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WO2016075703A3 - An improved process for preparation of 5-amino-2,4-di-tert- butylphenol or an acid addition salt thereof - Google Patents

An improved process for preparation of 5-amino-2,4-di-tert- butylphenol or an acid addition salt thereof Download PDF

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Publication number
WO2016075703A3
WO2016075703A3 PCT/IN2015/000421 IN2015000421W WO2016075703A3 WO 2016075703 A3 WO2016075703 A3 WO 2016075703A3 IN 2015000421 W IN2015000421 W IN 2015000421W WO 2016075703 A3 WO2016075703 A3 WO 2016075703A3
Authority
WO
WIPO (PCT)
Prior art keywords
butylphenol
tert
preparation
amino
acid addition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/IN2015/000421
Other languages
French (fr)
Other versions
WO2016075703A2 (en
Inventor
Suresh Thatipally
Venkata Krishna REDDY
Venkata Lakshmi Narasimha Rao Dammalapati
Seeta Rama Anjaneyulu GORANTLA
Satyanarayana Chava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laurus Labs Pvt Ltd
Original Assignee
Laurus Labs Pvt Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Pvt Ltd filed Critical Laurus Labs Pvt Ltd
Publication of WO2016075703A2 publication Critical patent/WO2016075703A2/en
Publication of WO2016075703A3 publication Critical patent/WO2016075703A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/08—Preparation of nitro compounds by substitution of hydrogen atoms by nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/74—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C215/76—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention generally relates to an improved process for preparation of 5- Amino-2,4-di-tert-butylphenol or hydroxyl derivative thereof or an acid addition salt thereof, which is an intermediate of Ivacaftor. More specifically the present invention relates to a process for preparation of hydrochloric acid salt of 5-Arnino-2,4-di-tert- butylphenol.
PCT/IN2015/000421 2014-11-13 2015-11-13 An improved process for preparation of 5-amino-2,4-di-tert- butylphenol or an acid addition salt thereof Ceased WO2016075703A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN5705/CHE/2014 2014-11-13
IN5705CH2014 2014-11-13

Publications (2)

Publication Number Publication Date
WO2016075703A2 WO2016075703A2 (en) 2016-05-19
WO2016075703A3 true WO2016075703A3 (en) 2016-08-18

Family

ID=55955216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2015/000421 Ceased WO2016075703A2 (en) 2014-11-13 2015-11-13 An improved process for preparation of 5-amino-2,4-di-tert- butylphenol or an acid addition salt thereof

Country Status (1)

Country Link
WO (1) WO2016075703A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110092717A (en) * 2019-05-31 2019-08-06 江苏极易新材料有限公司 A kind of preparation method of antioxidant 3,5- methyl esters

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1993360T (en) 2005-12-28 2017-05-25 Vertex Pharma Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
EP3344249B1 (en) 2015-09-02 2020-10-28 Laurus Labs Limited Processes for the preparation of ivacaftor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014125506A2 (en) * 2013-02-15 2014-08-21 Laurus Labs Private Limited A process for the preparation of ivacaftor and its intermediates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014125506A2 (en) * 2013-02-15 2014-08-21 Laurus Labs Private Limited A process for the preparation of ivacaftor and its intermediates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110092717A (en) * 2019-05-31 2019-08-06 江苏极易新材料有限公司 A kind of preparation method of antioxidant 3,5- methyl esters

Also Published As

Publication number Publication date
WO2016075703A2 (en) 2016-05-19

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