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WO2016097427A1 - Composition d'émollient naturel - Google Patents

Composition d'émollient naturel Download PDF

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Publication number
WO2016097427A1
WO2016097427A1 PCT/EP2015/080896 EP2015080896W WO2016097427A1 WO 2016097427 A1 WO2016097427 A1 WO 2016097427A1 EP 2015080896 W EP2015080896 W EP 2015080896W WO 2016097427 A1 WO2016097427 A1 WO 2016097427A1
Authority
WO
WIPO (PCT)
Prior art keywords
emulsion composition
skin
emollient
oil
emollient emulsion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2015/080896
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English (en)
Inventor
Paul Ryan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2016097427A1 publication Critical patent/WO2016097427A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/33—Free of surfactant

Definitions

  • the invention relates to emollient emulsion compositions, and uses thereof in the topical treatment of human skin.
  • emollients available in the marketplace that are designed to increase the skin's appearance and/or hydration content. These products typically include large numbers of complex ingredients to ensure that the product delivers one or more of the following functions, hydration, water loss reduction, improve appearance, pleasant sensory experience and ensure product through life stability.
  • Some ingredients utilised to formulate the emulsion are skin sensitising agents that can have short and long term negative impact to the skin. Examples include Sodium Lauryl Sulfate (or other emulsifiers), stabilisers and perfumes.
  • ingredients added to address a specific skin defect such as blemishes, wrinkles, blotches, laxity and pigmentation or to address the general effects of aging.
  • these ingredients facilitates particular claims on pack, e.g., 'anti-wrinkle', 'skin brightening cream' and 'visibly younger skin in just seven days'.
  • Retinol (form of vitamin A): Reduces fine lines and pores
  • Epidermal Growth Factor (low-molecular- weight polypeptide): stimulates cell renewal and collagen protection to reduce fine lines, wrinkles and sagging
  • Peptides acts of a signal to the skin that it needs to produce more collagen. More collagen counters the skin aging process. In many cases the benefits of these large ingredient based creams are limited to cosmetic and have no impact on the health of the skin. In fact a significant number can damage the skin, can aggravate and in some cases cause skin sensitisation and conditions such as eczema.
  • US2014/0328774 describes an oil-in-water emulsion skincare composition comprising 2-15% silicone particles, 3-25% oil, 0.1-5% emulsifier and 30-90% water.
  • US2005/0053634 describes talc-containing cosmetic cleansing emulsions that contain surfactant for the purpose of cleaning the skin, and having no skin hydration function.
  • WO2014184228 describes cosmetic compositions comprising a natural organic oil and about 2% by weight of porous crosslinked polymethylmethacrylate beads having a particle size (Dso) of 6-15 ⁇ .
  • an effective emollient composition that has a non-greasy skin- feel and can effectively hydrate the skin can be provided using as few as three ingredients and in the absence of convention skin sensitizing emulsifiers and stabilising agent.
  • the three ingredients are liquid paraffin or a natural oil (for example a vegetable oil or a mineral oil) provided in about one part, water provided in about two parts, and a minor amount of an acrylate gelling agent.
  • the acrylate gelling agent when mixed with the water, forms a polymeric matrix or lattice that helps emulsify the oil phase when added into the gel, promotes formation of small oil droplets, and stabilises the formed oil-in-water emulsion.
  • the invention provides an emollient emulsion composition
  • an emollient emulsion composition comprising (or consisting essentially of) about one third oil, about two thirds water, a minor amount of a water soluble acrylate gelling agent, and optionally a suitable preservative.
  • An emollient emulsion composition according to the invention provides a stable, oil in water, emulsion that provides a non-greasy sensory feeling when applied to the skin and that can be prepared without conventional emulsifiers or stabilising agents.
  • the composition can be prepared with as few as three ingredients using uncomplicated processing methods.
  • the invention also provides a method of making an emollient emulsion composition comprising mixing about one part water with a minor amount of an acrylate-based gelling agent to solubilise the gelling agent and form a gel, and adding oil to the gel with application of shear forces to form the emollient emulsion composition.
  • the term "emollient emulsion composition” means a cream comprising an oil- in-water emulsion that is suitable for application to the skin of a human and is capable of hydrating and moisturising the skin, preventing or inhibiting dry skin, or increasing the elasticity of the skin.
  • the term "about one third" as applied to the oil means 30-40% of the composition (v/v).
  • the term "minor amount” as applied to the water soluble acrylate gelling agent means about less than 3%, typically about 0.2 to 2% of the composition (v/v).
  • water soluble acrylate gelling agent means a gelling agent comprising optionally cross-linked, optionally modified, acrylate or polyacrylate groups that is soluble in water in amounts of up to 3% (w/v).
  • the gelling agent is provided as a powder having a D50 particle size of less than 1 ⁇ .
  • the gelling agent is an alkyl acrylate crosspolymer.
  • the gelling agent is a C10-C30 alkyl acrylate crosspolymer.
  • alkyl acrylate crosspolymers include EDT2020, Ultraz20, Ultraz21 and Pemulen TRl.
  • additional water soluble acrylate gelling agents include ARONVIS, JUNLON, RHEOGIC.
  • the term excludes gelling agents in bead form.
  • oil means an oil of vegetable or non-vegetable origin. Examples are provided below.
  • the oil comprises or consists essentially of liquid paraffin.
  • suitable preservative means a preservative commonly used in emolient or moisturiser composition. Examples will be known to the person skilled in the art and include sodium benzoate and benzalkonium chloride. Other examples are provided below.
  • the composition comprises less than 0.2% preservative (w/v). In one embodiment, the composition comprises less than 0.2%, 0.15% or 0.1% preservative (w/v).
  • the composition does not include an emulsifier.
  • the composition comprises or consists essentially of:
  • a preservative at less than 0.1%
  • fragrance/perfume less than 0.1%
  • the composition comprises or consists essentially of:
  • fragrance/perfume optionally a fragrance/perfume.
  • the composition comprises or consists essentially of:
  • a preservative at less than 0.1%
  • the composition comprises or consists essentially of:
  • a preservative at less than 0.1%
  • fragrance/prfume optionally a fragrance/prfume
  • the oil is a mineral oil.
  • the composition comprises 30-36% oil (v/v).
  • the composition comprises 31-35% oil (v/v).
  • the composition comprises 32-34% oil (v/v).
  • the composition comprises about 33% oil (v/v).
  • the oil has a viscosity of 50-500 centipoise (as determined using the method described below).
  • the composition comprises 0.5 to 1.5% water soluble acrylate gelling agent (w/v).
  • the composition comprises 0.5 to 1.0% water soluble acrylate gelling agent (w/v).
  • the composition comprises 0.5 to 0.75% water soluble acrylate gelling agent (w/v).
  • the water soluble acrylate gelling agent is a crosslinked acrylate copolymer.
  • the acrylate copolymer is a polyacrylic acid copolymer.
  • the crosslinked acrylate copolymer is hydrophobically modified.
  • the crosslinked acrylate copolymer is selected from ETD2020 (an example of cross linked polyacrylic acid copolymer), Ultrez20 or Ultra21 (examples of a hydrophobically modified cross linked acrylate copolymer).
  • the soluble acrylate gelling agent comprises a hydrophobic comonomer. Examples include PEMULEN TR1 and TR2.
  • the composition comprises no more than 6 ingredients.
  • the composition comprises no more than 5 ingredients.
  • the composition comprises no more than 4 ingredients.
  • the composition consists essentially of water, oil, water soluble acrylate-based gelling agent, and preservative, and optionally one or more of a colouring agent and a fragrance.
  • the composition is free of silicone particles.
  • the composition is free of surfactant.
  • the composition is free of talc.
  • the invention also provides a non-therapeutic method of treating the skin of a human to hydrate or moisturise the skin, the method comprising a step of administering an emollient emulsion composition of the invention topically to the skin.
  • the invention also provides a non-therapeutic method of treating the skin of a human to reduce the appearance of wrinkles, the method comprising a step of administering an emollient emulsion composition of the invention topically to the skin.
  • the invention also provides a non-therapeutic method of treating the skin of a human to increase the elasticity of the skin, the method comprising a step of administering an emollient emulsion composition of the invention topically to the skin.
  • the invention also provides a use of an emollient emulsion composition of the invention as an emollient for human skin.
  • the invention also provides a use of an emollient emulsion composition of the invention as a skin care product.
  • the invention also provides a method of making an emollient emulsion composition comprising mixing about one part water with a minor amount of an acrylate-based gelling agent to solubilise the gelling agent and form a gel, and adding oil to the gel with application of shear forces to form the emollient emulsion composition.
  • Fig. 1 Bar chart showing the rating of the six samples
  • Fig. 2 Bar chart showing values recorded for the parameters of firmness, consistency, cohesiveness and index of viscosity for the six samples analysed.
  • Fig. 3 Interaction plot of the variable factors: OC X PC; OC X PT; PC X PT
  • Fig. 4 Bar chart showing percentage weight loss upon drying; Sample size: 3.0 g; Temperature: 105 °C; Duration: 48 hours
  • Figs 5-10 show the TGA profiles of the semi-solid preparations evaluated; each sample was tested in triplicate.
  • the Y-l axis shows the percentage weight loss with increasing temperature, while the Y-2 axis expresses the derivative (with respect to time) data. It can be seen that the trends of weight loss with increasing temperature are reasonably reproducible for each product.
  • Figs 11-16 show the continuous flow plots produced for each of the semi-solids tested.
  • the X-axis displays Shear rate (s 1 ), the Y-l axis Shear Stress (Pa) and the Y-2 axis Apparent Viscosity (Pa.s).
  • the plots show considerable differences in the rheological profiles of the BHP product and the newly developed products compared with the commercial products tested.
  • the present invention is a skin cream composition composed primarily of water and oil blended together to create a stable oil in water emollient that delivers a non-greasy sensory experience when applied to the skin.
  • the only additional required ingredient is a small percentage, typically less than 2%, of a hydrogel.
  • the emollient locks the water onto the skin.
  • the oils are similar to oils found in the skin, and reduce water loss (moisture barrier) while simultaneously increasing the smoothness of the skin.
  • the water hydrates the skin, increases skin' s elasticity and prevents dry skin. Hydrated skin helps to keep skin younger as well as allowing skin to be brighter and more radiant.
  • the emollient contains either a single oil or a blend of oils to deliver unique sensory experiences.
  • the present invention relates to an emollient that provides improved skin moisturisation with a better sensory feel as a result of it being a different architecture to other available emollients.
  • the invention is directed to skin care formulations comprising a polymer formed lattice wherein there is dispersed oil droplets in an oil in water formulation. When applied to the skin the lattice network locks oil onto the skin.
  • the polymers may be made from a variety of materials and can include but are not limited to organic materials and inorganic materials. Examples of such materials include ETD2020 @ 0.6% w/v, Ultrez20 @ 0.6% w/v, Ultrez 21, PEMULEN polymeric emulsifiers such as TR1 or TR2, and the like.
  • An emollient is an oleaginous or oily substance which helps to smooth and soften the skin and may also reduce its roughness, cracking or irritation.
  • the oils used include organic and inorganic oils. These include but are not limited to mineral oils having a viscocity in the range of 50-500 centripoise (cps), lanolin oil, triglycerides and free fatty acids, cholesterol, phospholipids, ceramides, squalene, and phytosterol, colloidal oatmeal, bees wax, suitable preservative, cocoa butterhyaluronic acid coconut oil, cocoa butter, olive oil, almond oil, macadamia nut oil, aloe extracts such as aloe vera lipoquinone, synthetic jojoba oils, natural Sonora jojoba oils, safflower oil, corn oil, liquid lanolin, avocado oil, sweet almond oil, aloe vera extract, liquid paraffin, cottonseed oil, grapeseed oil, sweet almond oil and peanut oil and
  • compositions of the present invention may contain a wide range of additional optional components which can also include components generally known as botanical agents.
  • CTFA Cosmetic Ingredient Handbook Seventh Edition 1997 and the Ninth Edition 2002 particularly at page XV, which is incorporated by reference herein in its entirety, describes a wide variety of cosmetic and botanical agents and active ingredients commonly used in skin care compositions which are suitable for use in the compositions of the present invention.
  • Examples of these functional classes disclosed in this reference include: absorbents, abrasives, anti-caking agents, anti-foaming agents, anti-oxidants, binders, biological additives, buffering agents, bulking agents, chelating agents, chemical additives, colourants, cosmetic astringents, cosmetic biocides, denaturants, drug astringents, external analgesics, film formers, fragrance components, humectants, opacifying agents, pH adjusters, plasticizers, reducing agents, skin bleaching agents, skin conditioning agents (emollient, such as silicones, humectants, miscellaneous and occlusive), skin protectants, solvents, foam boosters, hydrotropes, solubilizing and emulsifying agents, suspending agents (nonsurfactant), sunscreen agents, ultraviolet light absorbers, SPF boosters, waterproofing agents and viscosity increasing agents (aqueous and non-aqueous).
  • absorbents e.g., abrasives
  • compositions which, when applied to human skin impart thereto an appearance similar to that achieved by exposing the skin to natural or artificial sunlight.
  • a humectant is a moisturizing agent that promotes retention of water due to its hygroscopic properties.
  • Suitable humectants include glycerin and polymeric glycols.
  • Fragrances are aromatic substances which can impart an aesthetically pleasing aroma to the emollient.
  • Typical fragrances include aromatic materials extracted from botanical sources (rose petals, gardenia blossoms, jasmine flowers etc) which can be used alone or in combination to create essential oils.
  • alcoholic extracts may be prepared for compounding fragrances.
  • synthetically prepared fragrances particularly in high volume products.
  • Anti-inflammatory agents such as glycyrrhetinic acid, N-palmitoylthanolamine may also be added.
  • Additional preservatives may also be used if desired and include well known preservative compositions such as benzyl alcohol, benzalkonium chloride, phenyl ethyl alcohol, benzoic acid, urea, diazolydinyl, chlorphenesin, iodopropynyl butyl carbamate and ethylhexyl glycerin among others.
  • preservative compositions such as benzyl alcohol, benzalkonium chloride, phenyl ethyl alcohol, benzoic acid, urea, diazolydinyl, chlorphenesin, iodopropynyl butyl carbamate and ethylhexyl glycerin among others.
  • composition if the invention can further comprise skin protectant active agents, including allantoin, aluminium hydroxide gel, calamine, cod liver oil, colloidal oatmeal, dimethicone, glycerin, hard fat, kaolin, petrolatum, sodium bicarbonate, white petrolatum, zinc acetate, zinc carbonate.
  • skin protectant active agents including allantoin, aluminium hydroxide gel, calamine, cod liver oil, colloidal oatmeal, dimethicone, glycerin, hard fat, kaolin, petrolatum, sodium bicarbonate, white petrolatum, zinc acetate, zinc carbonate.
  • compositions of the invention may further include insect repelling components i.e. N,N- Diethyl-m-toluamide, frequently called 'DEET and available in the form of a concentrate containing at least about 95% DEET.
  • insect repelling components i.e. N,N- Diethyl-m-toluamide, frequently called 'DEET and available in the form of a concentrate containing at least about 95% DEET.
  • ETD2020 @ 0.6% w/v is dissolved in deionised water._Once fully dissolved, the solution was neutralized to pH 7 with NaOH 18% w/v. 0.005% Bezalkonium chloride is added as a preservative. Then the cream is made by adding 33% (volume per weight of finished composition) paraffin oil to the gel using mortar and pestle. A fine cream was obtained.
  • ETD2020 @ 0.6% w/v is dissolved in deionised water._Once fully dissolved, the solution was neutralized to pH 7 with NaOH 18% w/v. 0.005% Bezalkonium chloride is added as a preservative. Then the cream is made by adding 33% (volume per weight of finished composition) soybean oil to the gel using mortar and pestle. A fine cream was obtained.
  • ETD2020 @ 0.6% w/v is dissolved in deionised water._Once fully dissolved, the solution was neutralized to pH 7 with NaOH 18% w/v. 0.005% Bezalkonium chloride is added as a preservative. Then the cream is made by adding 33% (volume per weight of finished composition) paraffin oil to the gel using mortar and pestle. A fine cream was obtained.
  • TR1 @ 1.2% w/v is dissolved in deionised water ._Once fully dissolved, the solution was neutralized to pH 7 with NaOH 18% w/v. 0.005% Bezalkonium chloride is added as a preservative. Then the cream is made by adding 33% (volume per weight of finished composition) paraffin oil to the gel using mortar and pestle. A fine cream was obtained.
  • Example 5 is repeated with the exception that 31 % paraffin oil was employed. A fine cream was obtained.
  • Example 5 is repeated with the exception that 35% paraffin oil was employed. A fine cream was obtained.
  • the VO and Sodium Hydroxide were obtained from Sigma- Aldrich (Ireland); Acrylate polymers were a generous gift from Surfachem Group Limited (Leeds, UK). These materials were used for the formulation of the semi-solid preparations.
  • TPA of each formulation was carried out using a Stable Micro Systems TA.XTplus texture analyser with the A/BE back extrusion rig and a 45 mm compression disc. Samples were loaded into the standard size back extrusion container, taking care to avoid the introduction of air bubbles, and were evaluated at ambient temperature. The probe was compressed once into each sample to a depth of 25 mm at a rate of 2 mm s "1 . The profiles generated were analysed using a modified version of the pre-installed macro for analysis of moisturising cream samples. The firmness of the sample is given by the maximum positive peak value, the consistency by the area of the positive curve, the cohesiveness by the maximum negative peak and the index of viscosity by the area of the negative peak.
  • a 2 3 factorial design was designed using Minitab 16 software and in conjunction with texture profile analysis it was used to evaluate the effect of formulation changes on the four measurable variables in the final product; firmness, consistency, cohesiveness and index of viscosity.
  • the three variables used were oil concentration, polymer concentration and polymer type, each at two levels. The significance of these effects was assessed by means of a two way analysis of variance (ANOVA), where P ⁇ 0.05 represented significance.
  • the water and volatile content of the samples was determined by LOD; approximately 3.0 g of preparation was loaded into formed aluminium containers. Samples were maintained at 105 °C for 24 hours, and then until constant mass at 48 hours.
  • TGA Thermo gravimetric Analysis
  • FIG 3 shows an interaction plot of the data presented above for the cohesiveness parameter. It is clear that there is no interaction between any of the variable factors, as indicated by the parallel lines on each of the plots.
  • Figures 5-10 show the TGA profiles of the semi-solid preparations evaluated; each sample was tested in triplicate.
  • the Y-l axis shows the percentage weight loss with increasing temperature, while the Y-2 axis expresses the derivative (with respect to time) data. It can be seen that the trends of weight loss with increasing temperature are reasonably reproducible for each product.
  • the continuous flow plots produced for each of the semi-solids tested can be seen in Figures 11- 16.
  • the X-axis displays Shear rate (s 1 ), the Y-l axis Shear Stress (Pa) and the Y-2 axis Apparent Viscosity (Pa.s).
  • the plots show considerable differences in the rheological profiles of the BHP product and the newly developed products compared with the commercial products tested.
  • the invention is not limited to the embodiment hereinbefore described which may be varied in construction and detail without departing from the spirit of the invention.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition en émulsion d'émollient comprenant, en poids de la composition finale, environ un tiers d'huile, environ deux tiers d'eau, une quantité mineure d'un agent gélifiant d'acrylate hydrosoluble, et éventuellement un conservateur approprié. Généralement, l'agent gélifiant d'acrylate hydrosoluble est un polymère croisé d'acrylate d'alkyle.
PCT/EP2015/080896 2014-12-19 2015-12-21 Composition d'émollient naturel Ceased WO2016097427A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201422783 2014-12-19
GB1422783.9 2014-12-19

Publications (1)

Publication Number Publication Date
WO2016097427A1 true WO2016097427A1 (fr) 2016-06-23

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004598A (en) * 1986-11-10 1991-04-02 The B. F. Goodrich Company Stable and quick-breaking topical skin compositions
WO2000021491A1 (fr) * 1998-10-08 2000-04-20 L'oreal Emulsion huile-dans-eau stable, son procede de fabrication et son utilisation dans les domaines cosmetique et dermatologique
US20040265259A1 (en) * 2001-10-05 2004-12-30 Alicia Roso Use of alkylpolyxylosides in cosmetics
US20050053634A1 (en) * 2001-12-13 2005-03-10 Beiersdorf Ag Talc-containing cosmetic cleansing emulsions
US20060159649A1 (en) * 2005-01-14 2006-07-20 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Wet-skin treatment compositions using specific gum and acrylate systems for enhanced rheology

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004598A (en) * 1986-11-10 1991-04-02 The B. F. Goodrich Company Stable and quick-breaking topical skin compositions
WO2000021491A1 (fr) * 1998-10-08 2000-04-20 L'oreal Emulsion huile-dans-eau stable, son procede de fabrication et son utilisation dans les domaines cosmetique et dermatologique
US20040265259A1 (en) * 2001-10-05 2004-12-30 Alicia Roso Use of alkylpolyxylosides in cosmetics
US20050053634A1 (en) * 2001-12-13 2005-03-10 Beiersdorf Ag Talc-containing cosmetic cleansing emulsions
US20060159649A1 (en) * 2005-01-14 2006-07-20 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Wet-skin treatment compositions using specific gum and acrylate systems for enhanced rheology

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