SG11201403835UA - Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine - Google Patents
Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazineInfo
- Publication number
- SG11201403835UA SG11201403835UA SG11201403835UA SG11201403835UA SG11201403835UA SG 11201403835U A SG11201403835U A SG 11201403835UA SG 11201403835U A SG11201403835U A SG 11201403835UA SG 11201403835U A SG11201403835U A SG 11201403835UA SG 11201403835U A SG11201403835U A SG 11201403835UA
- Authority
- SG
- Singapore
- Prior art keywords
- phenylsulfanyl
- piperazine
- dimethyl
- phenyl
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261582527P | 2012-01-03 | 2012-01-03 | |
| DKPA201200006 | 2012-01-03 | ||
| PCT/EP2012/076377 WO2013102573A1 (en) | 2012-01-03 | 2012-12-20 | Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201403835UA true SG11201403835UA (en) | 2014-10-30 |
Family
ID=48744991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201403835UA SG11201403835UA (en) | 2012-01-03 | 2012-12-20 | Process for the manufacture of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US9133144B2 (en) |
| EP (1) | EP2800746B1 (en) |
| JP (1) | JP6018644B2 (en) |
| KR (1) | KR102008039B1 (en) |
| CN (1) | CN104011034B (en) |
| AU (1) | AU2012364402B2 (en) |
| BR (1) | BR112014016322B8 (en) |
| CA (1) | CA2860103C (en) |
| CL (1) | CL2014001765A1 (en) |
| CO (1) | CO7000771A2 (en) |
| CY (1) | CY1121629T1 (en) |
| DK (1) | DK2800746T3 (en) |
| HR (1) | HRP20190769T1 (en) |
| IL (1) | IL233093A (en) |
| LT (1) | LT2800746T (en) |
| MX (1) | MX344144B (en) |
| PL (1) | PL2800746T3 (en) |
| RS (1) | RS58683B1 (en) |
| RU (1) | RU2608307C2 (en) |
| SG (1) | SG11201403835UA (en) |
| SI (1) | SI2800746T1 (en) |
| SM (1) | SMT201900248T1 (en) |
| WO (1) | WO2013102573A1 (en) |
| ZA (1) | ZA201404881B (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015044963A1 (en) | 2013-09-30 | 2015-04-02 | Cadila Healthcare Limited | An amorphous vortioxetine and salts thereof |
| EP2878596A1 (en) * | 2013-11-29 | 2015-06-03 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)lithium intermediates |
| EP2894154A1 (en) | 2014-01-14 | 2015-07-15 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates |
| CN103788019B (en) * | 2014-01-22 | 2015-10-07 | 苏州明锐医药科技有限公司 | The fertile preparation method for Xi Ting |
| CN103788020B (en) * | 2014-01-22 | 2015-11-04 | 苏州明锐医药科技有限公司 | The preparation method of vortioxetine |
| EA029060B1 (en) | 2014-01-31 | 2018-02-28 | Эгиш Дьёдьсердьяр Зрт. | Process for the preparation of vortioxetine salts |
| EP2930171A1 (en) | 2014-04-07 | 2015-10-14 | LEK Pharmaceuticals d.d. | Synthesis of vortioxetine via (2,4-dimethylphenyl)(2-iodophenyl)sulfane intermediate |
| CN104974110A (en) * | 2014-04-10 | 2015-10-14 | 江苏豪森药业股份有限公司 | New crystal form of 1-[2-(2,4-dimethylphenylsulfenyl)phenyl]piperazine hydrobromide, preparation method and application thereof |
| ES2913282T3 (en) * | 2014-05-09 | 2022-06-01 | Shanghai Syncores Tech Inc Ltd | Intermediate product of vortioxetine and method of synthesis thereof |
| CN105254590B (en) * | 2014-05-09 | 2019-09-03 | 江苏豪森药业集团有限公司 | Vortioxetine hydrobromate crystal form and its preparation method and application |
| CN104059030B (en) * | 2014-05-30 | 2016-05-04 | 镇江圣安医药有限公司 | Derivative and pharmaceutical composition and the purposes of [(benzene sulfanyl)-phenyl] piperazine |
| CN104292183B (en) * | 2014-09-29 | 2016-01-06 | 杨献美 | A kind of antidepressant drug irrigates the preparation method for Xi Ting |
| WO2016079751A2 (en) | 2014-11-17 | 2016-05-26 | Megafine Pharma (P) Ltd. | A process for preparation of vortioxetine and polymorphs thereof |
| EP3023417B1 (en) * | 2014-11-21 | 2017-06-28 | Dipharma Francis S.r.l. | Process for the preparation of an antidepressant and the intermediates thereof |
| CN104356092B (en) * | 2014-11-27 | 2017-03-22 | 合肥创新医药技术有限公司 | Preparation method for vortioxetine |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| US10227317B2 (en) | 2015-02-25 | 2019-03-12 | Lupin Limited | Process for the preparation of vortioxetine |
| CN104650004B (en) * | 2015-03-06 | 2017-06-06 | 中山万汉制药有限公司 | A kind of preparation method of hydrobromic acid Vortioxetine |
| CN105061364A (en) * | 2015-08-17 | 2015-11-18 | 河北国龙制药有限公司 | Vortioxetine hydrobromide preparation method |
| WO2017029377A1 (en) * | 2015-08-19 | 2017-02-23 | Amneal Pharmaceuticals Company Gmbh | Process for preparation of vortioxetine hydrobromide |
| CN106556663B (en) * | 2015-09-30 | 2018-05-29 | 成都弘达药业有限公司 | A kind of detection method of 1- [2- (2,4- dimethylphenylsulfanyls) phenyl] piperazines or its salt |
| US9820984B1 (en) | 2016-07-01 | 2017-11-21 | H. Lundbeck A/S | Dosing regimens for fast onset of antidepressant effect |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| CN106831652B (en) * | 2017-01-23 | 2019-01-11 | 齐鲁天和惠世制药有限公司 | A kind of preparation method of Wo Saiting |
| CN108017595A (en) * | 2017-12-20 | 2018-05-11 | 安徽源久源科技有限公司 | A kind of preparation method of 1- [2- (2,5- dimethyl benzenes sulfenyl) phenyl] piperazine |
| US11198671B2 (en) | 2018-06-20 | 2021-12-14 | Vio Ag Pharmaceuticals S.A. | One-pot organo-pseudocatalytic C—H activation approach for the preparation of vortioxetine and vortioxetine intermediate |
| EP3870292A4 (en) | 2018-10-26 | 2022-11-09 | The Research Foundation for The State University of New York | COMBINATION OF A SPECIFIC SEROTONIN REUPSORPTION INHIBITOR AND A SEROTONIN 1A RECEPTOR PARTIAL AGONIST TO REDUCE L-DOPA-INDUCED DYSKINESIA |
| CN109438390A (en) * | 2018-11-26 | 2019-03-08 | 合肥创新医药技术有限公司 | A kind of synthetic method of hydrobromic acid Vortioxetine impurity |
| US12281088B2 (en) | 2020-09-10 | 2025-04-22 | Suzhou Fude Zhaofeng Biochemical Technology Co., Ltd | Process for the synthesis of vortioxetine |
| CN112250642A (en) * | 2020-10-28 | 2021-01-22 | 合肥亿帆生物制药有限公司 | Preparation method of hydrobromic acid vortioxetine impurity standard substance |
| CN115368318B (en) * | 2022-06-22 | 2023-11-03 | 山东辰龙药业有限公司 | Synthesis method and application of voathixetine |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07110050A (en) | 1993-10-13 | 1995-04-25 | Daikin Mfg Co Ltd | Torsional vibration damping device |
| UA81749C2 (en) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Derivated of phenylpiperazine as serotonin reuptake inhibitorS |
| IL161966A0 (en) * | 2001-12-20 | 2005-11-20 | Lundbeck & Co As H | Aryloxyphenyl and arylsulfanylphenyl |
| US8722684B2 (en) * | 2006-06-16 | 2014-05-13 | H. Lundbeck A/S | 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
-
2012
- 2012-12-20 SI SI201231600T patent/SI2800746T1/en unknown
- 2012-12-20 SG SG11201403835UA patent/SG11201403835UA/en unknown
- 2012-12-20 PL PL12815676T patent/PL2800746T3/en unknown
- 2012-12-20 MX MX2014008052A patent/MX344144B/en active IP Right Grant
- 2012-12-20 AU AU2012364402A patent/AU2012364402B2/en active Active
- 2012-12-20 JP JP2014550676A patent/JP6018644B2/en active Active
- 2012-12-20 US US14/370,322 patent/US9133144B2/en active Active
- 2012-12-20 CA CA2860103A patent/CA2860103C/en active Active
- 2012-12-20 CN CN201280065665.XA patent/CN104011034B/en active Active
- 2012-12-20 DK DK12815676.7T patent/DK2800746T3/en active
- 2012-12-20 WO PCT/EP2012/076377 patent/WO2013102573A1/en not_active Ceased
- 2012-12-20 HR HRP20190769TT patent/HRP20190769T1/en unknown
- 2012-12-20 EP EP12815676.7A patent/EP2800746B1/en active Active
- 2012-12-20 LT LTEP12815676.7T patent/LT2800746T/en unknown
- 2012-12-20 SM SM20190248T patent/SMT201900248T1/en unknown
- 2012-12-20 RS RS20190553A patent/RS58683B1/en unknown
- 2012-12-20 BR BR112014016322A patent/BR112014016322B8/en active IP Right Grant
- 2012-12-20 KR KR1020147018202A patent/KR102008039B1/en active Active
- 2012-12-20 RU RU2014131943A patent/RU2608307C2/en active
-
2014
- 2014-06-12 IL IL233093A patent/IL233093A/en active IP Right Grant
- 2014-06-27 CO CO14139608A patent/CO7000771A2/en unknown
- 2014-06-30 CL CL2014001765A patent/CL2014001765A1/en unknown
- 2014-07-02 ZA ZA2014/04881A patent/ZA201404881B/en unknown
-
2019
- 2019-05-07 CY CY20191100483T patent/CY1121629T1/en unknown
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