HK1225953A1 - Porous acupuncture needle and method for manufacturing same - Google Patents
Porous acupuncture needle and method for manufacturing sameInfo
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- HK1225953A1 HK1225953A1 HK16114210.7A HK16114210A HK1225953A1 HK 1225953 A1 HK1225953 A1 HK 1225953A1 HK 16114210 A HK16114210 A HK 16114210A HK 1225953 A1 HK1225953 A1 HK 1225953A1
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- needle
- porous
- acupuncture needle
- porous acupuncture
- pores
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Description
Technical Field
The present invention relates to an acupuncture needle having a plurality of micro-or nano-scale holes formed on the surface thereof and a method for preparing the same.
Background
The needle is a device formed to penetrate the skin, and is generally made of metal whose strength and biosafety are confirmed, and the conventional acupuncture needle is composed of a needle tip, a needle body and a needle handle as shown in fig. 1, and is made of materials such as stone, gold, silver, copper, iron, bone and thorns. In recent years, stainless steel 304 or 316L, which is strong and hard to break, has high corrosion resistance, and is harmless to the human body, has been used as a needle material with the progress of technology.
Since a patient feels pain when pricking a needle according to the thickness and surface condition of a general multipurpose injection needle, a plurality of prior arts have been developed in a direction of reducing the pain of the patient. For example, as a method of reducing friction between the needle and human tissue when puncturing the needle, a silicone layer is coated on the surface of the needle, or the surface roughness is reduced by processing the surface of the needle to be smooth, thereby reducing resistance generated when the needle punctures the tissue to relieve pain felt by the patient. Also, the thinner the needle thickness is, the less pain the patient experiences when pricking the needle, and thus needles manufactured and used at present tend to be thinner and thinner.
The purpose of use of an injection needle (injection needle) is to inject a specific drug into body tissues such as blood vessels, muscles, etc. through the injection needle, but direct therapeutic effects are not expected for the insertion of the injection needle itself. However, the acupuncture needle is not intended to inject a medicine, but is intended to achieve therapeutic effects by inserting the needle into a specific site such as meridians and acupoints. The fundamental difference between the two is therefore the purpose of inserting the needle into the tissue.
That is, unlike an injection needle, the key of an acupuncture needle is a physical stimulus to body tissue at the time of puncturing. However, in spite of the acupuncture effect, the acupuncture needle is prepared in the same manner as a general injection needle for smoothing the surface of the needle only in order to reduce the pain felt by the patient at the time of puncturing. Also, the pain felt by the patient can be reduced according to the surface state of the needle, but there is no experimental result indicating the same therapeutic effect.
On the contrary, according to the research on the needle and the tissue (h.langevin, 2002, fasteb), there is reported a research result that the connective tissue is wound around the surface of the needle by rotating the needle left and right after the puncture needle, and the needle therapeutic effect is generated by the stimulation at this time. The results of this study indicate that the binding force between the needle surface and the connective tissue is important for the therapeutic effect of the needle. That is, this means that if the binding force between the needle surface and the needle surface is improved by giving a change to the physical properties of both, the needle treatment effect can be improved. However, to date, techniques for reducing the roughness of the surface of the needle have been used when preparing acupuncture needles, which suggests that research has been directed only toward reducing the binding force between the two.
On the other hand, a technique for changing the physical properties of the surface of a needle, which is generally used for manufacturing a needle, is to coat a chemical substance on the surface of the needle. The purpose of this technology is roughly divided into two types according to the coating material: the case of coating a material such as silicone resin for lubrication purposes and the case of coating a material such as salicylic acid for antibacterial and therapeutic purposes. However, the needle manufactured by this technique has a problem that the bonding force between the needle surface and the connective tissue is reduced.
On the other hand, stainless steel, which is the most commonly used material for general injection needles and acupuncture needles, is mainly SS304 and SS0316L, which are all of the austenitic series. One of the methods of reducing the surface roughness of these stainless steels is an electrolytic polishing method, which is a technique particularly commonly applied to SS304 and SS 0316L. The electrolytic polishing comprises the following steps: the application of electricity to the metal to be ground in an electrolyte produces a viscous initial oxide layer on the surface of the metal by electrolysis to form a passive film of metal oxide, so that the relatively tortuous and protruding faces are shaved off, making the metal surface as a whole flat. The surface roughness of the stainless steel is adjusted by applying this technique.
Another technique is a technique of processing a surface by using a powerful laser (laser ablation), which is a method of forming a pattern by temporarily ablating surface substances by causing a powerful laser pulse light beam to be incident on a metal. At this time, the depth of the pattern can be adjusted by adjusting the laser power. This technique is currently used not only for metals, but also for marking silicon wafers for semiconductor production. On the other hand, the most commonly used method of surface treatment of acupuncture needles is a mechanical abrasion method, which has been developed in a direction of forming the tip portion of the needle and reducing the surface roughness. However, these techniques have difficulty in forming a surface having directionality.
In this regard, a preparation technology of an acupuncture needle for increasing the binding force of the both by expanding the effective area of the needle surface contacting with the binding tissue by giving a physical morphological change to the needle surface has been proposed (korean patent laid-open No. 2008-0112759), but it has a problem of damaging the skin due to the roughness of the needle surface.
Disclosure of Invention
Problems to be solved by the invention
The present invention provides a new needle which can prevent the skin damage caused by the rough surface of the existing needle and can effectively deliver the medicine into the body through the needle, and a method for efficiently preparing the needle.
Means for solving the problems
In order to achieve the above object, the present invention relates to a porous acupuncture needle characterized in that the needle has a diameter of 100 μm2(× horizontal, 10 μm × 10 μm) surface area comprising 5-20 holes (hole).
According to a preferred embodiment of the present invention, the porous acupuncture needle of the present invention is characterized in that the average diameter of the pores is 0.05 to 3 μm and the average depth of the pores is 1 to 3 μm.
According to a preferred embodiment of the present invention, the porous acupuncture needle of the present invention is characterized in that the pores are loaded with a drug.
According to a preferred embodiment of the present invention, the porous needle of the present invention is characterized in that the specific surface area is 0.0100m or more when measured according to a method of calculating the specific surface area after measuring the amount of methylene blue solution stained on the surface of the needle2Preferably 0.0150 to 0.0350 m/g2/g。
According to a preferred embodiment of the present invention, the porous acupuncture needle of the present invention includes 45 to 46% of iron (Fe), 17 to 19% of chromium (Cr), 30 to 34% of carbon (C), 2 to 3% of nickel (Ni), and 1.5 to 2% of aluminum (Al).
Another aspect of the present invention relates to a method for preparing the above-mentioned porous acupuncture needle of the present invention, which is characterized in that a porous structure is formed on the surface of the needle by subjecting the needle to an anodizing process.
According to a preferred embodiment of the present invention, a process of cleaning the needle may be performed before the anodizing process is performed, and the cleaning process may be performed by performing ultrasonic treatment in ethanol after the needle before the anodizing process is subjected to ultrasonic treatment in acetone, and then performing ultrasonic treatment in purified water.
According to a preferred embodiment of the present invention, the anodizing treatment process is performed in an electrolyte solution including the needle and a carbon electrode, the needle serves as a (+) pole and the carbon electrode serves as a (-) pole, and the anodizing treatment process is performed by applying a direct current voltage of 20V to 38V for 30 minutes to 2 hours.
According to another preferred embodiment of the present invention, the production method of the present invention is characterized in that the electrolyte includes at least one selected from the group consisting of a glycol solution and a glycerin solution.
According to another preferred embodiment of the present invention, the method for preparing the same is characterized in that the electrolyte is a glycol solution containing 0.1 to 0.5% by weight of ammonium fluoride and 1 to 5% by weight of water.
According to another preferred embodiment of the present invention, the manufacturing method of the present invention is characterized in that the needle before the anodizing process comprises 43.5 to 45% of iron (Fe), 11.5 to 13% of chromium (Cr), 35 to 37% of carbon (C), 5 to 6.5% of nickel (Ni), and 0.5 to 1.2% of aluminum (Al), as measured using an Energy Dispersive Spectrometer (EDS).
According to another preferred embodiment of the present invention, the manufacturing method of the present invention is characterized in that the needle after the anodizing process includes 45-46% of iron (Fe), 17-19% of chromium (Cr), 30-34% of carbon (C), 2-3% of nickel (Ni), and 1.5-2% of aluminum (Al) when measured using EDS.
ADVANTAGEOUS EFFECTS OF INVENTION
According to the acupuncture needle of the present invention, since the hole having a shape recessed inward is formed instead of protruding outward as in the conventional acupuncture needle, there is no problem of damaging the skin, and the surface area is greatly increased since the plurality of micro-or nano-sized holes are uniformly formed on the surface of the needle, thereby improving the physiological therapeutic effect of the needle. Also, the drug is loaded in the holes formed on the surface of the needle and is injected into the body, so that the effect of the needle can be maximized.
Drawings
FIG. 1 shows an example of the production of a porous acupuncture needle of the present invention by an anodic oxidation process, which is a schematic view about the production process.
Fig. 2 shows Scanning Electron Microscope (SEM) measurement photographs of the surface of the acupuncture needle before and after the anodization treatment, in which the left side needle of the portion (a) in fig. 2 shows a photograph of the acupuncture needle before the anodization treatment, and the right side needle of the portion (a) in fig. 2 is a porous needle after the anodization treatment. In addition, the second part in fig. 2 is an SEM photograph of the surface of the acupuncture needle before the anodizing treatment, and the third and fourth parts in fig. 2 are SEM photographs of the surface of the acupuncture needle after the anodizing treatment.
FIGS. 3 to 9 are SEM photographs of respective porous needles prepared in examples 1 to 7, respectively.
FIG. 10 shows the results of absorbance measurement for measuring the specific surface area of a porous needle in Experimental example 3.
Detailed Description
The term "hole" used in the present invention means a hole formed in a shape recessed from the surface direction of the needle toward the inner direction of the needle.
The present invention will be described in more detail below.
The present invention relates to an acupuncture needle having a plurality of pores formed on the surface thereof, which can be manufactured by performing an anodic oxidation treatment process to form micro-or nano-scale pores on the surface of the needle.
Also, the needle can be used after passing through a cleaning process before passing through the anodizing process. At this time, a cleaning process for removing foreign substances on the surface of the needle may be used, which may be performed using a method conventional in the art, and preferably, the cleaning process may be performed by ultrasonic treatment of the needle in acetone, followed by ultrasonic treatment in ethanol, and then ultrasonic treatment in purified water. In this case, the ultrasonic treatment time is not particularly limited, and is preferably about 5 to 20 minutes.
In addition, a needle generally available on the market before the anodizing process may be used, and preferably, a needle including 43.5 to 45% of iron (Fe), 11.5 to 13% of chromium (Cr), 35 to 37% of carbon (C), 5 to 6.5% of nickel (Ni), and 0.5 to 1.2% of aluminum (Al) when measured by an Energy Dispersive Spectrometer (EDS) may be used.
And, as for the anodizing process, after the needle is connected to the (+) pole and the carbon electrode is connected to the (-) pole, the needle and the carbon electrode are immersed in the electrolyte, and a Direct Current (DC) voltage of 20 to 38V, preferably 25 to 35V, and more preferably 28 to 32V is applied for 30 minutes to 2 hours, so that micro-or nano-scale holes as shown in fig. 2 may be formed on the surface of the needle. If the voltage is less than 20V, holes cannot be formed on the surface of the needle, and if the voltage is more than 38V, the needle is oxidized and broken, and therefore, it is preferable to apply a voltage within the above range.
In the present invention, the electrolyte used in the anodizing treatment process may be an electrolyte used in an anodizing process in the art, and is preferably an electrolyte including at least one selected from a glycol solution and a glycerin solution. As a specific example, Ammonium Fluoride (NH) may be used in an amount of 0.1 to 0.5 wt%4F) 1-5 wt% of water and the balance of ethylene glycol.
In the ethylene glycol solution, the ammonium fluoride (NH)4F) For dissolving the component in an aqueous solution by combining with the oxidized component of the needle, the content of the component is 0.1 to 0.5 wt%, preferably 0.2 to 0.4 wt%. In this case, if the content is less than 0.1 wt%, the number of holes generated on the surface of the needle is reduced and the average depth and size are reduced, and if the content is more than 0.5 wt%, the holes are not generated on the surface of the needle and the surface is cracked, and thus it is preferable to use them within the above range.
By adjusting the voltage intensity, the anodic oxidation treatment time, and NH4The concentration of F and other anodic oxidation conditions can be adjustedAverage diameter and average depth of the nodal pores, if the voltage is increased, the anodizing treatment time is prolonged or NH is increased4The concentration of F tends to increase the average diameter and the average depth of pores. According to a preferred embodiment, it is possible to perform the anodization treatment at a voltage of 30V for a period of 1 hour and 0.3 wt% NH4Anodizing under the condition of F concentration, in this case, the voltage intensity, the anodizing time and NH are respectively reduced or increased4The concentration of F can be adjusted to allow for the depth of the pores and/or the size of the pores.
The average diameter of the pores formed in the needle subjected to the anodizing process may be equal to or less than 3 μm, preferably 0.05 to 3 μm, and more preferably 0.05 to 1 μm. The average depth of the pores formed may be 1 to 3 μm, preferably 2 to 3 μm.
The composition of the needle after the anodizing process is the same as that of the needle before the anodizing process, for example, when the needle before the anodizing process having the above-mentioned composition is subjected to the anodizing process and then measured using EDS, the composition of the needle is 45 to 46% of iron (Fe), 17 to 19% of chromium (Cr), 30 to 34% of carbon (C), 2 to 3% of nickel (Ni), and 1.5 to 2% of aluminum (Al), and thus it is seen that the composition of the acupuncture needle does not change greatly within the measurement error range.
Also, the porous acupuncture needle prepared by performing the anodic oxidation treatment process in the above-described manner may be washed in purified water, and then subjected to a process of ultrasonic treatment in a solution containing acetone to prepare the porous acupuncture needle.
As described above, the porous acupuncture needle of the present invention manufactured by the anodic oxidation process is used at every 100 μm2(longitudinal × lateral, 10 μm × 10 μm) the surface area may comprise 5 to 20 concave-shaped pores, preferably 8 to 20 pores, more preferably 10 to 20 pores, and the specific surface area of the porous acupuncture needle of the present invention may be equal to or greater than 0.0100m when measured according to a method of calculating the specific surface area after measuring the amount of methylene blue solution smeared on the surface of the above acupuncture needle2/gPreferably 0.0150 to 0.0350m2(iv)/g, more preferably 0.0300 to 0.0350m2The specific surface area is larger, so that the function of transferring electrons to the nervous system of the meridian is improved, and the treatment effect of the acupuncture can be greatly improved.
Also, it is possible to carry a drug in the pores formed in the porous acupuncture needle of the present invention to perform an acupuncture operation such that the drug is directly delivered into the body, thereby improving the therapeutic efficacy of the acupuncture operation.
Hereinafter, the present invention will be better understood from examples for illustrating the present invention, but should not be construed as being limited thereto.
[ examples ]
Example 1
The needle obtained from Toho medical instruments Co., Ltd was cleaned by subjecting it to ultrasonic treatment in acetone, ethanol and purified water at 40kHz for 10 minutes, as shown on the left side of the photograph of part (a) in FIG. 2.
Next, as shown in fig. 1, after the cleaned needles were connected to the (+) pole and the carbon electrode was connected to the (-) pole, the needles and the carbon electrode were put into an electrolyte and subjected to an anodizing treatment by applying a voltage of 30VDC for 1 hour, thereby producing porous needles as shown in (a) of fig. 2, in which the needles shown on the right side were porous needles after being subjected to the anodizing treatment.
In this case, 50ml of ethylene glycol (C) was used as an electrolyte solution for the anodic oxidation treatment2H4(OH)2) A solution comprising 0.3% by weight of ammonium fluoride and 2% by weight of purified water.
Experimental example 1 measurement by Scanning Electron Microscope (SEM)
The photographs of the needles used in example 1 before the anodization treatment measured by SEM (product name: S-4800, manufactured by Hitachi Ltd.) are shown in the second part of FIG. 2, while the photographs of the porous acupuncture needles prepared in example 1 measured by SEM on the surface are shown in the third part of FIG. 2, the fourth part of FIG. 2 and FIG. 3.
When the SEM photographs of the section (two), (three), and (four) of FIG. 2 are compared, it is understood that the needle before the anodizing treatment has a smooth surface, and instead, the needle after the anodizing treatment has pores having a size of 3,000nm or less.
In addition, it can be seen from the (fourth) part of FIG. 2 that each 100 μm2(longitudinal × transverse, 10 μm × 10 μm) with at least 10 pores formed in the surface area.
Also, it can be seen from FIG. 3 that the depth of the holes is about 2.58 μm.
EXAMPLE 2 determination by an Energy Spectrometer (EDS)
The compositional change of the needles used in example 1 was measured by EDS measurement of the needles before/after the anodizing treatment, and the results thereof are shown in table 1 below.
At this time, the EDS measurement is performed in such a manner that a specific X-ray obtained by irradiating a high energy beam of 20keV to the surface of the needle is detected and analyzed.
TABLE 1
As can be seen from the EDS measurement results of table 1 above, the composition of the needle before/after the anodizing process is not changed, that is, it can be determined that the composition of the needle before/after the anodizing process is hardly changed in consideration of the error range that may occur in the characteristics of EDS.
Example 2
A porous needle was prepared in the same manner as in example 1, except that a DC voltage of 35V was applied for 1 hour to prepare a porous needle. The SEM measurement was performed in the same manner as in example 1, and the measurement results are shown in fig. 4.
As can be seen from fig. 4, the holes are formed well, however, uniformity of the holes tends to be lowered as compared with example 1.
Example 3
A porous needle was prepared in the same manner as in example 1, except that a DC voltage of 40V was applied for 1 hour to prepare a porous needle. The SEM measurement was performed in the same manner as in example 1, and the measurement results are shown in fig. 5. It can be seen from fig. 5 that the holes are partially formed but are not uniformly distributed, and the problem of breakage of the needle occurs.
Example 4
A porous needle was prepared in the same manner as in example 1, except that a DC voltage of 25V was applied for 1 hour to prepare a porous needle. The SEM measurement was performed in the same manner as in example 1, and the measurement results are shown in fig. 6. As can be seen from fig. 6, the holes were formed well, but the uniformity of the holes tended to be reduced as compared with example 1.
Example 5
A porous needle was prepared in the same manner as in example 1, except that a DC voltage of 20V was applied for 1 hour to prepare a porous needle. The SEM measurement was performed in the same manner as in example 1, and the measurement results are shown in fig. 7. As can be seen from fig. 7, the holes were formed well, but the uniformity of the holes tended to be reduced as compared with example 1.
Example 6
A porous needle was prepared in the same manner as in example 1, except that a DC voltage of 50V was applied for 1 hour to prepare a porous needle. The SEM measurement was carried out in the same manner as in example 1, and as a result of the measurement, as shown in fig. 8, there was a problem that the needle was broken, and there were some portions formed with the hole portion, but there was a problem that most of the surface of the needle was formed in a shape similar to a molten shape.
Example 7
A porous needle was prepared in the same manner as in example 1, except that a DC voltage of 10V was applied for 1 hour to prepare a porous needle. The SEM measurement was performed in the same manner as in example 1, and the measurement results are shown in fig. 9. As can be seen from fig. 9, almost no holes were formed.
Experimental example 3 measurement of specific surface area
Specific surface area measurement experiments were performed on the porous needles prepared in examples 1 to 7, and the results are shown in tables 2 and 10 below. And, the specific surface area experimental procedure is as follows: after the acupuncture needle was immersed in the methylene blue solution, the acupuncture needle was taken out and loaded in a beaker containing distilled water, and the beaker was shaken so that the methylene blue solution loaded in the acupuncture needle was dissolved in the distilled water. Next, the absorbance of the distilled water in which the methylene blue solution is dissolved is measured to determine the amount of methylene blue loaded in the porous acupuncture needle. Thus, the measurement was performed by a method of calculating a specific surface area after measuring the amount of the methylene blue solution stained on the surface of the needle. At this time, the method of calculating the specific surface area is as follows: the specific surface area is measured by measuring the absorbance of a methylene blue solution loaded on the needle before/after the anodization according to the following equation 1 to obtain the concentration of methylene blue, and then substituting the concentration into the following proportional equation 1.
[ mathematical formula 1]
Concentration (M) ═ 1.667e-5(M/Abs) × Absorbance (Abs)
In mathematical formula 1, 1.667e-5(M/Abs) is the conversion factor obtained by absorbance experiments for solutions of methylene blue of known concentration.
[ proportional formula 1]
Concentration 1:0.0017 (m)2Concentration 2: specific surface area of needle after anodic oxidation
In the proportional formula 1, the concentration 1 is the concentration of methylene blue loaded in the acupuncture needle before being subjected to the anodic oxidation, and the concentration 2 is the concentration of methylene blue loaded in the acupuncture needle after being subjected to the anodic oxidation. In addition, the specific surface area before the anodic oxidation was 0.0017 (m)2And/g) is calculated from the thickness, length and weight of the needle.
TABLE 2
As can be seen from Table 2 above, in the case of examples 1, 2, 4 and 5 in which the anodic oxidation treatment process was performed at a voltage of DC 20-38V, the specific surface area was 0.0100m or more2/g。
However, in the case of examples 3 and 6 having voltage strengths of DC40V and 50V, the needle was broken and almost no hole was formed, and the specific surface area could not be measured.
In example 7 in which the voltage intensity was DC10V, the formation of the hole was insufficient,the results showed less than 0.0100m2Low specific surface area in g.
As can be seen from FIG. 10, example 1 in which the anodic oxidation reaction was performed at a voltage intensity of 30V showed the highest absorbance, and the porous acupuncture needles of examples 2 and 4 in which the anodic oxidation reactions were performed at voltage intensities of 35V and 25V also showed high absorbance. In example 5 having a voltage intensity of 20V, the absorbance was lower than in examples 1, 2 and 4, but was much higher than in example 7 having a voltage intensity of 10V.
Preparation example 1 preparation of drug-loaded porous acupuncture needle
The drugs were loaded in the pores of the porous acupuncture needle in a manner of immersing the porous acupuncture needle prepared in example 1 in a methylene blue solution.
Also, the weight of the dye-loaded porous needle was measured, and the measurement results showed that the weight of the needle before loading the dye was 0.1517g and the weight of the needle after loading the dye was 0.01520g, i.e., the weight of the porous needle increased by about 0.2%, whereby it was revealed that the drug was effectively loaded in the pores.
It was confirmed through the examples and experimental examples that the pores are well formed on the surface of the porous acupuncture needle of the present invention to have a high specific surface area, and the drug is also smoothly loaded in the pores formed on the surface. It is expected that the therapeutic effect of the acupuncture can be greatly improved by using the porous needle of the present invention.
Claims (10)
1. A porous acupuncture needle characterized by being 100 μm in each2The surface area comprises 5-20 holes.
2. The porous acupuncture needle as claimed in claim 1, wherein the average diameter of the pores is 0.05 to 3 μm.
3. The porous acupuncture needle as claimed in claim 1, wherein the average depth of the pores is 1 to 3 μm.
4. The porous acupuncture needle as claimed in claim 1, wherein the pores are loaded with a drug.
5. The porous acupuncture needle as claimed in any one of claims 1 to 4, wherein the specific surface area is from 0.0150 to 0.0350 square meters per gram, as measured by the method of calculating the specific surface area after measuring the amount of the methylene blue solution stained on the surface of the needle.
6. The porous acupuncture needle of claim 5, comprising 45 to 46% of iron (Fe), 17 to 19% of chromium (Cr), 30 to 34% of carbon (C), 2 to 3% of nickel (Ni), and 1.5 to 2% of aluminum (Al) when measured by an Energy Dispersive Spectrometer (EDS).
7. A method for manufacturing a porous acupuncture needle, characterized in that a porous structure is formed on the surface of the needle by subjecting the needle to an anodic oxidation treatment process.
8. The method of preparing a porous acupuncture needle according to claim 7, wherein the anodizing process is performed in an electrolyte comprising the needle and a carbon electrode, the needle serves as a (+) pole and the carbon electrode serves as a (-) pole, and the anodizing process is performed by applying a direct current voltage of 20V to 38V for 30 minutes to 2 hours.
9. The method of manufacturing a porous acupuncture needle as claimed in claim 8, wherein the electrolyte includes at least one selected from a glycol solution and a glycerin solution.
10. The method of manufacturing a porous acupuncture needle as claimed in claim 8, wherein the electrolyte is a glycol solution containing 0.1 to 0.5% by weight of ammonium fluoride and 1 to 5% by weight of water.
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| Application Number | Priority Date | Filing Date | Title |
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| KR10-2014-0022655 | 2014-02-26 | ||
| KR1020140022655A KR101458486B1 (en) | 2014-02-26 | 2014-02-26 | Porous acupuncture-needle and Manufacturing method thereof |
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| HK1225953A1 true HK1225953A1 (en) | 2017-09-22 |
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| US (1) | US10245211B2 (en) |
| EP (1) | EP3100709B1 (en) |
| JP (2) | JP6367350B2 (en) |
| KR (1) | KR101458486B1 (en) |
| CN (1) | CN106061455B (en) |
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| WO (1) | WO2015129967A1 (en) |
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| CN106521604A (en) * | 2016-10-17 | 2017-03-22 | 北京科技大学 | Method for preparing nano-porous structure on surfaces of stainless steel and cobalt alloy |
| CN108048894B (en) * | 2017-12-08 | 2019-11-29 | 广东工业大学 | A kind of preparation method of metal-surface nano hole array film |
| KR102060011B1 (en) * | 2019-02-28 | 2019-12-27 | 양판정 | Acupuncture needle packing method and acupuncture needle |
| RU189268U1 (en) * | 2019-03-22 | 2019-05-17 | Артем Олегович Бахметьев | ACUPUNCTURE NEEDLE |
| CN112294640B (en) * | 2020-10-29 | 2023-02-24 | 河北工业大学 | Acupuncture needles with micro-nano surface structure |
| CN119162563A (en) * | 2023-06-19 | 2024-12-20 | 阿特姆·奥列戈维奇·巴赫梅捷夫 | Acupuncture needle for adsorbing heavy metals and toxic metal ions and preparation method and use thereof |
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| JP2008038237A (en) * | 2006-08-10 | 2008-02-21 | National Institute For Materials Science | Method for producing alumina porous structure |
| JP4954656B2 (en) * | 2006-09-28 | 2012-06-20 | 凸版印刷株式会社 | Acicular body and method for producing acicular body |
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| CN101632621B (en) * | 2008-07-22 | 2011-07-13 | 庆达科技股份有限公司 | Porous acupuncture needle |
| US20110245856A1 (en) * | 2010-03-30 | 2011-10-06 | Taiwan Shan Yin International Co., Ltd. | Porous acupuncture needle |
| KR101281722B1 (en) * | 2010-04-09 | 2013-07-04 | 서울대학교산학협력단 | A manufacturing method for enhancing biomolecule loading property implant materials by using porous titania layer and Implant materials fabricated there by |
| DE102010025287A1 (en) * | 2010-06-28 | 2012-01-26 | Stahlwerk Ergste Westig Gmbh | Chromium-nickel steel |
| JP6564187B2 (en) * | 2011-12-05 | 2019-08-21 | ナノ プレシジョン メディカル インコーポレイテッドＮａｎｏ Ｐｒｅｃｉｓｉｏｎ Ｍｅｄｉｃａｌ， Ｉｎｃ． | Drug delivery device having titania nanotube membrane |
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- 2014-02-26 KR KR1020140022655A patent/KR101458486B1/en active Active
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- 2014-07-17 WO PCT/KR2014/006505 patent/WO2015129967A1/en not_active Ceased
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2018
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