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WO2016079751A3 - A process for preparation of vortioxetine and polymorphs thereof - Google Patents

A process for preparation of vortioxetine and polymorphs thereof Download PDF

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Publication number
WO2016079751A3
WO2016079751A3 PCT/IN2015/000414 IN2015000414W WO2016079751A3 WO 2016079751 A3 WO2016079751 A3 WO 2016079751A3 IN 2015000414 W IN2015000414 W IN 2015000414W WO 2016079751 A3 WO2016079751 A3 WO 2016079751A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
vortioxetine
polymorphs
present
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2015/000414
Other languages
French (fr)
Other versions
WO2016079751A2 (en
Inventor
Vijayavitthal Thippannachar Mathad
Dattatray Gulabrao Deshmukh
Anil Chaturlal Mali
Mukunda Rajendra PATEKAR
Bhaskar Suresh GADEKAR
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Megafine Pharma P Ltd
Original Assignee
Megafine Pharma P Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Megafine Pharma P Ltd filed Critical Megafine Pharma P Ltd
Publication of WO2016079751A2 publication Critical patent/WO2016079751A2/en
Publication of WO2016079751A3 publication Critical patent/WO2016079751A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for preparation of vortioxetine or pharmaceutically acceptable salts thereof. The present invention also relates to new process for the preparation of vortioxetine or pharmaceutically acceptable salts thereof. The present invention further relates to novel polymorphs of vortioxetine hydrobromide and process for preparation thereof.
PCT/IN2015/000414 2014-11-17 2015-11-10 A process for preparation of vortioxetine and polymorphs thereof Ceased WO2016079751A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3612MU2014 2014-11-17
IN3612/MUM/2014 2014-11-17

Publications (2)

Publication Number Publication Date
WO2016079751A2 WO2016079751A2 (en) 2016-05-26
WO2016079751A3 true WO2016079751A3 (en) 2016-07-14

Family

ID=55305032

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000414 Ceased WO2016079751A2 (en) 2014-11-17 2015-11-10 A process for preparation of vortioxetine and polymorphs thereof

Country Status (1)

Country Link
WO (1) WO2016079751A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017154016A1 (en) * 2016-03-07 2017-09-14 Msn Laboratories Private Limited Novel crystalline polymorphs of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine hydrobromide and process for preparation thereof
JP2019525900A (en) * 2016-06-16 2019-09-12 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． Diarylthioether piperazine compounds, their preparation and use
CN106349132B (en) * 2016-08-30 2018-02-02 重庆植恩药业有限公司 Vortioxetine intermediate impurities and its production and use
CN106518807A (en) * 2016-09-17 2017-03-22 北京万全德众医药生物技术有限公司 Preparation method of lactic acid vortioxetine crystal form
CN107843656B (en) * 2016-09-21 2021-02-26 成都弘达药业有限公司 Detection method of 2, 4-dimethylthiophenol related substances
CN107915694A (en) * 2016-10-09 2018-04-17 北京阜康仁生物制药科技有限公司 1 [2 (2,4 3,5-dimethylphenyl sulfydryl) phenyl] piperazine hydrochloride and preparation method thereof
CN107954947A (en) * 2016-10-14 2018-04-24 北京莱瑞森医药科技有限公司 Vortioxetine hydrobromate crystal form C and preparation method thereof
US10519121B2 (en) 2016-12-30 2019-12-31 Apicore Us Llc Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts
WO2018154451A1 (en) * 2017-02-23 2018-08-30 Unichem Laboratories Ltd An improved process for preparation and purification of vortioxetine hydrobromide
CN108929287A (en) * 2017-05-26 2018-12-04 万全万特制药江苏有限公司 The purification of Vortioxetine
KR102026337B1 (en) 2017-07-07 2019-09-27 영진약품 주식회사 Novel 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine salt and method for preparing the same
CN108017595A (en) * 2017-12-20 2018-05-11 安徽源久源科技有限公司 A kind of preparation method of 1- [2- (2,5- dimethyl benzenes sulfenyl) phenyl] piperazine
CN110790727A (en) * 2019-09-30 2020-02-14 杭州和康药业有限公司 Preparation method of vortioxetine hydrobromide α type crystal
WO2021115372A1 (en) * 2019-12-10 2021-06-17 江苏恩华药业股份有限公司 Vortioxetine prodrug and use thereof
CN115160258B (en) * 2022-06-24 2023-11-17 辰欣药业股份有限公司 Preparation method of vortioxetine hydrobromide gamma crystal form
CN115181077B (en) * 2022-07-27 2024-03-29 安徽峆一药业股份有限公司 Synthesis method of vortioxetine with low impurity content
CN115894314A (en) * 2022-12-20 2023-04-04 苏州敬业医药化工有限公司 A kind of preparation technology of 2'-amino-(2,4-dimethyl) diphenyl sulfide
CN120774863A (en) * 2024-04-02 2025-10-14 王春刚 Alkyl diamine substituted diaryl heterocyclic thioether compound, preparation thereof and application thereof in preparing medicaments for treating and/or preventing tumors

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103788019A (en) * 2014-01-22 2014-05-14 苏州明锐医药科技有限公司 Preparation method of vortioxetine
CN103788020A (en) * 2014-01-22 2014-05-14 苏州明锐医药科技有限公司 Preparation method of vortioxetine
CN103936694A (en) * 2014-04-23 2014-07-23 中国药科大学 Preparation method of antidepressant vortioxetine
WO2014161976A1 (en) * 2013-04-04 2014-10-09 Lek Pharmaceuticals D.D. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
CN104230852A (en) * 2014-08-29 2014-12-24 成都倍特药业有限公司 Synthetic method of vortioxetine
CN104628676A (en) * 2013-11-08 2015-05-20 上海医药工业研究院 Preparation method of Vortioxetine
WO2015114395A1 (en) * 2014-01-31 2015-08-06 Egis Gyógyszergyár Zrt. Process for the preparation of vortioxetine salts
WO2015166379A2 (en) * 2014-04-28 2015-11-05 Alembic Pharmaceuticals Limited Novel polymorphic forms of vortioxetine and its pharmaceutically acceptable salts
WO2016004908A1 (en) * 2014-07-08 2016-01-14 Zentiva, K.S. Method of preparing vortioxetine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA81749C2 (en) 2001-10-04 2008-02-11 Х. Луннбек А/С Derivated of phenylpiperazine as serotonin reuptake inhibitorS
TW201033181A (en) 2009-02-17 2010-09-16 Lundbeck & Co As H Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine
SG11201403835UA (en) 2012-01-03 2014-10-30 Lundbeck & Co As H Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014161976A1 (en) * 2013-04-04 2014-10-09 Lek Pharmaceuticals D.D. New process for the synthesis of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine
CN104628676A (en) * 2013-11-08 2015-05-20 上海医药工业研究院 Preparation method of Vortioxetine
CN103788019A (en) * 2014-01-22 2014-05-14 苏州明锐医药科技有限公司 Preparation method of vortioxetine
CN103788020A (en) * 2014-01-22 2014-05-14 苏州明锐医药科技有限公司 Preparation method of vortioxetine
WO2015114395A1 (en) * 2014-01-31 2015-08-06 Egis Gyógyszergyár Zrt. Process for the preparation of vortioxetine salts
CN103936694A (en) * 2014-04-23 2014-07-23 中国药科大学 Preparation method of antidepressant vortioxetine
WO2015166379A2 (en) * 2014-04-28 2015-11-05 Alembic Pharmaceuticals Limited Novel polymorphic forms of vortioxetine and its pharmaceutically acceptable salts
WO2016004908A1 (en) * 2014-07-08 2016-01-14 Zentiva, K.S. Method of preparing vortioxetine
CN104230852A (en) * 2014-08-29 2014-12-24 成都倍特药业有限公司 Synthetic method of vortioxetine

Also Published As

Publication number Publication date
WO2016079751A2 (en) 2016-05-26

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