WO2016000075A1 - System and method for increasing the length of telomeres - Google Patents

Abstract

A device, method and system for the microwave resonance therapy of the chromosomes, telomeres and DNA, and extending the length of telomeres, by generating a wide and uniformly distributed spectrum of electromagnetic frequencies and ultrasound vibrations that induce electromagnetic and ultrasonic resonance in chromosomes and telomeres, and electromagnetic resonance in DNA. A plurality of sharp conductive pins mounted on the surface of a board, excited by sharp and short alternating electric pulses, create complex electrostatic fields that excite a mass of piezoelectric crystal grains, having a wide and uniform distribution of size, filling the space around the pins. Also, a wide band electromagnetic oscillator for DNA resonance is disclosed. One embodiment of an applied system is presented, with a plurality of telomeric resonators embedded in a blanket or pad, and the driving apparatus.

Description

SYSTEM AND M ETHOD FOR I NCREASI NG TH E LENGTH OF TELOM ERES

[0001] FIELD OF I NVENTION

[0002] This invention relates generally to the field of medical therapeutic, health, wellness and longevity technologies, bio-physics, bio-electromagnetics, bio-resonance, microwave resonance therapy, anti-aging and life extension and more particularly, to a method, device and system effective in the rejuvenation of the chromosomes, telomeres and the DNA, extending the length of the telomeres and stimulation of the catalytic activity of telomerase, and in slowing, stopping and reversing the aging process of living things in general and humans in particular.

[0003] BACKGROU N D OF I NVENTION

[0004] Telomeres are repeat protein-DNA complexes forming a protective cap at the ends of linear and X chromosomes. The normal cell division results in a progressive shortening of the telomere length. After a certain degree of shortening, the cells lose the ability to divide and replicate, leading to cell senescence and death.

[0005] A growing body of evidence has demonstrated the length of the telomeres is the source and the basis of the "biological clock", as they shorten with age.

[0006] The length of the telomeres is determined in part and cumulates the influence of genetic and epigenetic factors, sex hormones, the reactive oxidative stress, the inflammatory reactions, the environmental stressors, and also internal and external stress factors, including intrinsic and extrinsic factors acting both at the level of the whole organism and the level of a singular cell. The influence of all these factors is independent of the chronological age.

[0007] The length of the telomeres shortens with each cell division and correlates inversely with age.

[0008] One of the key biomarker of the biological age is the telomere length of the somatic cells. A minimum length of telomeres reaching a critical level, triggers a cell cycle arrest or senescence of the cell and death.

[0009] The telomeric DNA and the accompanied proteins maintain a "capped" structure called also a "functional telomere" and protect the end of the chromosome from illegitimate recombination and fusion with another telomere or DNA end.

[0010] The shortening of the telomeres that happen on each cell division was shown to occur both in vitro and in vivo, where the age reflects the total and cumulative effect of cell divisions - the biological clock. This phenomenon was demonstrated in human fibroblasts, hematopoietic stem cells, leukocytes, keratinocytes, epithelial and endothelial cells.

[0011] It is largely accepted that telomere length reflects two aspects:

1. - a biological indicator of the replication history of the cell, and

2. - as a factor determining the replicative capacity of normal somatic cells

One of the main mechanism that produces and increases telomere elongation is facilitated by telomerase, a ribonucleic protein enzyme that can synthesize new telomere G- rich strands using its own telomere sequence-specific RNA template. Telomerase catalytic activity requires the association of two subunits: RNA (TER) and telomerase reverse transcriptase (TERT).

[0012] Studies have clearly demonstrated a direct relation between the level of oxidative stress, and the production and processivity of the telomerase and its catalytic activity in the production and the length of the telomeres. The antioxidants modulate the genes and proteins activity which influence, regulate and control the telomerase activity, with a direct impact on the telomeres maintenance and length. [0013] Telomere length results from a dynamic balance between elongation and shortening of the chromosome ends. The mean telomere length within cells is a d irect function of the level of telomerase activity.

[0014] However, telomere length and telomerase activity do not always tightly corre late in somatic cells, like activated lymphocytes or the senescence of hematopoietic stem cells.

[0015] The human telomere length extend in a limited range of 10-20 Kb, dependent on tissue type. In vitro stud ies revealed that with every cell d ivision, 40-200 bp are lost until they reach a critical length of 4-5 Kb - the Hayflick's limit, although this level varies between cell types and individ uals.

[0016] Other stud ies demonstrated the d irect relation between the shortening of the telomeres and various diseases.

[0017] For example, the shortening of the leukocyte's telomeres has been shown in several large studies to pred ict cardiovascular morbidity and mortality, includ ing myocard ial infarction, congestive heart failure, and death, and a lso associations with risk factors for coronary artery d isease.

[0018] The immune system also, is highly sensitive to shortening of telomeres. Its ability depends tightly on cell renewal and clonal expansion of T- and B-cell populations. Cells of the immune system a re uniq ue a mong normal somatic cells as they can up-regulate telomerase, the telomere extending enzyme, and limit telomere attrition in the process of cell

[0019] proliferation undergoing in activated cells. Immuno-senescence is characterized by a special remodeling of the immune system induced by antigen exposure and oxidative stress. In ageing, the immune system adaptive immunity deteriorates because of a progressive decline of the T and B cells and decrease of absolute numbers of T and B lymphocytes.

[0020] It is commonly understood and accepted in the art, that finding ways to rejuvenate the telomeres and extend their length and elongation, and to stimulate the catalytic activity of telomerase, has a d irect positive impact on the perceived age and the health and wellness of the body. Ultimately, rejuvenating a nd extend ing the length of the telomeres has a direct effect in extend the life span of anima ls in general and humans in particula r. [0021] BACKGROU N D OF TH E RELATED ART

[0022] There are severa l ways found in the art, for rejuvenating and extending the length of the telomeres, stimulating the production and catalytic activity of the telomerase, or ind irectly rejuvenating and influencing the length and condition of telomeres.

[0023] The work and research of Russian scientist Dr. Peter P. Gariaev, is mostly presented in the Russian patents 2355009 and 2383133. Dr. Gariaev has demonstrated the wave structure of DNA and the resonant interactions of chromosomes, telomeres, the genes, and the environment. His "Wave Genetics" method and therapy uses electromagnetic waves, also laser light and acoustic waves too.

[0024] One good reference about Dr. Gariaev work, is the paper titled "Crisis in Life Sciences. The Wave Genetics Response." by P.P. Gariaev, M.J. Friedman, and E.A. Leonova- Ga riaeva, with other good references can be found at this link:

http://www.emergentmind.org/gariaev06.htm. Another paper titled "The Essence of Linguistic & Wave Genetics in Theory and Practice" by Peter Ga riaev can be found at:

http://t.co/gYZCY43S20.

[0025] Dr. Gariaev applied method has successful regenerative and anti-aging applications. His method was successfully and independently tested and demonstrated in 2001, at the University of Toronto, Canada.

[0026] Another large body of work, research, results and applications, can be found in the Microwave Resonance Therapy (MRT), originally developed in Ukra ine and Russia, and now widely used in the Russian Federation, in U kra ine, in Europe, a nd to some extend worldwide.

[0027] The M icrowave Resonance Therapy (M RT) involves the application of

electromagnetic freq uencies of low spectral density, with frequency range of 30-300 GHz, mostly in the DNA resonance range of 52-78 GHz, for therapeutic effects. The application is done mostly to acupuncture points, but not only.

[0028] The M icrowave Resonance Therapy is considered as an efficient non-invasive biophysical medical treatment. The M RT therapy is well described and a pplied in the patents of Sergei P. Sit'ko: Ukraine patent N 2615, Russian patent N 2053757, and USA patent 5507791 A.

[0029] The best therapeutic results of MRT were obtained for: surgery, orthopedic and traumatology, neurology, psychiatry, addiction, cardiology, urology, gynecology,

gastroenterology, upper respiratory tract, pulmology, dermatology, allergology,

immunology, endocrinology, dentistry, hematology, strokes diabetes, pain relief, and oncology. Promising result were obtained in the treatment of cancer patients in stage lll-IV. The list is still open, being continuously extended.

[0030] There is a very large body of research in the field of Microwave Resonance Therapy, mostly from the following scientists: Sit'ko, Andreev, Beli, Deviatkov, Zalubovskaya,

Cherkasov, Nedzvetsky, Tkachenko, Kozhemyakin, Zhukovsky, Besonov, Golant, Temuryanc, Macheret, Lebedeva, Betsky, Zaporozhan, Kuz'menko, Rodschtadt, Grubnik, Kovalenko, Vebb, Griindler, Keilmann, Morel, and others.

[0031] Some other good references of the Microwave Resonance Therapy are:

- "Microwave Resonance Therapy" by Zlata Jovanovic Ignjatic, MD Medica Data/Vol. 4, NO 1 / III 2012.

"An Overview of Microwave Resonance Therapy" by Dr. Rakovic et all .

"Equipment and technologies of low intensity millimeter therapy" by Yanenko et all .

[0032] The Microwave Resonance Therapy is officially approved by Ministry of Healthcare of the Russian Federation and in Ukraine. The VIDHUK R&D Center of Quantum Medicine, a leading organization of the Ministry of Public Health of Ukraine, founded by Prof. Sit'ko, have been cured more than 600,000 patients, using the Microwave Resonance DNA Therapy.

[0033] There are different commercial apparatuses on the market, with different methods used for generating the MRT resonance frequencies, the spectrum and the generation methods. For example, the devices branded as "Yav-1", "Electronika-KVCh" and "RAMED- Expert", create sets of harmonic signals with fixed operating frequencies. The devices

[0034] "AMRT-01", "AMRT-02", "Electronics", "AMT-Covert-04" and "ARIA-SC", create «broadband generators* of the harmonic noise. Devices like "Porig-1", "Porig-3", "Artsakh", "Shlem" and "MU-2001", use the creation of broadband noise signals. Devices like AMRT-01 or Artsakh are combined devices generating noise as harmonic signals. The "AMT-04-Kovert"

[0035] and "ARIA-SC" use additional modes of quasi noise signals generated due to

«spectrum spilling» of the harmonic signals, sweep within the operating frequency range. All of these devices are characterized by low output power (10^-6 to 10^-13 W) and use mostly 37.5 to 78.3 GHz frequency range.

[0036] It is obvious that is highly desired to generate a spectrum of frequencies with a distribution as uniform as possible for the higher efficiency of the MRT therapy. This is also emphasized in the "An Overview of Microwave Resonance Therapy" paper by Dr. Rakovic, in the last paragraph of page 5.

[0037] One of the main limitations of the devices mentioned here, generating the frequencies for the Microwave Resonance DNA Therapy, is that the spectrum of frequencies generated is not uniform, with gaps between, or with large differences of the level of intensity distribution across the desired spectrum, depending on the used method of generation.

[0038] It is one of the objective of the present invention to provide a new and novel method and device of generating a uniformly distributed spectru m of frequencies that overcome the current limitations in the art.

[0039] In the US patent 20110077727 Al, Dr. Norman Shealy presents an application of the Microwave Resonance Therapy mentioned above, using the DNA resonance frequencies of 54 to 78 GHz, to extend the length of telomeres and rejuvenate the DNA.

[0040] Dr. Shealy proved the efficiency of telomere rejuvenation and elongation, with his method and device, and published the results in the paper titled "Telomere Rejuvenation— Key To Health and Longevity" published in the "Anti-Aging Therapeutics" volume 12, by the American Academy of Anti-Aging Medicine (A4M; www.worldhealth.net). One of Dr. Shealy's subsequent study, done with his commercial device RejuvaMatrix Solar Homeopathy^® achieved a significant increase of the telomere length, with an average growth of 5.9%, for [0041] There are a number of limitations with the device described above. First, a Tesla coil is an inductive device, and it inherently limits the generation of very high frequencies and very high harmonics. The field intensity of the frequencies and harmonics generated by a Tesla coil, drops exponentially and dramatically with higher frequencies over 1 GHz, and it is

[0042] extremely low or hard to measure at the 54 and 78 GHz. As a result, the efficiency of generating these DNA frequencies, is very low. Therefore the efficiency of stimulating the telomeres is very low. For the same reason, the distribution of frequencies is not uniform over the desired spectrum.

[0043] Secondly, the output voltage of the device is 20,000 to 50,000 volts, which is very high voltage that can be very dangerous for the patient in different situations, like if the users spill accidentally a drink over the device-mattress.

[0044] One objective of the present invention is to overcome the above limitations, and to provide novel and better methods and designs for generating and applying the

chromosomes, telomeres and DNA resonant frequencies.

[0045] Other methods known in the art, for elongating the telomeres use the enhancing hTERT expression in the cell and by increasing the processivity of telomerase in the cells.

[0046] For example Patent WO 2006066247 A2 describes a method of telomere elongation by transiently enhancing the hTERT expression, by using endogenous or exogenous methods like creating hypoxic conditions. Other options presented are regulating, activating or modulating one or more genes that are responsible and are associated with telomerase processivity.

[0047] Patent WO 2004099385 A2 describes how to affect the telomere elongation by fusing a polypeptide having telomerase catalytic activity, with a telomere binding

polypeptide, comprising the catalytic protein subunit of telomerase reverse transcriptase (hTERT).

[0048] Patents US 20110236483 Al and US 20110237653 Al describe microscopic medical payload delivery devices that act as a transport vector to deliver a variety of cellular ribonucleic acid molecules to the cells in the body. When reaching the destination, the medical payload delivery devices insert their payload of cellular ribonucleic acid molecules into the target cells. By delivering cellular ribonucleic acid molecules into specific cells, the gene expression is capable of being modulated, and telomere synthesis is enhanced.

[0049] A similar method is described in the US 20090142408 Al patent. The human telomerase or its catalytic subunit hTERT is delivered to the cells by a biodegradable nanoparticle carrier, thus treating more generic problems of human aging.

[0050] These methods described above have limitations, like requiring very advanced equipment and relatively high skilled medical or scientific personnel to operate them effectively. Also, the methods can be applied only in a lab environment, require visits to specialized clinic or labs, are very expensive and are difficult to apply to the general public.

[0051] Other methods for enhancing the telomere elongation are using a variety of compounds, formulations, and dietary supplements. Some dietary supplements support an increased life span by enhancing metabolic function, activating anti-aging genes, and encouraging the production of new cells with longer telomeres (patent US 20120251500 Al), maintaining the telomeres on new stem cells as well as existing cells (patent US

20130115195 Al).

[0052] Some other natural or synthetic products influence the lengthening telomeres by inducing the production of telomerase (patent WO 2012106692 Al), or by promoting expression or enhanced expression of a sirtuin (SIRT-1) gene or protein (patent US

20130072574 Al), or inhibitory effect on telomere shortening (patent US 20060078633 Al).

[0053] The patent CA 2745376 Al describes the use of certain antioxidants for increasing telomerase activity in healthy and stressed cells using antioxidants that modulate gene activity and/or proteins which influence, regulate, and/or control telomerase activity, the maintenance of the telomere unit and associated components, or directly the telomere

[0054] length. The technique is based on modulating or influencing the lifespan of cells, tissues, organs, and organisms, by modulating the activity of the gene maintenance process in order to influence the length and/or structural integrity of the telomere in living cells. Examples of the antioxidants proposed include natural and synthetic antioxidants, such as [0055] plant antioxidant and polyphenol compounds derived from coffee cherry, tea, berry, and so forth, including but not limited to caffeic acid, chlorogenic acid, ferulic acid, quinic acid, proanthocyanidins, ubiquinone and idebenone.

[0056] The main limitation of these approaches to anti-aging, is that they are based on biochemistry, involving the users to get a biochemical substance or agent in their bodies, which may have other side effects, or not too effective.

[0057] Another main limitation of some of these patents, is that the proposed methods tackle the support and the maintenance of the body (like overcoming the oxidative stress), and the support functions of the telomeres, but not directly the telomeres and the

"biological clock".

[0058] BRI EF DESCRI PTION OF TH E I NVENTION

[0059] There is a continuous need for a method and a system that can use the bio-effects of the electromagnetic fields, and mechanical vibrations in a more efficient way, non- chemical and non-invasive, user friendly, with a holistic approach, for rejuvenating and increasing the telomere length, stimulating the processivity and catalytic activity of telomerase, and increasing the reproductive capacity of the cells, and to slow, stop and reverse the biological aging process, and extend the life span of mammalians in general and humans in particular.

[0060] Such device should be able to generate a more uniformly distributed

electromagnetic DNA spectrum of resonance in a better and much more efficient way. Also it should be able to generate electromagnetic and mechanical resonance at the chromosomal and telomere level too, again, with a uniform intensity distribution across the desired spectrum.

[0061] And such device should be light and easy for transportation, very safe in operation, and easy and simple to use, and user friendly to be operated by the user himself. [0062] The present invention overcomes all the limitations described above in the current state of the art section and it fulfills the needs described above, and other needs.

[0063] A new and novel method and system is described in this invention, for using electromagnetic and mechanical oscillations, designed with the purpose of rejuvenating and increasing the length of the telomeres, stimulating the catalytic activity and processivity of telomerase, that is also capable to slow, stop and reverse the shortening of telomeres and as a result, the biological clock of the mammalians in general and humans in particular.

[0064] Instead of using biochemical agents to stimulate the processivity of telomerase and increase the length of the telomeres, the present patent uses the resonant effects of electromagnetic and mechanical vibrations, tuned specifically to resonate with the chromosomes, the telomeres and the DNA, with direct impact on the rejuvenation and increase of the length of telomeres.

[0065] These objectives are accomplished in the instant method and system, and also the telomeric resonator device, which is the main component of this invention. This device generates a novel and complex radial and longitudinal electrostatic fields, and a wide and uniformly distributed band of electromagnetic spectrum and ultrasound spectrum of frequencies.

[0066] The complex electrostatic fields serve mainly as an excitation mechanism for a mass of crushed piezoelectric crystal grains of different sizes that are part of the telomeric resonator. The crystal grains have a uniform and continuous distribution of sizes, from the tiniest to the largest. Upon each electrostatic excitation, all the crystals as a mass, generate a wide and uniformly distributed band of electromagnetic spectrum, and a wide band of uniformly distributed ultrasound vibrations.

[0067] The complex electrostatic fields created inside of the telomeric resonator get combined with the wide band of electromagnetic spectrum generated by the crystals, and also with the electromagnetic frequencies created by a wide band oscillator that is part of the same device. This complex combination of electromagnetic spectrum of frequencies get also combined with the wide band of ultrasound vibrations generated by the crystal grains. All these fields, frequencies and vibrations, are designed and tuned for resonance with the chromosomes and the telomeres.

[0068] As a result of this novel resonance, the induced effect is rejuvenation of the chromosomes, the telomeres and the DNA, stimulated catalytic activity of the telomerase, all resulting in the increase elongation of the telomeres, and a general effect of slowing, stopping and even reversing the aging process of shortening of the telomeres which is the biological clock of the body.

[0069] The anti-aging system presented in this invention comprises a plurality of such devices - the telomeric resonators described above - all of them being part of a user-friendly anti-aging device, like an anti-aging blanket or duvet, a sleeping bag, a panel, a mat or a pad, or chair or chair cover, or other possible embodiments; any of these embodiments is controlled and driven by a main controller apparatus, responsible to generate all the electric signals required by each component of the system.

[0070] It is commonly accepted from research, studies and patents, that the resonant frequency domain of the human DNA is between 54 GHz to 78 GHz. Immersing the cells of human - or a mammalian - and implicitly the chromosomes, the telomeres and the genetic material, in an electromagnetic field with such frequencies, has beneficial rejuvenating and anti-aging effects. This band of frequencies create electromagnetic resonance at the DNA level, thus the micro currents and fields having a catalytic and resetting effect on the DNA, the telomeres, and implicitly an anti-aging effect at the macro level of the body.

[0071] What is as important, is to generate not just a particular frequency or a narrow band of frequencies, but a wide and uniform spectrum of frequencies, having a uniform intensity across the spectrum, covering not only the band of DNA resonance, but also the specific spectrums of the chromosomes and telomeres.

[0072] The chromosomes of a cell have a very similar shape with a tuning fork. They are natural resonators, both, from an electromagnetic perspective and a mechanical-vibrational perspective. The telomeres being positioned at the end of the chromosome arms, are the ones that have the largest amplitude during the oscillations of the chromosomes, both from an electromagnetic and mechanical-vibrational perspective. The shape of a chromosome provides a great electromagnetic resonant circuit, and the perfect mechanical vibrational resonant shape.

[0073] The vibrations and oscillations of the chromosomes - and indirectly the telomeres, both electromagnetic and mechanical-vibrational, have the effect of a micro-massage, stimulating the catalytic activity of the telomerase, and the rejuvenation of the

chromosomes in general and the telomeres in particular.

[0074] The typical human chromosome length is from 1 x 10^"6 meters to 20 x 10^"6 meters, with a median average of about 7 x 10^"6m. From an electromagnetic perspective, the shape of the chromosomes make them also a perfect resonant circuit or antenna.

[0075] The longitudinal resonant frequency is based on the fact that the length of a telomere is half the wavelength of the electromagnetic resonant frequency, or multiple half- lengths for higher harmonics.

[0076] Knowing the speed of electromagnetic waves in water-based solution, like the intracellular medium, to be about 225 x 10⁶m/s, and the longitudinal length of the chromosomes to be between 5 to 9 x 10^-6m - which is the longitudinal half-wave length, then we get the electromagnetic resonant frequency of the chromosomes to be between 12 to 22 THz, with a Gaussian median value at around 16 THz (16 xl0¹²Hz).

[0077] This corresponds to the frequency band of the very far infrared light. This is confirmed and it does correspond with the thermal emission of the human temperature, or the color temperature of a black box device heated at about 36°Celsius, the natural temperature of the humans.

[0078] Now if we look at the transversal resonance, the X shape of the chromosomes make a base parallel LC circuit, or a more complex series of multi-parallel LC circuits. There are two base circuits, back-to-back, connected to the median point, each one formed by the two arms of the chromosomes on the same side. The resonant electromagnetic frequency of each open loop, or parallel LC circuit can be derived from the geometry of the chromosome, and it overlaps with the DNA resonant spectrum, in the tens of GHz band.

[0079] The X chromosome is also a perfect tuning fork from a mechanical-vibrational perspective. The two opposing arms of both sides of the chromosomes act as the arms of a tuning fork, vibrating in the same plan, but in a transversal axis, when facing the

chromosome from the front.

[0080] Having the speed of sound in a saline serum, like the intracellular medium, to be about 1550 to 1680 m/s, and the half of the resonant wave-length being equal to the distance between the arms of the chromosome, at an average of 2 to 3 x 10^-6m , the resonant frequency for mechanical vibration of the chromosomes, is in a range of about 100

MHz to 1000 MHz with a Gaussian median value at about 300 MHz.

[0081] Thus, bringing the chromosomes at electromagnetic and mechanical-vibrational resonance for a period of times, induces the maxim rejuvenation effect, and the increase in the telomere length, thus having an effective, direct and strong anti-aging effect.

[0082] Previous devices that are known in the art, cannot generate a relatively wide and uniformly distributed spectrum of electromagnetic and mechanical-vibrational frequencies required for the resonance of the chromosomes, telomeres and the DNA.

[0083] BRI EF DESCRI PTION OF DRAWI NGS

[0084] The structure, operation and advantages of the presently presented embodiments of this invention will become further apparent upon consideration of the following description, taken in conjunction with the accompanying drawings, wherein:

[0085] FIG. 1 is a cross-section view through the telomeric resonator, showing the interior components and the structure of the device.

[0086] FIG. 2 is a top view of the PCB board described in FIG. 1. [0087] FIG. 3 is top view schematic illustration of another embodiment of the PCB board presented in FIG. 1.

[0088] FIG. 4 is a schematic illustration of top view of a small section of the PCB 1. It is a functional drawing, showing the interaction of the electrical fields between the pins 4 described in FIG. 1.

[0089] FIG. 5 is a schematic illustration of the cross section of a small area of the telomeric resonator presented in FIG. 1. It is a functional drawing explaining the fields interaction between the components, and the generation of electromagnetic and ultrasound waves.

[0090] FIG. 6 is a schematic illustration of the layer 3 of the PCB 1.

[0091] FIG. 7 is a schematic representation of a possible applied embodiment of the anti- aging system presented in this invention.

[0092] FIG. 8 is a block diagram of the components of the main controller apparatus 28.

[0093] FIG. 9 is a schematic of the electric signal that drives the telomeric resonator presented in FIG. 1.

[0094] DETAI LED DISCLOSURE OF TH E I NVENTION

[0095] The core device described in this patent I call it generically the telomeric resonator, because the main and key purpose is to bring the telomeres of the chromosomes to electromagnetic and ultrasonic vibrational resonance.

[0096] The structure of the telomeric resonator is shown in FIG. 1, which is a vertical cross section through the device.

[0097] The telomeric resonator is composed of a board 1 made of an insulation material, most preferably a printed circuit board (PCB), having two or more layers. In this preferred embodiment, the PCB 1 has two layers, the top layer and circuit 2, and the bottom layer and circuit 3. The electrical circuit making the top layer 2 of the PCB, forms a certain circuit and it

[0098] connects a plurality of metallic or conductive pins 4 in a certain pattern, as being described in the FIG. 2 and FIG. 3. The top layer 2 of the PCB 1 is made usually from copper, preferable plated with silver or gold. The pins 4 are soldered or welded on the surface of the PCB 2 by solder 5, on the same side of the circuit 2, which is the top layer and the active side of the PCB 1.

[0099] The bottom layer 3 or the PCB 1, forms another electrical circuit, as being described in FIG. 6. The layer and circuit 3 of the PCB 1 forms a series of concentric arc circles, with an angle offset between each other, which upon activation, generate a large spectrum of electromagnetic frequencies, with the magnetic component polarized perpendicular to the surface of the support PCB 1. The layer 3 of the PCB 1 is made usually of copper, and it should be preferable coated or electroplated with silver or gold for a better electrical response at high frequencies.

[0100] The pins 4 are metallic or made from other composite and electrically conductive material, like conductive ceramics, and they have very sharp top tips. The best

implementation is to have the pins made of stainless steel or brass, and have them coated or electroplated with silver or gold for the minimum impedance at high frequencies. The pins

[0101] are interconnected as in FIG. 2 or FIG. 3, in such a way that each pin having one type of polarity at an instance, is surrounded by pins having the opposite polarity at the same instance. The sharpness at the end of the pins 4 create a local electric field with a very high intensity, mostly on the vertical coordinate. On the horizontal plan, parallel with the PCB 1, the two presented layouts of the pins also create the highest possible radial electric field between the pins 4.

[0102] The pins are surrounded with quality crushed piezoelectric crystals 6, like natural or cultured electronic grade quartz, berlinite, topaz, tourmaline, barium titanate, sodium potassium niobate, bismuth ferrite or other natural or synthetic piezoelectric crystals. The size of the crystal grains have a large variety of dimensions, generally varying between

[0103] crystal powder, having sizes of a few micrometers, and going to large crystal grain or crystal nuggets of several millimeters diameter. The upper range of grain sizes, depends a lso by the size of the PCB, the size and distance between the pins 4, and the size of the enclosure, the larger the enclosure, the larger the bigger grain sizes. The size distribution of the crystal grains is uniform and continuous. That is, for all the crystal grains that go inside of a telomeric resonator, the number of crystal grains having the same size range, is relatively equal with the amount of crystal grains having any other size range.

[0104] The top layer and circuit 2 of the PCB 1, and the bottom layer and circuit 3 of the PCB 1, are connected electrically in parallel, to the resistor 12, and to the two electrical wires 14 that feed the telomeric resonator with the driving electrical signal.

[0105] All the components described up to this point are housed in a tight enclosure or case, made of two components, the bottom part of the case 8 and the top part of the case 7.

[0106] The enclosure of the telomeric resonator, is best made of an electrical insulation material like PVC, ABS, polycarbonate, glass, reinforced fiberglass, resins, or other suitable electrical insulation material that is evident for those skilled in the art.

[0107] The bottom part of the box 8 has side walls 9 going up to the total interior height of the box, for easy and tighter holding the components inside and for an easier assembly.

[0108] Also, the bottom part 8 of the enclosure is equipped with the small studs 11, which have the role to stiffen and increase the mechanical resistance of the enclosure. The length of the studs 11 is such a way that when the bottom part 8 of the enclosure is assembled with the top part 7, the two of them assemble properly, and the studs 11 just touch the top part 7 of the enclosure.

[0109] The enclosure is equipped with elastic or pressure-activated click hooks 10, located between the walls 9 and the top part 7 of the enclosure. Once assembled and pressed against each other, the hooks 10 would click and lock-in tight the two parts 7 and 8 of the enclosure, making the assembly of the device easy to perform.

[0110] Also, the two components of the enclosure 7 and 8, have a small housing 13 at one side of the box, designed to house the exit of the wires 14 and to prevent them for disconnecting from the PCB 1 when pulled strongly from the outside. The housing 13 is designed with curved channels for the wires 14, in such a way that when the wires 14 are

[0111] pulled away from the enclosure, the curved channels of the wires oppose the exterior mechanical stress, without applying any mechanical stress on the electrical connections of the wires 14 with the PCB 1, typically a soldered connection having way less mechanical resistance than the wires themselves being curved-channeled in the housing 13.

[0112] Before the two components 7 and 8 of the enclosure are assembled and locked-in together by the side hooks, a thin layer of suitable sealer, like silicone or glue is applied on the edges of the bottom part 8, or the inner edges of the top part 7, more exactly on the side walls 9. This will ensure that upon the assembly of all the internal components of the telomeric resonator, the sealer will seal the interior of the enclosure to protect the components inside the telomeric resonator against moisture, liquids, dust, or other foreign substance that could affect the well-functioning of the device.

[0113] FIG. 2 presents a top view of the PCB board 1 that was presented also in FIG. 1. The top side of the PCB is presented, with the electrical circuit and layer 2, and the pins 4, soldered on the same face of the PCB, with solder 5. The two polarities of the circuit 2 connect the pins 4 in such a way, that each individual pin is surrou nded by the other pins having opposite polarity, at the closest proximity. The two wires 14 feeding the whole assembly, are connected and soldered on the PCB 1, at the input of the circuit 2. The resistor 12 connects in parallel to the input of the circuit 2.

[0114] In this embodiment, the pins soldered on each branch of the circuit 2 having the same polarity, are interposed with branches of the circuit 2 having opposed polarity. Also the pins of one polarity are aligned parallel on both sides of the ci rcuit branches with opposing polarity, but with an offset, in such a way that each pin of one polarity is approximately surrounded at the closest proximity, with pins of opposing polarity. The layout of the pins is a square or a rhomb.

[0115] FIG. 3 represents an alternative embodiment of the layout of the pins 4 on the PCB 1, and the connecting circuit 2. The main layout unit of the pins 4 is a hexagon, where there is a pin at each corner of the hexagon, connected in such a way by the circuit 2, that when the pins are electrically excited, each pin of one polarity is surrounded by the three closest proximity pins having opposite polarity. [0116] It is clear for those skilled in the art, that other possible alternative embodiments are possible, without departing from the scope and spirit of this invention.

[0117] FIG. 4 presents in more detail the layout presented in FIG. 3 and specifically the electric field pattern and the electric field interaction between the pins 4, and the other components of the telomeric resonator, from a top view of the PCB 1 board .

[0118] The two electrical conduits feeding the telomeric resonator, Conduit 1 and 2, have alternate pulsed polarities. Let's take a point in time where conduit 1 is polarized "+" and

Conduit 2 is polarized The branches of Conduit 1, are B, D and F, are all polarized "+", and all the pins soldered on these branches Bl, B2, B3, Dl, D2, D3, D4, Fl, F2 and F3 are polarized "+" as well.

[0119] The branches of conduit 2 are all polarized Branches A, C, and E, and the pins solders on these branches, Al, A2, A3, A4, CI, C2, C3, El, E2, E3 and E4, are all polarized "-" (minus) as well.

[0120] Let's take one particular pin, for example C2 and analyze what happens there. In this example the conduit 2 feeding the telomeric resonator is shortly polarized with "- "(minus), therefore, the conduit C is polarized and all the pins on conduit C, including C2 is polarized Around pin C2, there is an electrical field, surrounding the C2 pin radially, and upwards. In this example we will analyze what happens with the radial electrical field, from a top view of the PCB 1. The G vectors pointing radially from C2 represent the line of force of the electrical field created around the C2 pin.

[0121] The pins in the most proximity to C2, are pins B2, D2 and D3, all polarized with the "+" in this point in time, that is the opposite polarity of the pin C2. The opposite polarity of the most proximity pins surrounding pin C2 will increase the intensity of the electrical field around C2 to the maximum level, available by this configuration. The radial component of

[0122] the electrical field surrounding C2, shown in FIG. 4 by the electrical lines of force G, and the lines of equal field intensity H, is quasy-circular, and for a given excitation voltage feeding the two conduits of the telomeric resonator, such a pattern creates the highest possible intensity of the radial component of the electric field around the pins 4. [0123] One of the features of the design presented in this invention, is to create a maximum intensity of the radial component of the electrical field surrounding each pin, while getting the maximum effect as a whole, for the entire board PCB 1. This is achieved by choosing a layout of the pins and energizing electrically the pins in such a way, that each pin polarized by one polarity, has the surrounding pins in the closest proximity being polarized with the opposite polarity.

[0124] It is clear for those skilled in the art, that this pattern of the electrical field, and the maximization of the intensity of the radial electrical field of each pin, is repeated for the pins having the opposite polarity, and for every pin of this device, except the pins at the edge of the device, where the symmetry is broken.

[0125] Also, this effect is the same for other embodiments, like the one explained in FIG. 2, or other similar embodiments or changes that are not described here, but should be understood by those skilled in the art, without departing from the scope and the teachings of this invention.

[0126] The enclosure of the telomeric resonator, and all the space on the top of the PCB 1 and the space between the pins 4, is filled with crushed piezoelectric crystals, like quartz, or any other good quality crushed piezoelectric crystal grains. Therefore, all the pins 4 are all surrounded by the grains of different sizes of the crushed piezoelectric crystals. The size of the crystal grains is between Ο.ΐμιη and 0.1 m, preferable between Ιμιη and 0.02m and most preferable between ΙΟμιη and 1 cm. The mix of crushed crystals have a uniform and continuous distribution of all the sizes of grains, from the smallest to the largest.

[0127] FIG. 5 represent a small view of a vertical section of the telomeric resonator. The PCB 1, has the upper layer 2 that feeds electrically the pins 4 soldered on the layer 2 with the soldering 5. The bottom layer 3 of the PCB 1 sits tightly on the bottom 8 of the enclosure. The top tips of the pins 4 have a very sharp ending 18. The pins are surrounded by the grains of crushed piezoelectric crystal grains 6, like crushed quartz. The top part of the enclosure 7 is at some distance from the tips 18 of the pins 4. [0128] For a better explanation, in FIG. 5, only three pins are represented. As explained above, one pin 4 is always polarized with the opposite polarity of the closest proximity surrounding pins. In this figure, the center pin is polarized with the opposite polarity of the pins on the sides. For this reason, the electric field G created between the pins, is radial from the axis of the pins 4.

[0129] The grains of crushed quartz 6 that are located between the pins 4 are stimulated by the short spikes of the radial electric field between the pins, as shown in FIG. 9. The short spike of the electrical field G excites every grain of piezoelectric crystal with a short impulse and it electrically energizes each crystal grain. The piezoelectric crystal grains 6 have a high Q

[0130] factor, which is the capacity of the crystal to continue amortized oscillations, after the exciting impulse have been removed. Each grain of crystal will continue to self-oscillate until the oscillation are fully and naturally amortized. During this oscillation process, each grain of crystal will generate an electromagnetic wave and a mechanical vibration, having the frequency depending of, mostly, by the size of the crystal grain, and also by the piezoelectric properties of the crystal.

[0131] Since the grains of the crushed piezoelectric crystals 6 filling the telomeric resonator have a large and uniform distribution of sizes, the resulting mix of frequencies will cover an ultra-wide band of electromagnetic frequencies and mechanical-ultrasonic spectrum of vibrations. The size range of crystal grains are chosen in such way, so the frequency range covers the resonant frequency range of the chromosomes, the telomeres and the DNA.

[0132] The signal used to drive the telomeric resonators is represented in FIG. 9. The signal is composed of very short pulses of alternating polarity, with the ideal pulse being as close as possible to a Dirac impulse. The repeating frequency of the pulses is between 100 Hz and 1 GHz, preferable between 1 KHz and 500 KHz, and most preferable between 10 KHz and 100

[0133] KHz. The voltage of the signal can be between O.lv to 50Kv, preferable between IV and 1KV, and the most preferable between 10V and 200V. The duration of each pulse is between 0.01 nanoseconds to 1 millisecond, preferable between 0.1 nanosecond to 100 nanoseconds, and the most preferable between 1 nanosecond to 10 nanoseconds. [0134] A good comparing example of the basic generation of an electromagnetic wave and a ultrasonic vibration from each grain of piezoelectric crystal that happens inside of the telomeric resonator, is the mechanical poking of a crystal glass. After the poking, the glass will continue to vibrate and generate an amortized sound, for a period of time. The tone of the sound is determined by the size or the dimensions of the crystal glass - the smaller the glass, the higher the pitch (or the frequency). The tone is also dependent of the mechanical properties of material the glass is made of.

[0135] In a similar mode, in this invention, the equivalent poking of each grain of piezoelectric crystal, is made electrically, by the very short electrical impulse, as being described in FIG. 9, being applied to the pins 4 of the telomeric resonator device. Because of the specific arrangement of the pins 4 described by this current invention, the radial

[0136] electrical field G created between them have the maximum possible intensity, as a whole, taking the surface of the whole PCB board 1. This short pulse of electric field will energize electrically each grain of crystal. After the disappearance of the field, the crystals will continue to oscillate, each one on its own frequency, until the oscillations amortize

[0137] naturally. The best results are achieved by using high quality natural or cultured piezoelectric quartz or other piezoelectric crystal, with good Q factor, higher than 10⁵, preferable higher than 1 x 10⁶ and most preferable higher than 3 x 10⁶. The crystal grains must have good piezoelectric properties, and have the grain sizes of a wide and uniform variety of sizes, between 10 cm and 0.001 nm, preferably between 2 cm and 0.001 mm, and most preferable between 1 cm and 0.01 mm.

[0138] The excitation of all the crystal grains inside the telomeric resonator, with the very short electric pulses, has a result that all the crystals 6 will start to self-oscillate, both electrically and mechanically, each one on its own resonant frequency. The oscillation will decay in time, with each oscillation, and after a period of time, they will stop. The sum of all

[0139] the oscillations, makes the ultra-wide band of frequencies generated by each telomeric oscillator. Because the size of the crystal grains is relatively uniform distributed in the whole mass of crushed crystals 6 filling the telomeric resonator, the result is that the spectrum of the frequencies generated is relatively uniformly distributed across the ultra- [0140] wide electromagnetic band generated by the device. In a similar way, the spectrum of mechanical vibrations generated by the whole mass of crushed crystals filling the telomeric resonator, is relatively uniformly distributed across the ultra-wide band of ultrasound vibrations generated by the device. Because the orientation of each crystal grains is random inside of the telomeric resonator, the sum of all electromagnetic oscillation will be relatively evenly distributed in all directions.

[0141] The spectrum of uniform intensity electromagnetic frequencies generated by the telomeric resonator, mostly by the mass or crushed crystals, is between 100 KHz to 10 GHz, preferable between 1 MHz to 1000 MHz, and most preferable between 100 MHz to 1000 MHz, depending mostly by the size range of the crystal grains, and the piezoelectric properties of the used crystal.

[0142] The layers 2 and 3 of the PCB1 act as a reflector for the electromagnetic waves generated by each crystal grain in particular, and by the whole mass of crystals inside the telomeric resonator in general, thus increasing the intensity of the electromagnetic waves generated in the directions of the pins 4, which is the active side of the device, facing the user, like in the embodiment presented in FIG. 7.

[0143] The pins 4 are made from a conductive material, like most metals, stainless steel, brass, titanium, or a conductive composite, preferable coated or electroplated with silver or gold. The outer tips - (the top tips) 18 of the pins 4 are very sharp. When each pin is energized electrically with the short electrical impulse, the very sharp point 18 at the tip of

[0144] each pin 4, creates a very high intensity of the electrical field in the area surrounding the sharp tip 14, much higher than the intensity of the electrical potential G applied between the pins. The local lines of electrical field vectors E generated by the sharp tips 18 are exemplified in FIG. 5. Unlike the electrical field G generated between the pins 4, which is predominantly radial, the electrical field E generated at the tips 18 of the pins, is

predominantly longitudinal, mostly along the direction of the pins. [0145] Because of the sharpness of the tip 18 of the pins 4, the local intensity of the electric field in this area E is much higher than the intensity of the radial electrical field G between the pins - a well-known effect in the electrical science. If the tips 18 of the pins 4 are sharp enough, a localized Corona effect will happen in the close proximity area of the sharp tip 18 of each pin 4. That is a very strong local electric field E, surrounding the tip 18 of the pins 4, as being described in FIG. 5.

[0146] For this reason, the crystal grains 6 located in this area E, around the tip 18 of each of the pins 4, are stimulated even stronger than the crystal grains located between the pins. The principle of electrical poking effect on the crystals is the same in this area E, but with much higher energy and efficiency around the sharp tips 18 of the pins 4, than the effect in the G area, between the pins 4.

[0147] The very high intensity of the electrical field around the tips 18 diminishes after a certain radius from the tip 18 of the pins. However, the effect of higher intensity of electrical field around a sharp tip, is a better way to amplify the overall efficiency of production of a wide range of electromagnetic and ultrasound waves. It means that, indirectly, a lower voltage can drive the telomeric resonator, making the whole device and system much efficient, much safer for the usage, and using less energy.

[0148] The electromagnetic waves 15 generated by the piezoelectric oscillation of the crystals 6 are shown in FIG. 5. The ultrasound vibration generated by the piezoelectric oscillation of the crystals are marked as 16 in the same FIG. 5.

[0149] Another key benefit of using the corona effect of amplifying the electrical field at the sharp tip 18 of the pins 4, and subsequently, amplifying the generation of the ultra-wide band of electromagnetic and ultrasound waves, is the fact that the voltage of the pulses required to drive the telomeric resonator, is much smaller. A much smaller voltage means higher safety for the users of this device and the avoidance of electrocution hazard, or electric shocks, and it means also lower energy to drive the device.

[0150] The layer 3 of the PCB 1 has imprinted a flat concentric set of circle arcs or arc segments, as presented in FIG. 6, with an angle offset from each other, which makes a novel wide-band resonator, generating a second spectrum of electromagnetic frequencies. This spectrum has a quasi-uniform distribution of intensity on the whole range of the spectrum,

[0151] tuned on the DNA resonance spectrum of frequencies, that is between 50 GHz to 80 GHz for humans, or about 30 GHz to 70 GHz for animals. The DNA has piezoelectric properties, so activating the DNA with its resonant frequencies has a resetting, rejuvenating and anti-aging effect. This second spectrum of electromagnetic frequencies 15 generated by

[0152] the layer 3 of the PCB, combine with the first electromagnetic spectrum of frequencies generated by the mass of crushed crystals 6. Together, they are generating an ultra-wide band and spectrum of frequencies, between 100 to 1000 MHz for the resonance of the chromosomes and the telomeres, and the 50 to 80 GHz spectrum for human DNA resonance, or 30 GHz to 70 GHz for animals.

[0153] Adding to this, the device generates a wide spectrum of uniform intensity ultrasound vibrations, just right for this biological application, necessary for the mechanical- vibrational resonance of the chromosomes and the telomeres. Depending of the size of the device and the chosen sizes of the crystal grains, the spectrum of ultrasound frequencies generated, are between 100 KHz to 10 GHz, preferable between 1 MHz to 1000 MHz, and most preferable between 100 MHz to 1000 MHz.

[0154] The arc segments of layer 3 are made of the conduit pattern designed on the surface of the PCB 1, usually made of copper or other highly conductive material, and it can be coated or electroplated with a top layer of silver or gold for a better conductivity at higher frequencies.

[0155] The layer 3 of the PCB 1 is shown in FIG. 6. Each concentric circle or closed loop is divided in three arcs at about 120° from each other, forming three arc segments, like one of the outer arc segments 20. The next inner loop is divided the same in three parts, but with a circular offset of 60° from the outer loop. The three one-third coils are coupled together at

[0156] the ends by the capacitance 19 formed between the ends. The outside one-third loops 20 and 21 are couple inductively and capacitively with the inner one-third lops, and so on. When stimulated with very short pulses at the two inputs the whole oscillator generates a wide spectrum of frequencies, with relative uniform intensity distribution in the range of this spectrum, which is in the high, human DNA resonance spectrum of 50 GHz to 80 GHz, or about 30 GHz to 70 GHz for animals.

[0157] Compared with the classic Lakhovsky coil, the current design moves the whole band of frequencies higher than the Lakhovsky design, by multiplying the band of frequencies, depending mostly on the number or arc segments on each circle, and the gap size and distance between the arc segments.

[0158] One major advantage is the fact that the resonator on the layer 3 gets activated not only from the driving signal, but also from the electromagnetic waves generated by the mass of piezoelectric crystal grains. Being in the close proximity of the mass of crystal grains, this additional activation enhances even more the spectrum of electromagnetic radiation generated by this wide spectrum oscillator.

[0159] Yet another advantage of this design is the fact that the circuit of layer 2 supporting the pins 4, and the resonator of layer 3, are coupled not just galvanic, at the input of the device, through the wires 14, but also capacitively and inductively. Since both circuits 2 and 3 are excited both synchronously in phase, this coupling generates even more frequencies and harmonics, contributing to the overall electromagnetic spectrum of frequencies, and to the efficiency of generation.

[0160] Another advantage is the fact that the resonator on the layer 3 acts also as an active reflector for the electromagnetic waves 15 generated by the mass of crushed quartz. First, these waves get reflected back, towards the active side of the telomeric resonator device. Second, the waves 15 stimulate farther the layer 3 resonator, having an active role in the excitation of the resonator and its level of efficiency.

[0161] Since the location of this wide-band oscillator must be in the close proximity to the mass or piezoelectric crystal grains, there is another advantage in the fact that it is very easy to implement on the same PCB board, because there is anyway at least one extra PCB layer available for this purpose. [0162] It is very clear for someone skilled in the a rt, that more embodiments of this design presented in FIG. 6 are possible, where each loop is divided in four, or five, or a plurality of arc segments, with the a rc segments of the next inner loop having a n angular offset from the outside loop, with an angle such that the gap of the two endings of two inner arc segments is positioned on the midd le of the outer arc segment. Such embodiments would ma intain the teachings of the original design concepts and embod iments presented in this invention.

[0163] Also in other embod iments, it is possible to have a plurality of layers 3 stack on the top of each other, each one having one or more of such designs, and still maintain the principle and spirit of the current invention.

[0164] Such embodiments maintain the current principles of functioning and the design described by this invention, and they should be understood by those skilled in the art that various changes may be made and equivalents substituted for elements thereof without departing from the scope of the invention. I n addition, many mod ifications may be made to

[0165] adapt a particula r situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is i ntended that the invention not be limited to the particular embod iments d isclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embod iments falling within the scope of the appended claims.

[0166] The electromagnetic spectrum of waves 17 that are generated by the multiband oscillator of layer 3, of the PCB 1, are presented in FIG. 5. This spectrum 17 combines together with the wide electromagnetic spectrum of waves 15 generated by the

piezoelectric crystal grains 6. Additionally, the electric signa l that feeds the telomeric resonator, has very sharp fronts, both rising and trailing, and therefore, this signal is very rich in high freq uency harmonics, that add up to the overall ultra-wide band of electromagnetic spectrum generated by the other components of the telomeric resonator.

[0167] All the ultra-wide spectrum of electromagnetic frequencies have the effect of inducing electromagnetic bio-resonance at the chromosomes, telomeres and the DNA level, having a rejuvenation effect on the body in general, and on the chromosomes and the telomeres in particular, extending the length of the telomeres, stimulating the catalytic activity of telomerase, and generating a strong overall anti-aging effect.

[0168] Also, the wide spectrum of ultrasound waves 16 ( FIG. 5) induce mechanical- vibrational resonance on the chromosomes and the telomeres, again, having a strong rejuvenation on the chromosomes and the telomeres, stimulating the catalytic activity of telomerase, extend ing the length of the telomeres, and a strong overall rejuvenation and anti-aging effect.

[0169] The telomeric resonators described above, must be used at a relative close proximity to the body of the person or animal using them. Especially the ultrasonic vibrations get attenuated very quickly in the air with the distance.

[0170] The rejuvenation and anti-aging outcome of induced bio-resonance on the chromosomes and telomeres, has the maximum effect during sleep time, at night time, when the body goes through the maximum regenerative process. Also, the effect is somehow effective too, at rest times or nap times.

[0171] For these reasons, one possible application of the telomeric resonator device presented in this invention, is the system presented in FIG. 7. The system proposed here, utilize a plurality of telomeric resonators as described above, imbedded in a user friendly format device, like a blanket or duvet device.

[0172] A plurality of telomeric resonators 23 a re embedded in the bla nket or d uvet device 24, which is part of the overall anti-aging system. The blanket or duvet 24 is used by the users d uring the sleep time or rest time, being covered with it. All the telomeric resonators 24 a re connected together in parallel with the very flexible conductors 25, which is part of a

[0173] multi-line conductor cable. The embedded telomeric resonators 23 are set-up inside the blanket 24 in such a way that the all of them face the same d irection, facing one side of the blanket 24, which is the active side, facing the user. The active face of the telomeric resonators is the one with the pins, and the cover 7 of the enclosure.

[0174] When the electric signal generated by the controller apparatus 28 gets a pplied to all telomeric resonators that are embedded and part of the blanket 24, the body of the user gets immersed in a bath of ultra-wide spectrum of ultrasound and electromagnetic waves, tuned to resonate with the chromosomes and the telomeres of the cells, and the DNA, thus supporting the telomere rejuvenation, stimulating the catalytic activity of telomerase, stimulating the elongation of the telomeres, and slowing down, stopping and reversing the biological clock of the body.

[0175] The blanket 24 may also be embedded with a plurality of infrared and far infrared LEDs, that together, generate an electromagnetic spectrum between 600 nm to 2000 nm, preferable between 700 nm to 1800 nm, and most preferable between 800 nm to 1500 nm, which is the resonant electromagnetic spectrum of the chromosomes. This would provide even more support to the rejuvenation of the chromosomes and the telomeres supporting and improving the overall anti-aging performance of the system as a whole.

[0176] The whole system can be used during the relaxing periods of time during a day, but most preferably and being the most effective is during the sleep at night time, because this is when the body goes through the most regenerative period of the day.

[0177] The cable 25 connects with all the telomeric resonators embedded in the anti-aging blanket 24, and with the other possible components, like the far-infrared LEDs. From the blanket and the connecting cable 25, there is one multi-conduit cable 26 that has a connector 27 at the end, which connects into the driving apparatus 28.

[0178] The driving apparatus 28 generates the electrical signal as presented in FIG. 9 required by the telomeric resonators 23, and for the other possible supporting components of the blanket 24. All these signals are driven through the cable 26.

[0179] Other possible applications and embodiments are possible and understood by those skilled in the art. For example, the telomeric resonator device could be used stand-alone, or a plurality of devices could be grouped together in panels, chair covers, therapeutic pads, or in other forms or systems. Various changes may be made and equivalents substituted for

[0180] elements thereof without departing from the scope, the spirit and the teachings of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed here as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the appended claims.

[0181] The device 28 is the main controlling apparatus, generating the electrical signals that drive one or more telomeric resonators, or other possible systems and embodiments as the one presented in FIG. 7.

[0182] The controlling apparatus 28 is composed of the following logical blocks, as presented in FIG. 8. The main control processing unit is designed around a microcontroller CPU 29, the real time clock RTC 31, the memory module 32 holding the software and the data, the serial port 33 used for external communication, sensors 34, an interactive touch

[0183] screen 35, used for the graphical user interface, a module 36 to process the keys and buttons interfacing with the user, a sound module 37 for generating complementary of sounds, music and alarms, a signal generation board 38 that generates the signals sent to the devices or the systems comprising telomeric resonator devices, connected through the connecting jack 39. Also, the control apparatus 28 has a power supply 41 that feeds all of the other modules described above.

[0184] The signal generation module 38, receives the signal generation commands from the main CPU module 29 (in FIG. 8) through the signal command bus 42. This bus contains signal generation commands in the form of a communication protocol, to control the signal driving the telomeric resonators, and possible other supporting devices and systems. The

[0185] signal command bus 42 provides commands for the start and stop of each signal, enable commands, and other parameters like the polarity, number of pulses on each polarity, pulsed width modulation parameters, frequency of the signals, the modulating frequencies and bursts duration, and other possible parameters. In turn, it generates the basic electric signal that is represented in FIG. 9.

[0186] The signal that drives the one or more telomeric resonators, has a frequency between 100 Hz and lGHz, preferable between 1 KHz and 500 KHz, and most preferable between 10 KHz and 100 KHz. The voltage of the signal can be between O.lv to 50Kv, preferable between IV and 1KV, and most preferable between 10V and 200V. The shape of

[0187] the signal, as presented in FIG. 9 is very short in duration, and very sharp, with a fast raising and fast trailing fronts. The duration of each pulse is between 0.01 nanoseconds to 1 millisecond, preferable between 0.1 nanosecond to 100 nanoseconds, and the most preferable between 1 nanosecond to 10 nanoseconds.

[0188] The signal is delivered through the output bus, to the fixed connector 39. The output signal is relatively high in voltage, but with relatively small current. The signal generator board 38, for driving the telomeric resonators 23, has a sub-module 40 for detecting if the load made of the network of telomeric resonators 23, has a short circuit, or a local or general interruption of the circuit.

[0189] If the module 40 detects any of these situations, it sends an alert signal back to the main CPU unit 29, through the communication bus 42. If such an alert occurs, the bus 42 will inform the CPU 29 and the controlling apparatus 28 will display this fault on the main touch screen 35.

[0190] Prior to using the system and the apparatus, the user will configure the apparatus 28 by entering a number of parameters, like the wake-up time and the start and stop time of the telomeric resonators 23.

[0191] Also, other parameters may be entered during the configuration phase, like the intensity of each function, the level of modulation, the driving frequencies, and other possible parameters.

[0192] When the user goes to rest or sleep, he or she will push the "START" button of the apparatus 28. This action will initiate the apparatus 28 to run the sequence of activation of the components 23, based on the configuration preferences introduced by the user at the initial configuration time. The apparatus 28 can start and stop the telomeric resonators 23, or other supporting devices or components of the system, or some of them or all of them, at the same time, or in sequence, or in overlapped sequences, depending of the preferences of the user, or the prescribed sequence of activation, from a specialist. [0193] All sequences of activation will stop when the user wakes up, since this information is known by the apparatus 28 d uring the initialization a nd setup time. Also, the user can stop all the sequences of activation, upon pressing the 'STOP" button of the apparatus 28.

[0194] The apparatus 28 can receive and upload custom sequences, designed and prescribed for example by specialists. Such custom programs can be customized for different situations, like the age and condition of the user, or other possible affections. They can be sent on-line, like by email, or downloaded over internet, and it could be uploaded into the apparatus 28, using the serial communication port 33 of the apparatus.

[0195] A number of other features are built and programmed in the functionality of the controlling apparatus 28, like security mechanisms, privileges and access levels, fault a nd ala rm annunciation, history logging, networking with other measurement and diagnostic devices and integration with other systems.

[0196] TH E BEST MODE FOR CARRYI NG OUT TH E I NVENTION

[0197] The best way to make the PCB 1 of the telomeric resonator presented in FIG. 1 is from a two layer or a multi-layered printed circuit board (PCB). Both, layer 2 and layer 3 a re made from electrolytic copper, electroplated or coated with silver or gold .

[0198] The pins 4 (FIG. 1) are made of stainless steel, or brass, preferably plated with silver or gold . The pins 4 are soldered on the layer 2 of the PCB with normal solder.

[0199] The piezoelectric crystal grains 6 (FIG. 1) are best made of crushed piezoelectric quartz, that can be from natural sources or cultured qua rtz for the electronics industry. In either case, the q uartz should have a Q factor equal or better than 10⁶ for best results. The crystal grains should have a wide and uniform variety of sizes, between 0.001 mm and 10 cm, preferably between 0.001 mm and 2 cm, and most preferable between 0.01 mm and 10 mm.

[0200] The two parts, top 7 and bottom 8 of the enclosure of telomeric resonator ( FIG. 1) can be best made using a typical plastic injection technology, using plastic materials like polycarbonate (PC) or ABS plastic, or fiber-glass-reinforced ABS.

[0201] The best cables 14 that can be used (FIG. 1) are very flexible, made of thin multi- stranded cond uctors, insulated with a silicon based insulator, for maximum possible flexibility.

[0202] The telomeric resonator gives the best results when it's excited with a pulsed electric signal of very short and repeating pulses, having fast raising fronts and fast decaying trails, having frequencies between 100 Hz and lGHz, preferable between 1 KHz a nd 500KHz, and most preferable between lOKHz and lOOKHz. The voltage of the signal ca n be between

[0203] O.lv to 50Kv, preferable between IV and 1KV, and most preferable between 10V a nd 200V. The shape of the signal is very short in d uration, and very sharp, with a fast raising and fast trailing fronts. The duration of each pulse is between 0.01 nanoseconds to 1 millisecond, preferable between 0.1 nanosecond to 100 nanoseconds, and the most preferable between 1 nanosecond to 10 nanoseconds.

[0204] The best way to implement the bla nket, quilt, pad, chair cover or d uvet device 24 presented in FIG. 7, is by using multilayered textile fabric, like cotton or silk, filled with down, feathers, or a synthetic fiber like microfiber, depend ing on the desired thickness. The telomeric resonators 23 can be embedded between the layers of the fabric that make the blanket or d uvet 24.

[0205] Alternatively, the fabric of the blanket, pad, chair cover or d uvet 24, can have stitched pockets of fa bric inside, where the telomeric resonators 23 can be inserted. The pockets can be secured with stiches, with zippers or with Velcro tape. The blanket or duvet 24 can be inserted in a duvet envelope or d uvet cover, such way that the blanket 24 itself does not need to be washed after usage, only the d uvet cover.

[0206] Also the best way to implement the connecting ca bles 25 and 26 (FIG. 7), is with multi-stranded and flexible cond uctors, isolated with silicon insulation or other very flexible insulator. The cables are ran between the fabric layers of the blanket, pad, panel or cha ir cover 24, or other possible embodiment, preferable in such a way that is not noticea ble by the users. [0207] The best effect of rejuvenation and extension of the length of the telomeres and overall anti-aging results can be obtained when the user rests or sleeps, while having one or more telomeric resonators either in direct contact with the skin, or in very close proximity with the body, like using a blanket or pad as the one presented in FIG. 7. The

[0208] electromagnetic spectrum of frequencies generated by the telomeric resonator is relatively low power, which is in line with the power levels generally used by the Microwave Resonance Therapy technologies. For this reason, and in accordance with the same technologies, the application of the frequencies is done with the device either in contact with the body of the user or patient, or in very close proximity.

[0209] Also, the application of the ultrasound vibrations for bringing the chomosomes and the telomeres to mechanical resonance, for purpose of rejuvenation and extension of the length of the telomeres, has the best results when the telomeric resonator device or devices, are applied in direct contact with the body of the user, or in very close proximity. The

[0210] ultrasound vibrations generated by the telomeric resonator have a relatively high spectrum of frequencies that do not propagate well through the air. For this reason, the one or more telomeric resonators that are part of the application or the therapeutic system, should be either in contact with the body of the user or patient, or in very close proximity, like in the embodiment presented in FIG. 7.

[0211] While the invention has been described with reference to a particular embodiment, it should be understood by those skilled in the art that various changes may be made and equivalents substituted for elements thereof without departing from the scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiments disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments falling within the scope of the appended claims.

Claims

CLAIMS I claim:

1. A device for generating electromagnetic frequencies and ultrasound vibrations related to microwave resonance therapy and increasing the length of telomeres, comprising: a printed circuit board, with two or more circuit layers;

a resistor connected electrically in parallel at the input of the circuits of the printed circuit board;

a plurality of metallic or conductive pins with sharp tops, welded or soldered on the circuit layer of one side of the printed circuit board, in such a pattern that when this circuit is electrically activated, each pin energized with one polarity is surrounded by, at the closest proximity, by pins having the opposite polarity;

a flat electric circuit pattern, printed on the other layer or layers of the printed circuit board, made of a plurality of conductive and concentric arc segments separated by gaps, where each arc segment has an angular offset from the near interior or exterior arc segment, equal to half or more of the angle of the arc segment;

a quantity of mixed particulate grains of piezoelectric crystals, having a wide, uniform and continuous range of grain sizes, filling all the space between the conductive pins and covering the sharp tops of the pins;

an enclosure made of electric insulation material, hosting inside the printed circuit board with dual or multiple circuit layers, the resistor, the conductive pins with sharp tops, and the mass of particulate grains of piezoelectric crystals, the enclosure having inside a plurality of studs, side click hooks, and a housing compartment for the entrance of the wires;

electric wires connecting the circuits on the printed circuit board, used for driving the device with electric signals;

2. The device of claim 1, wherein the generated electromagnetic oscillations make a uniformly distributed spectrum of frequencies, and the generated ultrasound vibrations make also a uniformly distributed spectrum of frequencies.

3. The device of claim 1, wherein the driving electrical signal is made of very short and repeating pulses of alternant polarity, having the voltage of the signal higher than IV, the pulse duration less than 100 nanoseconds, and the frequency higher than 100 Hz.

4. A method for generating electromagnetic frequencies and ultrasound vibrations related to microwave resonance therapy, and extending the length of telomeres, comprising: causing an electric circuit to produce short pulses of alternate polarity, wherein the circuit drives a plurality or conductive pins, connected in a pattern wherein each pin of one polarity is surrounded, at the closest proximity, by pins of the opposite polarity, wherein the sharp tops of the pins generate a n electric corona effect;

a mass of piezoelectric crystal grains, with different grain sizes, having a uniform and continuous distribution of grain sizes, filling the space between the pins and the top of the pins, wherein the mass of piezoelectric crystal grains is electrically driven by the electrostatic field of the pins, and excited to oscillate and generate a wide and uniform first spectrum of electromagnetic frequencies and a wide and uniform spectrum of ultrasound vibrations;

an electric circuit made of a plurality of conductive concentric arc segments separated by gaps, where each arc segment has an angular offset from the near interior or exterior arc segment, equal to half or more of the angle of the arc segment, wherein this circuit is set in close proximity to the mass or piezoelectric crystal grains, wherein this circuit is primarily driven by the same pulses of alternate polarity driving the pins, generating a second wide and quasi-uniform spectrum of electromagnetic frequencies, and wherein the electromagnetic oscillations of this circuit are farther stimulated by the

electromagnetic oscillations of the mass of piezoelectric crystal grains.

5. The method of claim 4, wherein:

- the first continuous and uniformly distributed electromagnetic spectrum has frequencies from about 100 KHz to 10 GHz, preferable from 1 MHz to 1000 MHz, and most preferable from 100 MHz to 1000 MHz;

- the second quasi-continuous and uniformly distributed electromagnetic spectrum has frequencies from about 50 GHz to 80 GHz;

- and wherein the spectrum of continuous and uniformly distributed ultrasound vibrations has frequencies between about 100 kHz and 10 GHz, preferably between 1 MHz and 1000 MHz, and most preferably between 100 MHz and 1000 MHz.