120251500 Al), maintaining the telomeres on new stem cells as well as existing cells (patent US 20120251500 Al), maintaining the telomeres on new stem cells as well as existing cells (patent US 20120251500 Al), maintaining the telomeres on new stem cells as well as existing cells (patent US
  • telomere lengthening telomeres by inducing the production of telomerase (patent WO 2012106692 Al), or by promoting expression or enhanced expression of a sirtuin (SIRT-1) gene or protein (patent US 20140052]
  • the patent CA 2745376 Al describes the use of certain antioxidants for increasing telomerase activity in healthy and stressed cells using antioxidants that modulate gene activity and/or proteins which influence, regulate, and/or control telomerase activity, the maintenance of the telomere unit and associated components, or directly the telomere
  • [0054] length The technique is based on modulating or influencing the lifespan of cells, tissues, organs, and organisms, by modulating the activity of the gene maintenance process in order to influence the length and/or structural integrity of the telomere in living cells.
  • the antioxidants proposed include natural and synthetic antioxidants, such as [0055] plant antioxidant and polyphenol compounds derived from coffee cherry, tea, berry, and so forth, including but not limited to caffeic acid, chlorogenic acid, ferulic acid, quinic acid, proanthocyanidins, ubiquinone and idebenone.
  • Such device should be able to generate a more uniformly distributed
  • a new and novel method and system is described in this invention, for using electromagnetic and mechanical oscillations, designed with the purpose of rejuvenating and increasing the length of the telomeres, stimulating the catalytic activity and processivity of telomerase, that is also capable to slow, stop and reverse the shortening of telomeres and as a result, the biological clock of the mammalians in general and humans in particular.
  • the present patent uses the resonant effects of electromagnetic and mechanical vibrations, tuned specifically to resonate with the chromosomes, the telomeres and the DNA, with direct impact on the rejuvenation and increase of the length of telomeres.
  • telomeric resonator device which is the main component of this invention.
  • This device generates a novel and complex radial and longitudinal electrostatic fields, and a wide and uniformly distributed band of electromagnetic spectrum and ultrasound spectrum of frequencies.
  • the complex electrostatic fields serve mainly as an excitation mechanism for a mass of crushed piezoelectric crystal grains of different sizes that are part of the telomeric resonator.
  • the crystal grains have a uniform and continuous distribution of sizes, from the tiniest to the largest.
  • all the crystals as a mass generate a wide and uniformly distributed band of electromagnetic spectrum, and a wide band of uniformly distributed ultrasound vibrations.
  • the complex electrostatic fields created inside of the telomeric resonator get combined with the wide band of electromagnetic spectrum generated by the crystals, and also with the electromagnetic frequencies created by a wide band oscillator that is part of the same device.
  • This complex combination of electromagnetic spectrum of frequencies get also combined with the wide band of ultrasound vibrations generated by the crystal grains. All these fields, frequencies and vibrations, are designed and tuned for resonance with the chromosomes and the telomeres.
  • the induced effect is rejuvenation of the chromosomes, the telomeres and the DNA, stimulated catalytic activity of the telomerase, all resulting in the increase elongation of the telomeres, and a general effect of slowing, stopping and even reversing the aging process of shortening of the telomeres which is the biological clock of the body.
  • the anti-aging system presented in this invention comprises a plurality of such devices - the telomeric resonators described above - all of them being part of a user-friendly anti-aging device, like an anti-aging blanket or duvet, a sleeping bag, a panel, a mat or a pad, or chair or chair cover, or other possible embodiments; any of these embodiments is controlled and driven by a main controller apparatus, responsible to generate all the electric signals required by each component of the system.
  • the resonant frequency domain of the human DNA is between 54 GHz to 78 GHz.
  • Immersing the cells of human - or a mammalian - and implicitly the chromosomes, the telomeres and the genetic material, in an electromagnetic field with such frequencies, has beneficial rejuvenating and anti-aging effects.
  • This band of frequencies create electromagnetic resonance at the DNA level, thus the micro currents and fields having a catalytic and resetting effect on the DNA, the telomeres, and implicitly an anti-aging effect at the macro level of the body.
  • the chromosomes of a cell have a very similar shape with a tuning fork. They are natural resonators, both, from an electromagnetic perspective and a mechanical-vibrational perspective.
  • the telomeres being positioned at the end of the chromosome arms are the ones that have the largest amplitude during the oscillations of the chromosomes, both from an electromagnetic and mechanical-vibrational perspective.
  • the shape of a chromosome provides a great electromagnetic resonant circuit, and the perfect mechanical vibrational resonant shape.
  • telomeres in general and the telomeres in particular.
  • the typical human chromosome length is from 1 x 10 "6 meters to 20 x 10 "6 meters, with a median average of about 7 x 10 "6 m. From an electromagnetic perspective, the shape of the chromosomes make them also a perfect resonant circuit or antenna.
  • the longitudinal resonant frequency is based on the fact that the length of a telomere is half the wavelength of the electromagnetic resonant frequency, or multiple half- lengths for higher harmonics.
  • the X shape of the chromosomes make a base parallel LC circuit, or a more complex series of multi-parallel LC circuits.
  • the resonant electromagnetic frequency of each open loop, or parallel LC circuit can be derived from the geometry of the chromosome, and it overlaps with the DNA resonant spectrum, in the tens of GHz band.
  • the X chromosome is also a perfect tuning fork from a mechanical-vibrational perspective.
  • the two opposing arms of both sides of the chromosomes act as the arms of a tuning fork, vibrating in the same plan, but in a transversal axis, when facing the
  • the resonant frequency for mechanical vibration of the chromosomes is in a range of about 100
  • FIG. 1 is a cross-section view through the telomeric resonator, showing the interior components and the structure of the device.
  • FIG. 2 is a top view of the PCB board described in FIG. 1.
  • FIG. 3 is top view schematic illustration of another embodiment of the PCB board presented in FIG. 1.
  • FIG. 4 is a schematic illustration of top view of a small section of the PCB 1. It is a functional drawing, showing the interaction of the electrical fields between the pins 4 described in FIG. 1.
  • FIG. 5 is a schematic illustration of the cross section of a small area of the telomeric resonator presented in FIG. 1. It is a functional drawing explaining the fields interaction between the components, and the generation of electromagnetic and ultrasound waves.
  • FIG. 6 is a schematic illustration of the layer 3 of the PCB 1.
  • FIG. 7 is a schematic representation of a possible applied embodiment of the anti- aging system presented in this invention.
  • FIG. 8 is a block diagram of the components of the main controller apparatus 28.
  • FIG. 9 is a schematic of the electric signal that drives the telomeric resonator presented in FIG. 1.
  • the core device described in this patent I calls it generically the telomeric resonator, because the main and key purpose is to bring the telomeres of the chromosomes to electromagnetic and ultrasonic vibrational resonance.
  • FIG. 1 is a vertical cross section through the device.
  • the telomeric resonator is composed of a board 1 made of an insulation material, most preferably a printed circuit board (PCB), having two or more layers.
  • the PCB 1 has two layers, the top layer and circuit 2, and the bottom layer and circuit 3.
  • the electrical circuit making the top layer 2 of the PCB forms a certain circuit and it
  • [0098] connects a plurality of metallic or conductive pins 4 in a certain pattern, as being described in the FIG. 2 and FIG. 3.
  • the top layer 2 of the PCB 1 is made usually from copper, preferable plated with silver or gold.
  • the pins 4 are soldered or welded on the surface of the PCB 2 by solder 5, on the same side of the circuit 2, which is the top layer and the active side of the PCB 1.
  • the bottom layer 3 or the PCB 1 forms another electrical circuit, as being described in FIG. 6.
  • the layer and circuit 3 of the PCB 1 forms a series of concentric arc circles, with an angle offset between each other, which upon activation, generate a large spectrum of electromagnetic frequencies, with the magnetic component polarized perpendicular to the surface of the support PCB 1.
  • the layer 3 of the PCB 1 is made usually of copper, and it should be preferable coated or electroplated with silver or gold for a better electrical response at high frequencies.
  • the pins 4 are metallic or made from other composite and electrically conductive material, like conductive ceramics, and they have very sharp top tips. The best
  • implementation is to have the pins made of stainless steel or brass, and have them coated or electroplated with silver or gold for the minimum impedance at high frequencies.
  • the pins made of stainless steel or brass, and have them coated or electroplated with silver or gold for the minimum impedance at high frequencies.
  • each pin having one type of polarity at an instance is surrounded by pins having the opposite polarity at the same instance.
  • the sharpness at the end of the pins 4 create a local electric field with a very high intensity, mostly on the vertical coordinate.
  • the two presented layouts of the pins also create the highest possible radial electric field between the pins 4.
  • the pins are surrounded with quality crushed piezoelectric crystals 6, like natural or cultured electronic grade quartz, berlinite, topaz, tourmaline, barium titanate, sodium potassium niobate, bismuth ferrite or other natural or synthetic piezoelectric crystals.
  • the size of the crystal grains have a large variety of dimensions, generally varying between
  • crystal powder having sizes of a few micrometers, and going to large crystal grain or crystal nuggets of several millimeters diameter.
  • the upper range of grain sizes depends a lso by the size of the PCB, the size and distance between the pins 4, and the size of the enclosure, the larger the enclosure, the larger the bigger grain sizes.
  • the size distribution of the crystal grains is uniform and continuous. That is, for all the crystal grains that go inside of a telomeric resonator, the number of crystal grains having the same size range, is relatively equal with the amount of crystal grains having any other size range.
  • top layer and circuit 2 of the PCB 1, and the bottom layer and circuit 3 of the PCB 1, are connected electrically in parallel, to the resistor 12, and to the two electrical wires 14 that feed the telomeric resonator with the driving electrical signal.
  • the enclosure of the telomeric resonator is best made of an electrical insulation material like PVC, ABS, polycarbonate, glass, reinforced fiberglass, resins, or other suitable electrical insulation material that is evident for those skilled in the art.
  • the bottom part of the box 8 has side walls 9 going up to the total interior height of the box, for easy and tighter holding the components inside and for an easier assembly.
  • the bottom part 8 of the enclosure is equipped with the small studs 11, which have the role to stiffen and increase the mechanical resistance of the enclosure.
  • the length of the studs 11 is such a way that when the bottom part 8 of the enclosure is assembled with the top part 7, the two of them assemble properly, and the studs 11 just touch the top part 7 of the enclosure.
  • the enclosure is equipped with elastic or pressure-activated click hooks 10, located between the walls 9 and the top part 7 of the enclosure. Once assembled and pressed against each other, the hooks 10 would click and lock-in tight the two parts 7 and 8 of the enclosure, making the assembly of the device easy to perform.
  • the two components of the enclosure 7 and 8 have a small housing 13 at one side of the box, designed to house the exit of the wires 14 and to prevent them for disconnecting from the PCB 1 when pulled strongly from the outside.
  • the housing 13 is designed with curved channels for the wires 14, in such a way that when the wires 14 are
  • the curved channels of the wires oppose the exterior mechanical stress, without applying any mechanical stress on the electrical connections of the wires 14 with the PCB 1, typically a soldered connection having way less mechanical resistance than the wires themselves being curved-channeled in the housing 13.
  • a thin layer of suitable sealer like silicone or glue is applied on the edges of the bottom part 8, or the inner edges of the top part 7, more exactly on the side walls 9. This will ensure that upon the assembly of all the internal components of the telomeric resonator, the sealer will seal the interior of the enclosure to protect the components inside the telomeric resonator against moisture, liquids, dust, or other foreign substance that could affect the well-functioning of the device.
  • FIG. 2 presents a top view of the PCB board 1 that was presented also in FIG. 1.
  • the top side of the PCB is presented, with the electrical circuit and layer 2, and the pins 4, soldered on the same face of the PCB, with solder 5.
  • the two polarities of the circuit 2 connect the pins 4 in such a way, that each individual pin is surrou nded by the other pins having opposite polarity, at the closest proximity.
  • the two wires 14 feeding the whole assembly are connected and soldered on the PCB 1, at the input of the circuit 2.
  • the resistor 12 connects in parallel to the input of the circuit 2.
  • the pins soldered on each branch of the circuit 2 having the same polarity are interposed with branches of the circuit 2 having opposed polarity. Also the pins of one polarity are aligned parallel on both sides of the ci rcuit branches with opposing polarity, but with an offset, in such a way that each pin of one polarity is approximately surrounded at the closest proximity, with pins of opposing polarity.
  • the layout of the pins is a square or a rhomb.
  • FIG. 3 represents an alternative embodiment of the layout of the pins 4 on the PCB 1, and the connecting circuit 2.
  • the main layout unit of the pins 4 is a hexagon, where there is a pin at each corner of the hexagon, connected in such a way by the circuit 2, that when the pins are electrically excited, each pin of one polarity is surrounded by the three closest proximity pins having opposite polarity.
  • FIG. 4 presents in more detail the layout presented in FIG. 3 and specifically the electric field pattern and the electric field interaction between the pins 4, and the other components of the telomeric resonator, from a top view of the PCB 1 board .
  • Conduit 2 is polarized
  • the branches of Conduit 1, are B, D and F, are all polarized "+”, and all the pins soldered on these branches Bl, B2, B3, Dl, D2, D3, D4, Fl, F2 and F3 are polarized "+" as well.
  • branches of conduit 2 are all polarized Branches A, C, and E, and the pins solders on these branches, Al, A2, A3, A4, CI, C2, C3, El, E2, E3 and E4, are all polarized "-" (minus) as well.
  • the pins in the most proximity to C2 are pins B2, D2 and D3, all polarized with the "+" in this point in time, that is the opposite polarity of the pin C2.
  • the opposite polarity of the most proximity pins surrounding pin C2 will increase the intensity of the electrical field around C2 to the maximum level, available by this configuration.
  • the electrical field surrounding C2 shown in FIG. 4 by the electrical lines of force G, and the lines of equal field intensity H is quasy-circular, and for a given excitation voltage feeding the two conduits of the telomeric resonator, such a pattern creates the highest possible intensity of the radial component of the electric field around the pins 4.
  • One of the features of the design presented in this invention is to create a maximum intensity of the radial component of the electrical field surrounding each pin, while getting the maximum effect as a whole, for the entire board PCB 1. This is achieved by choosing a layout of the pins and energizing electrically the pins in such a way, that each pin polarized by one polarity, has the surrounding pins in the closest proximity being polarized with the opposite polarity.
  • the enclosure of the telomeric resonator, and all the space on the top of the PCB 1 and the space between the pins 4, is filled with crushed piezoelectric crystals, like quartz, or any other good quality crushed piezoelectric crystal grains. Therefore, all the pins 4 are all surrounded by the grains of different sizes of the crushed piezoelectric crystals.
  • the size of the crystal grains is between ⁇ . ⁇ and 0.1 m, preferable between ⁇ and 0.02m and most preferable between ⁇ and 1 cm.
  • the mix of crushed crystals have a uniform and continuous distribution of all the sizes of grains, from the smallest to the largest.
  • FIG. 5 represent a small view of a vertical section of the telomeric resonator.
  • the PCB 1 has the upper layer 2 that feeds electrically the pins 4 soldered on the layer 2 with the soldering 5.
  • the bottom layer 3 of the PCB 1 sits tightly on the bottom 8 of the enclosure.
  • the top tips of the pins 4 have a very sharp ending 18.
  • the pins are surrounded by the grains of crushed piezoelectric crystal grains 6, like crushed quartz.
  • the top part of the enclosure 7 is at some distance from the tips 18 of the pins 4.
  • FIG. 5 only three pins are represented. As explained above, one pin 4 is always polarized with the opposite polarity of the closest proximity surrounding pins. In this figure, the center pin is polarized with the opposite polarity of the pins on the sides. For this reason, the electric field G created between the pins, is radial from the axis of the pins 4.
  • the grains of crushed quartz 6 that are located between the pins 4 are stimulated by the short spikes of the radial electric field between the pins, as shown in FIG. 9.
  • the short spike of the electrical field G excites every grain of piezoelectric crystal with a short impulse and it electrically energizes each crystal grain.
  • the piezoelectric crystal grains 6 have a high Q
  • factor which is the capacity of the crystal to continue amortized oscillations, after the exciting impulse have been removed.
  • Each grain of crystal will continue to self-oscillate until the oscillation are fully and naturally amortized.
  • each grain of crystal will generate an electromagnetic wave and a mechanical vibration, having the frequency depending of, mostly, by the size of the crystal grain, and also by the piezoelectric properties of the crystal.
  • the grains of the crushed piezoelectric crystals 6 filling the telomeric resonator have a large and uniform distribution of sizes, the resulting mix of frequencies will cover an ultra-wide band of electromagnetic frequencies and mechanical-ultrasonic spectrum of vibrations.
  • the size range of crystal grains are chosen in such way, so the frequency range covers the resonant frequency range of the chromosomes, the telomeres and the DNA.
  • the signal used to drive the telomeric resonators is represented in FIG. 9.
  • the signal is composed of very short pulses of alternating polarity, with the ideal pulse being as close as possible to a Dirac impulse.
  • the repeating frequency of the pulses is between 100 Hz and 1 GHz, preferable between 1 KHz and 500 KHz, and most preferable between 10 KHz and 100
  • the voltage of the signal can be between O.lv to 50Kv, preferable between IV and 1KV, and the most preferable between 10V and 200V.
  • the duration of each pulse is between 0.01 nanoseconds to 1 millisecond, preferable between 0.1 nanosecond to 100 nanoseconds, and the most preferable between 1 nanosecond to 10 nanoseconds.
  • a good comparing example of the basic generation of an electromagnetic wave and a ultrasonic vibration from each grain of piezoelectric crystal that happens inside of the telomeric resonator, is the mechanical poking of a crystal glass. After the poking, the glass will continue to vibrate and generate an amortized sound, for a period of time.
  • the tone of the sound is determined by the size or the dimensions of the crystal glass - the smaller the glass, the higher the pitch (or the frequency). The tone is also dependent of the mechanical properties of material the glass is made of.
  • the best results are achieved by using high quality natural or cultured piezoelectric quartz or other piezoelectric crystal, with good Q factor, higher than 10 5 , preferable higher than 1 x 10 6 and most preferable higher than 3 x 10 6 .
  • the crystal grains must have good piezoelectric properties, and have the grain sizes of a wide and uniform variety of sizes, between 10 cm and 0.001 nm, preferably between 2 cm and 0.001 mm, and most preferable between 1 cm and 0.01 mm.
  • the oscillations makes the ultra-wide band of frequencies generated by each telomeric oscillator. Because the size of the crystal grains is relatively uniform distributed in the whole mass of crushed crystals 6 filling the telomeric resonator, the result is that the spectrum of the frequencies generated is relatively uniformly distributed across the ultra- [0140] wide electromagnetic band generated by the device. In a similar way, the spectrum of mechanical vibrations generated by the whole mass of crushed crystals filling the telomeric resonator, is relatively uniformly distributed across the ultra-wide band of ultrasound vibrations generated by the device. Because the orientation of each crystal grains is random inside of the telomeric resonator, the sum of all electromagnetic oscillation will be relatively evenly distributed in all directions.
  • the spectrum of uniform intensity electromagnetic frequencies generated by the telomeric resonator is between 100 KHz to 10 GHz, preferable between 1 MHz to 1000 MHz, and most preferable between 100 MHz to 1000 MHz, depending mostly by the size range of the crystal grains, and the piezoelectric properties of the used crystal.
  • the layers 2 and 3 of the PCB1 act as a reflector for the electromagnetic waves generated by each crystal grain in particular, and by the whole mass of crystals inside the telomeric resonator in general, thus increasing the intensity of the electromagnetic waves generated in the directions of the pins 4, which is the active side of the device, facing the user, like in the embodiment presented in FIG. 7.
  • the pins 4 are made from a conductive material, like most metals, stainless steel, brass, titanium, or a conductive composite, preferable coated or electroplated with silver or gold.
  • the outer tips - (the top tips) 18 of the pins 4 are very sharp. When each pin is energized electrically with the short electrical impulse, the very sharp point 18 at the tip of
  • each pin 4 creates a very high intensity of the electrical field in the area surrounding the sharp tip 14, much higher than the intensity of the electrical potential G applied between the pins.
  • the local lines of electrical field vectors E generated by the sharp tips 18 are exemplified in FIG. 5.
  • the electrical field E generated at the tips 18 of the pins is
  • FIG. 5 The electromagnetic waves 15 generated by the piezoelectric oscillation of the crystals 6 are shown in FIG. 5.
  • the ultrasound vibration generated by the piezoelectric oscillation of the crystals are marked as 16 in the same FIG. 5.
  • Another key benefit of using the corona effect of amplifying the electrical field at the sharp tip 18 of the pins 4, and subsequently, amplifying the generation of the ultra-wide band of electromagnetic and ultrasound waves, is the fact that the voltage of the pulses required to drive the telomeric resonator, is much smaller. A much smaller voltage means higher safety for the users of this device and the avoidance of electrocution hazard, or electric shocks, and it means also lower energy to drive the device.
  • the layer 3 of the PCB 1 has imprinted a flat concentric set of circle arcs or arc segments, as presented in FIG. 6, with an angle offset from each other, which makes a novel wide-band resonator, generating a second spectrum of electromagnetic frequencies.
  • This spectrum has a quasi-uniform distribution of intensity on the whole range of the spectrum,
  • the layer 3 of the PCB combine with the first electromagnetic spectrum of frequencies generated by the mass of crushed crystals 6. Together, they are generating an ultra-wide band and spectrum of frequencies, between 100 to 1000 MHz for the resonance of the chromosomes and the telomeres, and the 50 to 80 GHz spectrum for human DNA resonance, or 30 GHz to 70 GHz for animals.
  • the device Adding to this, the device generates a wide spectrum of uniform intensity ultrasound vibrations, just right for this biological application, necessary for the mechanical- vibrational resonance of the chromosomes and the telomeres.
  • the spectrum of ultrasound frequencies generated are between 100 KHz to 10 GHz, preferable between 1 MHz to 1000 MHz, and most preferable between 100 MHz to 1000 MHz.
  • the arc segments of layer 3 are made of the conduit pattern designed on the surface of the PCB 1, usually made of copper or other highly conductive material, and it can be coated or electroplated with a top layer of silver or gold for a better conductivity at higher frequencies.
  • the layer 3 of the PCB 1 is shown in FIG. 6.
  • Each concentric circle or closed loop is divided in three arcs at about 120° from each other, forming three arc segments, like one of the outer arc segments 20.
  • the next inner loop is divided the same in three parts, but with a circular offset of 60° from the outer loop.
  • the three one-third coils are coupled together at
  • the outside one-third loops 20 and 21 are couple inductively and capacitively with the inner one-third lops, and so on.
  • the whole oscillator When stimulated with very short pulses at the two inputs the whole oscillator generates a wide spectrum of frequencies, with relative uniform intensity distribution in the range of this spectrum, which is in the high, human DNA resonance spectrum of 50 GHz to 80 GHz, or about 30 GHz to 70 GHz for animals.
  • the current design moves the whole band of frequencies higher than the Lakhovsky design, by multiplying the band of frequencies, depending mostly on the number or arc segments on each circle, and the gap size and distance between the arc segments.
  • One major advantage is the fact that the resonator on the layer 3 gets activated not only from the driving signal, but also from the electromagnetic waves generated by the mass of piezoelectric crystal grains. Being in the close proximity of the mass of crystal grains, this additional activation enhances even more the spectrum of electromagnetic radiation generated by this wide spectrum oscillator.
  • the resonator on the layer 3 acts also as an active reflector for the electromagnetic waves 15 generated by the mass of crushed quartz. First, these waves get reflected back, towards the active side of the telomeric resonator device. Second, the waves 15 stimulate farther the layer 3 resonator, having an active role in the excitation of the resonator and its level of efficiency.
  • the electric signa l that feeds the telomeric resonator has very sharp fronts, both rising and trailing, and therefore, this signal is very rich in high freq uency harmonics, that add up to the overall ultra-wide band of electromagnetic spectrum generated by the other components of the telomeric resonator.
  • All the ultra-wide spectrum of electromagnetic frequencies have the effect of inducing electromagnetic bio-resonance at the chromosomes, telomeres and the DNA level, having a rejuvenation effect on the body in general, and on the chromosomes and the telomeres in particular, extending the length of the telomeres, stimulating the catalytic activity of telomerase, and generating a strong overall anti-aging effect.
  • the wide spectrum of ultrasound waves 16 induce mechanical- vibrational resonance on the chromosomes and the telomeres, again, having a strong rejuvenation on the chromosomes and the telomeres, stimulating the catalytic activity of telomerase, extend ing the length of the telomeres, and a strong overall rejuvenation and anti-aging effect.
  • telomeric resonators described above, must be used at a relative close proximity to the body of the person or animal using them. Especially the ultrasonic vibrations get attenuated very quickly in the air with the distance.
  • the rejuvenation and anti-aging outcome of induced bio-resonance on the chromosomes and telomeres has the maximum effect during sleep time, at night time, when the body goes through the maximum regenerative process. Also, the effect is somehow effective too, at rest times or nap times.
  • telomeric resonator device presented in this invention, is the system presented in FIG. 7.
  • the system proposed here utilize a plurality of telomeric resonators as described above, imbedded in a user friendly format device, like a blanket or duvet device.
  • the blanket or duvet 24 is used by the users d uring the sleep time or rest time, being covered with it. All the telomeric resonators 24 a re connected together in parallel with the very flexible conductors 25, which is part of a
  • telomeric resonators 23 are set-up inside the blanket 24 in such a way that the all of them face the same d irection, facing one side of the blanket 24, which is the active side, facing the user.
  • the active face of the telomeric resonators is the one with the pins, and the cover 7 of the enclosure.
  • the body of the user gets immersed in a bath of ultra-wide spectrum of ultrasound and electromagnetic waves, tuned to resonate with the chromosomes and the telomeres of the cells, and the DNA, thus supporting the telomere rejuvenation, stimulating the catalytic activity of telomerase, stimulating the elongation of the telomeres, and slowing down, stopping and reversing the biological clock of the body.
  • the blanket 24 may also be embedded with a plurality of infrared and far infrared LEDs, that together, generate an electromagnetic spectrum between 600 nm to 2000 nm, preferable between 700 nm to 1800 nm, and most preferable between 800 nm to 1500 nm, which is the resonant electromagnetic spectrum of the chromosomes. This would provide even more support to the rejuvenation of the chromosomes and the telomeres supporting and improving the overall anti-aging performance of the system as a whole.
  • the whole system can be used during the relaxing periods of time during a day, but most preferably and being the most effective is during the sleep at night time, because this is when the body goes through the most regenerative period of the day.
  • the cable 25 connects with all the telomeric resonators embedded in the anti-aging blanket 24, and with the other possible components, like the far-infrared LEDs. From the blanket and the connecting cable 25, there is one multi-conduit cable 26 that has a connector 27 at the end, which connects into the driving apparatus 28.
  • the driving apparatus 28 generates the electrical signal as presented in FIG. 9 required by the telomeric resonators 23, and for the other possible supporting components of the blanket 24. All these signals are driven through the cable 26.
  • telomeric resonator device could be used stand-alone, or a plurality of devices could be grouped together in panels, chair covers, therapeutic pads, or in other forms or systems.
  • Various changes may be made and equivalents substituted for
  • the device 28 is the main controlling apparatus, generating the electrical signals that drive one or more telomeric resonators, or other possible systems and embodiments as the one presented in FIG. 7.
  • the controlling apparatus 28 is composed of the following logical blocks, as presented in FIG. 8.
  • the main control processing unit is designed around a microcontroller CPU 29, the real time clock RTC 31, the memory module 32 holding the software and the data, the serial port 33 used for external communication, sensors 34, an interactive touch
  • screen 35 used for the graphical user interface, a module 36 to process the keys and buttons interfacing with the user, a sound module 37 for generating complementary of sounds, music and alarms, a signal generation board 38 that generates the signals sent to the devices or the systems comprising telomeric resonator devices, connected through the connecting jack 39.
  • the control apparatus 28 has a power supply 41 that feeds all of the other modules described above.
  • the signal generation module 38 receives the signal generation commands from the main CPU module 29 (in FIG. 8) through the signal command bus 42.
  • This bus contains signal generation commands in the form of a communication protocol, to control the signal driving the telomeric resonators, and possible other supporting devices and systems.
  • signal command bus 42 provides commands for the start and stop of each signal, enable commands, and other parameters like the polarity, number of pulses on each polarity, pulsed width modulation parameters, frequency of the signals, the modulating frequencies and bursts duration, and other possible parameters. In turn, it generates the basic electric signal that is represented in FIG. 9.
  • the signal that drives the one or more telomeric resonators has a frequency between 100 Hz and lGHz, preferable between 1 KHz and 500 KHz, and most preferable between 10 KHz and 100 KHz.
  • the voltage of the signal can be between O.lv to 50Kv, preferable between IV and 1KV, and most preferable between 10V and 200V.
  • the signal, as presented in FIG. 9 is very short in duration, and very sharp, with a fast raising and fast trailing fronts.
  • the duration of each pulse is between 0.01 nanoseconds to 1 millisecond, preferable between 0.1 nanosecond to 100 nanoseconds, and the most preferable between 1 nanosecond to 10 nanoseconds.
  • the signal is delivered through the output bus, to the fixed connector 39.
  • the output signal is relatively high in voltage, but with relatively small current.
  • the signal generator board 38, for driving the telomeric resonators 23, has a sub-module 40 for detecting if the load made of the network of telomeric resonators 23, has a short circuit, or a local or general interruption of the circuit.
  • the module 40 If the module 40 detects any of these situations, it sends an alert signal back to the main CPU unit 29, through the communication bus 42. If such an alert occurs, the bus 42 will inform the CPU 29 and the controlling apparatus 28 will display this fault on the main touch screen 35.
  • the user Prior to using the system and the apparatus, the user will configure the apparatus 28 by entering a number of parameters, like the wake-up time and the start and stop time of the telomeric resonators 23.
  • the apparatus 28 can receive and upload custom sequences, designed and prescribed for example by specialists. Such custom programs can be customized for different situations, like the age and condition of the user, or other possible affections. They can be sent on-line, like by email, or downloaded over internet, and it could be uploaded into the apparatus 28, using the serial communication port 33 of the apparatus.
  • a number of other features are built and programmed in the functionality of the controlling apparatus 28, like security mechanisms, privileges and access levels, fault a nd ala rm annunciation, history logging, networking with other measurement and diagnostic devices and integration with other systems.
  • PCB 1 of the telomeric resonator presented in FIG. 1 is from a two layer or a multi-layered printed circuit board (PCB). Both, layer 2 and layer 3 a re made from electrolytic copper, electroplated or coated with silver or gold .
  • the pins 4 are made of stainless steel, or brass, preferably plated with silver or gold .
  • the pins 4 are soldered on the layer 2 of the PCB with normal solder.
  • the piezoelectric crystal grains 6 are best made of crushed piezoelectric quartz, that can be from natural sources or cultured qua rtz for the electronics industry. In either case, the q uartz should have a Q factor equal or better than 10 6 for best results.
  • the crystal grains should have a wide and uniform variety of sizes, between 0.001 mm and 10 cm, preferably between 0.001 mm and 2 cm, and most preferable between 0.01 mm and 10 mm.
  • telomeric resonator The two parts, top 7 and bottom 8 of the enclosure of telomeric resonator ( FIG. 1) can be best made using a typical plastic injection technology, using plastic materials like polycarbonate (PC) or ABS plastic, or fiber-glass-reinforced ABS.
  • the best cables 14 that can be used are very flexible, made of thin multi- stranded cond uctors, insulated with a silicon based insulator, for maximum possible flexibility.
  • the telomeric resonator gives the best results when it's excited with a pulsed electric signal of very short and repeating pulses, having fast raising fronts and fast decaying trails, having frequencies between 100 Hz and lGHz, preferable between 1 KHz a nd 500KHz, and most preferable between lOKHz and lOOKHz.
  • the voltage of the signal ca n be between
  • O.lv to 50Kv preferable between IV and 1KV, and most preferable between 10V a nd 200V.
  • the shape of the signal is very short in d uration, and very sharp, with a fast raising and fast trailing fronts.
  • the duration of each pulse is between 0.01 nanoseconds to 1 millisecond, preferable between 0.1 nanosecond to 100 nanoseconds, and the most preferable between 1 nanosecond to 10 nanoseconds.
  • the best way to implement the bla nket, quilt, pad, chair cover or d uvet device 24 presented in FIG. 7, is by using multilayered textile fabric, like cotton or silk, filled with down, feathers, or a synthetic fiber like microfiber, depend ing on the desired thickness.
  • the telomeric resonators 23 can be embedded between the layers of the fabric that make the blanket or d uvet 24.
  • the fabric of the blanket, pad, chair cover or d uvet 24, can have stitched pockets of fa bric inside, where the telomeric resonators 23 can be inserted.
  • the pockets can be secured with stiches, with zippers or with Velcro tape.
  • the blanket or duvet 24 can be inserted in a duvet envelope or d uvet cover, such way that the blanket 24 itself does not need to be washed after usage, only the d uvet cover.
  • the best way to implement the connecting ca bles 25 and 26 is with multi-stranded and flexible cond uctors, isolated with silicon insulation or other very flexible insulator.
  • the cables are ran between the fabric layers of the blanket, pad, panel or cha ir cover 24, or other possible embodiment, preferable in such a way that is not noticea ble by the users.
  • the best effect of rejuvenation and extension of the length of the telomeres and overall anti-aging results can be obtained when the user rests or sleeps, while having one or more telomeric resonators either in direct contact with the skin, or in very close proximity with the body, like using a blanket or pad as the one presented in FIG. 7.
  • the best effect of rejuvenation and extension of the length of the telomeres and overall anti-aging results can be obtained when the user rests or sleeps, while having one or more telomeric resonators either in direct contact with the skin, or in very close proximity with the body, like using a blanket or pad as the one presented
  • electromagnetic spectrum of frequencies generated by the telomeric resonator is relatively low power, which is in line with the power levels generally used by the Microwave Resonance Therapy technologies. For this reason, and in accordance with the same technologies, the application of the frequencies is done with the device either in contact with the body of the user or patient, or in very close proximity.
  • the application of the ultrasound vibrations for bringing the chomosomes and the telomeres to mechanical resonance, for purpose of rejuvenation and extension of the length of the telomeres has the best results when the telomeric resonator device or devices, are applied in direct contact with the body of the user, or in very close proximity.
  • ultrasound vibrations generated by the telomeric resonator have a relatively high spectrum of frequencies that do not propagate well through the air. For this reason, the one or more telomeric resonators that are part of the application or the therapeutic system, should be either in contact with the body of the user or patient, or in very close proximity, like in the embodiment presented in FIG. 7.

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Abstract

La présente invention concerne un dispositif, un procédé et un système pour la thérapie par résonance hyperfréquence des chromosomes, des télomères et de l'ADN, et l'extension de la longueur des télomères, par la génération d'un spectre large et uniformément réparti de fréquences électromagnétiques et de vibrations ultrasonores qui induisent une résonance électromagnétique et ultrasonore dans les chromosomes et les télomères, et une résonance électromagnétique dans l'ADN. Une pluralité de tiges conductrices pointues montées sur la surface d'une carte, excitées par impulsions électriques alternatives courtes et précises, créent des champs électrostatiques complexes qui excitent une masse de grains cristallins piézoélectriques, présentant une large et uniforme distribution des tailles, remplissant l'espace autour des tiges. L'invention concerne également un oscillateur électromagnétique à large bande pour la résonance de l'ADN. Selon un mode de réalisation, l'invention concerne un système appliqué, une pluralité de résonateurs télomères étant incorporés dans une couche ou un coussin, et l'appareil de commande.
PCT/CA2015/050612 2014-07-03 2015-07-02 Système et procédé d'augmentation de la longueur des télomères Ceased WO2016000075A1 (fr)

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ITUA20164151A1 (it) * 2016-06-07 2017-12-07 Gianluca Spennato Materasso e/o cuscino per magnetoterapia
CN108904995A (zh) * 2018-07-13 2018-11-30 广州易和医疗技术开发有限公司 一种多功能治疗仪
CN110982812A (zh) * 2018-10-02 2020-04-10 金贤锡 细胞的端粒延长方法
EP3862428A4 (fr) * 2018-10-02 2021-11-10 STEMON Inc. Procédé d'allongement de telomère cellulaire
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US11316560B1 (en) 2020-10-23 2022-04-26 Nxp B.V. Magnetic induction device
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CN116029216A (zh) * 2023-02-17 2023-04-28 中国石油大学(华东) Fpso动态管缆线型智能优化方法、系统及应用

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Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITUA20164151A1 (it) * 2016-06-07 2017-12-07 Gianluca Spennato Materasso e/o cuscino per magnetoterapia
CN108904995A (zh) * 2018-07-13 2018-11-30 广州易和医疗技术开发有限公司 一种多功能治疗仪
CN108904995B (zh) * 2018-07-13 2023-12-19 广州易和医疗技术开发有限公司 一种多功能治疗仪
CN110982812B (zh) * 2018-10-02 2023-07-11 金贤锡 细胞的端粒延长方法
CN110982812A (zh) * 2018-10-02 2020-04-10 金贤锡 细胞的端粒延长方法
EP3862428A4 (fr) * 2018-10-02 2021-11-10 STEMON Inc. Procédé d'allongement de telomère cellulaire
US20220025352A1 (en) * 2018-10-02 2022-01-27 Stemon Inc. Method for extending telomere of cell
US20220073901A1 (en) * 2018-10-02 2022-03-10 Stemon Inc. Composition for extending telomere of cell and preparation method therefor
US12241056B2 (en) * 2018-10-02 2025-03-04 Stemon Inc. Method for extending telomere of cell
US11316560B1 (en) 2020-10-23 2022-04-26 Nxp B.V. Magnetic induction device
EP3989450A1 (fr) * 2020-10-23 2022-04-27 Nxp B.V. Dispositif d'induction magnétique
FR3115998A1 (fr) * 2020-11-07 2022-05-13 Benjamin PONS lit de soins pour traiter un sujet utilisant notamment l’ultrasonothérapie et la lithothérapie
CN116029216B (zh) * 2023-02-17 2023-06-09 中国石油大学(华东) Fpso动态管缆线型智能优化方法、系统及应用
CN116029216A (zh) * 2023-02-17 2023-04-28 中国石油大学(华东) Fpso动态管缆线型智能优化方法、系统及应用

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