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WO2016068405A1 - Aiguille d'acupuncture à main poreuse et son procédé de fabrication - Google Patents

Aiguille d'acupuncture à main poreuse et son procédé de fabrication Download PDF

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Publication number
WO2016068405A1
WO2016068405A1 PCT/KR2015/002432 KR2015002432W WO2016068405A1 WO 2016068405 A1 WO2016068405 A1 WO 2016068405A1 KR 2015002432 W KR2015002432 W KR 2015002432W WO 2016068405 A1 WO2016068405 A1 WO 2016068405A1
Authority
WO
WIPO (PCT)
Prior art keywords
needle
resin needle
porous resin
porous
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2015/002432
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English (en)
Korean (ko)
Inventor
인수일
김혜림
김현식
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daegu Gyeongbuk Institute of Science and Technology
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Daegu Gyeongbuk Institute of Science and Technology
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Filing date
Publication date
Application filed by Daegu Gyeongbuk Institute of Science and Technology filed Critical Daegu Gyeongbuk Institute of Science and Technology
Publication of WO2016068405A1 publication Critical patent/WO2016068405A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/08—Devices for applying needles to such points, i.e. for acupuncture ; Acupuncture needles or accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture

Definitions

  • the present invention relates to a resin needle and a method of manufacturing the same in which a large amount of holes of micro to nano size are formed on a surface thereof.
  • Acupuncture is a device made to penetrate the skin, and is generally made of a metal whose strength and biological safety has been confirmed, and a conventional resin needle is composed of acupuncture, stagnation, and acupuncture as shown in FIG. 1, and includes stones, gold, silver, Made using materials such as copper, iron, bone and barbed.
  • stainless steel 304 or 316L is used as a saliva material, which is hard and not easily broken, resistant to corrosion and harmful to humans.
  • a silicone film was applied to the needle surface to reduce friction between the needle and human tissue during needle acupuncture, and the needle surface was smoothed to reduce the surface roughness, thereby reducing the resistance caused when the needle penetrates into the tissue. To reduce the pain the patient feels.
  • thinner needles are manufactured and used more and more, because the pain of the patient is reduced when the needle is inserted.
  • injection needles The purpose of using needles (injection needles) is to inject certain drugs into body tissues such as blood vessels and muscles through needles, and does not expect a direct therapeutic effect by inserting the needles.
  • resin needles do not aim to inject drugs, and the needle is inserted into specific sites such as meridians and acupuncture points to achieve a therapeutic effect.
  • needles are considered to have important physical stimulation of body tissues when sleeping.
  • needles are made in a manner similar to a method of manufacturing a general needle that smoothes the surface of the needle for the purpose of reducing the pain felt by the patient when sleeping.
  • the pain felt by the patient according to the condition of the surface of the saliva can be reduced, but there is no experimental result that the acupuncture treatment effect is the same.
  • a technique for changing the needle surface properties which are generally used for needle production, was to apply a chemical to the needle surface.
  • the purpose of this technique can be divided into two types according to the application materials, such as the application of materials such as silicone (silicone) for lubrication purposes and the application of salicylic acid for antibacterial and therapeutic purposes, but these techniques
  • the needle produced by this is a problem that the adhesion between the needle surface and the connective tissue is reduced.
  • the main needle and resin needles are mainly used for stainless steel, and among them, ss304 (STS304) is used a lot, all of which belong to the austenitic series.
  • One method of reducing the surface roughness of such stainless steels is electropolishing, and is a technique particularly well applied to ss304 (STS304).
  • electropolishing is applied to the metal to be polished in the electrolytic solution, a viscous initial oxide layer is formed on the surface of the metal by electrolysis, and a passivation film of metal oxide is formed so that the protruding surface is more bent due to the relatively curved surface. It is a technique that the metal surface becomes flat as a whole. This technique is applied to adjust the surface roughness of the stainless steel.
  • Another technique is the use of powerful lasers to process the surface (laser ablation), which injects a powerful laser pulse beam into the metal to instantaneously ablate the surface material to form a pattern. At this time, the depth of the pattern can be adjusted by adjusting the output of the laser.
  • the technology is currently used for marking not only metals but also silicon wafers for semiconductor manufacturing.
  • the most widely used method for surface treatment of resin needles has been developed in the direction of forming needle tip and reducing surface roughness by mechanical grinding. However, this technique is difficult to form directional surfaces.
  • the present invention not only prevents skin damage due to the surface roughness of the existing resin needles, but also provides a new resin needle and a method for effectively producing the resin needles that can effectively deliver the drug through the resin needles in the human body.
  • the present invention relates to a porous resin needle, characterized in that it comprises 15 to 200 holes per 100 ⁇ m 2 (width ⁇ length, 10 ⁇ m ⁇ 10 ⁇ m) of the surface area of the needle Can be.
  • the holes may have an average diameter of 0.3 ⁇ m to 1.5 ⁇ m, and the holes may have an average depth of 0.2 ⁇ m to 1 ⁇ m.
  • the porous resin needle of the present invention may be characterized in that the drug is supported in the hole.
  • the porous resin needle of the present invention is measured on the basis of the method of calculating the specific surface area after measuring the amount of methylene blue solution buried on the surface of the resin needle, the specific surface area of 9.0 m 2 / g or more, preferably Preferably, the specific surface area may be 10.0 m 2 / g to 11.5 m 2 / g.
  • the porous resin needle of the present invention is iron (Fe) 24% ⁇ 28%, chromium (Cr) 6% ⁇ 10%, carbon (C) 61.5% ⁇ 66%, nickel (Ni) 1.5 % To 3.5% and silicon (Si) 0.1% to 0.5%, preferably 25% to 27% iron (Fe), 7% to 9% chromium (Cr), 62% to 64% carbon (C) (Ni) 2% to 3% and silicon (Si) may be characterized in that it comprises 0.2% to 0.3%.
  • Another aspect of the present invention relates to a method for manufacturing the porous resin needle of the present invention described above, it may be characterized in that to produce a porous resin needle by forming a porous structure on the surface of the needle by performing anodizing process of the needle. .
  • a step of washing the saliva may be performed before the anodizing process, and the washing process may be performed by treating the saliva before anodizing with sonication in acetone, and then in ethanol. After sonication, it may be performed by sonication again in purified water.
  • the anodizing process is carried out in an electrolyte containing the needle and the carbon electrode, the needle is used as a (+) electrode, the carbon electrode is used as a (-) electrode
  • the anodizing process is carried out in an electrolyte containing the needle and the carbon electrode
  • the needle is used as a (+) electrode
  • the carbon electrode is used as a (-) electrode
  • it may be performed by applying a DC of 12V to 30V for 10 minutes to 1 hour.
  • the electrolyte in the preparation method of the present invention, may be characterized in that it comprises one or more selected from aqueous solution of ethylene glycol, and aqueous solution of glycerol.
  • the electrolyte in the preparation method of the present invention, is 0.1 to 0.5% by weight of ammonium fluoride and 1 to 5% by weight of water, preferably 0.1 to 0.3% by weight of ammonium fluoride, and It may be characterized in that the aqueous solution of ethylene glycol containing 1-3% by weight of water.
  • the needle before the anodizing step is 37% to 42.5% of iron (Fe), chromium (Cr) 9.5 when measuring EDS (Energy Dispersive Spectometer) % To 15%, carbon (C) 39% to 45%, nickel (Ni) 2.5% to 6% and silicon (Si) 0.3% to 0.8%, preferably iron (Fe) 38% to 42%, chromium (Cr) 10% to 14%, carbon (C) 40% to 44%, nickel (Ni) 3% to 5% and silicon (Si) may be characterized in that it comprises 0.3% to 0.6%.
  • the porous resin needle after the anodizing process iron (Fe) 24% ⁇ 28%, chromium (Cr) when measuring EDS (Energy Dispersive Spectometer) 6% to 10%, carbon (C) 61.5% to 66%, nickel (Ni) 1.5% to 3.5% and silicon (Si) 0.1% to 0.5%, preferably iron (Fe) 25% to 27%, 7% to 9% of chromium (Cr), 62% to 64% of carbon (C), 2% to 3% of nickel (Ni), and 0.2% to 0.3% of silicon (Si).
  • EDS Electronic Data Dispersive Spectometer
  • the resin needle of the present invention is formed with a hole in the form recessed inward rather than a shape derived from the outside of the needle like a conventional resin needle, there is no problem of skin damage, and a plurality of micro size to nano size on the surface of the needle Since the hole having is uniformly formed, the surface area is significantly increased, and thus the physiological treatment effect by saliva can be increased.
  • the drug can be added to the human body by supporting the drug formed in the hole formed on the surface of the saliva can maximize the effect by the saliva.
  • FIG. 1 is a schematic diagram of a method for producing the porous resin needle of the present invention by an anodizing method.
  • FIG. 2 is a SEM measurement photograph of the surface of the resin needle before and after anodization treatment.
  • the left resin needle of FIG. 2 (a) is a photograph of the resin needle before anodization treatment
  • the right resin needle of FIG. It is a porous resin needle.
  • 2B is a SEM photograph of the surface of the resin needle before anodizing
  • FIGS. 2C and 2D are SEM photographs of the surface of the resin needle after anodizing. .
  • FIG. 3 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodizing treatment of Example 1 performed in Experimental Example 1.
  • FIG. 3 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodizing treatment of Example 1 performed in Experimental Example 1.
  • FIG. 4 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Example 2.
  • FIG. 4 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Example 2.
  • FIG. 5 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 3.
  • FIG. 5 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 3.
  • FIG. 6 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 4.
  • FIG. 6 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after the anodization treatment prepared in Example 4.
  • FIG. 7 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 1.
  • FIG. 7 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 1.
  • FIG. 8 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 2.
  • FIG. 8 is an SEM measurement photograph obtained by enlarging and measuring the surface of the resin needle after anodizing prepared in Comparative Example 2.
  • hole used in the present invention means a hole formed in a concave shape in the direction of the needle in the surface direction of the needle.
  • the resin needle of the present invention relates to a resin needle having a porosity formed on the surface of the needle, and may be prepared by forming an nano-sized hole on the surface of the needle by performing an anodizing process.
  • the needle before the anodizing process may be used after performing the washing process, wherein the washing process is to remove foreign substances, etc. on the surface of the needle, it is possible to use a general method in the art, preferably After sonication in acetone, and then sonicated in ethanol, it can be carried out again by sonication in purified water again.
  • each of the ultrasonic treatment time is not particularly limited, but 5 minutes to 20 minutes are appropriate.
  • the needle before the anodizing process may use a needle that is generally sold, preferably 37% to 42.5% of iron (Fe), 9.5% to chromium (Cr) when measuring EDS (Energy Dispersive Spectometer) 15%, 39% to 45% of carbon (C), 2.5% to 6% of nickel (Ni) and 0.3% to 0.8% of silicon (Si), more preferably 38% to 42 of iron (Fe)
  • a needle containing%, chromium (Cr) 10% to 14%, carbon (C) 40% to 44%, nickel (Ni) 3% to 5% and silicon (Si) 0.3% to 0.6% may be used.
  • the needle and the carbon electrode are immersed in an electrolyte, and a DC voltage of 12 V to 30 V is preferable.
  • a voltage of 12V to 28V, more preferably a voltage of 15V to 26V is applied for 10 minutes to 1 hour, preferably 20 minutes to 40 minutes, and the micro size to nano surface of the needle as shown in FIG. It is possible to form holes of size.
  • the voltage is less than 12V, there may be a problem that the hole does not occur on the surface of the resin needle, and if it exceeds 30V, there may be a problem that the resin needle is oxidized and broken, it is preferable to apply a voltage within the above range.
  • the electrolyte solution used in the anodizing process may be used an electrolyte solution used in the anodizing process in the art, preferably at least one selected from an aqueous solution of ethylene glycol and an aqueous solution of glycerol It is good to use an electrolyte containing.
  • aqueous solution of ethylene glycol containing 0.1 to 0.3% by weight of ammonium, 1 to 3% by weight of water and the remaining amount of ethylene glycol, more preferably 0.15 to 0.25% by weight of ammonium fluoride, 1.5 to 2.5% by weight of water, and Ethylene glycol aqueous solution containing the residual amount of ethylene glycol can be used.
  • the ammonium fluoride (NH 4 F) is combined with the oxidized component of the resin needle to play a role of melting the component toward the aqueous solution, 0.1 to 0.5% by weight, preferably 0.1 to 0.3 It is preferable to use it so as to contain a weight%, more preferably 0.2 to 0.25 weight%, if the content is less than 0.1 weight%, the number of holes formed on the surface of the resin needle is reduced, there may be a problem that the average depth and size decreases If the content is more than 0.5% by weight, holes may not be formed on the surface of the resin needle and may be cracked. Therefore, it is preferable to use within the above range.
  • the voltage intensity, the anodizing process time, NH 4 F concentration, etc. There the adjustable average diameter and an average depth of the hole by controlling the anodizing process condition, the voltage is high, or anodizing treatment time longer or NH 4 F concentration of Increasing the value increases the average diameter of the hole and tends to deepen the average depth.
  • the voltage strength 20V, anodizing time is 30 minutes, anodizing may be performed under conditions of NH 4 F concentration of 0.2% by weight, in this case, voltage strength, anodizing time, NH 4
  • the depth of the hole and / or the size of the hole can be adjusted by decreasing or increasing the F concentration, respectively.
  • the average diameter of the holes formed in the needles subjected to the anodizing process may be 1.5 ⁇ m or less, preferably 0.3 ⁇ m to 1.5 ⁇ m, and more preferably 0.3 ⁇ m to 1.2 ⁇ m.
  • the average depth of the formed holes may be 0.2 ⁇ m to 1 ⁇ m, preferably 0.3 ⁇ m to 0.8 ⁇ m.
  • the needle after anodization may change the needle and components before the anodization process.
  • EDS Electronic Dispersive Spectrometer
  • the components of the saliva are iron (Fe) 24% to 28%, chromium (Cr) 6% to 10%, carbon (C) 61.5% to 66%, nickel (Ni) 1.5% to 3.5% and silicon (Si).
  • porous needle prepared by performing the anodizing treatment in the same manner as described above may be washed with purified water, and then subjected to a sonication process in an acetone-containing solution to prepare a porous resin needle.
  • the porous resin needle of the present invention prepared by the anodization process as described above has 15 to 200 concave-shaped holes, preferably 100 to 100 ⁇ m 2 (width ⁇ length, 10 ⁇ m ⁇ 10 ⁇ m). It may have 180 holes, more preferably 100 to 150 holes.
  • the porous resin needle of the present invention measures the amount of the methylene blue solution buried on the surface of the resin needle, and then, based on the method of calculating the specific surface area, the specific surface area is measured from 4.5 m 2 / g to 12 m 2 / g, Preferably it can have a very high specific surface area of 6.0 m 2 / g to 11.5 m 2 / g, more preferably 10.0 m 2 / g to 11.5 m 2 / g, which doubles the electron transfer function to the nervous system located in the meridians. Treatment efficacy by the procedure can be greatly increased.
  • the resin needle is carried out, thereby directly delivering the drug in the human body, thereby doubling the therapeutic efficacy of the acupuncture.
  • the resin needles on the market were washed with acetone, ethanol, and purified water for 10 minutes each at 40 kHz intensity, and the washed resin needles were on the left side of the photograph of FIG.
  • FIG. 1 After connecting the washed resin needle to the (+) electrode and the carbon electrode to the (-) electrode, the resin needle and the carbon electrode were put into the electrolyte solution, and then DC 20V was applied for 30 minutes.
  • the porous resin needle was prepared by anodizing, and a photograph thereof is shown in FIG. 2 (a), and the right resin needle of FIG. 2 (a) is the porous resin needle after anodizing treatment.
  • the electrolyte solution used was ethylene glycol containing 0.2 wt% of ammonium fluoride (NH 4 F) and 2 wt% of purified water (Etlylene Glycole, C 2 H 4 (OH) 2 ) 50 ml of aqueous solution was used.
  • NH 4 F ammonium fluoride
  • Etlylene Glycole, C 2 H 4 (OH) 2 purified water
  • the component change of the resin needle was measured by measuring the EDS of the resin needle before and after the anodizing treatment used in Example 1, and the results are shown in Table 1 below.
  • the EDS measurement was measured by detecting and analyzing a specific X-ray obtained by emitting a high energy beam of 20k on the needle surface.
  • a porous resin needle was prepared in the same manner as in Example 1, but a voltage was applied at DC 15V for 30 minutes to prepare a porous resin needle, and the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 4. Indicated.
  • a porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 25V for 30 minutes, and the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 5. Indicated. Looking at Figure 5, it can be seen that it is well formed, but when compared with Example 1, the hole size was small and the thickness of the needle tended to decrease.
  • a porous resin needle was prepared in the same manner as in Example 1, and a porous resin needle was prepared by applying a voltage at 30V for 30 minutes. And, the SEM measurement thereof was measured in the same manner as in Example 1, the results are shown in Figure 6, it can be seen that the hole is well formed. However, compared with Example 1, the hole size was small and the thickness of the needle tended to decrease.
  • a porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 10V for 30 minutes. And, the SEM measurement thereof was measured in the same manner as in Example 1, the results are shown in Figure 7, it was confirmed that the hole is hardly formed, which results in a low voltage, insufficient to form the hole It is judged by the result of applying the voltage.
  • a porous resin needle was prepared in the same manner as in Example 1, but a porous resin needle was prepared by applying a voltage at DC 40V for 30 minutes.
  • the SEM measurement thereof was measured in the same manner as in Example 1, and the results are shown in FIG. 8, and the resin needles were mostly melted, and it was confirmed that there was a problem that the needle was broken in the middle.
  • the method for obtaining the specific surface area is based on Equation 1 below, by measuring the absorbance of the aqueous methylene blue solution supported on the resin needle before and after anodization to determine the concentration of methylene blue (Concentration), using the following proportional formula 1
  • the specific surface area was measured by substitution.
  • Equation 1 1.667e -5 (M / Abs) is a conversion factor obtained through an absorbance experiment of methylene blue aqueous solution having a known concentration.
  • Concentration 1 is the concentration of methylene blue supported on the resin needle before anodization
  • Concentration 2 is the concentration of methylene blue supported on the resin needle after anodization.
  • the specific surface area before the anodization is 0.0017 (m 2 / g), which is calculated through the thickness, length, and weight of the needle.
  • Example 4 in which the voltage intensity was performed at DC 30V, the number of holes was formed the most, but the specific surface area was lower than 5.0 m 2 / g when compared to Examples 1 to 3.
  • Example 1 which performed anodization at 20V voltage intensity was the highest, and the porous resin needle of Example 2 which performed anodization at 15V voltage intensity also showed high absorbance.
  • Example 4 which was carried out at 30 V voltage intensity, absorbance results were lower than those of Examples 1, 2, and 3.
  • the drug may be supported in the hole of the porous resin needle by dipping the porous resin needle prepared in Example 1 in a methylene blue solution.
  • the weight of the resin needle was 0.1 mg before the dye was loaded, the weight was 0.1007 mg, 0.7% increased after loading the dye, through which the drug effectively It could be confirmed that it is supported.
  • the hole was well formed on the surface of the porous resin needle of the present invention, and it was confirmed that it had a high specific surface area, and it was also confirmed that the drug was well supported in the hole formed on the surface.
  • porous resin needle of the present invention can be achieved a significant therapeutic effect through the resin needle treatment, it is possible to provide a medical resin needle having this effect.

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  • Health & Medical Sciences (AREA)
  • Rehabilitation Therapy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Finger-Pressure Massage (AREA)

Abstract

La présente invention concerne une aiguille d'acupuncture à main poreuse et un procédé de fabrication associé, et plus spécifiquement une aiguille d'acupuncture à main poreuse et son procédé de fabrication, où une zone de surface spécifique de l'aiguille est maximisée par formation de trous micrométriques ou nanométriques sur la surface d'une aiguille d'acupuncture à main.
PCT/KR2015/002432 2014-10-27 2015-03-13 Aiguille d'acupuncture à main poreuse et son procédé de fabrication Ceased WO2016068405A1 (fr)

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KR1020140146230A KR101615750B1 (ko) 2014-10-27 2014-10-27 다공성 수지침 및 이의 제조방법

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008079919A (ja) * 2006-09-28 2008-04-10 Toppan Printing Co Ltd 針状体および針状体の製造方法
KR20080112759A (ko) * 2007-06-22 2008-12-26 이승호 표면 형태와 물성에 변화를 준 한방 침
US20110245856A1 (en) * 2010-03-30 2011-10-06 Taiwan Shan Yin International Co., Ltd. Porous acupuncture needle
KR20110113589A (ko) * 2010-04-09 2011-10-17 서울대학교산학협력단 다공성 티타늄 산화막을 이용하여 생체활성 물질의 담지율을 높이는 임플란트 재료의 제조방법 및 이에 의한 임플란트 재료

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR200433930Y1 (ko) 2006-09-29 2006-12-13 김세영 복합 기능성 한방침

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008079919A (ja) * 2006-09-28 2008-04-10 Toppan Printing Co Ltd 針状体および針状体の製造方法
KR20080112759A (ko) * 2007-06-22 2008-12-26 이승호 표면 형태와 물성에 변화를 준 한방 침
US20110245856A1 (en) * 2010-03-30 2011-10-06 Taiwan Shan Yin International Co., Ltd. Porous acupuncture needle
KR20110113589A (ko) * 2010-04-09 2011-10-17 서울대학교산학협력단 다공성 티타늄 산화막을 이용하여 생체활성 물질의 담지율을 높이는 임플란트 재료의 제조방법 및 이에 의한 임플란트 재료

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