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WO2016086448A1 - Système de mesure de glycémie non-invasive basé sur une technique de spectroscopie, et son procédé de mesure - Google Patents

Système de mesure de glycémie non-invasive basé sur une technique de spectroscopie, et son procédé de mesure Download PDF

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Publication number
WO2016086448A1
WO2016086448A1 PCT/CN2014/093775 CN2014093775W WO2016086448A1 WO 2016086448 A1 WO2016086448 A1 WO 2016086448A1 CN 2014093775 W CN2014093775 W CN 2014093775W WO 2016086448 A1 WO2016086448 A1 WO 2016086448A1
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WIPO (PCT)
Prior art keywords
infrared light
blood glucose
measurement
module
invasive blood
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Ceased
Application number
PCT/CN2014/093775
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English (en)
Chinese (zh)
Inventor
张贯京
陈兴明
葛新科
王海荣
张少鹏
方静芳
程金兢
梁艳妮
周荣
高伟明
徐之艳
周亮
穆桑特·卢卡
萨拉斯瓦特·马扬克
克里斯基捏·普拉纽克
古列莎·艾琳娜
梁昊原
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Bio-Tech Academy(china) Co Ltd
E-Techno Information Technologies Co Ltd
Shenzhen Qianhai AnyCheck Information Technology Co Ltd
Original Assignee
Bio-Tech Academy(china) Co Ltd
E-Techno Information Technologies Co Ltd
Shenzhen Qianhai AnyCheck Information Technology Co Ltd
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Publication of WO2016086448A1 publication Critical patent/WO2016086448A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor

Definitions

  • the invention relates to the technical field of blood glucose measurement, in particular to a non-invasive blood glucose measuring system based on spectroscopy technology and a measuring method thereof.
  • Insufficient measurement resolution Using infrared light to measure blood glucose concentration, from the actual process, because the amount of blood in the last blood is small, the amount of infrared light absorbed by blood glucose is small, resulting in a small resolution of measurement. .
  • the measurement repeatability is not good: the existing scheme can not adjust the stress and tightness of the measurement point, can not solve the measurement accuracy problem of different body types, resulting in poor measurement repeatability.
  • the accuracy of the measurement problem Because the existing program uses the last blood, the infrared light absorption of the end of the measurement site is smaller than the infrared absorption of other tissues of the human body, so there is a large measurement error.
  • the main object of the present invention is to solve the problem that the conventional non-invasive blood glucose measuring method has poor measurement accuracy of blood glucose, low resolution, and low measurement repeatability.
  • the present invention provides a non-invasive blood glucose measuring system based on a spectroscopy technique, the non-invasive blood glucose measuring system based on spectroscopy comprising:
  • An infrared light emitting module configured to emit infrared light of a preset wavelength to the measuring portion
  • a concentrating module is disposed at a front end of the infrared emitting portion of the infrared light emitting module, and is configured to collect the infrared light of the preset wavelength emitted by the infrared light emitting module;
  • the infrared light receiving module is configured to receive the infrared spectrum signal after the attenuation of the infrared light of the preset wavelength, and convert the received infrared spectrum signal into an analog electrical signal;
  • a signal conversion and processing module connected to the infrared light receiving module, configured to convert the analog electrical signal into a digital signal, perform analysis and calculation, and obtain a measurement result of a blood glucose concentration of the human body;
  • the first driving module is connected to the infrared light emitting module and the infrared light receiving module, and is configured to adjust positions of the infrared light emitting module and the infrared light receiving module to determine that the infrared light absorption rate of the preset wavelength is the largest. The position is used as the measurement site.
  • the spectroscopy-based non-invasive blood glucose measurement system further comprises:
  • the data communication module is connected to the signal conversion and processing module for remotely transmitting the measurement result of the blood glucose concentration of the human body.
  • the spectroscopy-based non-invasive blood glucose measuring system further comprises a pressure regulating module, the pressure regulating module comprising:
  • a pressure sensor disposed on a side of the infrared light emitting module and/or the infrared light receiving module adjacent to the measuring portion for detecting a pressure received by the measuring portion;
  • the second driving module is connected to the infrared light emitting module and the infrared light receiving module, and is configured to adjust the pressure received by the measuring portion to a preset pressure range.
  • the spectroscopy-based non-invasive blood glucose measurement system further comprises:
  • the data communication module is connected to the signal conversion and processing module for remotely transmitting the measurement result of the blood glucose concentration of the human body.
  • the spectroscopy-based non-invasive blood glucose measurement system further comprises:
  • the human-computer interaction module is connected to the signal conversion and processing module for receiving an instruction input by the user, and displaying the measurement result of the blood glucose concentration of the human body or broadcasting the measurement result of the blood glucose concentration of the human body by voice.
  • the measurement site is a cervical artery.
  • the infrared light emitting module comprises at least three infrared light emitting tubes of different wavelengths, and the infrared light emitting tubes can emit infrared light having a wavelength ranging from 800 nm to 3800 nm.
  • the driving signal of the infrared light emitting module is a pulse signal, and the duty ratio of the pulse signal ranges from 1:20 to 1:1.5.
  • the present invention also provides a non-invasive blood glucose measuring method, the non-invasive blood glucose measuring method comprising the following steps:
  • Step 1 The first driving module adjusts the positions of the infrared light emitting module and the infrared light receiving module, and collects the infrared light of the preset wavelength emitted by the infrared light emitting module by using the concentrating module to determine the preset wavelength
  • the position of the infrared light absorption rate is the current measurement part; the infrared light emitted by the infrared light emitting module has a wavelength of 1600 nm to 2300 nm;
  • Step 2 measuring a current absorption rate B1 of the infrared light of the current measurement site with respect to the wavelength ⁇ 1, and a current absorption rate B2 of the infrared light of the measurement site for the wavelength ⁇ 2; wherein, 1600 nm ⁇ ⁇ 1 ⁇ 2300 nm, 1400 nm ⁇ ⁇ 2 ⁇ 1600 nm;
  • Step 3 Calculate the current blood glucose according to B1, B2, and the pre-stored initial blood glucose concentration value A0, the initial absorption rate A1 of the infrared light of the measurement site with the wavelength ⁇ 1, and the initial absorption rate A2 of the infrared light of the wavelength ⁇ 2. Concentration value D0.
  • the method for non-invasive blood glucose measurement further comprises the following steps:
  • the initial absorption rate of light is A2.
  • the method for non-invasive blood glucose measurement further comprises step four:
  • the pressure adjustment module adjusts the pressure experienced by the current measurement site to a preset pressure range.
  • the method for non-invasive blood glucose measurement further comprises the following steps:
  • the initial absorption rate of light is A2.
  • the current blood glucose concentration value D0 is calculated using the following formula:
  • D0 A0 ⁇ (B1 - B2) / (A1 - A2) + k; where k is a constant and 0 ⁇ k ⁇ 0.5.
  • the method for non-invasive blood glucose measurement comprises the step 6:
  • the data communication module remotely transmits the current blood glucose concentration value D0.
  • the measurement site is a cervical artery.
  • the infrared light emitting module emits infrared light of a preset wavelength to the measuring part by the infrared light emitting module, and the concentrating module gathers the infrared light of the preset wavelength, and receives the attenuated infrared spectrum signal through the infrared light receiving module and converts the same into
  • the analog electrical signal, signal conversion and processing module converts the analog electrical signal into a digital signal and performs analysis and calculation to obtain a measurement result of the blood glucose concentration of the human body, thereby improving the accuracy and resolution of the blood glucose measurement; in addition, adjusting the infrared through the first driving module
  • the position of the light emitting module and the infrared light receiving module to determine the position of the infrared light having the largest absorption rate of the preset wavelength as the measuring portion improves the repeatability of the measurement.
  • FIG. 1 is a schematic structural view of a first embodiment of a non-invasive blood glucose measuring system based on spectral technology according to the present invention
  • FIG. 2 is a schematic structural view of a second embodiment of a non-invasive blood glucose measuring system based on a spectral technique of the present invention
  • FIG. 3 is a schematic structural view of a third embodiment of a non-invasive blood glucose measuring system based on a spectral technique of the present invention
  • FIG. 4 is a schematic structural view of a fourth embodiment of a non-invasive blood glucose measuring system based on a spectral technique according to the present invention.
  • FIG. 5 is a schematic flow chart of a first embodiment of a non-invasive blood glucose measuring method based on a spectral technique according to the present invention
  • FIG. 6 is a schematic flow chart of a second embodiment of a non-invasive blood glucose measuring method based on spectral technology according to the present invention.
  • FIG. 7 is a schematic flow chart of a third embodiment of a non-invasive blood glucose measuring method based on spectral technology according to the present invention.
  • FIG. 8 is a schematic flow chart of a fourth embodiment of a non-invasive blood glucose measuring method based on spectral technology according to the present invention.
  • the present invention provides a non-invasive blood glucose measuring system based on spectroscopy.
  • FIG. 1 is a schematic structural view of a first embodiment of a non-invasive blood glucose measuring system based on a spectral technique according to the present invention.
  • a non-invasive blood glucose measurement system based on spectroscopy includes:
  • the infrared light emitting module 10 is configured to emit infrared light of a preset wavelength to the measuring portion; and emit infrared light to the measuring portion in real time during the measuring;
  • the concentrating module 20 is disposed at the front end of the infrared emitting portion of the infrared light emitting module, and is configured to collect the infrared light of the preset wavelength emitted by the infrared light emitting module; and gather the scattered infrared light emitted by the infrared light emitting module 10;
  • the infrared light receiving module 30 is configured to receive the infrared spectrum signal after the attenuation of the infrared light of the preset wavelength, and convert the received infrared spectrum signal into an analog electrical signal;
  • the signal conversion and processing module 40 is connected to the infrared light receiving module, and is configured to convert the analog electrical signal into a digital signal and perform analysis and calculation to obtain a measurement result of the blood glucose concentration of the human body;
  • the first driving module 50 is connected to the infrared light emitting module and the infrared light receiving module, and is configured to adjust the positions of the infrared light emitting module and the infrared light receiving module to determine a position where the infrared light absorption rate of the preset wavelength is the largest. Measuring part.
  • System initialization is initiated after the system starts up, including reading the initial infrared light absorption value and the body blood glucose constant value from the memory, including initializing some parameters and data (in the beginning of data collection, minimally invasive blood glucose measurement is required)
  • the method obtains the blood glucose level of the specific measuring person, and the blood sugar value can be manually input into the system, and the infrared spectroscopy is used to measure the blood sugar, and the infrared light blood glucose inner code value is obtained.
  • the system checks whether the detection signal is connected, and checks whether there is any tester to measure the blood sugar. If there is a detection signal input, the signal is processed and analyzed, such as debounce the signal data.
  • Digital filtering processing such as thorns, and some dynamic data analysis and judgment on the data, judging the trend and trend of the data, until the measured data tends to be stable, reading the stable data, and then calculating the mathematical model, thereby calculating The blood glucose concentration measurement value of the person to be measured; finally, the obtained measurement result is output.
  • the measurement site selected in this embodiment may be the position of the neck artery of the measurer, because the neck artery is located at a shallow surface of the body surface, the blood flow is large, the signal-to-noise ratio of the measurement signal is high, and the measurement accuracy is high; infrared light emission
  • the module 10 can emit infrared light of at least three different wavelengths, that is, an infrared light emitting tube including at least three different wavelengths, and the infrared light that can be emitted has a wavelength ranging from 800 nm to 3800 nm.
  • the infrared light emitting module 10 emits infrared light having a wavelength ranging from 1600 nm to 2300 nm in real time; and the infrared light emitting module 10 is disposed by the concentrating module 20 disposed at the front end of the infrared emitting portion of the infrared light emitting module 10.
  • the infrared light is concentrated to make the scattered infrared light gather to overcome the problem of light scattering and interference of the infrared light, so that the measured infrared light passes through the tissue to be measured to the maximum, and the resolution and repeatability of the measurement system are improved.
  • the module 20 can adopt a concentrating device such as a condensing mirror, a lenticular lens, and an LED lamp cup; when determining the measurement portion, the first driving module 50 controls the infrared light emitting module 10 and the infrared light receiving module 30 through the MCU microprocessor.
  • the position is finely adjusted, and the position at which the infrared light absorption rate of the preset wavelength is the largest is selected as the measurement portion, and the position at which the infrared light absorption rate of the predetermined wavelength is the largest is usually the position where the blood vessel area through which the infrared light is transmitted is the largest.
  • a characteristic spectrum of glucose (for example, 1650 nm) is first needed to initially measure the absorption of characteristic light by glucose.
  • a characteristic spectrum of glucose for example, 1650 nm
  • water interferes with the measurement of glucose, that is, water absorbs the infrared light of the characteristic wavelength of glucose, so it is necessary to measure the absorption of infrared light by the characteristic wavelength of water to glucose, and then in the original glucose pair.
  • the amount of partial glucose characteristic light absorbed by the water is removed to obtain the absolute total amount of glucose absorbed by the characteristic light.
  • glucose absorbs less infrared light at 1400 nm, and water absorbs infrared light of this wavelength, so that the absorption of characteristic light of water by glucose can be replaced by measuring the absorption of infrared light by 1400 nm by water. (eg 1650 nm) to eliminate the interference of water on glucose content measurements.
  • the infrared light receiving module 30 receives the attenuated spectral signal, and converts the spectral signal into an analog electrical signal, and the size of the simulated electrical signal and the blood glucose concentration of the human body exhibit a certain mathematics.
  • Model relationship specifically, during the measurement process, water interferes with the measurement of glucose, that is, water absorbs the infrared light of the characteristic wavelength of glucose, so it is necessary to measure the absorption of infrared light by the characteristic wavelength of water to glucose.
  • the amount of partial glucose characteristic light absorbed by the water is removed on the basis of the amount of absorption of the characteristic light by the original glucose to obtain the absolute total amount of glucose absorbed by the characteristic light.
  • the signal conversion and processing module 40 filters and amplifies the analog electrical signal reflecting the blood glucose concentration of the human body, converts it into a digital signal acceptable to the microprocessor module, and then performs analysis. Calculate and obtain the measurement result of human blood sugar concentration.
  • the infrared light emitting module 10 emits infrared light of a preset wavelength to the measurement site, and the concentrating module 20 gathers the infrared light of the preset wavelength, and receives the attenuated infrared spectrum signal through the infrared light receiving module 30.
  • the signal conversion and processing module 40 converts the analog electrical signal into a digital signal and performs an analysis and calculation to obtain a measurement result of the blood glucose concentration of the human body, thereby improving the accuracy and resolution of the blood glucose measurement;
  • a driving module 50 adjusts the positions of the infrared light emitting module and the infrared light receiving module to determine a position where the infrared light absorption rate of the preset wavelength is the largest as a measuring portion, thereby improving the repeatability of the measurement.
  • the driving signal of the infrared light emitting module 10 is a pulse signal
  • the duty ratio of the pulse signal ranges from 1:20 to 1:1.5.
  • the duty ratio of the pulse wave is from 1:1.5 to 1:20, which better solves the problem of infrared light driving fluctuation.
  • the duty ratio is less than 1:20, the intensity and luminous flux of the emitted characteristic light are too small, the penetration effect is not good, and the measurement requirement is not met; when the duty ratio is greater than 1:1.5, the characteristic light emitted is The light intensity and the luminous flux are greatly fluctuated, and the error of the measurement result is large, and the measurement needs are not met.
  • the non-invasive blood glucose measuring system based on the spectroscopy technology further includes a driving power source for driving the infrared light emitting module 10 and the infrared light receiving module 30, and the ripple of the driving power source is less than 100 mV. Since the infrared light emitted by the infrared light emitting tube is different under the same power supply, it always has fluctuations, which causes a large error in the measurement. In the embodiment, in order to reduce such an error, the driving power sources of the infrared light emitting module 10 and the infrared light receiving module 30 are the same, and when the ripple of the power source voltage is small, the luminous flux change rate of the infrared light can be reduced. The fluctuation of the infrared light emitted by the infrared light emitting tube is also small. Specifically, the ripple of the power source is less than 100 mv.
  • the input signal voltage difference of the signal conversion and processing module 40 is less than 50 mv, and the signal conversion rate of the signal conversion and processing module 40 is 10 Hz to 1000 Hz.
  • the output signal of the sensor is a small signal, generally below 10mv, and the voltage difference at the signal input terminal is less than 50mv, because the amplification factor of the amplifier can be up to 100 times. Exceeding this voltage will cause the range of the output voltage of the amplifier and the failure of the amplifier.
  • the reason for choosing 10HZ to 1000HZ is: if it is less than 10HZ, the data sampling and analysis speed is too slow to achieve the purpose of real-time measurement. If it is greater than 1000HZ, the sampling rate is too fast, which will result in many data not being analyzed. It will be discarded, and the sampling rate that is too high will also cause the sampled data to be unstable.
  • the infrared light emitting module 10 includes an infrared light emitting circuit and a power circuit
  • the infrared light receiving module 30 includes an infrared light receiving circuit and a power circuit
  • the signal converting and processing module 40 includes a filter circuit, a signal amplifying circuit, a signal selecting circuit, and a signal. Conversion circuit, microprocessor circuit and power circuit.
  • FIG. 2 is a schematic structural view of a second embodiment of a non-invasive blood glucose measuring system based on a spectral technique according to the present invention.
  • the spectroscopy-based non-invasive blood glucose measurement system further includes a pressure adjustment module 60, and the pressure adjustment module 60 includes:
  • the pressure sensor 61 is disposed on a side of the infrared light emitting module and/or the infrared light receiving module near the measuring portion for detecting the pressure received by the measuring portion;
  • the second driving module 62 is connected to the infrared light emitting module and the infrared light receiving module for adjusting the pressure received by the measuring portion to a preset pressure range.
  • a pressure sensor 61 is disposed on a side of the infrared light emitting module 10 and/or the infrared light receiving module 30 close to the measuring portion, and detects the pressure of the infrared light emitting module 10 and the infrared light receiving module 30 received by the measuring portion of the human body in real time, and The detected pressure value is sent to the MCU microprocessor, and the MCU microprocessor controls the second driving module 62 to operate according to the preset pressure range to adjust the tightness of the infrared light emitting module 10 and the infrared light receiving module 30 contacting the measuring portion of the human body. Degree to adjust the pressure applied to the measurement site to a preset pressure range.
  • the pressure of the measuring portion is detected by the pressure sensor 61, and the force and the tightness of the measuring point are adjusted according to the magnitude of the pressure within the preset pressure range, thereby solving the measurement accuracy problem of different body types and improving the measurement repetition. Sex.
  • FIG. 3 is a schematic structural view of a third embodiment of a non-invasive blood glucose measuring system based on a spectral technique according to the present invention.
  • the spectroscopy-based non-invasive blood glucose measurement system further includes:
  • the data communication module 70 is connected to the data processing module for remotely transmitting the measurement result of the blood glucose concentration of the human body; the data communication module 70 includes a microprocessor circuit and a data communication circuit.
  • the data communication module 70 is connected to the signal conversion and processing module 40. After the signal conversion and processing module 40 measures the measurement result of the human blood glucose concentration, the data communication module 70 transmits the measurement result to the health management platform or the like for providing health service.
  • the platform can also be transmitted to a terminal device such as a user's mobile phone for self-management or supervision and management, thereby realizing information service functions such as remote data transmission of a non-invasive blood glucose measurement system based on spectral technology.
  • FIG. 4 is a schematic structural view of a fourth embodiment of a non-invasive blood glucose measuring system based on a spectral technique according to the present invention.
  • the non-invasive blood glucose measurement system based on the spectral technique further includes:
  • the human-computer interaction module 80 is configured to receive a command input by the user, and display a measurement result of the blood glucose concentration of the human body or broadcast the measurement result of the blood glucose concentration of the human body through a voice; the human-machine interaction module 80 includes a micro-processing Circuit, information input circuit and display circuit.
  • the human-computer interaction module 80 can provide a control button or control interface for the user to control the system to be turned on and off for the user to input an open command or a close command; and, after the signal conversion and processing module 40 calculates the measurement result of the human blood glucose concentration, the human The machine interaction module 80 displays the measurement result of the blood glucose concentration of the human body, or broadcasts the measurement result of the blood glucose concentration of the human body by means of voice broadcast.
  • the invention also provides a non-invasive blood glucose measuring method.
  • FIG. 5 is a schematic flow chart of a first embodiment of a non-invasive blood glucose measuring method based on a spectral technique according to the present invention.
  • the non-invasive blood glucose measuring method includes:
  • Step 1 The first driving module adjusts the positions of the infrared light emitting module and the infrared light receiving module, and collects the infrared light of the preset wavelength emitted by the infrared light emitting module through the concentrating module to determine the infrared of the preset wavelength. The position with the highest light absorption rate is taken as the current measurement site;
  • the measurement site selected in this embodiment may be the position of the neck artery of the measurer, because the neck artery is located at a shallow surface of the body surface, the blood flow is large, the signal-to-noise ratio of the measurement signal is high, and the measurement accuracy is high; infrared light emission
  • the module can emit infrared light of at least three different wavelengths, that is, an infrared light emitting tube including at least three different wavelengths, and the infrared light that can be emitted has a wavelength ranging from 800 nm to 3800 nm.
  • the infrared light emitting module 10 emits infrared light with a wavelength ranging from 1600 nm to 2300 nm in real time; and the infrared light emitted by the infrared light emitting module is performed by a concentrating module disposed at the front end of the infrared emitting portion of the infrared light emitting module. Aggregation, so that the scattered infrared light is gathered to overcome the problem of light scattering and interference of infrared light, so that the measured infrared light passes through the tissue to be measured to the greatest extent, and the resolution and repeatability of the measurement system are improved, and the concentrating module can be adopted.
  • a concentrating mirror, a lenticular lens, and an LED lamp cup have a collecting function; when determining the measuring portion, the MCU microprocessor controls the first driving module to finely adjust the position of the infrared light emitting module and the infrared light receiving module, and selects the pre-predetermined
  • the position at which the infrared light absorption rate of the wavelength is the largest is used as the measurement portion, and the position at which the infrared light absorption rate of the predetermined wavelength is the largest is usually the position where the area of the blood vessel through which the infrared light is transmitted is the largest.
  • step two measuring the current absorption rate B1 of the infrared light of the current measurement site to the wavelength ⁇ 1, and the current absorption rate B2 of the infrared light of the measurement site to the wavelength ⁇ 2; wherein, 1600 nm ⁇ ⁇ 1 ⁇ 2300 nm, 1400 nm ⁇ ⁇ 2 ⁇ 1600 nm;
  • step three according to B1, B2, and the pre-stored initial blood glucose concentration value A0, the initial absorption rate A1 of the infrared light of the measurement site to the wavelength ⁇ 1, and the initial absorption rate A2 of the infrared light of the measurement site of the wavelength ⁇ 2 Current blood glucose concentration value D0.
  • the current measurement site determined by the infrared light having the wavelength ⁇ 1 is irradiated, and the infrared light absorption rate B1 of the wavelength is obtained, and the current measurement site is irradiated with the infrared light having the wavelength ⁇ 2.
  • the infrared light emitting module emits infrared light of a preset wavelength to the measuring portion
  • the concentrating module gathers the infrared light of the preset wavelength
  • the infrared light receiving module receives the attenuated infrared spectral signal and converts the same into
  • the analog electrical signal, signal conversion and processing module converts the analog electrical signal into a digital signal and performs analysis and calculation to obtain a measurement result of the blood glucose concentration of the human body, thereby improving the accuracy and resolution of the blood glucose measurement; in addition, adjusting the infrared through the first driving module
  • the position of the light emitting module and the infrared light receiving module to determine the position of the infrared light having the largest absorption rate of the preset wavelength as the measuring portion improves the repeatability of the measurement.
  • FIG. 6 is a schematic flow chart of a second embodiment of a non-invasive blood glucose measuring method based on spectral technology according to the present invention.
  • the non-invasive blood glucose measuring method further includes:
  • the pressure adjustment module adjusts the pressure received by the current measurement site to a preset pressure range.
  • the pressure adjustment module includes a pressure sensor and a second driving module.
  • the pressure sensor is disposed on a side of the infrared light emitting module and/or the infrared light receiving module near the measuring portion for detecting the pressure received by the measuring portion; the second driving The module 62 is coupled to the infrared light emitting module and the infrared light receiving module for adjusting the pressure applied to the measurement site to a preset pressure range.
  • a pressure sensor is disposed on a side of the infrared light emitting module and/or the infrared light receiving module near the measuring portion, and the pressure of the infrared light emitting module and the infrared light receiving module received by the measuring portion of the human body is detected in real time, and the detected pressure value is detected.
  • the MCU microprocessor controls the operation of the second driving module according to the preset pressure range, to adjust the tightness of the measuring portion of the infrared light emitting module and the infrared light receiving module contacting the human body, so as to receive the measuring part
  • the pressure is adjusted to a preset pressure range.
  • the pressure sensor detects the pressure of the measuring part, and adjusts the force and tightness of the measuring point according to the pressure within the preset pressure range, thereby solving the measurement accuracy problem of different body types and improving the measurement repeatability. .
  • FIG. 7 is a schematic flow chart of a third embodiment of a non-invasive blood glucose measuring method based on spectral technology according to the present invention.
  • the non-invasive blood glucose measuring method before the execution of S10, further includes:
  • step 5 obtaining the initial blood glucose concentration value A0 of the user to be tested by the minimally invasive blood glucose measurement method, and measuring the initial absorption rate A1 of the infrared light having the wavelength ⁇ 1 of the measurement site of the user to be tested, and the wavelength of the measurement site is The initial absorption rate of infrared light of ⁇ 2 is A2.
  • the initial blood glucose concentration value A0 of the user to be tested Before measuring the blood glucose concentration of the user in real time, it is necessary to pre-store the initial blood glucose concentration value A0 of the user to be tested, and measure the initial absorption rate A1 of the infrared light having the wavelength ⁇ 1 of the measurement site of the user to be tested, and the measurement site has a wavelength of ⁇ 2.
  • the initial absorption rate of infrared light is A2. That is, the true value of the blood glucose concentration of the user is obtained, and the inner blood glucose concentration code value of the user measurement site is measured by infrared spectroscopy, and specifically, the real blood glucose concentration value A0 of the user to be tested is acquired while the infrared light irradiation measurement of the wavelength ⁇ 1 is performed.
  • the currently measured infrared light absorption rate A1 is a preliminary measurement of the blood glucose concentration value at the measurement site.
  • other components mainly water
  • Glucose absorbs infrared light having a wavelength of 1600 nm to 2300 nm, and water absorbs infrared light having a wavelength in this range. Therefore, the infrared light of the wavelength ⁇ 2 is irradiated to the measurement site by the characteristic spectrum of water.
  • the absorption point A2 of the infrared light having a wavelength of ⁇ 2 is measured at the measurement site, and the infrared light having a wavelength of ⁇ 2 is less absorbed by the glucose, so that the measurement site can be replaced by the absorption rate A2 of the infrared light having the wavelength of ⁇ 2.
  • the absorption rate of water to infrared light having a wavelength of ⁇ 1 is subtracted from A2 by A1, that is, the absorption rate of glucose at the measurement site to infrared light having a wavelength of ⁇ 1 is obtained.
  • the true blood glucose level A0 corresponds to the inner code value (A1-A2) of the infrared light measurement glucose concentration.
  • the measured initial blood glucose concentration value A0 of the user to be tested, the initial absorption rate A1 of the infrared light of the wavelength of the measurement site to be measured by the user, and the initial absorption rate of the infrared light of the measurement site to the wavelength ⁇ 2 Stored so that when the user needs to monitor the user's current blood glucose concentration in real time for a period of time (one month or one week), the above A0 is obtained.
  • the values of A1 and A2 calculate the current blood glucose concentration of the user.
  • FIG. 8 is a schematic flow chart of a fourth embodiment of a non-invasive blood glucose measuring method based on spectral technology according to the present invention.
  • the method of non-invasive blood glucose measurement includes:
  • step 6 the data communication module transmits the current blood glucose concentration value D0 remotely.
  • the measurement result is transmitted to a platform for providing health service such as a health management platform through a data communication module, or may be transmitted to a terminal device such as a mobile phone of the user for self-management or Supervised management to realize information service functions such as remote data transmission of non-invasive blood glucose measurement system based on spectroscopy technology.
  • a platform for providing health service such as a health management platform through a data communication module
  • a terminal device such as a mobile phone of the user for self-management or Supervised management to realize information service functions such as remote data transmission of non-invasive blood glucose measurement system based on spectroscopy technology.

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Abstract

L'invention concerne un système de mesure de glycémie non-invasive basé sur une technologie de spectroscopie et son procédé de mesure, le système de mesure comprenant : un module d'émission de lumière infrarouge (10) pour émettre de la lumière infrarouge à longueur d'onde prédéfinie à un site de mesure; un module de concentrateur (20) pour concentrer la lumière infrarouge à longueur d'onde prédéfinie émise par le module d'émission de lumière infrarouge (10); un module de récepteur de lumière infrarouge (30) pour recevoir un signal de spectroscopie infrarouge après l'atténuation de la lumière infrarouge à longueur d'onde prédéfinie, et convertir le signal de spectroscopie infrarouge reçu en un signal électrique analogique; un module de conversion et de traitement de signal (40) pour une analyse et un calcul pour obtenir un résultat de mesure de concentration de glycémie humaine une fois que le signal électrique analogique est converti en un signal numérique; un premier module d'entraînement (50) pour régler des positions du module d'émission de lumière infrarouge (10) et du module de récepteur de lumière infrarouge (30) pour déterminer une position ayant un taux d'absorption maximum de la lumière infrarouge à longueur d'onde prédéfinie comment étant le site de mesure. Le système de mesure ci-dessus et son procédé de mesure abordent le problème d'une faible précision, d'une faible solution et d'une faible reproductibilité de mesure dans des procédés de mesure de glycémie non-invasive actuels.
PCT/CN2014/093775 2014-12-06 2014-12-13 Système de mesure de glycémie non-invasive basé sur une technique de spectroscopie, et son procédé de mesure Ceased WO2016086448A1 (fr)

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CN114894739A (zh) * 2022-05-06 2022-08-12 杭州电子科技大学平湖数字技术创新研究院有限公司 一种用于检测蔗糖溶液浓度的装置及方法

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